ENAGenomicsBioNut, Karolinska Institutethttps://www.ebi.ac.uk/ena/browser/view/PRJNA543233Mus musculusHutchinson-Gilford progeria syndrome (HGPS) is the result of a defective form of the lamin A protein called progerin. While progerin is known to disrupt the properties of the nuclear lamina, the underlying mechanisms responsible for the pathophysiology of HGPS remain less clear. Previous studies in our laboratory have shown that progerin expression in murine epidermal basal cells results in impaired stratification and halted development of the skin. Stratification and differentiation of the epidermis is regulated by asymmetric stem cell division. In this dataset, we include the expression data using Affymetrix array. The samples were obtained from basal and suprabasal keratinocyes from 4-day old wild-type and bitransgenic (BT) mice. Overall design: 12 samples were analyzed. We generated the following pairwise comparisons: bt_low vs wt_low; bt_high vs wt_high;wt_high vs wt_low; bt_high vs bt_low. Unpaired, 2-sided student's t-test and FDR was used to compare the groups. Array: MTA-1_0, mm10.ENADm DWnt3/5, biological signaling, DWnt-5, Nuclear Membranes, DWnt-4, Dint-1, DmelCG4889, Phases, impaired, Gene, l(2)wg, Nuclear Envelopes, Divisions, DWnt-3/5, dysfunctional, wnt-4, int-1, Dm-1, Dm-2, Dm-3, DmelCG1916, Gene Products, Dm Wg, Wnt-4, l(2)02657, Wnt-1, Wnt-3, Wnt-2, M Phases, Cell Division Phase, I, DmelCG6407, Envelope, M, dysfunction, Envelopes, Cell Division, proteins, dWnt, Division, DWnt5, Wnt/Wg, Wnt, WNT, DWnt4, DWnt3, Wnt1, DWnt2, Wnt3, wnt4, Division Phase, wnt3, wnt2, wnt1, Wnt3/5, DmelCG4698, Dwnt5, signaling process, Dwnt4, wnt5, Br, dWnt2, associated, wnt, Sp, single organism signaling, l(2)rO727, Proteins, Cell Divisions, Cell, wgl, partial functionality, spd, clone 2.4, D-wnt-2, Protein, Nuclear, DWint-1, M Phase, CG4889, DWnt3/5, fg, Membranes, Phase, anon-WO03040301.228, Protein., anon-EST:Liang-2.4, WG, CG4698, pooled, Dwnt-2, Dwnt-3, lacks function of type, Membrane, Dm DWnt2, Dm DWnt4, low functionality, signalling, Protein Gene Products, Nuclear Membrane, Gene Proteins, having decreased function, CG1916, signalling process, Dwnt-5, Wg, DWnt-3, DWnt-2, DWnt-1, Gla, CG6407Dm DWnt3/5, biological signaling, DWnt-5, Nuclear Membranes, DWnt-4, Dint-1, DmelCG4889, Phases, impaired, Gene, l(2)wg, Nuclear Envelopes, Divisions, DWnt-3/5, dysfunctional, wnt-4, int-1, Dm-1, Dm-2, Dm-3, DmelCG1916, Gene Products, Dm Wg, Wnt-4, l(2)02657, Wnt-1, Wnt-3, Wnt-2, M Phases, Cell Division Phase, I, DmelCG6407, Envelope, M, dysfunction, Envelopes, Cell Division, proteins, dWnt, Division, DWnt5, Wnt/Wg, Wnt, WNT, DWnt4, DWnt3, Wnt1, DWnt2, Wnt3, wnt4, Division Phase, wnt3, wnt2, wnt1, Wnt3/5, DmelCG4698, Dwnt5, signaling process, Dwnt4, wnt5, Br, dWnt2, associated, wnt, Sp, single organism signaling, l(2)rO727, Proteins, Cell Divisions, Cell, wgl, partial functionality, spd, clone 2.4, D-wnt-2, Protein, Nuclear, DWint-1, M Phase, CG4889, DWnt3/5, fg, Membranes, Phase, anon-WO03040301.228, Protein., anon-EST:Liang-2.4, WG, CG4698, pooled, Dwnt-2, Dwnt-3, lacks function of type, Membrane, Dm DWnt2, Dm DWnt4, low functionality, signalling, Protein Gene Products, Nuclear Membrane, Gene Proteins, having decreased function, CG1916, signalling process, Dwnt-5, Wg, DWnt-3, DWnt-2, DWnt-1, Gla, CG64070.00.00.00.00.0falseAccumulation of progerin affects the symmetry of cell division and is associated with impaired Wnt signaling and the mislocalization of nuclear envelope proteins [Affymetrix]Accumulation of progerin affects the symmetry of cell division and is associated with impaired Wnt signaling and the mislocalization of nuclear envelope proteins [Affymetrix]2022-07-182019-08-16PRJNA543233GSE1313103112820310090