ENAapplication/xmlftp.sra.ebi.ac.uk/vol1/fastq/SRR114/097/SRR11469697/SRR11469697.fastq.gzftp.sra.ebi.ac.uk/vol1/fastq/SRR114/006/SRR11469706/SRR11469706.fastq.gzftp.sra.ebi.ac.uk/vol1/fastq/SRR114/002/SRR11469702/SRR11469702.fastq.gzftp.sra.ebi.ac.uk/vol1/fastq/SRR114/005/SRR11469705/SRR11469705.fastq.gzftp.sra.ebi.ac.uk/vol1/fastq/SRR114/003/SRR11469703/SRR11469703.fastq.gzftp.sra.ebi.ac.uk/vol1/fastq/SRR114/099/SRR11469699/SRR11469699.fastq.gzftp.sra.ebi.ac.uk/vol1/fastq/SRR114/098/SRR11469698/SRR11469698.fastq.gzftp.sra.ebi.ac.uk/vol1/fastq/SRR114/004/SRR11469704/SRR11469704.fastq.gzftp.sra.ebi.ac.uk/vol1/fastq/SRR114/007/SRR11469707/SRR11469707.fastq.gzftp.sra.ebi.ac.uk/vol1/fastq/SRR114/001/SRR11469701/SRR11469701.fastq.gzftp.sra.ebi.ac.uk/vol1/fastq/SRR114/008/SRR11469708/SRR11469708.fastq.gzftp.sra.ebi.ac.uk/vol1/fastq/SRR114/000/SRR11469700/SRR11469700.fastq.gzprimaryOK200GenomicsUC San Diegohttps://www.ebi.ac.uk/ena/browser/view/PRJNA622650We show that the UPR and the IRE1a -XBP1 axis are activated in macrophages during tumor growth, that the conditional knock-out of IRE1a in macrophages regulates the acquisition of a mixed pro-inflammatory/immune suppressive phenotype and is also sufficient to restrain tumor development in vivo. Importantly, we discovered that IRE1a signaling regulates PD-L1 expression in murine and in tumor-infiltrating macrophages in humans.ENA929, B7H1, DmelCG8669, CD274, B7 homolog 1, Programmed death ligand 1, macrophage polarization, 3.1.26.-, 9030414B18Rik, Ire1alpha, hIRE1p, IRE1P, C85377, AI225830, IRE1, Ire1, PD-L1, Tumor, Ire1-alpha, Ire1p, ATF-4, 2.7.11.1, IRE1a, survival, dATF-4, PDCD1LG1, PDCD1L1, Serine|threonine-protein kinase, time of survival., B7-H, ERN1, Ern1, Inositol-requiring protein 1, CG8669, PDCD1 ligand 1, Ire1a, l(2)crc, Ire1b, ATF4/crc, B7-H1, PDL1, Endoribonuclease, Endoplasmic reticulum-to-nucleus signaling 1, Atf40.00.00.00.00.0falseIRE1a controls macrophage polarization, PD-L1 expression and tumor survival2022-05-312020-04-03PRJNA62265010090