ENAapplication/xmlftp.sra.ebi.ac.uk/vol1/fastq/SRR142/079/SRR14208179/SRR14208179.fastq.gzftp.sra.ebi.ac.uk/vol1/fastq/SRR142/076/SRR14208176/SRR14208176.fastq.gzftp.sra.ebi.ac.uk/vol1/fastq/SRR142/085/SRR14208185/SRR14208185.fastq.gzftp.sra.ebi.ac.uk/vol1/fastq/SRR142/074/SRR14208174/SRR14208174.fastq.gzftp.sra.ebi.ac.uk/vol1/fastq/SRR142/077/SRR14208177/SRR14208177.fastq.gzftp.sra.ebi.ac.uk/vol1/fastq/SRR142/083/SRR14208183/SRR14208183.fastq.gzftp.sra.ebi.ac.uk/vol1/fastq/SRR142/081/SRR14208181/SRR14208181.fastq.gzftp.sra.ebi.ac.uk/vol1/fastq/SRR142/075/SRR14208175/SRR14208175.fastq.gzftp.sra.ebi.ac.uk/vol1/fastq/SRR142/072/SRR14208172/SRR14208172.fastq.gzftp.sra.ebi.ac.uk/vol1/fastq/SRR142/086/SRR14208186/SRR14208186.fastq.gzftp.sra.ebi.ac.uk/vol1/fastq/SRR142/073/SRR14208173/SRR14208173.fastq.gzftp.sra.ebi.ac.uk/vol1/fastq/SRR142/084/SRR14208184/SRR14208184.fastq.gzftp.sra.ebi.ac.uk/vol1/fastq/SRR142/080/SRR14208180/SRR14208180.fastq.gzftp.sra.ebi.ac.uk/vol1/fastq/SRR142/078/SRR14208178/SRR14208178.fastq.gzftp.sra.ebi.ac.uk/vol1/fastq/SRR142/082/SRR14208182/SRR14208182.fastq.gzprimaryOK200GenomicsBiochemistry and Biophysics, University of North Carolina at Chapel Hillhttps://www.ebi.ac.uk/ena/browser/view/PRJNA721187Homo sapiensWe overproduced human cyclin E from a stably-integrated inducible CCNE1 transgene in RPE1-hTERT cells over a period of weeks. CCNE1 overproduction induced replication stress, then slow proliferation, followed by adaptation to normal growth phenotype. We analyzed mRNA transcripts at key points of the timecourse: control, 2 days, 15-18 days, 39-51 days, and at a point several weeks after induction was withdrawn Overall design: Retinal pigmented epithelial (RPE1-hTERT) mRNA profiles of CCNE1 overexpression in adaptation experiment over period of up to 51 daysENAReplications, Ccne, cyclinE, CCNE, AW538188, cycE3, CycE1, Autonomous Replications, CYCLE., DNA, Autonomous Replication, Replication, ccne, DNA Replications, AutonomousReplications, Ccne, cyclinE, CCNE, AW538188, cycE3, CycE1, Autonomous Replications, CYCLE., DNA, Autonomous Replication, Replication, ccne, DNA Replications, Autonomous0.00.00.00.00.0falseTranscriptional adaptation to DNA replication stress induced by CCNE1 overexpressionTranscriptional adaptation to DNA replication stress induced by CCNE1 overexpression2022-05-192021-10-03PRJNA721187GSE171845351730149606