ENAapplication/xmlftp.sra.ebi.ac.uk/vol1/fastq/SRR153/068/SRR15373268/SRR15373268.fastq.gzftp.sra.ebi.ac.uk/vol1/fastq/SRR153/064/SRR15373264/SRR15373264.fastq.gzftp.sra.ebi.ac.uk/vol1/fastq/SRR153/060/SRR15373260/SRR15373260.fastq.gzftp.sra.ebi.ac.uk/vol1/fastq/SRR153/069/SRR15373269/SRR15373269.fastq.gzftp.sra.ebi.ac.uk/vol1/fastq/SRR153/063/SRR15373263/SRR15373263.fastq.gzftp.sra.ebi.ac.uk/vol1/fastq/SRR153/061/SRR15373261/SRR15373261.fastq.gzftp.sra.ebi.ac.uk/vol1/fastq/SRR153/066/SRR15373266/SRR15373266.fastq.gzftp.sra.ebi.ac.uk/vol1/fastq/SRR153/062/SRR15373262/SRR15373262.fastq.gzftp.sra.ebi.ac.uk/vol1/fastq/SRR153/059/SRR15373259/SRR15373259.fastq.gzftp.sra.ebi.ac.uk/vol1/fastq/SRR153/067/SRR15373267/SRR15373267.fastq.gzftp.sra.ebi.ac.uk/vol1/fastq/SRR153/065/SRR15373265/SRR15373265.fastq.gzftp.sra.ebi.ac.uk/vol1/fastq/SRR153/070/SRR15373270/SRR15373270.fastq.gzprimaryOK200GenomicsThe Wistar Institutehttps://www.ebi.ac.uk/ena/browser/view/PRJNA752633Alternative cleavage and polyadenylation (APA) of pre-mRNAs yields multiple transcripts differing for their 3'end and its regulation is often dysregulated in human cancers, including prostate cancer (PC). Herein, we uncovered a novel mechanism of APA regulation that impinges on the functional interaction between the 5'-3' exonuclease XRN2 and the RNA binding protein Sam68.ENAK16E1_2, AtXRN2, prostate cancer cell, P62, Polyadenylations, dRAT1, Src-associated in mitosis 68 kDa protein, prostate tumour cell., CG10354, GAP-associated tyrosine phosphoprotein p62, Programs, prostate tumor cell, DmelCG10354, TAP1, K16E1.2, RAT1, dhp1, p62, HKE1, p21 Ras GTPase-activating protein-associated p62, p68, EXORIBONUCLEASE 2, exoribonuclease 2, Xrn2, XRN2, prostate carcinoma cell, Sam680.00.00.00.00.0falseA functional complex between XRN2 and Sam68 orchestrates an alternative polyadenylation program involved in prostate cancer cell cycle progression2022-05-232021-08-10PRJNA7526339606