ENAapplication/xmlftp.sra.ebi.ac.uk/vol1/fastq/SRR183/040/SRR18393840/SRR18393840_2.fastq.gzftp.sra.ebi.ac.uk/vol1/fastq/SRR183/042/SRR18393842/SRR18393842_2.fastq.gzftp.sra.ebi.ac.uk/vol1/fastq/SRR183/039/SRR18393839/SRR18393839_1.fastq.gzftp.sra.ebi.ac.uk/vol1/fastq/SRR183/041/SRR18393841/SRR18393841_1.fastq.gzftp.sra.ebi.ac.uk/vol1/fastq/SRR183/042/SRR18393842/SRR18393842_1.fastq.gzftp.sra.ebi.ac.uk/vol1/fastq/SRR183/039/SRR18393839/SRR18393839_2.fastq.gzftp.sra.ebi.ac.uk/vol1/fastq/SRR183/043/SRR18393843/SRR18393843_2.fastq.gzftp.sra.ebi.ac.uk/vol1/fastq/SRR183/038/SRR18393838/SRR18393838_1.fastq.gzftp.sra.ebi.ac.uk/vol1/fastq/SRR183/037/SRR18393837/SRR18393837_2.fastq.gzftp.sra.ebi.ac.uk/vol1/fastq/SRR183/044/SRR18393844/SRR18393844_1.fastq.gzftp.sra.ebi.ac.uk/vol1/fastq/SRR183/043/SRR18393843/SRR18393843_1.fastq.gzftp.sra.ebi.ac.uk/vol1/fastq/SRR183/037/SRR18393837/SRR18393837_1.fastq.gzftp.sra.ebi.ac.uk/vol1/fastq/SRR183/044/SRR18393844/SRR18393844_2.fastq.gzftp.sra.ebi.ac.uk/vol1/fastq/SRR183/038/SRR18393838/SRR18393838_2.fastq.gzftp.sra.ebi.ac.uk/vol1/fastq/SRR183/041/SRR18393841/SRR18393841_2.fastq.gzftp.sra.ebi.ac.uk/vol1/fastq/SRR183/040/SRR18393840/SRR18393840_1.fastq.gzprimaryOK200GenomicsGerman Cancer Research Centerhttps://www.ebi.ac.uk/ena/browser/view/PRJNA814832<![CDATA[Although colorectal cancer is among the most frequent malignant tumors, thereare currently no mouse models available that reliably mimic both tumor biology as well as treatmentresponse. In this article, we describe a novel mouse model in which mutations relevant to colorectalcancer are induced in mice, leading to tumor formation in the distal colon. The tumors are monitoredvia colonoscopy, and the survival and the histology of the tumors are examined. We demonstrate thatthis model can closely model the human disease clinically, histologically and genetically. In addition,the response of this model to classical colorectal cancer treatments is more realistic than that of othermouse models. The effects of different mutations in the Trp53 gene on tumor cells show strikingdifferences, similar to the effects in other tumor diseases. In summary, the new model allows moreENAmalignant tumor of the large bowel, carcinoma of large bowel, malignant tumor of large intestine, advanced, malignant large bowel tumor, malignant tumour of large bowel, antigen NY-CO-13, p53, carcinoma of the large intestine, malignant neoplasm of large bowel, carcinoma of colorectum, malignant large bowel neoplasm, large intestine carcinoma, somatic, LFS1, malignant large intestine neoplasm, autosomal dominant, Tp53, colorectal cancer, malignant neoplasm of large intestine, bbl, malignant large intestine tumor, colorectum cancer, cancer of colorectum, bfy, CRC, tumor suppressor p53, malignant neoplasm of the large intestine, TP53, large bowel cancer, colorectal cancer with chromosomal instability, malignant large intestine tumour, malignant tumor of large bowel, BCC7, large bowel carcinoma, susceptibility to, malignant tumour of the large intestine, malignant colorectal tumor, colorectum carcinoma, malignant colorectum neoplasm, cancer of large bowel, large intestine cancer, malignant neoplasm of the large bowel, cancer of the large intestine, Trp53, colon cancer, malignant colorectal neoplasm, malignant colorectal tumour, colorectal carcinoma, malignant neoplasm of colorectum, P53, phosphoprotein p53, malignant tumour of the large bowel, p44, malignant tumour of large intestine, cancer of the large bowel, bhy, malignant tumor of the large intestine, TRP53, cancer of large intestine, carcinoma of the large bowel, carcinoma of large intestine, colorectal (colon or rectal) cancer., malignant large bowel tumour, somatic mutation0.00.00.00.00.0falseDifferential Effects of Trp53 Alterations in Murine Colorectal Cancer2022-07-132022-03-20PRJNA81483210090