{"database":"PAXDB","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["http://pax-db.org/downloads/latest/datasets/bioprojects-abundance-files-v4.0.zip"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":{"citationCount":0,"reanalysisCount":0,"viewCount":0,"searchCount":0},"additional":{"omics_type":["Proteomics"],"submitter":["Christian von Mering"],"species":["7159"],"full_dataset_link":["https://pax-db.org/dataset/7159/2018568442"],"submitter_email":["mering@imls.uzh.ch"],"submitter_affiliation":["University of Zurich"],"sample_protocol":[""],"repository":["PAXDB"],"data_protocol":["For the rescaling, the\ndatasets are first parsed or processed such that the data reflect\nproportional abundances of whole protein molecules\n(i.e. proportionality to counts of complete, individual protein\nmolecules, not to molecular weights, protein volumes, or digested\npeptides). In the case of spectral counting data protein. The proportional abundances are rescaled linearly to add up\nto one million; this means the abundance of each protein of\ninterest is finally expressed in (parts per million,) relative to\nall other proteins in a sample. \nFor a given protein abundance dataset, we then compute\nthe absolute log abundance ratios of all pairs of proteins\nannotated to be functionally linked. The median of these absolute\nlog abundance ratios represents an indirect quality\nmetric: the closer it is to zero, the better (i.e. the more there\nis consistency between abundance values and functional annotations\nsuch as protein complexes or pathways). We then\ncompute a background expectation for this metric, by permuting\nthe abundance values in a given dataset randomly,\nand recomputing the median log abundance ratios. The permutation\nis repeated several times, yielding a distribution of\nmedians. The actually observed median is then expressed as a\nZ-score distance to the random distribution ofmedians—this\ndistance is termed the interaction consistency score."],"pubmed_abstract":["Insecticide resistance is a worldwide threat for vector control around the world, and Aedes aegypti, the main vector of several arboviruses, is a particular concern. To better understand the mechanisms of resistance, four isofemale strains originally from French Guiana were isolated and analysed using combined approaches. The activity of detoxification enzymes involved in insecticide resistance was assayed, and mutations located at positions 1016 and 1534 of the sodium voltage-gated channel gene, which have been associated with pyrethroid resistance in Aedes aegypti populations in Latin America, were monitored. Resistance to other insecticide families (organophosphates and carbamates) was evaluated. A large-scale proteomic analysis was performed to identify proteins involved in insecticide resistance. Our results revealed a metabolic resistance and resistance associated with a mutation of the sodium voltage-gated channel gene at position 1016. Metabolic resistance was mediated through an increase of esterase activity in most strains but also through the shifts in the abundance of several cytochrome P450 (CYP450s). Overall, resistance to deltamethrin was linked in the isofemale strains to resistance to other class of insecticides, suggesting that cross- and multiple resistance occur through selection of mechanisms of metabolic resistance. These results give some insights into resistance to deltamethrin and into multiple resistance phenomena in populations of Ae. aegypti."],"pubmed_title":["CYP450 core involvement in multiple resistance strains of Aedes aegypti from French Guiana highlighted by proteomics, molecular and biochemical studies."],"pubmed_authors":["Epelboin Yanouk Y, Wang Lanjiao L, Giai Gianetto Quentin Q, Choumet Valérie V, Gaborit Pascal P, Issaly Jean J, Guidez Amandine A, Douché Thibaut T, Chaze Thibault T, Matondo Mariette M, Dusfour Isabelle I"],"data_synonyms":["Add, DmelCG43443, ADD, ADD-87, Hts-RC, data, AU023367, Data Set, protein complex, supply, Proteins, Ovhts, Gene, HtsRC, CG9325, protein, neutral molecular compounds, protein-containing complex, Dmel_CG9325, Xt, Peptide, 1B1, add, Polypeptides, anon-EST:Posey9, protein polypeptide chains, native protein, peptido, htsRC, GLI3-190, natural protein, polypeptide chain, Add-hts, Protein, CG43443, Gene Products, l(2)k14523, Dmel_CG34197, l(2)00634, median, Ovhts-RC, background, supply and distribution, protein aggregate, all_pairs, molecule, Bph, molecula, Random selection by shearing, oligonucleotide random primer, proportion, HTS-R1, HTS, Hts, molecules, peptides, l(2)k06121, adducin, GLI3FL, distribution, AI854843, proportionality, add-like, HTS-RC, rate, proteins, Molekuel, Pdn, sample population, introduction, Protein Gene Products, Gene Proteins, Adducin, RANDOM, 10^[-6], ppm, sample, supply., quotient, Peptid, peptidos, Polypeptide, Attention Deficit Hyperactivity Disorder, l(2)01103, EST D, CG34197, HtsF, ratio"],"pubmed_title_synonyms":["Peptidomics., Stegomyia aegypti, Strain, nucleocapsid, Sprain, Aedes (Stegomyia) aegypti, core, yellow fever mosquito, Strains, Culex aegypti, Sprains, Strains and Sprains, Aedes aegypti"],"name_synonyms":["mesenteron."],"pubmed_abstract_synonyms":["decamethrin, A_IG005I10.21, 3R)-cis-3-(2, Resistances, Materials, Kinship, F14M4.21, DL3735W, F6G17_50, F14M4.22, MJB24.3, POLYPEPTIDE 7, pyrethroid resistance, FAMILY 77, MJB24.7, Organophosphate, A_IG005I10_21, insecticide susceptibility/resistance, prevention, T20B5_9, Mutations, MFB13_19, SUR2, Cytochrome P 450 Monooxygenase, F4P12.1, Cytochrome P 450 Oxygenase, F6G17_60, Organic Phosphates, F14P1_4, T11J7.16, T11J7.14, F3L17.70, Life Cycle, CYP77A7, Sodium Ion, myd, MOJ9.6, F6G17.50, T11J7_16, T11J7_14, Kinship Network, K24M7_14, MJJ3.9, plant peltate hair, ABERRANT INDUCTION OF TYPE THREE 1, CYP90A, F2P9_2, MFB13.19, Mbp-1, proteins, MDN11.4, CYTOCHROME P450 79F2, DL3710C, K24M7.14, P450 protein, F6G17.60, F3L17_70, T1E3_20, Insecticide Resistances, F6A4.110, Cytochrome P450, F22H5.19, T1E3.20, F6G17_80, CYTOCHROME P450, F13O11.20, F6A4.120, preventive therapy, Arthropod Borne Virus, F13O11.25, F13O11.23, F13O11.24, T29H11.210, THALIAN-DIOL DESATURASE, CYP450 Family, T1E3.4, Cytochrome P-450 Superfamily, cytochrome P450 activity, F6G17.80, DWF3, mKIAA0609, DL3720W, sodium, T22C12_3, DL3600C, natrium, (1S-(1alpha(R*), CYP703, fg, CYP89, F11C18.7, F11C18.9, 2-dibromovinyl)-2, F5G3_8, Cytochrome P 450 Enzymes, CBB3, T26C19.1, expanded, INSDC_feature:gene, MFD22.6, class, MDC1D, F5M6.19, LUTEIN DEFICIENT 5, enr, CYP90, Material, T5J17.120, Phosphoric, F13O11_20, T29H11.200, F5M6_19, Acids, Cytochrome P-450 Enzyme, School-Age Population, (1S-(1alpha(S*), F13O11_24, F13O11_25, F13O11_23, K9E15_12, F6A4.160, big, T4C9.140, DWARF 3, T12H17.80, Biocatalysts, peltate hair, K9E15.12, F1C12_160, F6A4.170, Ion Level, 3 alpha))-3-(2, large, Cytochrome P-450 Families, 3beta))-isomer, K16E1.5, K16E1.6, Gene Products, T12H17_80, Carbamic, YUP8H12R.1, T12H17_100, RED ELONGATED 1, Aedes aegypti, F12B17.50, School-Age Populations, F5A8_3, P-450 Enzymes, T4C9.160, MDDGB6, 2-dimethylcyclopropanecarboxylate, Population, insecticides, T29A15_200, T4C9.150, F21J6.102, Enzyme, SUBFAMILY A, T8K22_12, OMS 1998, F6F3.8, Acid Esters, F21J6.4, F21J6.2, Aminoformic Acids, F13D4_120, K15C23.6, ALTERED TRYPTOPHAN REGULATION 4, F17K2.9, F17K2.8, polypeptide 25, Family Research, LUT5, polypeptide 26, polypeptide 23, insecticide resistance, polypeptide 24, ATR4, polypeptide 21, polypeptide 22, polypeptide 20, K8K14_3, Proteins, polypeptide 18, polypeptide 19, polypeptide 16, polypeptide 17, Culex aegypti, CYTOCHROME P450 MONOOXYGENASE 71B2, T8K22.12, family 735, Family Members, Phosphoric Acid Esters, subfamily K, subfamily H, F5I10.21, subfamily F, subfamily G, RUNT 1, Organic, T4C9.170, subfamily D, native protein, subfamily B, polypeptide 14, F3M18.13, subfamily C, polypeptide 15, polypeptide 12, subfamily A, P450 Enzymes, polypeptide 13, polypeptide 10, polypeptide 11, Strain, proteomic analysis, CYTOCHROME P450 MONOOXYGENASE, Resistance, THAD, polypeptide 30 pseudogene, family 71 subfamily B, F3F19_13, Sodium, scales, K-othrin, KAO1, THAD1, P-450 Enzyme, T3A4.4, F3F19.10, F5I10_21, F3F19.11, F3F19.12, Sodium Ion Level, F3F19.13, RNT1, F1M20_23, School Age Populations., RED1, prophylaxis, ATT1, Na, Natrium, polypeptide 38, School Age Populations, Gene Proteins, Superfamily, T20P8.6, F18A5.160, T20P8.5, polypeptide 36, socioeconomic factors, polypeptide 37, control, polypeptide 34, Families, cytochrome P450, polypeptide 35, polypeptide 32, polypeptide 33, T18B16_200, polypeptide 30, polypeptide 31, F1M20.23, F1M20.22, polypeptide 29, polypeptide 27, polypeptide 28, Sodium 23, Relatives, CYTOCHROME P450 MONOOXYGENASE 83B1, General activity, Carbamate, F1M20_22, Networks, F18A5_160, scale tissue, T12C24_27, F7D19.15, Activity, Esters, selection process, Mbp1, REDUCED EPIDERMAL FLUORESCENCE 2, Cytochrome P 450, Aminoformic, MXI10.18, polypeptide 2, School-Age, polypeptide 1, ENT-KAURENOIC ACID OXYDASE 1, sodio, T9E8.50, MOJ9_6, polypeptide 8, F7D19_15, polypeptide 7, F3O9_20, polypeptide 9, polypeptide 4, polypeptide 3, Monooxygenase, polypeptide 6, polypeptide 5, Virus, deltamethrin, MXI10_18, T9E8_50, CYTOCHROME P450 MONOOXYGENASE 91A2, REF2, prevention and control, F3O9.20, family 703, Family Life Cycle, F13P17.35, F2P9.2, family 707, family 706, family 705, F14P1.4, UNFERTILIZED EMBRYO SAC 9, family 709, MDN11_4, SUPERROOT 2, T9I4.17, reference sample, enzymes, YUP8H12.23, F3F19_10, F25C20_25, F25C20_24, F3F19_12, F3F19_11, F3M18_13, family 710, MJJ3_9, CYP81F1, family 715, family 714, F13P17.22, F25C20.25, F25C20.24, family 712, preventive measures, family 718, T24P15_16, FCAALL.274, NRDC 161, FCAALL.270, Aedes (Stegomyia) aegypti, T20B5.9, T12C24.27, Strains, Family Life Cycles, T24P15.16, family 722, YUP8H12_23, T9I4_17, 3alpha))-isomer, family 721, MJB24_3, AT5G57250, MJB24_7, Cytochrome P 450 Enzyme System, F6A4_110, Arthropod-Borne, Cytochrome P450 Superfamily, gyltl1b-b, Arthropod-Borne Viruses, P 450 Enzyme, CYP, Sodium-23, F6A4_120, T22C12.3, Cytochrome P-450 Enzymes, School Age, MDDGA6, Stegomyia aegypti, P-450, F21F23_15, T5J17_120, T20D16.18, Genetic Materials, P450 Enzyme, Arthropod-Borne Virus, T20D16.15, Filiation, KIAA0609, F5G3.8, Arbovirus, Genetic Material, T20D16_15, CYTOCHROME P450 90A1, FCAALL.208, alpha-cyano-3-phenoxybenzyl (1R, F21F23.15, T20D16_18, Phosphates, Populations, gyltl1b, F12B17_50, mdc1d, F12B17.40, K16E1_6, K16E1_5, Cytochrome p450 Families, pyrethroid susceptibility/resistance, Life Cycles, T9E8.30, enlarged, F12B17_40, Biocatalyst, T9E8_30, Cistron, Strains and Sprains, CYTOCHROME P450 MONOOXYGENASE 81F1, Cytochrome, Insecticide, Family Member, Cytochrome P-450 Oxygenase, F17K2.10, F17K2.11, CABBAGE 3, Gene, KLU, Network, froggy, Gyltl1a, MYH9.18, Cytochrome P 450 Dependent Monooxygenase, T18B16.200, T4C9_140, F13D4.120, Phosphoric Acid, F5A8.3, MYH9_18, F6A4_160, Sprains, Level, Cytochrome P-450, T29H11.190, Genetic, Viruses, F11C18.12, Research, F14M2.15, LARGE, F14M2.14, F6A4_170, F6F3_8, P450, F14M2_14, F14M2_15, Decis, BPFD#36, CYP450 Superfamily, Cytochrome P 450 Enzyme, great, K15C23_6, cyano(3-phenoxyphenyl)methyl ester, CONSTITUTIVE PHOTOMORPHOGENIC DWARF, Kinship Networks, Organopyrophosphates, School Age Population, F6F3.25, Family, Controlled, Controlling, F21J6_102, (1R-(1 alpha(S*), T4C9_170, FCAALL.280, P 450 Enzymes, Sprain, Difexon, yellow fever mosquito, CYP450, FCAALL.277, enzyme activity, T20P8_6, KLUH, T20P8_5, Carbamic Acids, F6G17.1, Cistrons, F6G17.6, Cytochrome P-450-Dependent Monooxygenase, F6G17.5, F6G17.8, family 90, Enzymes, 2-dimethylcyclopropanecarboxylic acid, T3A4_4, CYP90A1, family 93, family 91, F6G17.10, family 98, family 97, Protein, F1C12.160B, F1C12.160A, F6G17_10, (1R-(1alpha(R*), F11F12_12, T29A15.200, family 83, Arthropod Borne Viruses, family 82, family 81, Cytochrome P-450 Monooxygenase, family 87, DL3725W, scale, family 86, T4C9_150, family 89, family 88, 2-dibromoethenyl)-2, F1C12.160, Butox, Cytochrome P 450 Superfamily, F6G17_20, F6G17.20, YUP8H12R_1, Protein Gene Products, T21P5.11, 11Na, F8N16.14, family 72, family 71, F8N16.15, ATKAO1, T4C9_160, family 76, Cytochrome P-450-Dependent, family 79, family 78, family 77, F11F12.12, F11F12.13, F8N16_14, F8N16_15, (1R-(1alpha(S*), T12H17.100, Cytochrome P 450 Families, K8K14.3, esterase activity, F11F12_13, T21P5_11"],"citation_count":["0"],"additional_accession":[]},"is_claimable":false,"name":"Aaegypti - Midgut, iBAQ (Epelboinetal,plosone2021)","description":"abundance based on iBAQ, Interaction consistency score: 18.5, Coverage: 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