PAXDB

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http://pax-db.org/downloads/latest/datasets/bioprojects-abundance-files-v4.0.zipprimaryOK2000000ProteomicsChristian von Mering665571https://pax-db.org/dataset/665571/2036724706mering@imls.uzh.chUniversity of ZurichPAXDBFor the rescaling, the datasets are first parsed or processed such that the data reflect proportional abundances of whole protein molecules (i.e. proportionality to counts of complete, individual protein molecules, not to molecular weights, protein volumes, or digested peptides). In the case of spectral counting data protein. The proportional abundances are rescaled linearly to add up to one million; this means the abundance of each protein of interest is finally expressed in (parts per million,) relative to all other proteins in a sample. For a given protein abundance dataset, we then compute the absolute log abundance ratios of all pairs of proteins annotated to be functionally linked. The median of these absolute log abundance ratios represents an indirect quality metric: the closer it is to zero, the better (i.e. the more there is consistency between abundance values and functional annotations such as protein complexes or pathways). We then compute a background expectation for this metric, by permuting the abundance values in a given dataset randomly, and recomputing the median log abundance ratios. The permutation is repeated several times, yielding a distribution of medians. The actually observed median is then expressed as a Z-score distance to the random distribution ofmedians—this distance is termed the interaction consistency score.Proteins carry out the vast majority of functions in all biological domains, but for technological reasons their large-scale investigation has lagged behind the study of genomes. Since the first essentially complete eukaryotic proteome was reported1, advances in mass-spectrometry-based proteomics2 have enabled increasingly comprehensive identification and quantification of the human proteome3-6. However, there have been few comparisons across species7,8, in stark contrast with genomics initiatives9. Here we use an advanced proteomics workflow-in which the peptide separation step is performed by a microstructured and extremely reproducible chromatographic system-for the in-depth study of 100 taxonomically diverse organisms. With two million peptide and 340,000 stringent protein identifications obtained in a standardized manner, we double the number of proteins with solid experimental evidence known to the scientific community. The data also provide a large-scale case study for sequence-based machine learning, as we demonstrate by experimentally confirming the predicted properties of peptides from Bacteroides uniformis. Our results offer a comparative view of the functional organization of organisms across the entire evolutionary range. A remarkably high fraction of the total proteome mass in all kingdoms is dedicated to protein homeostasis and folding, highlighting the biological challenge of maintaining protein structure in all branches of life. Likewise, a universally high fraction is involved in supplying energy resources, although these pathways range from photosynthesis through iron sulfur metabolism to carbohydrate metabolism. Generally, however, proteins and proteomes are remarkably diverse between organisms, and they can readily be explored and functionally compared at www.proteomesoflife.org.The proteome landscape of the kingdoms of life.Müller Johannes B JB, Geyer Philipp E PE, Colaço Ana R AR, Treit Peter V PV, Strauss Maximilian T MT, Oroshi Mario M, Doll Sophia S, Virreira Winter Sebastian S, Bader Jakob M JM, Köhler Niklas N, Theis Fabian F, Santos Alberto A, Mann Matthias MAdd, DmelCG43443, ADD, ADD-87, Hts-RC, data, AU023367, Data Set, protein complex, supply, Proteins, Ovhts, Gene, HtsRC, CG9325, protein, neutral molecular compounds, protein-containing complex, Dmel_CG9325, Xt, Peptide, 1B1, add, Polypeptides, anon-EST:Posey9, protein polypeptide chains, native protein, peptido, htsRC, GLI3-190, natural protein, polypeptide chain, Add-hts, Protein, CG43443, Gene Products, l(2)k14523, Dmel_CG34197, l(2)00634, median, Ovhts-RC, background, supply and distribution, protein aggregate, all_pairs, molecule, Bph, molecula, Random selection by shearing, oligonucleotide random primer, proportion, HTS-R1, HTS, Hts, molecules, peptides, l(2)k06121, adducin, GLI3FL, distribution, AI854843, proportionality, add-like, HTS-RC, rate, proteins, Molekuel, Pdn, sample population, introduction, Protein Gene Products, Gene Proteins, Adducin, RANDOM, 10^[-6], ppm, sample, supply., quotient, Peptid, peptidos, Polypeptide, Attention Deficit Hyperactivity Disorder, l(2)01103, EST D, CG34197, HtsF, ratiolife., total expressed protein, lifespan, Proteomes, entire lifespan, entire life cycleKoerper., organism, whole body, multi-cellular organism, whole organism, animal, bodyscale tissue, Product, FON1, Mbp1, Non-Governmental Organizations, protein, FLORAL ORGAN NUMBER 1, NK/GPI., Photosynthetic Carbon Fixation, peptide, Polypeptides, protein polypeptide chains, peptido, Biological, GRP1, Grp1, SUP, Living Arrangements, 26Fe, Analysis, Biological Product, Work Flow, protein aggregate, Transfer, Gpi-1, myd, Carbon Fixation, WMS, Divorced, Biologic Drugs, Man (Taxonomy), peptides, Genomes, Natural, Nlk, entire life cycle, plant peltate hair, Comparative Genomics, Machine, PTPSTEP, Bdr, Mbp-1, Homeostases, proteins, Divorces, Biological Drugs, Super protein, Calvin-Benson-Bassham, sp, SNAP-25, Biological Medicine, l(2)k08110, Medicine, Case Histories, Birth Place, Calvin, Medicines, Organizations, GPHYSD2, Biologic Drug, SGS, GPH, Gpi, Communities, Genomics, organisation, Biologic Products, gyltl1b-b, statistics and numerical data, Comparative, Modern, Learning, Calvin Benson Cycle, Functional Genomics, predicted, ACMICD, Spectroscopy, Workflows, Iron 56, mOC-X, Biopharmaceuticals, MDDGA6, mKIAA0609, 3.1.3.48, Neighborhood, Biologic Product, GENA70, numerical data, NK|GPI, Case Studies, KIAA0609, fg, carbohydrate metabolism, Org, ORG, gyltl1b, Iron, Step, CG11628, Biological Medicines, Nongovernmental, Biological Drug, life, administrative structure, mdc1d, expanded, Spectrometry, Gpi1-r, Calvin Benson Bassham Cycle, Gpi1-s, Biologics, Striatum-enriched protein-tyrosine phosphatase, MASS, Gpi1-t, human, Fe, organ system, MDC1D, Health, Eisen, enr, enlarged, STEP, Arrangement, Residence Characteristic, Polypeptide, Residential Selection, iron, Proteomes, Work Flows, Bglap-rs1, Community, sulphur metabolism, Gpi1s, FLORAL DEFECTIVE 10, big, lifespan, human being, GRP1/cytohesin 1, Biologic Pharmaceuticals, conformation, Health Resource, Peptidomics, AI461847, peltate hair, number, FBN, Gene, organization and administration, Protein Homeostasis, SUPERMAN, Reductive Pentose Phosphate Cycle, protein-containing complex, body system, froggy, Gyltl1a, Human, CG11633, cytohesin/GRP1, large, Structural, Homo sapiens, polypeptide chain, utilization, ECTOL1, Metabolism, Photosynthesis Dark Reactions, Cycle, single-organism carbohydrate metabolic process, Gene Products, Functional, system, Pgi, Non-Governmental, Separated, Man, Resources, Biologicals, Drugs, study, Transfer Learning, Organization, hierro, multicellular organismal carbohydrate metabolic process, anatomical systems, entire lifespan, Gpi-1r, MDDGB6, Gpi-1s, Spectrum, Phi, Natural Product, Gpi-1t, l(2)SH2 0323, LARGE, man, Case Study, Proteostases, OCTD, Living Arrangement, BPFD#36, Mif1, Domiciles, Living, Neural-specific protein-tyrosine phosphatase, Non-Governmental Organization, great, Calvin-Benson-Bassham Cycle, peptidos, species, organization, Dark Reactions of Photosynthesis, relational structural quality, Biologic, Pharmaceuticals, Products, data, Place of Birth, use, organizational structure, Biologic Medicines, protein complex, Photosynthetic, Proteins, Protein Homeostases, Photosynthesis Dark Reaction, fer, total expressed protein, stepk, Synaptosomal-associated 25 kDa protein, MF, Amf, Peptide, polypeptide, Neighborhoods, native protein, Resource, natural protein, Protein, Biopharmaceutical, sequence, MFS1, Calvin-Benson Cycle, scales, connected anatomical system, Nongovernmental Organizations, l(2)SH0323, WMS2, NK, sulfur metabolism, CYH1, administrative management, Separation, ferrum, Homeostasis, scale, Separations, sulphur metabolic process, FLO10, Iron-56, HERP, Carbohydrate, primary structure of sequence macromolecule, DmelCG11628, Protein Gene Products, Drug, Gene Proteins, Non Governmental Organizations, Calvin Cycle, SNAP, Modern Man, SSKS, cardinality, Natural Products, organizational management, Structural Genomics, Peptid, Calvin-Benson, Nongovernmental Organization, Domicile0falseS.thermophila DSM 6192 - Whole organism, SC (Muelleretal,nature2020)abundance based on Spectral counting, Interaction consistency score: 8.7, Coverage: 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