{"database":"PeptideAtlas","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Fasta":["ftp://ftp.peptideatlas.org/pub/PeptideAtlas/Repository/Leptospira_interrogans/PAe000350/PAe000350_469_searchdatabase_sequest.fasta"],"Other":["ftp://ftp.peptideatlas.org/pub/PeptideAtlas/Repository/Leptospira_interrogans/PAe000350/PAe000350_Search_Results_469_201106160815.tar.gz","ftp://ftp.peptideatlas.org/pub/PeptideAtlas/Repository/Leptospira_interrogans/PAe000350/PAe000350_mzXML_201106160814.tar.gz","ftp://ftp.peptideatlas.org/pub/PeptideAtlas/Repository/Leptospira_interrogans/PAe000350/PAe000350_mzXML_201106160814.properties","ftp://ftp.peptideatlas.org/pub/PeptideAtlas/Repository/Leptospira_interrogans/PAe000350/PAe000350_prot_469_201106160816.properties","ftp://ftp.peptideatlas.org/pub/PeptideAtlas/Repository/Leptospira_interrogans/PAe000350/PAe000350_README","ftp://ftp.peptideatlas.org/pub/PeptideAtlas/Repository/Leptospira_interrogans/PAe000350/PAe000350_469_search.params.tar.gz","ftp://ftp.peptideatlas.org/pub/PeptideAtlas/Repository/Leptospira_interrogans/PAe000350/PAe000350_469_sequest.params.gz","ftp://ftp.peptideatlas.org/pub/PeptideAtlas/Repository/Leptospira_interrogans/PAe000350/PAe000350_469_sequest.params","ftp://ftp.peptideatlas.org/pub/PeptideAtlas/Repository/Leptospira_interrogans/PAe000350/PAe000350_prot_469_201106160816.tar.gz","ftp://ftp.peptideatlas.org/pub/PeptideAtlas/Repository/Leptospira_interrogans/PAe000350/PAe000350_Search_Results_469_201106160815.properties"]},"type":"primary"},"statusCodeValue":200,"statusCode":"OK"}],"scores":null,"additional":{"submitter":["Malmstr�m J, Beck M, Schmidt A, Lange V, Deutsch EW, Aebersold R"],"disease":[""],"software":["TPP"],"full_dataset_link":["'https://db.systemsbiology.net/sbeams/cgi/PeptideAtlas/ManageTable.cgi?TABLE_NAME=AT_sample&sample_id=382'"],"synonyms":[""],"submitter_email":["","malmstroem@imsb.biol.ethz.ch"],"repository":["PeptideAtlas"],"sample_protocol":[""],"data_protocol":[""],"omics_type":["Proteomics"],"pubmed":[""],"instrument_platform":["LTQ FT"],"project_tag":[""],"species":["Leptospira Interrogans"],"publication":[""],"pubmed_abstract":["Mass-spectrometry-based methods for relative proteome quantification have broadly affected life science research. However, important research directions, particularly those involving mathematical modelling and simulation of biological processes, also critically depend on absolutely quantitative data--that is, knowledge of the concentration of the expressed proteins as a function of cellular state. Until now, absolute protein concentration measurements of a considerable fraction of the proteome (73%) have only been derived from genetically altered Saccharomyces cerevisiae cells, a technique that is not directly portable from yeast to other species. Here we present a mass-spectrometry-based strategy to determine the absolute quantity, that is, the average number of protein copies per cell in a cell population, for a large fraction of the proteome in genetically unperturbed cells. Applying the technology to the human pathogen Leptospira interrogans, a spirochete responsible for leptospirosis, we generated an absolute protein abundance scale for 83% of the mass-spectrometry-detectable proteome, from cells at different states. Taking advantage of the unique cellular dimensions of L. interrogans, we used cryo-electron tomography morphological measurements to verify, at the single-cell level, the average absolute abundance values of selected proteins determined by mass spectrometry on a population of cells. Because the strategy is relatively fast and applicable to any cell type, we expect that it will become a cornerstone of quantitative biology and systems biology."],"pubmed_title":["Proteome-wide cellular protein concentrations of the human pathogen Leptospira interrogans."],"pubmed_authors":["Malmström Johan J, Beck Martin M, Schmidt Alexander A, Lange Vinzenz V, Deutsch Eric W EW, Aebersold Ruedi R"],"additional_accession":[]},"is_claimable":false,"name":"Li_LTQFT","description":"Li_LTQFT","dates":{"publication":"2009-12-31","export":"2016-03-29"},"accession":"PAe000350","cross_references":{"pubmed":["19606093"],"IPI":["IPI00009866","IPI00009867","IPI00019359","IPI00021304","IPI00032541","IPI00174775","IPI00217963","IPI00218819","IPI00220327","IPI00240020","IPI00290078","IPI00295684","IPI00297795","IPI00300052","IPI00300053","IPI00383759","IPI00431749"],"NCBI":["45655586","45655587","45655593","45655594","45655596","45655598","45655603","45655605","45655609","45655610","45655611","45655612","45655613","45655614","45655615","45655618","45655619","45655620","45655627","45655631","45655632","45655633","45655637","45655641","45655645","45655647","45655648","45655660","45655661","45655663","45655665","45655666","45655668","45655672","45655673","45655676","45655679","45655680","45655681","45655683","45655684","45655685","45655696","45655697","45655698","45655718","45655719","45655720","45655723","45655724","45655725","45655726","45655727","45655728","45655730","45655735","45655738","45655742","45655743","45655744","45655747","45655748","45655754","45655757","45655767","45655772","45655773","45655774","45655776","45655777","45655780","45655784","45655785","45655788","45655789","45655796","45655797","45655798","45655800","45655802","45655803","45655806","45655807","45655808","45655814","45655815","45655816","45655817","45655824","45655825","45655829","45655834","45655839","45655840","45655841","45655845","45655847","45655849","45655850","45655916","45655919","45655920","45655923","45655925","45655931","45655933","45655934","45655938","45655942","45655943","45655951","45655952","45655953","45655959","45655960","45655962","45655964","45655968","45655974","45655977","45655978","45655979","45655980","45655982","45655983","45655988","45655989","45655990","45655991","45655993","45655996","45656004","45656005","45656006","45656013","45656015","45656016","45656017","45656022","45656024","45656025","45656027","45656030","45656032","45656033","45656034","45656035","45656037","45656042","45656044","45656047","45656048","45656050","45656051","45656054","45656055","45656059","45656063","45656064","45656066","45656067","45656068","45656069","45656072","45656073","45656080","45656081","45656082","45656083","45656096","45656103","45656107","45656108","45656112","45656113","45656114","45656115","45656116","45656119","45656120","45656121","45656123","45656124","45656126","45656127","45656129","45656131","45656135","45656136","45656137","45656138","45656140","45656142","45656146","45656149","45656156","45656157","45656158","45656161","45656163","45656171","45656172","45656173","45656176","45656181","45656184","45656186","45656187","45656190","45656194","45656205","45656206","45656213","45656214","45656215","45656218","45656219","45656221","45656222","45656225","45656229","45656230","45656241","45656243","45656248","45656251","45656252","45656254","45656256","45656260","45656261","45656263","45656264","45656266","45656267","45656269","45656280","45656282","45656283","45656284","45656286","45656287","45656290","45656296","45656299","45656302","45656303","45656305","45656309","45656311","45656313","45656315","45656319","45656321","45656327","45656328","45656329","45656330","45656331","45656333","45656338","45656339","45656342","45656343","45656344","45656345","45656346","45656349","45656350","45656357","45656358","45656362","45656363","45656368","45656370","45656371","45656373","45656380","45656381","45656382","45656384","45656405","45656406","45656410","45656416","45656417","45656418","45656419","45656420","45656421","45656422","45656423","45656430","45656432","45656436","45656441","45656443","45656444","45656445","45656446","45656447","45656448","45656449","45656452","45656455","45656456","45656463","45656468","45656469","45656476","45656479","45656480","45656481","45656484","45656485","45656490","45656492","45656494","45656497","45656498","45656499","45656500","45656504","45656505","45656506","45656510","45656513","45656518","45656519","45656520","45656521","45656522","45656526","45656527","45656529","45656532","45656538","45656541","45656553","45656559","45656560","45656561","45656562","45656570","45656576","45656577","45656578","45656579","45656588","45656590","45656597","45656598","45656609","45656610","45656611","45656612","45656616","45656617","45656622","45656628","45656629","45656632","45656634","45656636","45656642","45656643","45656644","45656645","45656646","45656647","45656648","45656649","45656650","45656654","45656655","45656656","45656657","45656658","45656659","45656662","45656663","45656666","45656680","45656681","45656682","45656683","45656684","45656685","45656686","45656688","45656690","45656691","45656700","45656703","45656705","45656706","45656725","45656726","45656729","45656733","45656734","45656736","45656738","45656739","45656741","45656742","45656743","45656744","45656745","45656748","45656749","45656750","45656751","45656753","45656754","45656765","45656767","45656768","45656769","45656770","45656774","45656791","45656792","45656793","45656802","45656807","45656809","45656811","45656816","45656819","45656835","45656836","45656837","45656840","45656843","45656846","45656852","45656857","45656858","45656861","45656862","45656866","45656872","45656873","45656875","45656876","45656881","45656890","45656891","45656893","45656896","45656899","45656900","45656902","45656907","45656908","45656909","45656910","45656912","45656920","45656930","45656932","45656935","45656942","45656943","45656945","45656946","45656949","45656950","45656951","45656954","45656955","45656958","45656966","45656969","45656970","45656973","45656975","45656979","45656980","45656985","45656989","45656990","45656994","45656995","45656996","45656997","45656999","45657006","45657012","45657020","45657021","45657024","45657025","45657026","45657031","45657032","45657036","45657038","45657043","45657046","45657047","45657051","45657059","45657060","45657061","45657066","45657067","45657072","45657076","45657078","45657079","45657080","45657081","45657082","45657085","45657086","45657087","45657092","45657099","45657102","45657107","45657114","45657116","45657120","45657122","45657123","45657124","45657125","45657126","45657127","45657140","45657141","45657142","45657144","45657145","45657147","45657150","45657153","45657156","45657159","45657160","45657162","45657170","45657171","45657174","45657175","45657176","45657178","45657179","45657180","45657182","45657190","45657207","45657209","45657212","45657213","45657214","45657216","45657222","45657228","45657230","45657231","45657232","45657233","45657237","45657240","45657241","45657242","45657247","45657248","45657249","45657255","45657256","45657258","45657262","45657266","45657269","45657271","45657275","45657281","45657282","45657283","45657285","45657286","45657287","45657290","45657292","45657293","45657294","45657297","45657298","45657299","45657300","45657307","45657312","45657313","45657314","45657316","45657317","45657318","45657320","45657322","45657330","45657331","45657333","45657336","45657337","45657338","45657343","45657345","45657349","45657354","45657356","45657357","45657358","45657361","45657363","45657364","45657365","45657366","45657373","45657374","45657375","45657376","45657384","45657385","45657387","45657388","45657389","45657390","45657391","45657395","45657396","45657397","45657399","45657400","45657402","45657404","45657405","45657409","45657411","45657412","45657413","45657414","45657417","45657419","45657421","45657422","45657425","45657426","45657428","45657429","45657431","45657432","45657436","45657442","45657443","45657444","45657445","45657446","45657451","45657452","45657453","45657460","45657462","45657467","45657469","45657473","45657474","45657476","45657478","45657479","45657483","45657484","45657485","45657487","45657488","45657489","45657490","45657491","45657492","45657493","45657494","45657495","45657496","45657497","45657499","45657501","45657502","45657505","45657506","45657507","45657508","45657509","45657513","45657514","45657515","45657520","45657522","45657523","45657524","45657525","45657527","45657530","45657536","45657540","45657542","45657544","45657546","45657551","45657553","45657557","45657559","45657561","45657564","45657565","45657567","45657569","45657570","45657573","45657574","45657575","45657577","45657578","45657579","45657582","45657583","45657584","45657586","45657587","45657592","45657594","45657595","45657597","45657603","45657605","45657606","45657607","45657611","45657612","45657613","45657615","45657616","45657617","45657619","45657624","45657625","45657626","45657631","45657632","45657633","45657634","45657635","45657640","45657642","45657643","45657647","45657648","45657650","45657656","45657657","45657659","45657660","45657662","45657663","45657665","45657666","45657668","45657674","45657676","45657678","45657684","45657685","45657686","45657687","45657690","45657692","45657694","45657695","45657697","45657700","45657701","45657702","45657703","45657704","45657707","45657708","45657710","45657711","45657714","45657715","45657716","45657724","45657727","45657734","45657737","45657743","45657747","45657748","45657749","45657752","45657753","45657760","45657761","45657762","45657769","45657772","45657773","45657775","45657779","45657784","45657786","45657787","45657788","45657789","45657797","45657799","45657803","45657806","45657807","45657810","45657813","45657814","45657816","45657817","45657822","45657824","45657825","45657826","45657829","45657830","45657831","45657832","45657835","45657838","45657841","45657843","45657845","45657846","45657853","45657855","45657856","45657861","45657863","45657868","45657869","45657872","45657876","45657877","45657878","45657879","45657883","45657884","45657889","45657908","45657911","45657913","45657918","45657921","45657923","45657930","45657932","45657933","45657934","45657936","45657938","45657939","45657942","45657943","45657944","45657948","45657955","45657956","45657958","45657959","45657960","45657961","45657965","45657971","45657972","45657973","45657974","45657975","45657978","45657981","45657985","45657986","45657987","45657989","45657993","45657999","45658002","45658003","45658006","45658007","45658010","45658011","45658012","45658014","45658015","45658016","45658017","45658018","45658020","45658021","45658023","45658024","45658025","45658026","45658027","45658028","45658029","45658030","45658031","45658032","45658036","45658037","45658038","45658039","45658042","45658043","45658044","45658046","45658047","45658048","45658049","45658050","45658051","45658052","45658054","45658055","45658056","45658059","45658060","45658066","45658070","45658073","45658076","45658079","45658080","45658081","45658082","45658085","45658087","45658089","45658092","45658093","45658094","45658097","45658099","45658103","45658111","45658112","45658118","45658122","45658123","45658124","45658125","45658130","45658133","45658135","45658137","45658138","45658139","45658140","45658142","45658146","45658151","45658152","45658153","45658154","45658155","45658157","45658159","45658161","45658164","45658165","45658166","45658167","45658168","45658169","45658170","45658171","45658172","45658173","45658174","45658175","45658176","45658177","45658179","45658181","45658187","45658188","45658192","45658195","45658196","45658203","45658214","45658217","45658223","45658226","45658228","45658234","45658236","45658238","45658239","45658242","45658243","45658244","45658245","45658246","45658247","45658248","45658250","45658253","45658254","45658257","45658259","45658266","45658267","45658278","45658282","45658283","45658288","45658290","45658291","45658294","45658295","45658296","45658297","45658298","45658299","45658300","45658302","45658303","45658305","45658307","45658308","45658316","45658317","45658318","45658319","45658324","45658326","45658331","45658332","45658334","45658335","45658337","45658342","45658344","45658348","45658356","45658358","45658365","45658366","45658368","45658370","45658371","45658373","45658376","45658377","45658379","45658380","45658381","45658382","45658383","45658385","45658386","45658387","45658392","45658401","45658402","45658404","45658406","45658407","45658409","45658411","45658412","45658413","45658414","45658418","45658419","45658424","45658425","45658427","45658429","45658437","45658440","45658442","45658450","45658451","45658452","45658453","45658455","45658457","45658458","45658464","45658466","45658473","45658474","45658476","45658483","45658485","45658490","45658499","45658503","45658511","45658518","45658520","45658524","45658526","45658527","45658528","45658529","45658530","45658536","45658537","45658540","45658541","45658543","45658553","45658559","45658560","45658564","45658565","45658567","45658568","45658571","45658573","45658576","45658577","45658578","45658579","45658580","45658583","45658585","45658586","45658589","45658593","45658595","45658599","45658600","45658604","45658605","45658607","45658609","45658613","45658614","45658617","45658618","45658624","45658626","45658627","45658632","45658636","45658638","45658642","45658643","45658647","45658651","45658657","45658659","45658664","45658669","45658671","45658675","45658676","45658677","45658678","45658679","45658681","45658682","45658683","45658684","45658685","45658686","45658687","45658688","45658689","45658690","45658691","45658692","45658693","45658695","45658696","45658697","45658698","45658699","45658700","45658701","45658702","45658703","45658704","45658705","45658708","45658713","45658716","45658725","45658731","45658739","45658750","45658752","45658753","45658755","45658756","45658764","45658765","45658769","45658770","45658772","45658782","45658785","45658791","45658793","45658796","45658801","45658806","45658807","45658808","45658811","45658819","45658822","45658836","45658839","45658842","45658844","45658847","45658848","45658849","45658858","45658867","45658872","45658876","45658882","45658885","45658886","45658896","45658897","45658899","45658900","45658906","45658909","45658910","45658914","45658915","45658916","45658918","45658919","45658920","45658926","45658933","45658936","45658945","45658946","45658950","45658951","45658953","45658958","45658959","45658965","45658967","45658972","45658973","45658975","45658976","45658977","45658984","45658985","45658986","45658988","45658990","45658998","45659000","45659002","45659005","45659009","45659016","45659017","45659018","45659023","45659034","45659036","45659037","45659041","45659044","45659045","45659052","45659054","45659058","45659061","45659065","45659066","45659071","45659072","45659078","45659079","45659080","45659083","45659089","45659092","45659097","45659100","45659103","45659106","45659114","45659119","45659120","45659129","45659130","45659132","45659133","45659135","45659137","45659143","45659144","45659145","45659147","45659153","45659157","45659160","45659164","45659166","45659167","45659170","45659172","45659173","45659180","45659183","45659185","45659186","45659189","45659190","45659191","45659202","45659209","45659210","45659211","45659212","45659214","45659216","45659219","45659221","45659222","45659224","45659227","45659230","45659233","45659240","45659245","45659248","45659249","45659251","45659252","45659253","45659256","45659259","45659260","45659266","45659268","45659273","45659276","45659280","45659281","45659285","45659286","45659287","45659289","45659290","45659293","45659295","45659296","45659297","45659298","45659301","45659302","45659304","45659305","45659307"]}}