{"database":"PeptideAtlas","file_versions":[],"scores":null,"additional":{"submitter":["Wu L, Candille SI, Choi Y, Xie D, Jiang L, Li-Pook-Than J, Tang H, Snyder M"],"disease":[""],"software":["TPP"],"full_dataset_link":["'https://db.systemsbiology.net/sbeams/cgi/PeptideAtlas/ManageTable.cgi?TABLE_NAME=AT_sample&sample_id=6344'"],"synonyms":[""],"submitter_email":[""],"tissue":["Others"],"repository":["PeptideAtlas"],"sample_protocol":[""],"data_protocol":[""],"omics_type":["Proteomics"],"pubmed":[""],"instrument_platform":["LTQ Orbitrap Velos"],"project_tag":[""],"species":["Homo Sapiens (human)"],"publication":[""],"pubmed_abstract":["Gene expression differs among individuals and populations and is thought to be a major determinant of phenotypic variation. Although variation and genetic loci responsible for RNA expression levels have been analysed extensively in human populations, our knowledge is limited regarding the differences in human protein abundance and the genetic basis for this difference. Variation in messenger RNA expression is not a perfect surrogate for protein expression because the latter is influenced by an array of post-transcriptional regulatory mechanisms, and, empirically, the correlation between protein and mRNA levels is generally modest. Here we used isobaric tag-based quantitative mass spectrometry to determine relative protein levels of 5,953 genes in lymphoblastoid cell lines from 95 diverse individuals genotyped in the HapMap Project. We found that protein levels are heritable molecular phenotypes that exhibit considerable variation between individuals, populations and sexes. Levels of specific sets of proteins involved in the same biological process covary among individuals, indicating that these processes are tightly regulated at the protein level. We identified cis-pQTLs (protein quantitative trait loci), including variants not detected by previous transcriptome studies. This study demonstrates the feasibility of high-throughput human proteome quantification that, when integrated with DNA variation and transcriptome information, adds a new dimension to the characterization of gene expression regulation."],"pubmed_title":["Variation and genetic control of protein abundance in humans."],"pubmed_authors":["Wu Linfeng L, Candille Sophie I SI, Choi Yoonha Y, Xie Dan D, Jiang Lihua L, Li-Pook-Than Jennifer J, Tang Hua H, Snyder Michael M"],"pubmed_title_synonyms":["Controlling, preventive therapy, Man (Taxonomy), reference sample, protein complex, prophylaxis, Modern, Proteins, familial, Gene, humans., protein, protein-containing complex, prevention, genetic, Protein Gene Products, Human, preventive measures, Gene Proteins, native protein, Homo sapiens, control, Modern Man, Protein, Gene Products, inherited genetic, protein aggregate, constitutitional genetic, hereditary, prevention and control, Man, Controlled"],"description_synonyms":["Controlling, preventive therapy, Man (Taxonomy), reference sample, protein complex, prophylaxis, Modern, Proteins, familial, Gene, humans., protein, protein-containing complex, prevention, genetic, Protein Gene Products, Human, preventive measures, Gene Proteins, native protein, Homo sapiens, control, Modern Man, Protein, Gene Products, inherited genetic, protein aggregate, constitutitional genetic, hereditary, prevention and control, Man, Controlled"],"name_synonyms":["TPSG1, S-adenosyl-L-methionine:thiol S-methyltransferase activity, PRSS31., TMT, thiol methyltransferase activity"],"pubmed_abstract_synonyms":["protein levels, HapMap, Ribonucleic, HapMap Project, Genetic Locus, human being, Materials, DNS, single-organism process, (Deoxyribonucleotide)n, Transcriptome Profile, Processes, number, Gene Expression Profile, Gene, Human Haplotype Map, protein, Trait Loci, Profiles, Spectrum Analyses, protein-containing complex, 2610511A05Rik, Quantitative, presence, Deoxyribonucleic acids, Human, protrusion, BB234005, Human Haplotype Maps, Biological Processes, Biological Phenomenon, Homo sapiens, Deoxyribonucleic Acid, Messenger, Biological, Gene Products, Mass, Project, Analysis, protein aggregate, Phenomenon, Non Polyadenylated, Man, RNA Gene Products, Mass Spectroscopy, Map, Mass Spectrum Analysis, study, International HapMap Project, thymus nucleic acid, Gene Expressions, Genetic, Man (Taxonomy), Analyses, Polyadenylated Messenger, Profile, messenger RNA, Double Stranded, Trait Locus, Deoxyribonucleic acid, International HapMap Projects, Expressions, Signatures, Non-Polyadenylated RNA, genetic, template RNA, Expression Signature, physiological process, Loci, Transcriptomes, Protein G18, Double-Stranded DNA, Expression, (Deoxyribonucleotide)m, deoxyribonucleic acids, Quantitative Trait Loci Genes, DNAn, constitutitional genetic, TAG, BACTS2, Biologic, Gene., ahl4, RNA, International HapMap, anatomical protrusion, Transcriptome, Process, ribose nucleic acid, Polyadenylated, protein complex, DNAn+1, Modern, Proteins, Expression Profiles, Regulation of Gene Expression, ribonucleic acids, familial, Messenger RNA, Maps, total expressed protein, RNS, single organism process, Double-Stranded, Cistrons, Spectrum Analysis, Haplotype Maps, Gene Action, Spectroscopy, Quantitative Trait, (Deoxyribonucleotide)n+m, Gene Expression, count in organism, Expression Regulation, MS, native protein, Human Haplotype, yeast nucleic acid, Poly(A)+ mRNA, Cis, CIS, Ribonukleinsaeure, Quantitative Trait Locus, Expression Signatures, Protein, Gene Expression Signatures, Phenomena, G18, INSDC_feature:mRNA, pentosenucleic acids, Genetic Materials, Ribonucleic acids, Gene Expression Signature, Polyadenylated RNA, Biological Process, ds-DNA, desoxyribose nucleic acid, biological process, Expression Profile, Mass Spectrum Analyses, Genetic Material, Transcriptome Profiles, Polyadenylated Messenger RNA, ribonucleic acid, Acid, covalent modifier, Mass Spectrum, Biologic Phenomena, CIS-1, Epistemology, Poly(A)+ RNA, Non Polyadenylated mRNA, Exhibit, protein_coding_transcript, Projects, mRNA, Poly(A) Tail, Non Polyadenylated RNA, Non-Polyadenylated, Spectrometry, 9030605P22Rik, Ribonucleic Acid, Locus, human, Non-Polyadenylated mRNA, HapMap Projects, International, Protein Gene Products, Gene Action Regulation, Gene Proteins, Phenotypes, Haplotype Map, lymphoblastoid cell, Material, spine, SOCS, Gene Expression Profiles, Modern Man, ds DNA, Desoxyribonukleinsaeure, microarray, Cistron, inherited genetic, DNA, Signature, Polyadenylated mRNA, Suppressor of cytokine signaling, hereditary, Regulation, Poly(A) RNA, Proteomes"],"additional_accession":[]},"is_claimable":false,"name":"HapMap_LCL_TMT_quant_2","description":"Variation and genetic control of protein abundance in humans, 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