Prideapplication/xmlftp://ftp.pride.ebi.ac.uk/pride/data/archive/2016/02/PXD002769/experimentaldesignfile.txtftp://ftp.pride.ebi.ac.uk/pride/data/archive/2016/02/PXD002769/tables.pdfftp://ftp.pride.ebi.ac.uk/pride/data/archive/2016/02/PXD002769/20141113_QEp3_MiWi_SA_B_1.rawftp://ftp.pride.ebi.ac.uk/pride/data/archive/2016/02/PXD002769/20150214_QEp8_MiWi_SA_Bruno_ES2i_1.rawftp://ftp.pride.ebi.ac.uk/pride/data/archive/2016/02/PXD002769/20141103_QEp3_MiWi_SA_day2_2_141105182735.rawftp://ftp.pride.ebi.ac.uk/pride/data/archive/2016/02/PXD002769/20150214_QEp8_MiWi_SA_Bruno_ES2i_3.rawftp://ftp.pride.ebi.ac.uk/pride/data/archive/2016/02/PXD002769/20141103_QEp3_MiWi_SA_Ba_2_141104212541.rawftp://ftp.pride.ebi.ac.uk/pride/data/archive/2016/02/PXD002769/20141103_QEp3_MiWi_SA_day1_2.rawftp://ftp.pride.ebi.ac.uk/pride/data/archive/2016/02/PXD002769/20141103_QEp3_MiWi_SA_day2_2.rawftp://ftp.pride.ebi.ac.uk/pride/data/archive/2016/02/PXD002769/20141113_QEp3_MiWi_SA_B_2.rawftp://ftp.pride.ebi.ac.uk/pride/data/archive/2016/02/PXD002769/20150214_QEp8_MiWi_SA_Bruno_ES2i_2.rawftp://ftp.pride.ebi.ac.uk/pride/data/archive/2016/02/PXD002769/20141127_QEp3_MiWi_SA_Ba_3.rawftp://ftp.pride.ebi.ac.uk/pride/data/archive/2016/02/PXD002769/20141103_QEp3_MiWi_SA_day1_2_141105075605.rawftp://ftp.pride.ebi.ac.uk/pride/data/archive/2016/02/PXD002769/MaxQuantData.zipprimaryOK200003650mmann@biochem.mpg.deMichael WiererMass SpectrometryShotgun proteomicsNot availableReprogrammingQexactiveMaxlfqLc-ms/msB cellsIpshttp://www.ebi.ac.uk/pride/archive/projects/PXD002769B CellEmbryonic Stem CellCells were lysed in 6 M guanidinium chloride buffer, reduced with TCEP and alkylated with CAA. Samples were diluted 10-fold with digestion buffer (20 mM Tris-HCl, pH 8.5, and 10% ACN) and digested with Lys-C and Trypsin overnight. The resulting peptide mixture was desalted on StageTips containing SDB-RPS material. Peptides were separated on 50‐cm columns of ReproSil‐Pur C18‐AQ 1.9μm resin (Dr. Maisch) packed in‐house. Liquid chromatography was performed on an EASY‐nLC 1000 ultra‐high‐pressure system was coupled through a nanoelectrospray source to a Q Exactive mass spectrometer. Peptides were loaded in buffer A (0.1% (v/v) formic acid) and separated applying a non-linear gradient of 5–60% buffer B (0.1% (v/v) formic acid, 80% (v/v) acetonitrile) at a flow rate of 250 nl/min over 240 min. Data acquisition switched between a full scan and 5 data‐dependent MS/MS scans. Multiple sequencing of peptides was minimized by excluding the selected peptide candidates for 45 s.PrideNot availableNo PTMs are included in the datasetMass Spectrometry raw data was analyzed with the MaxQuant proteomics data analysis workflow version 1.5.1.668. Peak lists were searched against the mouse Uniprot FASTA database (2013_05 release) combined with 262 common contaminants by the integrated Andromeda search engine69. False discovery rate was set to 1% for both peptides (minimum length of 7 amino acids) and proteins. ‘Match between runs’ (MBR) with a maximum time difference of 0.7 min was enabled. Relative proteins amounts were determined by the MaxLFQ algorithm70, with a minimum ratio count of two peptides.ProteomicsMultiomicsMatthias MannQ ExactiveDepartment of Proteomics and Signal Transduction, Max-Planck Institute of Biochemistry, Am Klopferspitz 18, Martinsried, GermanyPARTIALMus Musculus (mouse)24336202 Di Stefano B, Sardina JL, van Oevelen C, Collombet S, Kallin EM, Vicent GP, Lu J, Thieffry D, Beato M, Graf T. C/EBPα poises B cells for rapid reprogramming into induced pluripotent stem cells. Nature. 2014 Feb 13;506(7487):235-9 10.1038/nature12885wierer@biochem.mpg.deBiologicalDepartment of Proteomics and Signal Transduction, Max-Planck Institute of Biochemistry, Martinsried, GermanyGermanyCCAAT/enhancer binding protein-α (C/EBPα) induces transdifferentiation of B cells into macrophages at high efficiencies and enhances reprogramming into induced pluripotent stem (iPS) cells when co-expressed with the transcription factors Oct4 (Pou5f1), Sox2, Klf4 and Myc (hereafter called OSKM). However, how C/EBPα accomplishes these effects is unclear. Here we find that in mouse primary B cells transient C/EBPα expression followed by OSKM activation induces a 100-fold increase in iPS cell reprogramming efficiency, involving 95% of the population. During this conversion, pluripotency and epithelial-mesenchymal transition genes become markedly upregulated, and 60% of the cells express Oct4 within 2 days. C/EBPα acts as a 'path-breaker' as it transiently makes the chromatin of pluripotency genes more accessible to DNase I. C/EBPα also induces the expression of the dioxygenase Tet2 and promotes its translocation to the nucleus where it binds to regulatory regions of pluripotency genes that become demethylated after OSKM induction. In line with these findings, overexpression of Tet2 enhances OSKM-induced B-cell reprogramming. Because the enzyme is also required for efficient C/EBPα-induced immune cell conversion, our data indicate that Tet2 provides a mechanistic link between iPS cell reprogramming and B-cell transdifferentiation. The rapid iPS reprogramming approach described here should help to fully elucidate the process and has potential clinical applications.C/EBPα poises B cells for rapid reprogramming into induced pluripotent stem cells.Di Stefano Bruno B, Sardina Jose Luis JL, van Oevelen Chris C, Collombet Samuel S, Kallin Eric M EM, Vicent Guillermo P GP, Lu Jun J, Thieffry Denis D, Beato Miguel M, Graf Thomas T365projections, B Cells, Materials, Bursa-Dependent Lymphocytes, Ass-1, IPS, Epithelial Mesenchymal Transition, B cell, ino1-B, pancreatic deoxyribonuclease, myc-B, DmelCG10798, MYC, Myc, protein, organ process., Atomkern, B430311C09Rik, Oct-4, Productivity, Oct-3, thymonuclease activity, School-Age, protein polypeptide chains, c-MYC, c-Myc, alkaline DNase activity, EG:BACN5I9.1, NF-A3, ips, Oct-3|4, AA408052, Ayu17-449, horsetail nucleus, bacterial-type proximal promoter sequence-specific DNA binding, Monocyte-Derived Macrophage, Oct3/4, EZF, AA959943, symptoms, fold, ARC, myc, Transdifferentiation, iPS cell, protein aggregate, primary stem, Chromatins, bacterial-type cis-regulatory region sequence-specific DNA binding, neuronal nucleus, nucleus atomi, c-myc, DNA endonuclease activity, Migrant Worker, mKIAA1546, dm/dMyc, Nonmigrant, isyna1, proteins, PMNC, Xsox-2, Transient, RGD1311625, DNase I, Acts, ASS, deoxyribonuclease A, B lymphocyte, idiopathic pneumonia syndrome, DNAase activity, papilla, chromosome scaffold, core promoter proximal region DNA binding, Squatters, house mouse, pancreatic DNase activity, bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding, TL, Acta-2, nuclear chromatin, screening, ichthyosis-prematurity syndrome, anatomical protrusion, ysb, dmyc1, AU016757, B Lymphocytes, 3.1.21.1, mouse, lamina, Actsk-1, flanges, Epithelial-Mesenchymal, PMN cell, IPS-1, ANOP3, Dm, School Age, ichthyosis congenita 4, Migrant, EMT, NOP, anop3, shelf, Genetic Materials, cell nucleus, tetraspanin2, Workers, dornava, mMyc, Migrants and Transients, activation, Genetic Material, Monocyte-Derived Macrophages, pancreatic dornase, l(1)G0354, Populations, Factors, sox-2, mice, Transdifferentiations, l(1)G0359, shelves, endodeoxyribonuclease I, promoter proximal region sequence-specific DNA binding, Deoxyribonuclease I, signs, Otf3-rs7, d-myc, projection, ridge, D-Myc, Myc2, DNA depolymerase activity, white blood cell, Sox-2, Niard, bacterial-type RNA polymerase enhancer sequence-specific DNA binding, Otf-4, OTF-3, Otf-3, myc2, primary axis, B-Lymphocyte, Material, spine, ACSVL4, enhancer sequence-specific DNA binding, Migrants, Cistron, deoxyribonuclease (pancreatic), Mouse, ino1-a, School-Age Population, Zie, dMyc1, MRTL, polymorphonuclear cell, CG10798, RGD1565646, cytoplasmic chromatin, noyau atomique, Epithelial Mesenchymal Transformation, dm/myc, Monocyte Derived Macrophages, lamellae, l(1)G0139, OCT4, Oct4, DNase activity, dornavac, Gene, stalk, Kern, Oct3, OCT3, protein-containing complex, Transcription Factor, process of organ, dMyc, dMYC, Migrant Workers, protrusion, lamella, anon-WO03040301.171, MYCC, polypeptide chain, c-myc II, Nop30, bHLHe57, bacterial-type RNA polymerase upstream activating sequence (UAS) sequence-specific DNA binding, IPS 1, nucleo atomico, nuclei, School-Age Populations, Transcription, B-cell, ichthyosis prematurity syndrome, Genetic, alkaline deoxyribonuclease activity, MCOPS3, nucleus of CNS, noyau, nucleo, Transients, E130014J05Rik, Dmyc, DMYc, Nonmigrants, eubacterial-type RNA polymerase regulatory transcription factor sequence-specific DNA binding, Bone Marrow-Derived Macrophage, deoxyribonucleic phosphatase activity, ridges, Worker, Population, epithelial-mesenchymal transition, culm, Gklf, Bone Marrow-Derived, Squatter, FATP4, RNCMYC, Nird, nucleus, transient structure, mesenchymal cell differentiation from epithelial cell, core promoter proximal region sequence-specific DNA binding, proximal promoter sequence-specific DNA binding, Otf4, OTF4, Otf3, OTF3, School Age Population, Oct-3/4, Transition, bHLHe39, laminae, dmyc, GKLF, Transformation, data, INO1, findings, immune cell, protein complex, axis, anatomical process, KIAA1546, cis-regulatory region binding, SRY-box2, enhancer binding, Monocyte Derived, Factor, Cistrons, Cell, MDS, Monocyte-Derived, iPSC, native protein, natural protein, Mus, nervous system nucleus, Protein, dornase activity, Cell Transdifferentiations, Escherichia coli endonuclease I, Nomad, ino1, Epithelial-Mesenchymal Transformation, DNA nuclease activity, flange, Macrophage, congenital ichthyosis type 4, leucocyte, Macrophages, lcc, Bursa-Equivalent Lymphocyte, Bone Marrow Derived Macrophages, ichthyosis congenita IV, nucleus of neuraxis, Otf3g, thymonuclease, Oct3|4, School Age Populations, neuraxis nucleus, processes, process, INOS, Nomads, Bone Marrow-Derived Macrophages, F3P11.18, mcops3, processus, B-lymphocyte, inos, F3P11_18Bru, IPP2A2, Raw, Peptidomics, False, Effects, Aminosaeure, Aminocarbonsaeure, Amino acid, Gene, Spectrum Analyses, alpha-amino acid, PHAPII, Long Term, CG7826, 5730420M11Rik, peptide, period, Polypeptides, peptido, template-activating factor I, Mass, Gene Products, CG7835, CG42273, Min, Del(8)44H, Analysis, Work Flow, Effect, Mass Spectroscopy, DmelCG42273, Mass Spectrum Analysis, Svc, SET, proportion, F, amino acids, peptides, Analyses, TAF-I, Longterm, phosphatase 2A inhibitor I2PP2A, ipp2a2, min, 2pp2a, mAPC, proteins, Long-Term, CG10574, DmelCG4299, AI047805, set, IGAAD, 2PP2A, DmelCG10574, taf-ibeta, dSET, dSet, peptidos, Long-Term Effect, house mouse, Long-Term Effects, ratio, phapii, data, DYRK1, Aminokarbonsaeure, Proteins, mouse, igaad, Longterm Effect, Dmel_CG7826, StF-IT-1, alpha-amino acids, Spectrum Analysis, Peptide, alpha-amino carboxylic acids, Spectroscopy, polypeptide, Workflows, count, Dm1, Mus, I-2PP2A, Dm I-2, Protein, Long Term Effects, I2PP2A, Dyrk1, Mass Spectrum Analyses, Dmel_CG7835, Data Base, Mnb, MNB, AU020952, Mass Spectrum, Amino Acid, Acid, Col4a-1, HLA-DR-associated protein II, Amino acids, DI-2, mice, I-2Dm, CC1, proportionality, Spectrometry, common, rate, CG4299, inhibitor of granzyme A-activated DNase, Amino, AW124434, Longterm Effects, ME-IV, I-2PP1, Protein Gene Products, Gene Proteins, dSET/TAF-Ibeta, 2610030F17Rik, TAF-IBETA, Data, quotient, Peptid, Mouse, TAF-Ibeta, Acids, Polypeptide, AA407739, i2pp2a, time, Peptide., Data Analyses, Work FlowsTaf[[II]]250, Taf200, dTAF[[II]]230, TAF[[II]]250, d230, dTAF[[II]]250, TAF[[II]]230, TFIID TAF250, cel, cell, TAF200, l(3)84Ab, dTAFII250, Taf1p, TAF[II]250, BG:DS00004.13, TAFII-250, CG17603, TAF250/230, TAF[[II]], EfW1, Cell, dTAF230, dTAF250, dmTAF[[II]]230, TAFII250, DmelCG17603, TAF1., Taf250, dmTAF1, SR3-5, Taf230, p230, TAF[[II]]250/230, TFIID, TAF, TAF230, TAF250Human Induced Pluripotent Stem Cells., Fibroblast-Derived IPS Cells, B-cell, B Cells, B lymphocyte, Fibroblast Derived Induced Pluripotent Stem Cells, Fibroblast-Derived IPS Cell, B-Lymphocyte, B Lymphocytes, Bursa-Dependent Lymphocytes, Induced Pluripotent Stem Cell, IPS, Cells, Fibroblast-Derived Induced Pluripotent Stem Cells, Fibroblast-Derived IPS, Fibroblast Derived IPS Cells, Bursa-Equivalent Lymphocyte, hiPSC, B-lymphocyte, Human Induced Pluripotent Stem Cell, Fibroblast-Derived, IPS Cell, IPS Cells, Cellsodium salt, ammonium formate, 13C-labeled, Sleep Apnea Syndromes, sleep apnea syndrome, cadmium salt, MeCN, NCMe, Ass-1, hypersomnia with periodic respiration, SDB, classic hairy cell leukaemia, zinc formate, lead salt, Hydrogenchlorid, magnesium formate, zinc salt, HCHWA, peptide, Polypeptides, Sleep Disordered Breathing, ammonium tetraformate, hydrogen chloride, ClvPrd, peptido, BANF, cobalt(II) formate dihydrate, AA408052, CH3-C#N, sleep apneas, fold, HCL-C, Min, mixed central and obstructive sleep apnea, present in fewer numbers in organism, DmelCG42273, Divorced, C79325, peptides, 2610036I19Rik, sleep, 2610510L13Rik, hypopnea, hypoplasia, min, mAPC, Divorces, copper, genetic, AI047805, ASS, fSAP152, Wasserstoffchlorid, decreased, lithium salt, Sleep-Disordered Breathing, ACN, Acn, breathing-related sleep disorder, Sleep, hypopneas, ammonium (2:1) salt, nickel salt, Mixed Sleep Apneas, Hypopneas, cobalt (+2) salt, Trypsin/K, familial, Liquid Chromatography, Dmel_CG7826, Sleep Hypopnea, mixed central and obstructive, classic hairy cell leukemia, mixed sleep apnea, Apnea Syndromes, hereditary cerebral hemorrhage with amyloidosis - Dutch type, Hypersomnia with Periodic Respiration, sodium (4:1:1) salt, magnesium salt, Dm1, HCL, Chlorwasserstoff, sleep hypopnea, leukemic reticuloendotheliosis, nickel (+2) salt, Dmel_CG7835, Mnb, MNB, ammonium salt, HCl, formate, Mixed Sleep Apnea, cobaltous formate, cromium (+3), AW124434, beta Trypsin, apnea syndromes, organ system, nanospray, breathing, copper salt, ammonium (4:1) salt, Polypeptide, mixed sleep Apneas, sleep disordered breathing, methyl cyanide, chlorane, lead (+2) salt, Mixed Central and Obstructive Sleep Apnea, sleep-disordered, apnea syndrome, dutch hereditary cerebral amyloid angiopathy, nickel formate dihydrate, lead formate, chlorure d'hydrogene, aluminum salt, cesium salt, Apnea, ACINUS, body system, sleep apnea, CG7826, Buffer, Sleep Apneas, formic acid, sleep hypopneas, Apnea Syndrome, potassium salt, Sleep Apnea, reduced, subnumerary, 14C-labeled, CG7835, CG42273, system, tiny, Separated, cloruro de hidrogeno, apneas, anatomical systems, Acinus, Hydrogen chloride, thallium (+1) salt, beta-Trypsin, rubidium salt, decreased number, calcium formate, methanoic acid, acinusL, hairy cell leukemia, Sleep Hypopneas, acinusS, apnea, peptidos, cromium (+3) salt, sodium formate, TCEP, small, Sleep Apnea Syndrome, DYRK1, data, nickel formate, 1-(14)C-labeled, 3H-labeled, TSH1, strontium formate, sleep-disordered breathing, chloridohydrogen, potassium formate, Mischung, copper (+2) salt, NY-CO-33, strontium salt, acetonitrile, buffer, Hypopnea, Cell, mKIAA0670, Peptide, CAA, polypeptide, [HCl], cupric formate, Hydrochloride, Apneas, Mixed, Dyrk1, connected anatomical system, aluminum formate, SDCCAG33, Breathing, ACETONITRILE, cyanomethane, AU020952, Separation, lithium formate, underdeveloped, mixed, Separations, CC1, Tripcellim, cerebral amyloid angiopathy, Sleep-Disordered, ethanenitrile, chromic formate, ME-IV, Trypure, calcium salt, Peptid, SCH, hereditary cerebral haemorrhage with amyloidosis - Dutch type, Peptide., hydrochloric acid, Mixed Central and Obstructivetranscription factor, T-cell leukemia, B Cells, ectopic, Effects, Bursa-Dependent Lymphocytes, IPS, AGL4, B cell, ino1-B, Gene, stalk, protein, SEPALLATA 2, protein-containing complex, Long Term, period, protein polypeptide chains, zinc ion regulated core promoter proximal region sequence-specific DNA binding, polypeptide chain, RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity, ips, Gene Products, Cell., sequence-specific DNA binding, IPS 1, protein aggregate, primary stem, Effect, B-cell, ichthyosis prematurity syndrome, reference sample, Longterm, F10N7_150, isyna1, proteins, Long-Term, RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity, free, culm, FATP4, B lymphocyte, RNA polymerase II proximal promoter sequence-specific DNA binding, idiopathic pneumonia syndrome, copper ion regulated proximal promoter sequence-specific DNA binding, AGAMOUS-like 4, zinc ion regulated proximal promoter sequence-specific DNA binding, Long-Term Effect, sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity, house mouse, high efficiency, Long-Term Effects, TRANSCRIPTION FACTOR, Controlled, RNA polymerase II distal enhancer sequence-specific binding, RNA polymerase II core promoter proximal region sequence-specific binding, Controlling, INO1, ichthyosis-prematurity syndrome, B Lymphocytes, axis, protein complex, Proteins, mouse, Longterm Effect, zinc ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, homeobox 1, metal ion regulated sequence-specific DNA binding RNA polymerase II transcription factor activity, IPS-1, Cell, transcription factor activity, mislocalized, native protein, natural protein, Mus, ichthyosis congenita 4, Long Term Effects, Protein, proteomic analysis, RNA polymerase II transcription factor activity, sequence-specific distal enhancer binding RNA polymerase II transcription factor activity, ino1, metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, KNOTTED1-like homeobox gene 5, congenital ichthyosis type 4, F14P3.4, mice, F14P3_4, Bursa-Equivalent Lymphocyte, ichthyosis congenita IV, sequence-specific DNA binding RNA polymerase II transcription factor activity, metal ion regulated core promoter proximal region sequence-specific binding, copper ion regulated core promoter proximal region sequence-specific binding, Transcription factor, F10N7.150, Longterm Effects, Protein Gene Products, Gene Proteins, primary axis, B-Lymphocyte, INOS, ACSVL4, copper ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, Mouse, ino1-a, B-lymphocyte, inos, metal ion regulated sequence-specific DNA binding, time, metal ion regulated proximal promoter sequence-specific DNA binding, sequence-specific transcription regulatory region DNA binding0trueHow C/EBPa creates an elite cell state for reprogramming to pluripotencyMouse B cells, upon ectopic expression of the transcription factor C/EBPalpha for 18h, can be reprogrammed to induced pluripotent stem (iPS) cells with extremely high efficiency. To understand the molecular control of this phenomenon we performed a time course proteomic analysis by label-free protein quantification of proteins during B cell reprogramming to iPS cells.2016-02-242015-08-20PXD0027694454464152446644991755825805931173880433309286643235983906288705108061119459932716024619624619716032933206375811363399981036358945327583851187947NCBITaxon:12805723071351225117750585557146835364916738721589103062915929158364151584938858033271591002263888691513558847518704359309451464796928123977133216413328038103430436545833398580818894621432059179392118259063295790690174934693812472725632273219286728139545132949140816918045416193453745713903634530114311402064119810871355477142450732644210435551274432149671428316669455972910039237514615754647842242208964139231744712701390114319338293550823074111481194669489693529372512646904106617275802405507216599366581216595294128213312832965431282128033952321818431832920435315228112454357554787498019575928459330797253623114367331159556444214321381849223948824261914548140479109697622615515311179573347205968798662330980058884558626528173630943179698936160488454745664162425678253175133204963035554320465650506326331299NCBITaxon:131345658606886076993894246887955453512014887519795921612941001602352642032890969456941016763107622853164351854312157457744491760445246794144242324113NCBITaxon:177321409292979310239101178709NCBITaxon:405597499079913652611227349821717018736745101161035856915693132842626587210360983341336795108944866330315819NCBITaxon:493299253068839100058987329940445861153571147161224911343053115631201755442193299358726317872366698724642615134588727421572678725476242231414611510416079129831530554689111800665564841255228562198822136162997679825102169982311746738976411676108077232642411557446894444741536776744685960039376520961182263573578458273068808637721663266689NCBITaxon:269704910312NCBITaxon:13898381920112413681089319975961230773197479465228329176196627766896059606157295137221446701711012567371233435335481052311009040544931799863878343061510429863578840193733496155087711982159739757498708782297197215407821190857075206189985076480256318418985623951655190264946454635286746360NCBITaxon:110719646375939288357461287460113450664912538458814594319722196381116752638588596NCBITaxon:6157977872379534408126338039452641145953612351786169407722724323074691123869978540979541NCBITaxon:29544243277627912924970361251804264307476792745961532848123136254264282573131504752697961029938865990346941713443386263475154155403632997966287732396440426289930629548657558462823823522862871736231399463601068842043601043994796858355859593218479968954440426071017316780781440772NCBITaxon:6191840231719931281183610036105023185579969484851908021878783749907038476641004116922596345910659212257862607046183260705334542260707NCBITaxon:780NCBITaxon:15024515166584578853187029442712115869103716478496209285747078124966842528619212638541094343197383379192875NCBITaxon:103592829126806395602959870448300641802242752266437310555242354432243081433614690081502575412983964271191364516996328104121697927262327262430085212389936436801097791356223347471821314269704958331361858030NCBITaxon:56938268830640297605277963818583342409061147787127441415368163958885813076749402243264081721281614055920425468761383708127442343427128509901191274420127442651953491137024924054373413164166081756261528235256750602853218951773119350184645145051149241215323956481882299673170915800257125614801549031384736031423166385962859631015101450520493227591428693732664179332648373153NCBITaxon:96152972210976771412621121114493760833341911079276283332518661006581237561266625555929248479148691774920036009491722617566143534073120325835247225944751750375451367830649908515151438992NCBITaxon:1155237453747243362020000-0002-0356-5571