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BenknerNot availableHeartCardiac Muscle Tissue Of Ventricle- protein extraction via bead mill and ultra-sonication from LV and RV of TAC, sham and baseline animals - pooling of protein extracts per group and time point - tryptic digestion (LysC and Trypsin) - desalting of digests with ZipTip µ-C18 - data dependent LC-ESI-MS/MS measurement on nano-UPLC/LTQ Orbitrap VelosPrideUwe VölkerLTQ Orbitrap VelosPARTIALDepartment of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany28973020 Rüdebusch J, Benkner A, Poesch A, Dörr M, Völker U, Grube K, Hammer E, Felix SB. Dynamic adaptation of myocardial proteome during heart failure development. PLoS One. 2017 12(10):e0185915 10.1371/journal.pone.0185915University Medicine Greifswaldvoelker@uni-greifswald.deMass SpectrometryShotgun proteomicsHeart FailureHeart failureHspb7Right ventricleProteomeLeft ventriclehttp://www.ebi.ac.uk/pride/archive/projects/PXD007171Label freeiodoacetamide derivatized residuemonohydroxylated residue- data processing via Rosetta Elucidator software package - identification via SEQUEST algorithm (Sage-N Sorcerer database search)ProteomicsMus Musculus (mouse)benknera@uni-greifswald.deBiologicalBiomedicalGermanyHeart failure (HF) development is characterized by huge structural changes that are crucial for disease progression. Analysis of time dependent global proteomic adaptations during HF progression offers the potential to gain deeper insights in the disease development and identify new biomarker candidates. Therefore, hearts of TAC (transverse aortic constriction) and sham mice were examined by cardiac MRI on either day 4, 14, 21, 28, 42, and 56 after surgery (n = 6 per group/time point). At each time point, proteomes of the left (LV) and right ventricles (RV) of TAC and sham mice were analyzed by mass spectrometry (MS). In TAC mice, systolic LV heart function worsened from day 4 to day 14, remained on a stable level from day 14 to day 42, and showed a further pronounced decline at day 56. MS analysis identified in the LV 330 and in RV 246 proteins with altered abundance over time (TAC vs. sham, fc≥±2). Functional categorization of proteins disclosed the time-dependent alteration of different pathways. Heat shock protein beta-7 (HSPB7) displayed differences in abundance in tissue and serum at an early stage of HF. This study not only provides an overview of the time dependent molecular alterations during transition to HF, but also identified HSPB7 as a novel blood biomarker candidate for the onset of cardiac remodeling.Dynamic adaptation of myocardial proteome during heart failure development.Rüdebusch Julia J, Benkner Alexander A, Poesch Axel A, Dörr Marcus M, Völker Uwe U, Grube Karina K, Hammer Elke E, Felix Stephan B SBAnimalia, n., data, 10^[-9], bead, grupo, protein complex, Sonications, beta-Trypsin, metazoans, Rest, Tripcellim, proteins, protein, protein-containing complex, truncus arteriosus, ESI, animals, beta Trypsin, group, multicellular animals, common aorticopulmonary trunk, persistent truncus arteriosus (disease), Trypure, protein polypeptide chains, salicylhydroxamate, SHAM, native protein, common arterial trunk, natural protein, polypeptide chain, grupos, C18, D1, Protein, Metazoa, B1, persistent truncus arteriosus, Animal, TAC, protein aggregate, time point, common truncus arteriosus, groupe, PTHB1, GruppeHeart, Left-Sided, Cardiac Failure, Decompensation, Left Sided Heart Failure, single-organism developmental process., Heart: [weak] or [failure NOS], total expressed protein, Left-Sided Heart Failure, Heart failure NOS, Heart Failure, Heart failure (disorder), Heart Decompensation, Heart failure NOS (disorder), Heart failure, heart failure, Left Sided, development, Congestive Heart Failure, unspecified, Cardiac, Cardiac failure, cardiac insufficiency, heart, Myocardial Failure, Right-Sided Heart Failure, failure, insufficiency, Right Sided Heart Failure, Weak heart, cardiac dysfunction, Proteomes, Congestive, Right Sided, Right-Sided, cardiac failureApplications Software, Open Source Softwares, Open Source, Software Applications, Computer Software, SAGE, Source Software, Software Application, Open, Engineering, Open Source Software, Computer Programs and Programming, Computer, Data Base., Source Softwares, Software Tools, Computer Software Application, Tool, Programs, Computer Programs, data analysis, Program, Computer Applications, Applications, Software Tool, data processing, Applications Softwares, Tools, Algorithm, Computer Applications Software, Computer Applications Softwares, Software Engineering, Softwares, Software, Computer Program, Application, Computer Software ApplicationsHeart, Recovery from surgery, 3.4.22.-, other disease, Ventricular, single-organism developmental process, Effects, Laboratory, Mus domesticus, Heart failure NOS, mini-ICE, Aortic, CASP-14, Spectrum Analyses, House Mouse, Long Term, Heart failure, period, common aorticopulmonary trunk, unspecified, salicylhydroxamate, Cardiac, Cardiac failure, cardiac insufficiency, common arterial trunk, diseases, House, Myocardial Failure, Mass, disease or disorder, Mus musculus domesticus, diseases and disorders, Analysis, Effect, cardiac dysfunction, Mice, Congestive, Mass Spectroscopy, CG1216, Mass Spectrum Analysis, human disease, Mri, MRI, Decompensation, Analyses, Longterm, Swiss, Swiss Mice, Long-Term, Constrictions, Heart failure NOS (disorder), non-neoplastic, Intraventricular Pressures, SHAM, grupos, Trunk of systemic arterial tree, Clampings, persistent truncus arteriosus, Ventricular Pressures, disorder, Homo sapiens disease, Long-Term Effect, Right-Sided Heart Failure, insufficiency, house mouse, TAC, Right Sided Heart Failure, time point, Long-Term Effects, DA, Cardiac Failure, grupo, DmelCG1216, Heart: [weak] or [failure NOS], mouse, disorders, Longterm Effect, medical condition, Hearts, Heart Failure, Aorta, Heart failure (disorder), Spectrum Analysis, group, heart failure, Spectroscopy, Left Sided, persistent truncus arteriosus (disease), development, Congestive Heart Failure, Mus, Pressure, Clamping, Long Term Effects, heart, Mini-ICE, Diseases, condition, failure, Weak heart, ARTERY, Mass Spectrum Analyses, Right Sided, cardiac failure, Intraventricular Pressure, Left-Sided, Trunk of aortic tree, Mus musculus, Mass Spectrum, Left Sided Heart Failure, AL023049, Caspase-14 subunit p10, dorsal aortic root, mice, constriction, dorsal aorta, Swiss Mouse, Rest, Spectrometry, Left-Sided Heart Failure, House Mice, Caspase-14 subunit p19, truncus arteriosus, MICE, Longterm Effects, Heart Decompensation, Laboratory Mice, domesticus, disease, Pressures, AORTA, Mass., Mouse, Intraventricular, aorta, time, common truncus arteriosus, Laboratory Mouse, groupe, Proteomes, Gruppe, Right-SidedHeart, Recovery from surgery, Herz, single-organism developmental process, determination, Laboratory, Blood, Mus domesticus, Heart failure NOS, DELTA AND GAMMA, adult heart, CASP-14, protein, betaTub1, Serum, House Mouse, Long Term, Heart failure, Circulatory Collapse, common aorticopulmonary trunk, circulatory vessel, protein polypeptide chains, unspecified, salicylhydroxamate, B1t, cardiac insufficiency, common arterial trunk, diseases, Hot, Myocardial Failure, Heat, diseases and disorders, Analysis, protein aggregate, Fs(3)Hor, cardiac dysfunction, Effect, Congestive, CG1216, Progression, Mass Spectrum Analysis, Shock, portion of tissue, human disease, DmelCG2684, Decompensation, kus, beta1tub, Analyses, CG9277, heart or heart like organ, Tissue, T, beta-particle, Age of onset, Swiss Mice, proteins, Constrictions, cardiac structure, NTef2, Heart failure NOS (disorder), 1t, reaction, e, e-, beta1Tub, Trunk of systemic arterial tree, Exacerbation, persistent truncus arteriosus, Cardiovascular heat shock protein, Hsp25-2, Homo sapiens disease, stage, insufficiency, time point, Long-Term Effects, DA, vertebrate heart, dorsal tube, Cardiac Failure, BETA 56D, Heat shock protein 25 kDa 2, DmelCG1216, Heart: [weak] or [failure NOS], Disease Exacerbation, mouse, Longterm Effect, Circulatory Failure, Aorta, Blood Serum, Heart failure (disorder), Spectrum Analysis, Fs(3)Sz11, Spectroscopy, Left Sided, persistent truncus arteriosus (disease), Congestive Heart Failure, chambered heart, l(1)G0108, Mini-ICE, Diseases, precocious, tissue portion, FLOWERING TIME CONTROL PROTEIN FCA ALPHA, simple tissue, cardium, failure, Weak heart, Right Sided, Left-Sided, Trunk of aortic tree, Mus musculus, beta-tub, Left Sided Heart Failure, Beta <eudicots>, Caspase-14 subunit p10, mice, dorsal aorta, Swiss Mouse, Spectrometry, Left-Sided Heart Failure, FCAALL.331, Caspase-14 subunit p19, beta56D, DmelCG9277, truncus arteriosus, MICE, early, domesticus, beta1-tub, beta(-), DTB2, disease, beta-Tub, AORTA, Horka, i6, DL4180C, CG2684, Fs(3)Horka, Hot Temperatures, Mouse, beta-Tub56D, aorta, time, Proteomes, cvHsp, cvHSP, betaTub, Specbeta, Gruppe, beta1-Tubulin, Right-Sided, 3.4.22.-, other disease, advanced, Effects, Circulatory, developmental stage, e(-), branchial heart, Gene, mini-ICE, Aortic, Spectrum Analyses, electron, protein-containing complex, Failure, period, Cardiac, Cardiac failure, polypeptide chain, B-spec, House, betaspec, Clinical Progression, Mass, Gene Products, disease or disorder, Mus musculus domesticus, DmF2, 27kDa, Mice, Mass Spectroscopy, lod, portion of blood, study, Mri, MRI, betatub(56D), Clinical, Longterm, Swiss, Elektron, beta[[1]] tubulin, beta1t, Long-Term, non-neoplastic, Hypovolemic Shock, anon-EST:fe1B3, Protein p19|6.8, Hypovolemic, cardiac pump, SHAM, Clinical Course, grupos, SPEC8, Clampings, disorder, Right-Sided Heart Failure, Long-Term Effect, CG5870, TAC, Right Sided Heart Failure, Age symptoms begin., beta-tubulin56D, Spec-beta, Disease, Dmbeta1, grupo, whole blood, protein complex, vertebrate blood, Proteins, disorders, Tubulin, medical condition, Hearts, function, Heart Failure, i168, group, heart failure, development, Temperatures, native protein, natural protein, Mus, Clamping, heart, chemical analysis, Long Term Effects, Protein, condition, betaSpec, HspB7, b-Spec, ARTERY, Mass Spectrum Analyses, cardiac failure, Mass Spectrum, Temperature, DmelCG5870, l(1)G0074, l(1)G0198, AL023049, negatron, dorsal aortic root, beta[[1]]-tubulin, constriction, Rest, b spectrin, House Mice, beta1, Lds, Longterm Effects, beta, Heart Decompensation, Laboratory Mice, Protein Gene Products, Collapse, Tub, Gene Proteins, beta-spec, BETA, assay, common truncus arteriosus, Laboratory Mouse, groupe, Spec, SerumsHeart, 3.4.22.-, Cardiac Failure, Ventricular, single-organism developmental process, Laboratory, Heart: [weak] or [failure NOS], Mus domesticus, mouse, total expressed protein, Heart failure NOS, mini-ICE, CASP-14, Heart Failure, Heart failure (disorder), House Mouse, Heart failure, heart failure, Left Sided, development, Congestive Heart Failure, unspecified, Cardiac, Cardiac failure, cardiac insufficiency, House, Mus, Pressure, heart, Myocardial Failure, Mini-ICE, Mus musculus domesticus, failure, Weak heart, cardiac dysfunction, Mice, Congestive, Mus musculus., Right Sided, cardiac failure, Intraventricular Pressure, Left-Sided, Mus musculus, Decompensation, Left Sided Heart Failure, Caspase-14 subunit p10, Swiss, mice, Swiss Mouse, Left-Sided Heart Failure, House Mice, Swiss Mice, Caspase-14 subunit p19, MICE, Heart Decompensation, Heart failure NOS (disorder), Laboratory Mice, domesticus, Intraventricular Pressures, Pressures, Ventricular Pressures, Right-Sided Heart Failure, Mouse, insufficiency, Right Sided Heart Failure, Intraventricular, Proteomes, Laboratory Mouse, Right-Sided416trueDynamic adaptation of myocardial proteome during heart failure development after induction of left ventricular pressure overload in miceWe analyzed time dependent global proteomic adaptations during heart failure (HF) progression in a mouse model, suffering from left ventricular pressure overload due to transverse aortic constriction (TAC), to gain deeper insights in the disease development and identify new biomarker candidates. The hearts from TAC and sham mice were examined by cardiac MRI on either day 4, 14, 21, 28, 42, and 56 after surgery (n=6 group/time point). At each time point, proteomes of the left (LV) and right ventricles (RV) of TAC and sham mice were analyzed by mass spectrometry 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