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Scaturro"],"software":["Not available"],"tissue":["Cell Culture","Neuronal Stem Cell"],"sample_protocol":["Human induced pluripotent stem cells (iPSC) generated from healthy patient fibroblasts were maintained in mTeSRTM 1 media (STEMCELL Technologies) on Geltrex (ThermoFischer Scientific) plates in the absence of feeders. The iPSC were regularly confirmed to be mycoplasma-negative. The protocol used for derivation of human neural progenitor cells (hNPC) has been previously described44 with modifications. Briefly, iPSC colonies were harvested with a cell scraper to ensure relatively big colonies remain and cultured in suspension to form embroid bodies (EBs) in DMEM/F-12, 0.5% N2 supplement (Gibco), 5μM Dorsomorphin (Sigma-Aldrich), 10μM SB431542 (Sigma-Aldrich) and 10 μM Rho-associated kinase inhibitor (ROCK) (Y-27632, StemCell Technologies). EB were grown for 5 days with media changed every other day before gentle trituration and attachment on poly-ornithine/laminin coated dishes in NPC media consisting of DMEM/F-12, 0.5% N2, 1% B27 supplement with 10 ng/ml bFGF (Peprotech 100-18B-50) and 10 μM ROCK. Three to four days after EB plating, neural rosettes were manually isolated, dissociated mechanically to single cells and plated on fresh poly-ornithine/laminin coated dishes in NPC media with 10 μM ROCK inhibitor. On the next day, the media was changed to NPC media without ROCK and NPCs were propagated for up to 12 passages by splitting with accutase when 70-80% confluency was reached. For short-term differentiation experiments (Fig. 3c, d, e and Extended Data Fig. 4), 2x105 cells were seeded on 6-well plates, transduced with empty lentiviruses (NT), lentiviruses expressing HCV- or ZIKV-NS4B or infected with 0.01 MOI of ZIKV H/PF/2013. Forty-height hours later differentiation was induced for 5 days by growth factor withdrawal and addition of 10 µM ROCK inhibitor, while undifferentiated cells were kept in NPC media in the presence of bFGF. In both cases media was replaced every other day. Cell pellets were harvested, snap-frozen and processed for LC-MS/MS analysis as described below."],"repository":["Pride"],"labhead":["Andreas Pichlmair"],"instrument_platform":["Q Exactive"],"submission_type":["PARTIAL"],"labhead_affiliation":["Immunopathology of Virus Infections Institute of Virology Technical University of Munich Munich, Germany"],"publication":["30177828 Scaturro P, Stukalov A, Haas DA, Cortese M, Draganova K, Płaszczyca A, Bartenschlager R, Götz M, Pichlmair A. An orthogonal proteomic survey uncovers novel Zika virus host factors. Nature. 2018 10.1038/s41586-018-0484-5"],"submitter_affiliation":["Systems Arbovirology, Leibniz Institute of Virology"],"labhead_mail":["andreas.pichlmair@tum.de"],"technology_type":["Mass Spectrometry","Shotgun proteomics"],"disease":["Zika Virus Congenital Syndrome"],"submitter_keywords":["Zikv","Proteome","Hnpc","Differentiation"],"full_dataset_link":["http://www.ebi.ac.uk/pride/archive/projects/PXD009557"],"quantification_method":["Label free"],"modification":["iodoacetamide derivatized residue","acetylated residue"],"data_protocol":["Peptide mixtures were separated on a 50 cm reversed-phase column (diameter of 75 μm packed in-house with ReproSil-Pur C18-AQ 1.9 μm resin [Dr. Maisch GmbH]) as previously described47. Raw MS files were processed within the MaxQuant environment (version 1.5.6) using the integrated Andromeda search engine with FDR ≤ 0.01 at the protein, peptide, and modification level. Proteome and phosphoproteome files were assigned to separate search parameter groups. The search included fixed modifications for carbamidomethyl (C) and variable modifications for oxidized methionine (M), acetylation (protein N-term). Peptides with at least six amino acids were considered for identification, and “match between runs” was enabled with a matching time window of 0.7 min to transfer MS1 identifications between runs. Peptides and proteins were identified using a UniProt FASTA database from human (UniprotKB release 2015_08 including isoforms and unreviewed sequences) and ZIKV virus polyprotein corresponding to the H/PF/2013 strain (NCBI GenBank KJ776791.2; individual viral cleavage products were manually annotated). MaxQuant output files (proteinGroups.txt) were processed by a combination of in-house R (version 3.3), Julia (version 0.5) and Stan (version 2.14) scripts as detailed in the Materials and methods of the related manuscript."],"omics_type":["Proteomics"],"species":["Zika Virus Zikv/h. Sapiens/frenchpolynesia/10087pf/2013","Homo Sapiens (human)"],"submitter_mail":["pietro.scaturro@tum.de"],"curator_keywords":["Biological","Biomedical"],"submitter_country":["Germany"],"pubmed_abstract":["Zika virus (ZIKV) has recently emerged as a global health concern owing to its widespread diffusion and its association with severe neurological symptoms and microcephaly in newborns1. However, the molecular mechanisms that are responsible for the pathogenicity of ZIKV remain largely unknown. Here we use human neural progenitor cells and the neuronal cell line SK-N-BE2 in an integrated proteomics approach to characterize the cellular responses to viral infection at the proteome and phosphoproteome level, and use affinity proteomics to identify cellular targets of ZIKV proteins. Using this approach, we identify 386 ZIKV-interacting proteins, ZIKV-specific and pan-flaviviral activities as well as host factors with known functions in neuronal development, retinal defects and infertility. Moreover, our analysis identified 1,216 phosphorylation sites that are specifically up- or downregulated after ZIKV infection, indicating profound modulation of fundamental signalling pathways such as AKT, MAPK-ERK and ATM-ATR and thereby providing mechanistic insights into the proliferation arrest elicited by ZIKV infection. Functionally, our integrative study identifies ZIKV host-dependency factors and provides a comprehensive framework for a system-level understanding of ZIKV-induced perturbations at the levels of proteins and cellular pathways."],"pubmed_title":["An orthogonal proteomic survey uncovers novel Zika virus host factors."],"pubmed_authors":["Scaturro Pietro P, Stukalov Alexey A, Haas Darya A DA, Cortese Mirko M, Draganova Kalina K, Płaszczyca Anna A, Bartenschlager Ralf R, Götz Magdalena M, Pichlmair Andreas A"],"sample_synonyms":["Fgf-2, liquid chromatography tandem mass spectroscopy, Forms, nuclear pore membrane protein, (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1, dlmo, dalpha-SNAP, B27, DLMO, determination, IPS, 5-a)pyrimidin-3-yl)pyridine, Rho A, SEC9, postnatal development, Fibroblast Derived IPS Cells, hiPSC, growth and development, (DL)-Isomer, bA416N4.2, HBGF-2, Fat tissue-specific low MW protein, height, hdp-a, dmTAF[[II]]230, dLmo, dLMO, Heparin-binding growth factor 2, DmelCG1004, neutrophilic leucocyte, rho-1, neutrophil leukocyte, bFGF, 5-Diaminopentanoic acid, 2, DRho, iPS cell, AAF01186, nucleopore, Laminin M, 2410008O07Rik, Pleuropneumonia Like Organisms, 8416, dJ1068F16.2, BFGF, alpha-SNAP, PIST, Dmrho, Fibroblast-Derived IPS Cells, opsin-2, 6-(4-(2-(1-Piperidinyl)ethoxy)phenyl)-3-(4-pyridinyl)pyrazolo(1, LCMSMS, nuclear pore complex, TFIID TAF250, Fat cell-specific low molecular weight protein, Basic fibroblast growth factor, cel, AA960360, ornithine, DMRHO, AI844555, chemical analysis., mature neutrocyte, rhoA, Ornithine Monohydrobromide, high grade, Rho1, RHO1, DEPP, SNAP-25, DmelCG8416, Bd, undifferentiated, hepatitis C virus HCV, Dlmo, rho1, polymorphonuclear leukocyte, polynuclear neutrophilic leucocyte, Fseg, dissociated, fliH, associated, Eperythrozoon, downregulation of kinase activity, Asteromyces , LC-MS2, human hepatitis C virus, dTAF[[II]]230, Rho-1, DmRHO-A, C21orf61, Bovimyces, RHOb, LC-MS/MS, TAF200, CG1004, HSC0013, Laminin, Ornithine Monoacetate, TAFII-250, Lentivirinae, TAF250/230, grade 4, Ornithine Dihydrochloride, Dm Rho1, rhom, (4(S)-trans)-isomer, shortened, neutrocyte, Fasting-induced gene protein, TAFII250, RhoN19, inhibition of kinase activity, Lentiviruses, RhoA, ve, RHOM, RhoM, 5-Diaminovaleric acid, compound C, Ornithine Phosphate (1:1), M Chain, RHOHP1, compound C dorsomorphin, HCV, GOPC1, Ornithine, NPC, Ptd, Haemobartonella, AA408785, absence, Orn, growth pattern, AI326383, D-Rho1, mature neutrophil leukocyte, non-developmental growth, G4, Ve, FGD2, Fibroblast-Derived IPS, Merosin, DMEM, expanded, CG8416, alphaSnap, RHO, Rho, Fibroblast-Derived, study protocol, CG17603, Pleuropneumonia, TAF[[II]], human, DMRHOa, DMRHOb, (D)-Isomer, Big, Taf250, enlarged, rhomboid/veinlet, SR3-5, liquid chromatography-tandem mass spectroscopy, Cells, RIC4, Fibroblast-Derived Induced Pluripotent Stem Cells, Lmo, LMO, (L)-Isomer, Laminin M Chain, 5-diaminopentanoic acid, Mycoplasma putrefaciens, ARHD, hdp, 4-(6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)pyrazolo(1, rho, short, Fibroblast, TAF230, 5 Diaminopentanoic Acid, Ornithine Sulfate (1:1), big, Dmelrho, polynuclear neutrophilic leukocyte, d230, human being, dalphaSNAP, Fibroblast-Derived IPS Cell, Asterococcus , DRORHO, Induced Pluripotent Stem Cell, Pleuropneumonia-Like Organisms, 5-a)pyrimidine, post-transfusion hepatitis non A non B virus, number, Arhd, dTAFII250, EfW1, IPS Cells, 2210402P09Rik, presence, Rho GTPase, FGFB, LC-MS-MS, method, large, DRhoA, dmTAF1, Taf230, dttg, method used in an experiment, l(3)77ABa, LC-MSMS, CG6625, l(3)77ABc, SB 431542, CG6500, (4(R)-trans)-isomer, RIC-4, TAF250, Chain, human hepatitis C virus HCV, DmelCG7615, grade IV, Taf200, dRhoA, dTAF[[II]]250, beadex/dLMO, cell, SB431542, Y27632, absent from organism, neutrophil leucocyte, inhibiteur, stubby, Borrelomyces, Taf1p, Big-3, EBS, AMPK inhibitor, neutrophilic leukocyte, DRho1, man, Human Induced Pluripotent Stem Cells, DrhoA, FALP, OPN2, dTAF250, mature neutrophilic leucocyte, inhibidor, Suspension, RhoHP1, great, Drho1, Mouse Neural Progenitor cell line, kinase inhibitor, Glycoprotein GP-2, dRho1, TAF, Fgfb, D-MEM, DmelCG6500, Glycoprotein GP 2, inhibitors, Decidual protein induced by progesterone, Rho kinase, data, DmelCG6625, TAF[[II]]250, dSNAP, SB-431542, ng/ml, mature neutrophil leucocyte, (trans)-isomer, l(2)52Fa, epidermolysis bullosa simplex, iks, GCCD2, Y-27632, l(3)84Ab, inhibitor, BG:DS00004.13, l(2)k02107b, dsnap, Cell, dTAF230, 5-Diaminopentanoic Acid, development, EEB, count in organism, LC/MS/MS, PPLO, DL-Ornithine, iPSC, Fibroblast Derived Induced Pluripotent Stem Cells, Y 27632, down regulation of kinase activity, p230, Ornithine Hydrochloride, CAL, TAF[[II]]250/230, TFIID, IPS Cell, dnRho, Taf[[II]]250, TAF[[II]]230, postnatal growth, E3.10/J3.8, patient, TAF[II]250, mature neutrophilic leukocyte, Ornithine Monohydrochloride, down-regulation of kinase activity, dJ94G16.2, plan specification, epidermolysis bullosa intraepidermic, hld, dihydrochloride, FIG, DmelCG17603, SNAP, PMN, CG7615, FGF-2, polymorphonuclear leucocyte, liquid chromatography tandem mass spectrometry, assay, quantitative, N-(4-pyridyl)-4-(1-aminoethyl)cyclohexanecarboxamide, poly, Human Induced Pluripotent Stem Cell, n(2)k07236, growth, polymorphonuclear neutrophil, Hepatitis C, TAF1, presence or absence in organism, snap"],"pubmed_title_synonyms":["ZikV, Virus, Zika Virus, host organism., Zika"],"data_synonyms":["Manuscripts., Bru, 2-amino-4-(methylsulfanyl)butanoic acid, human being, Raw, Procedures, Effects, Aminosaeure, Aminocarbonsaeure, L Isomer, cleavage, Amino acid, Gene, protein, alpha-amino acid, protein-containing complex, Long Term, CG7826, peptide, period, Polypeptides, protein polypeptide chains, L-Isomer Methionine, Techniques, Methionine, ClvPrd, peptido, polypeptide chain, Ms1, Method, B1, CG7835, Gene Products, Studies, L-Methionine, CG42273, Impacts, Min, Del(8)44H, Environmental Impacts, protein aggregate, Separated, Effect, Technique, Pedameth, DmelCG42273, Svc, Search Engines, Divorced, amino acids, peptides, MS1, Longterm, M, Acetylations, min, mAPC, Divorces, proteins, procedures, Long-Term, T6G21.3, man, ecotype, AI047805, Study, Environmental Impact, 2-amino-4-(methylthio)butanoic acid, column, Methodological Studies, male sterility 1, D1, peptidos, Long-Term Effect, metionina, Racemethionine, Long-Term Effects, PTHB1, DYRK1, Stars, DL-Methionine, protein complex, Aminokarbonsaeure, acetylation, Proteins, 2-Amino-4-(methylthio)butyric acid, Longterm Effect, Dmel_CG7826, total expressed protein, Search, alpha-amino acids, backward, Procedure, L-Isomer, Peptide, alpha-amino carboxylic acids, Engine, Impact, strain, polypeptide, Environmental, native protein, natural protein, Dm1, C18, Protein, Long Term Effects, Methionin, cultivar, methionine, Dyrk1, materials, Hmet, techniques, fixed, Dmel_CG7835, Met, Data Base, Mnb, MNB, AU020952, Amino Acid, Acid, Separation, Col4a-1, Amino acids, MALE STERILITY 1 PROTEIN, Separations, CC1, Striated muscle activator of Rho-dependent signaling, Methodological, Amino, AW124434, Methodological Study, human, Longterm Effects, ME-IV, Protein Gene Products, Gene Proteins, Environments, alpha-amino-gamma-methylmercaptobutyric acid, Peptid, Acids, Polypeptide, variable, STARS, Liquimeth, Proteomes, time, reversed, methodology"],"description_synonyms":["scale tissue, advanced, d230, Hmong American, Hmong, Asian, peltate hair, postnatal development, Nerve, post-transfusion hepatitis non A non B virus, number, Infestations and Infections, dTAFII250, Korean American, growth and development, EfW1, presence, dmTAF[[II]]230, Filipino American, dmTAF1, Taf230, Japanese, Asian Indian American, Vietnamese Americans, DmF2, Fs(3)Hor, TAF250, lod, human hepatitis C virus HCV, Taf200, American, DmelCG2684, dTAF[[II]]250, Vietnamese American, TFIID TAF250, cel, cell, plant peltate hair, Filipino, Taf1p, NTef2, ecotype, free, Asians, dTAF250, Infestation and Infection, Cambodian, hepatitis C virus HCV, Korean, scale (sensu Metazoa), Neuron, Infections and Infestations, TAF, Nerve Cell, Vietnamese, Chinese, Hmong Americans, Asian Indian Americans, Peptidomics., human hepatitis C virus, dTAF[[II]]230, TAF[[II]]250, TAF200, total expressed protein, l(3)84Ab, BG:DS00004.13, TAFII-250, TAF250/230, Korean Americans, Cell, Fs(3)Sz11, Asian unspecified, dTAF230, strain, Cambodian Americans, development, count in organism, TAFII250, Americans, p230, Infection, precocious, TAF[[II]]250/230, TFIID, Filipino Americans, cultivar, scales, HCV, Indian American, Asian Americans, Japanese American, Chinese American, Taf[[II]]250, Nerve Cells, TAF[[II]]230, scale, growth pattern, Asian American, non-developmental growth, postnatal growth, Infection and Infestation, TAF[II]250, Cambodian American, Lds, CG17603, TAF[[II]], early, Chinese Americans, Japanese Americans, DmelCG17603, Taf250, Horka, SR3-5, Cells, CG2684, Fs(3)Horka, quantitative, growth, Proteomes, Hepatitis C, TAF230, TAF1, presence or absence in organism"],"pubmed_abstract_synonyms":["l(4)13, PRKBA, DmErk, extracellular signal-regulated kinase activity, Akt/PKB, pp44mapk, Health Problem, Tyro5, FON1, DAKT1/PKB, fs(1)M37, Virus Infection, tef, AtrII, FLORAL ORGAN NUMBER 1, AKT1, infectivity, phosphorylation, LEF-1, Prp4 protein kinase activity, p38a, sckl1, Dmel_CG32005, atm/tefu, Zika Virus, LeMPK3, Microlissencephalies, ATP-protein transphosphorylase activity, Associations, p44mpk, LEF1/TCF, ATP:protein phosphotransferase (non-specific) activity, ARABIDOPSIS THALIANA ATAXIA TELANGIECTASIA-MUTATED AND RAD3-RELATED, Dp38, Abnormally small head, SAPK2, SEM, Sem, p38A, Health Problems, MAP-k, Zika virus infectious disease, pp42, BE2, EK5, Bdr, Dmmei41, Dsor2, Zika virus disease or disorder, virus process, proteins, Diffusions, Viruses infection, cTCF, sem, Sub-Fertility, SNAP-25, RacPK, Viruses caused disease or disorder, Reduced head circumference, Ataxia telangiectasia-mutated and RAD3-related, infertility, virus infection, telo1, Small head circumference, GAPO, Pan, PAN, single organism signaling, DmMPK2, p82 kinase activity, ERK-A, dpERK, dpErk, Global, ERK-1, betaIIPKC, ERK-2, TGF-beta, DmMAPK, RAC-PK-alpha, PMK-2, dp-ERK, PMK-1, Microlissencephaly, meiP41, CG7904, PMK-3, Wee-kinase activity, AKT/PKB, Atr88CD, Decreased circumference of cranium, Pathogenicity, pMAPK, pMapK, GENA70, p-Akt, D-MPK2, l(3)10460, panarteritis nodosa, mus(1)103, mus(1)104, DmelCG5475, DmERKA, rl/MAPK, F24J5.12, Zika, Classical Polyarteritis Nodosa, Panarteritis Nodosa, DTCF, DTcf, non-specific serine/threonine protein kinase activity, l(2)41Ac, Mtap2k, dAKT/dPKB, PKB/dAKT, human, International, F24J5_12, C78273, International Health Problems, mus-104, CT34260, mus-103, dpERk, serine-specific protein kinase activity, HIPK2, SAPK, ZikV, cytidine 3', Wee 1-like kinase activity, dTCF, dTcf, DmelCG4252, RAC-ALPHA, 9030612K14Rik, FLORAL DEFECTIVE 10, p44erk1, CG34403, D-p38 MAPK, DmelCG4006, glycogen synthase A kinase activity, Peptidomics, Microcephaly, Periarteritis Nodosa, glycogen synthase kinase 3 activity, 12559, Decreased size of head, SUPERMAN, body system, phosphorylase b kinase kinase activity, EK2-1, DmelCG6535, AA407128, dMPK2, Congenital Zika Syndrome, mei-195, Gene Products, Worldwide Health, Prkm1, Classic Polyarteritis Nodosa, Prkm3, system, sterile, ribosomal protein S6 kinase II activity, Mei-41, Erk, ERK, PRKM1, PRKM3, protein-serine kinase activity, PRKM2, anatomical systems, p38Ka, STK32, PCBC, man, erk, MHK7_5, protein-cysteine kinase activity, AKT, Akt, Hpr kinase activity, rll, STK26, viral disease, cob, p38-2, myelin basic protein kinase activity, Dp38a, Reproductive, 4252, l(3)j5A5, ZikV infection, DRT, Esrk1, Tgf-r, Zika Fever, akt, Proteins, stress-activated kinase activity, Abnormally small cranium, Phosphorylations, MAP-2 kinase activity, CG6535, DAkt1, Synaptosomal-associated 25 kDa protein, DAKT1, World Health, protein serine kinase activity, protein phosphokinase activity, PKB, PKA, CWS6, Zika virus disease, PKC, CG4252, stress-activated protein kinase activity, chemical analysis, mapk2, Infertile (finding), PKB-ALPHA, mapk1, CG4006, infertility disorder, Tcf/LEF, Congenital Zika Virus Infection, protein kinase p58 activity, small calvarium, Dakt1, serine/threonine protein kinase activity, periarteritis, AI256621, congenital Zika syndrome, Congenital Microcephaly, CG12559, Protein., P42MAPK, dpERK1, International Health Problem, Understanding, dsk1, cblB, Small head, CG32005, 5'-cyclic monophosphate-responsive protein kinase activity, atypical PKC activity, signalling, Gene Proteins, dAkt/PKB, AU018647, signalling process, dpMAPK, TGF-B, Congenital Microcephalies, Lef, Sterility, virulence, STK-C, MEI41/FRP1, p44mapk, protein serine-threonine kinase activity, Severe, SAP kinase activity, thymoma viral proto-oncogene, glycogen synthase kinase activity, host organism, Polyarteritis Nodosa, protein kinase A activity, single-organism developmental process, determination, Mpk2, SCKL1, p42mapk, Act-r, DmelCG34403, D-p38, IA5, Virus Disease, p38 alpha, FCTCS, SR2-1, mei41, ATRAD3, Readability, P44ERK1, DmelCG7904, SUP, kinase-related transforming protein, Virus, Problems, mitogen-activated protein kinase activity, mpk2, viral, mpk1, TELO1, viral infection, TCF/LEF, Erk/Map kinase, Zika virus infection, DERK-A, E(sina)7, Super protein, Rl, classic polyarteritis nodosa, PKB|Akt, sp, Raf kinase activity, AT1, at1, serine kinase activity, MP kinase activity, DERK, Dmp38a, atypical protein kinase C activity, signaling process, International Health, viral infectious disease, viral disorder, Fever, ATA, MBP kinase II activity, ATC, Mei-41/DATR, mitogen-activated S6 kinase activity, ATP - protein phosphotransferase (MAPKK-activated) activity, ATD, protein-aspartyl kinase activity, ATE, atrII, dERK, Decreased size of skull, CG5475, polyarteritis, ATM, Atm, Atr, Small skull, PKB alpha, ATR, sterility, MNK1, Mnk1, MAP kinase 2 activity, dakt, microencephaly, Mapk, Punt, Erk1, classical polyarteritis nodosa, ERK1, mapk1a, ERK2, Erk2, infections, infertile, l(3)89Bq, atm, LEF/TCF, D-P38a, atr, Dm Pan, Küssmaul-Maier disease, AKT1 kinase, M phase-specific cdc2 kinase activity, D-p38a, PKB/Akt, PKB/AKT, protein kinase B alpha, p41mapk, dAkt, dAKT, Abnormally small skull, MapK, mapk1b, PERIANTHIA, MAPK, Atr-II, PUNT, P38, DAkt, Problem, serine protein kinase activity, erk2, mapk, l(3)04226, DPKB, phosphorylase B kinase kinase activity, ERKa, DmATR, BcDNA:RE08694, pAkt, protein glutamyl kinase activity, l(2R)EMS45-39, CAPB, Zika Virus Disease, DmelCG12559, p38, proto-oncogene c-Akt, ATATR, CG17964, Zika virus caused disease or disorder, ATATM, protein kinase B, DpErk, DpERK, organ system, ErkA, ERKA, hydroxyalkyl-protein kinase activity, HUMKER1A, Health, WEE1Hu, Dakt, epsilon PKC, p41, mus103, dPKB, p40, Put, mus104, P44MAPK, p44, fertility disorders, Proteomes, pERK, DRAC-PK85, ribosomal S6 protein kinase activity, biological signaling, calcium/phospholipid-dependent protein kinase activity, human being, Tefu, pun, Infertile, GroupII, ARABIDOPSIS THALIANA ATAXIA-TELANGIECTASIA MUTATED, small cranium, XATR, LEF/TCF-1, ZikV Infection, Gene, polyarteritis nodosa, microcephaly (disease), Subfertility, Dpkb, dp38a, Hek5, HS44KDAP, Worldwide, C030026E19Rik, Zika fever, serine(threonine) protein kinase activity, p42-MAPK, T-antigen kinase activity, tel1, galactosyltransferase-associated kinase activity, infection, study, Viruses, fever, dlhC, xp42, MHK7.5, Tcf-1, d-TCF, p42 mitogen-activated protein kinase activity, CG18732, ATP:protein phosphotransferase (MAPKK-activated) activity, Mif1, protein kinase (phosphorylating) activity, Erk-1, Raf-1, Decreased size of cranium, Xatm, TCF/LEF1, Reproductive Sterility, Viruses infectious disease, DRAC-PK, chimpanzees, DmERK-A, Severe Congenital, casein kinase (phosphorylating) activity, Disease, sckl, ert1, Severe Congenital Microcephalies, World, DMPK2, FRP1, Dmel_CG17964, prkm2, prkm1, CT39192, total expressed protein, SCKL, TEM8, International Healths, development, p38delta, Global Health, twitchin kinase activity, Severe Congenital Microcephaly, pan.dTCF, Sterile, group 2, Protein, AP50 kinase activity, Infection, congenital Zika virus infection, MBP kinase I activity, TEL1, D-Akt, MEI41, Tcf, TCF, connected anatomical system, dATM, frp1, Xp42, Lef1, serine-threonine kinase Akt, threonine-specific protein kinase activity, MEC1, LEF1, akt1, dAkt1, mitogen activated kinase activity, Su(Raf)2B, microcephalus, DRAC-PK66, Microcephalies, Healths, FLO10, tcf, EY2-2, MAPK2, MAPK1, ataxia-telangiectasia mutated, HERP, l(4)102ABb, dp38, CFAP23, atdc, microcephaly, Protein Gene Products, periarteritis nodosa, dakt1, D-ERK, Ert2, ERT1, ERT2, ATDC, PKBalpha, EPHT3, p44-MAPK, p44-ERK1, dAKT1, assay, Rac, RAC, mec1, lef1, A-kinase activity, MAP kinase 1 activity, Viruses disease or disorder"],"name_synonyms":["total expressed protein, Proteomes."],"view_count":["515"],"additional_accession":[]},"is_claimable":true,"name":"Proteome of ZIKV-infected and NS4B-transduced hNPC (H/PF/2013)","description":"To investigate the effects of ZIKV infection or ZIKV-NS4B-transduction on the global proteome scale at early stages of hNPC differentiation into neurons, hNPC cells were infected with ZIKV (Asian strain: H/PF/2013; MOI=0.01) or transduced with ZIKV-NS4B or HCV-NS4B and one day later cells were either left under proliferative conditions or neuronal differentiation was induced with ROCK inhibitors treatment and growth factors withdrawals. 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proteomics.","dates":{"publication":"2018-09-03","submission":"2018-04-20"},"accession":"PXD009557","cross_references":{"TAXONOMY":["2806551","646099","180498","511145","42249","2156843","544071","284218","327042","3633","3635","11983","430066","3636","2758385","696363","1217666","68888","1114301","55571","145263","145262","3649","34613","126957","366649","2","391619","3641","3645","10665","68895","113636","476272","3661","1123294","42229","55583","2681304","2323","122586","3654","34607","92519","3659","10632","1432059","712938","655819","1250232","545371","1195774","81866","196821","586722","568076","1755437","35925","3668","58627","408169","180454","2787751","201089","225058","3674","1479564","100392","3694","2049433","445974","1420012","58641","935293","NCBITaxon:77643","6715","67593","643867","71605","40483","1315282","69304","562716","391624","29204","277944","762376","3696","1218100","329629","2211376","39486","39488","40479","NCBITaxon:2157","1315273","1051067","1250278","2059687","549779","2016516","368407","1736309","698936","104782","148364","32042","929410","1061","32049","1381693","743277","32046","640707","45351","11103","107806","217459","216129","288671","288676","4100","694569","4101","6763","4102","1076","1277351","1316582","1358430","1417298","174633","6754","128735","6756","84030","135062","1813019","4111","929439","367110","4113","64459","1394984","32025","301270","32022","1498751","104759","4120","478861","347495","153721","1097","1652998","2790513","55513","9803","1758543","9801","2608663","9808","13757","55518","32019","64471","9821","118503","114155","421932","55521","1383439","1193181","9813","9818","1026970","2663531","10699","55529","NCBITaxon:4751","8502","9833","5476","4146","5477","9825","102169","157273","9823","89764","84074","13735","1862870","5482","4153","NCBITaxon:50557","9844","67525","1000364","334147","5480","210","35974","13708","115466","5478","1215914","9835","322159","9838","10677","103481","9852","348780","42253","1488414","222863","22663","47946","1571871","2593991","59919","157295","29292","1175271","9860","1488406","334249","518691","234","235","238","152335","9858","9859","886559","74649","9870","392021","11072","63990","36352","7215","9874","1908","28743","94232","4182","35024","1451139","69293","1902","593907","1901","746360","12374","746361","7226","253","60013","197221","1915","85310","588596","9895","11051","9899","7237","9897","72000","263","419610","264","266","7227","588581","568996","287375","62690","7244","2023717","201999","8570","7240","747679","274","596153","335543","1931","1873496","16718","335541","84005","13686","150596","86662","1196174","86661","347515","36329","NCBITaxon:1763","286","287","11034","11033","348837","670580","271848","186536","8595","986075","755274","72036","105135","294","296","11009","84023","210007","348824","12336","36307","1047005","187878","945556","449447","NCBITaxon:1335626","266495","54195","913998","78168","11901","147828","1055524","NCBITaxon:9606","318178","135858","469008","1366848","1979153","51930","72859","300852","641140","9005","118499","526225","412133","75913","9014","38111","39442","35084","3704","167443","1204414","3708","351581","990119","51953","2590841","3701","3702","39432","227748","62615","83558","3715","3716","333760","57267","998086","3711","3712","190650","3714","75917","2073127","262981","27457","57270","9030","9031","637910","3728","1424337","142104","479249","11082","39412","NCBITaxon:9615","658858","147802","69266","1006581","3735","2750454","1356638","1647520","3750","644223","669502","1293497","9054","NCBITaxon:44689","632245","552536","51997","649908","1438992","3745","3747","264732","3760","264731","288705","595536","1416915","858653","252740","327160","29385","1149786","479436","3755","29382","479437","225117","75299","1204474","167387","217509","1938441","3765","93934","34739","327159","100226","3767","42344","42345","46700","1287689","591198","46704","146479","29365","28034","28038","28035","1080348","330779","179392","1126212","295027","1131","1803738","6819","1126","526997","102862","252739","10760","159736","1143","242507","1140","981087","1355477","43658","1424507","229533","79698","204232","124223","321803","369822","130080","34708","1645733","1858897","1654675","99287","77020","38293","1412529","5508","1148","1744888","643745","2649997","283035","718308","5507","176299","707678","92683","70415","1562887","651388","563924","56115","29320","2086595","5516","5518","113549","1432137","159749","535026","1432138","58781","707683","194963","401614","28005","31646","862751","104660","381518","45474","48500","97476","97477","1180","51240","1748418","55601","555479","204274","381513","5535","2014887","1105325","44139","329726","1005941","28909","316435","1211604","9900","13894","382835","4232","4233","1082934","1220585","604162","9913","112273","170187","9915","429131","267818","1871049","316407","299467","1442368","303","337330","485264","638301","1306413","9925","306","4236","9923","121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