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Verano-Braga"],"technology_type":["Mass Spectrometry","Shotgun proteomics"],"software":[""],"submitter_keywords":["Human","Mia paca-2","Cho","Alamandine treatment"],"full_dataset_link":["https://www.ebi.ac.uk/pride/archive/projects/PXD018529"],"sample_protocol":["Mia Paca-2 and CHO-MrgD cells were treated with alamandine. Protein extraction was using SDC 1% and digested with trypsin. Samples were labeled with iTRAQ 4-plex. Phospho enrichment was performed by SIMAC."],"repository":["Pride"],"quantification_method":[""],"modification":[""],"data_protocol":["Mass spectra data (.raw files) regarding Mia-PaCa-2 cells were processed using Proteome Discoverer (Version 1.2, Thermo Fisher, Waltham, MA) and submitted to search engine against Swissprot Homo sapiens fasta file (downloaded at 2016, 20145 entries) using Proteome Discovery (version) and MASCOT search engine. Trypsin was chosen as the enzyme allowing up to two missed cleavages. Carbamidomethyl (Cys) was defined as a fixed modification. Oxidation (Met), acetyl (protein N-terminus), phosphorylation (Ser, Thr, and Tyr) and iTRAQ reagents (protein N-terminus and Lys side chain) were defined as dynamic modifications. Only peptides with up to 1% false discovery rate (FDR) were considered for further analysis.  Mass spectra data (.raw files) regarding CHO-MrgD cells were searched against UniProtKB Cricetulus griseus fasta file (downloaded at 2018, 34975 entries) using MaxQuant software (version 1.6.1.0) and Andromeda search engine. Database search parameters included common contaminants, first search peptide tolerance set at 20 ppm, and main search peptide tolerance set at 4.5 ppm.  iTRAQ reagents (protein N-terminus and Lys side chain) were defined as fixed modifications. Trypsin was set and allowing up to 2 missed cleavages. Carbamidomethyl (Cys) was set as fixed modification. Oxidation (Met), acetyl (protein N-terminal) and phosphorylation (Ser, Thr, and Tyr) were set as variable modifications. “Match between runs” was enabled with matching time window of 0.7 min and an alignment time window of 20 min. For identification, a minimum of 1 minimum razor + unique peptide was used. Peptide FDR was set as < 1% and revert decoy mode was used."],"omics_type":["Proteomics"],"labhead":["Thiago Verano Braga"],"instrument_platform":[""],"submission_type":["PARTIAL"],"labhead_affiliation":["Departamento de Fisiologia e Biofísica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil."],"species":["Homo Sapiens (human)","Cricetulus Griseus (chinese Hamster) (cricetulus Barabensis Griseus)"],"publication":["35652611 da Silva FA, Rodrigues-Ribeiro L, Melo-Braga MN, Passos-Silva DG, Sampaio WO, Gorshkov V, Kjeldsen F, Verano-Braga T, Santos RAS. Phosphoproteomic studies of alamandine signaling in CHO-MrgD and human pancreatic carcinoma cells: An antiproliferative effect is unveiled. Proteomics. 2022:e2100255 10.1002/pmic.202100255"],"submitter_mail":["npf.ufmg@gmail.com"],"curator_keywords":["Human proteome project","Biology/disease-driven human proteome project (b/d-hpp)"],"submitter_affiliation":["Federal University of Minas Gerais"],"submitter_country":["Brazil"],"pubmed_abstract":["Alamandine is a heptapeptide from the renin-angiotensin system (RAS) with similar structure/function to angiotensin-(1-7) [ang-(1-7)], but they act via different receptors. It remains elusive whether alamandine is an antiproliferative agent like ang-(1-7). The goal of this study was to evaluate the potential antiproliferative activity of alamandine and the underlying cellular signaling. We evaluated alamandine effect in the tumoral cell lines Mia PaCa-2 and A549, and in the nontumoral cell lines HaCaT, CHO and CHO transfected with the alamandine receptor MrgD (CHO-MrgD). Alamandine was able to reduce the proliferation of the tumoral cell lines in a MrgD-dependent fashion. We did not observe any effect in the nontumoral cell lines tested. We also performed proteomics and phosphoproteomics to study the alamandine signaling in Mia PaCa-2 and CHO-MrgD. Data suggest that alamandine induces a shift from anaerobic to aerobic metabolism in the tumoral cells, induces a negative regulation of PI3K/AKT/mTOR pathway and activates the transcriptional factor FoxO1; events that could explain, at least partially, the observed antiproliferative effect of alamandine. This study provides for the first time a comprehensive investigation of the alamandine signaling in tumoral (Mia PaCa-2) and nontumoral (CHO-MrgD) cells, highlighting the antiproliferative activity of alamandine/MrgD and its possible antitumoral effect."],"pubmed_title":["Phosphoproteomic studies of alamandine signaling in CHO-MrgD and human pancreatic carcinoma cells: An antiproliferative effect is unveiled."],"pubmed_authors":["da Silva Filipe Alex FA, Rodrigues-Ribeiro Lucas L, Melo-Braga Marcella Nunes MN, Passos-Silva Danielle Gomes DG, Sampaio Walkyria Oliveira WO, Gorshkov Vladimir V, Kjeldsen Frank F, Verano-Braga Thiago T, Santos Robson Augusto Souza RAS"],"pubmed_title_synonyms":["Carcinoma, uvrc homolog protein, human being, endonuclease cho, exocrine cancer, CHO, Chinese Hamster Ovary cell, Neoplasms, Modern, familial, Pancreas Cancer, Pancreas Cancers, Ala-Arg-Val-Tyr-Ile-His-Pro, CHAMPIGNON, Pancreas Neoplasm, Pancreatic Neoplasm, Human, TUBULIN FOLDING COFACTOR D, TITAN 1, Homo sapiens, cho, Pancreatic Cancer, Neoplasm, Pancreatic Acinar, Cell., pancreatic carcinoma, TFC D, Pancreatic, Cancer of the Pancreas, Man, Pancreatic Carcinomas, Carcinomas, carcinoma of pancreas, Cancer of Pancreas, Man (Taxonomy), Pancreatic Carcinoma, Acinar Carcinoma, Exocrine pancreas carcinoma, Pancreatic carcinoma, Cancers, Pancreatic Cancers, man, Pancreas, EMBRYO DEFECTIVE 133, human, Pancreatic Acinar Carcinoma, signalling process, EMB133, Modern Man, Pancreas Neoplasms, Pancreatic Acinar Carcinomas, Acinar Carcinomas, single organism signaling, Cancer"],"description_synonyms":["Focal Adhesion, PRKBA, Akt/PKB, 2610315D21Rik, dP60, Vps34, DAKT1/PKB, Metabolic Concepts, BcDNA:LD15217, Tumor, AKT1, VPS34, 11621, Long Term, DmTOR, PI-3 kinase, p110-alpha, Polypeptides, RNASE5, RNASE4, RAFT1, Metabolism Concept, Mammalian target of rapamycin, treatment, Dp60, catabolism, PI3K_59F, Cell-Matrix Adherens Junctions, PI3-kinase activity, metabolic process resulting in cell growth, proteins, Structures, PI3Kgamma, RacPK, MCAP, AL033337, PI3K 68D, cellular growth, Adherens Junction, Microfilaments, Adhesion Plaque, ATP - 1-phosphatidyl-1D-myo-inositol 3-phosphotransferase activity, single organism signaling, Tumors, Plaque, PAT, dVps34, CHO, Chinese Hamster Ovary cell, Focal Contacts, metabolism resulting in cell growth, rea, Cell-Matrix, Longterm Effect, p50alpha, CG2699, Ala-Arg-Val-Tyr-Ile-His-Pro, DmelCG5373, Rnase5a, AKT/PKB, Benign, C530050K14, cho, type-1 PI3K, p-Akt, secretion, Actin Microfilament, Ala-Arg-Val-Tyr-Ile-His-Pro., CG11621, Rapamycin and FKBP12 target 1, Benign Neoplasms, dAKT/dPKB, PKB/dAKT, DmelCG4141, Cell-Matrix Adherens, human, F8A5_4, Plaques, Malignant Neoplasms, APDS, Garz, PI3KBETA, Amino Acid Sequences, RAC-ALPHA, DmelCG4006, Effects, Peptidomics, Processes, Neoplasms, Kern, Metabolic Processes, body system, Human, Filament, PIK3, TITAN 1, dVps34/PI3K59F, Pi3Kp60, PI3K-dp110, Gene Products, system, dPI3K, anon-92Ed, TOR, nucleo atomico, Man, class I, anatomical systems, Bx34, Longterm, Metabolic Concept, tor, Tpr, TPR, Long-Term, Pi3Kp110, man, Structure, focal contact, P110BETA, Neoplasias, PI3K21B, Microfilament, AKT, Akt, EMB133, peptidos, MCM, Frap1, Cancer, Cpk, Malignant Neoplasm, AA414921, degradation, akt, class II, type III phosphoinositide 3-kinase activity, Proteins, DAkt1, FRAP1, Primary, DAKT1, FRAP2, mTOR, Cell, CHAMPIGNON, PI(3)K, cpk, Concept, PI3K-92E/Dp110, Sequences, PIK3C1, TUBULIN FOLDING COFACTOR D, PKB, MT, Ang1, CWS6, native protein, CWS5, Long Term Effects, PKB-ALPHA, Neoplasm, ArfGEF, CG4006, Protein Structures, metabolism, Ang, Metabolic Phenomenon, Dakt1, multicellular organism metabolic process, Cell Matrix Adherens Junctions, primary cancer, nucleus of neuraxis, Cancers, DmelCG11621, FRAP, ang, malignant tumor, neuraxis nucleus, Longterm Effects, Gene Proteins, caPI3K, dAkt/PKB, CLOVE, CT16317, signalling process, DmVps34, IMD14, PI3K_68D, PI3K-92D, MTOR, Dmp110, Neoplasia, Anabolism, biochemical pathways, Metabolic Process, MIA PaCa-2, CG5373, ATVPS34, FKBP12-rapamycin complex-associated protein, PI3K, Dp110, protein, Adherens Junctions, l(2)k03905, Atomkern, PHOSPHATIDYLINOSITOL 3-KINASE, peptido, DmelCG2699, Cytoskeletons, F8A5.4, horsetail nucleus, Concepts, p110alpha, phosphatidylinositol 3-kinase activity, Focal Contact, Phenomenon, Effect, adhesion plaque, neuronal nucleus, nucleus atomi, hemi-adherens junction, A-549, Man (Taxonomy), peptides, Pi3K92D, CG4141, Focal, non-developmental growth of a unicellular organism, catalyst activity, Pi3k, Rnase5, RAA1, PI[[3]]K, PKB|Akt, dtor, Adhesions, p55alpha, malignant neoplasm, Adhesion, disease management, Therapies, CG 8487, biotransformation, Malignancies, Pi3K, PI3k, Contacts, Adhesion Plaques, Catabolism, MCMTC, Long-Term Effects, dTOR, dTor, FK506-binding protein 12-rapamycin complex-associated protein 1, Therapy, Primary Protein Structure, Mechanistic target of rapamycin, PI3K68D, uvrc homolog protein, dakt, Process, P110DELTA, PtdIns-3-kinase activity, Modern, l(3)89Bq, results, vacuolar protein sorting 34, dPIK, 1-phosphatidylinositol 3-kinase activity, PKB/Akt, PKB/AKT, Raa2, dAkt, dAKT, Cell-Matrix Adherens Junction, non-developmental cell growth, cell nucleus, DAkt, RAPT1, l(3)04226, Amino Acid, DPKB, pAkt, p85alpha, 2010317E24Rik, Actin, Filaments, PI3K 68_D, Junction, Treatments, EMBRYO DEFECTIVE 133, organ system, p110D, Dakt, GBF1, 5092, dPKB, Polypeptide, p120-PI3K, droPIK57, DRAC-PK85, human being, noyau atomique, CG8487, PI3K92E, CG5092, Benign Neoplasm, Pi3K_59F, Gene, type I phosphatidylinositol kinase activity, Malignant, l(2)k17004, phosphatidylinositol 3-kinase, Dpkb, Homo sapiens, p60, Metabolism, ANRT, PHOSPATIDYLINOSITOL 3-KINASE, TFC D, Metabolism Phenomena, Dp110/PI3K, PI3K-68D/E, DmelCG8274, nuclei, study, Malignancy, growth of cell, Actin Microfilaments, nucleus of CNS, nucleo, noyau, flat, PI3'K, Junctions, PI3K-68D, Actin Filaments, nucleus, 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SUPPRESSOR OF DRM1 DRM2 CMT3, Proteins, beta-Trypsin, Tripcellim, SDC, Gene, proteins, protein, protein-containing complex, CD138, EMBRYO DEFECTIVE 133, CHAMPIGNON, Cell, Ala-Arg-Val-Tyr-Ile-His-Pro, Synd-1, Protein Gene Products, Gene Proteins, Trypure, protein polypeptide chains, TUBULIN FOLDING COFACTOR D, TITAN 1, native protein, natural protein, polypeptide chain, cho, EMB133, Protein, SYND1, Gene Products, TFC D, protein aggregate, SDC1, T17A5.18, beta Trypsin."],"pubmed_abstract_synonyms":["RAS, Ras, PRKBA, l(1)G0098, Akt/PKB, 2610315D21Rik, dP60, 2410041A17Rik, Vps34, DAKT1/PKB, BcDNA:LD15217, fs(1)M34, Ras-1, AKT1, VPS34, 11621, Long Term, DmTOR, DmelCG12051, PI-3 kinase, p110-alpha, ras, c-ras2, RNASE5, RNASE4, Line, HEL-176, CG4601, RAFT1, Mammalian target of rapamycin, A, C, FOXO1A, Dp60, cyt5C, DHO, PI3K_59F, FKH1, CG18572, PI3-kinase activity, PI3Kgamma, RacPK, MCAP, AL033337, PI3K 68D, ACT, Act, ATP - 1-phosphatidyl-1D-myo-inositol 3-phosphotransferase activity, CG1799, single organism signaling, PAT, dVps34, Ras2, RAS2, Ras1, RAS1, Actin/BAP47, CHO, CTE-II, Chinese Hamster Ovary cell, Fkhr, AACT, rea, CTE-IIa, Longterm Effect, act, p50alpha, Ach1, hBACH, ACH1, CG2699, Ala-Arg-Val-Tyr-Ile-His-Pro, DmelCG5373, act42A, Renin Angiotensin Aldosterone System, GIG25, Rnase5a, AKT/PKB, C530050K14, Su(b), cho, AFFX-Dros-ACTIN_M_r_at, GIG24, type-1 PI3K, dRas85D, FKHR, actin, p-Akt, ras1, LACH, ras2, BcDNA:RE36103, Ala-Arg-Val-Tyr-Ile-His-Pro., CG11621, DmelCG4027, Rapamycin and FKBP12 target 1, Hras-1, Dm Ras1, dAKT/dPKB, PKB/dAKT, DmelCG4141, F8A5_4, APDS, RasI, Garz, actin5C, PI3KBETA, BACH, Harvey-ras, Hras1, RAC-ALPHA, l(1)Ab, Act5c, DmelCG4006, conformation, Peptidomics, Effects, dRas, CG1167, H-ras, ACT5C, DRAS1, DRas2, IMPDH, Bach, LD06825, Dras2, Dras1, PIK3, TITAN 1, D-Ras, dVps34/PI3K59F, Pi3Kp60, PI3K-dp110, Kras-2, Cell growth-inhibiting gene 24|25 protein, dPI3K, anon-92Ed, TOR, IMPdH, Ha-ras, Dras, class I, ras 1, Renin-Angiotensin-Aldosterone 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E(sev)3C, Dp110, l(2)k03905, csp2, Act5, CG11485, l(1)G0420, PHOSPHATIDYLINOSITOL 3-KINASE, DmelCG2699, F8A5.4, p110alpha, phosphatidylinositol 3-kinase activity, Foxo1a, Effect, D-Ras1, A-549, RTK, Pi3K92D, CG4141, l(1)G0436, catalyst activity, Pi3k, ras85B, ras85D, Rnase5, RAA1, PI[[3]]K, PKB|Akt, dtor, D-ras-2, p55alpha, act 42A, Ac5C, CG4027, CG 8487, Pi3K, PI3k, FoxO1A, MCMTC, Long-Term Effects, dTOR, dTor, FK506-binding protein 12-rapamycin complex-associated protein 1, Mechanistic target of rapamycin, l(3)s1747, PI3K68D, l(1)G0330, uvrc homolog protein, dakt, Ki-ras, P110DELTA, PtdIns-3-kinase activity, l(3)89Bq, LACH1, vacuolar protein sorting 34, dPIK, 1-phosphatidylinositol 3-kinase activity, PKB/Akt, PKB/AKT, Raa2, dAkt, dAKT, Alpha-1-antichymotrypsin His-Pro-less, DFNA26, p21[Ras1], dRas1, dRAS1, DAkt, Dras85D, GAT, DFNA20, RAPT1, ras-2, Lines, l(3)04226, FoxO1, DPKB, l(1)G0351, LD02673, pAkt, p85alpha, DmelCG1799, c-Ha-ras, System, D-ras1, l(1)G0238, l(1)G0117, D-ras2, C-ras1, 2010317E24Rik, Actin, Dras64B, PI3K 68_D, C-ras2, beta-actin/Bap47, EMBRYO DEFECTIVE 133, l(3)06677, l(1)G0486, l(1)G0002, l(1)G0245, l(1)G0482, p110D, Dakt, GBF1, l(1)G0009, c-H-ras, ACTL3, Lach1, 5092, l(1)G0127, dPKB, p120-PI3K, droPIK57, DRAC-PK85, l(1)G0010, CG8487, RasV12, PI3K92E, CG5092, Kras2, Goal, CG12051, Pi3K_59F, DmelCG9375, Serpin A3, type I phosphatidylinositol kinase activity, RCB0098, l(2)k17004, phosphatidylinositol 3-kinase, l(1)G0388, l(1)G0025, Dpkb, p60, ANRT, PHOSPATIDYLINOSITOL 3-KINASE, TFC D, l(1)G0380, Dp110/PI3K, PI3K-68D/E, DmelCG8274, p21B, study, act5C, Renin-Angiotensin, dras1, Dm-ras-64B, flat, PI3'K, l(1)G0391, Ras 85D, Act42a, PI3K-68D, 1700027G07Rik, DRAC-PK, A549 cell, Long-Term Effect, ras-l, relational structural quality, CT24817, Cte-II, l(1)G0056, l(1)G0177, dP110, data, 6330412C24Rik, AI876417, endonuclease cho, CG9375, p120, Cell Lines, p110, K-ras, Vps34p, FRAP/TOR, Renin Angiotensin System, DmelCG8487, DmelCG5092, AngII, AI385586, fs(3)05703, 2.7.11.1, ATP:1-phosphatidyl-1D-myo-inositol 3-phosphotransferase activity, CAD, HEL168, vps34, EP(X)1093, ALS9, dp110, D-Akt, AI929937, ACTA3, PI3CG, PI-3-K, l(1)G0079, PI3K-59F, PI3K-Dp110, akt1, dAkt1, VSCM, DRAC-PK66, act 5C, class III, CT24745, Rapamycin target protein 1, AI327068, 6030458L21Rik, p110gamma, Su(tor)3-2, dakt1, CG8274, PKBalpha, dAKT1, RAC, Rac, Angiotensin, Actin5C"],"name_synonyms":["Carcinoma, uvrc homolog protein, human being, endonuclease cho, exocrine cancer, CHO, Chinese Hamster Ovary cell, Neoplasms, Modern, familial, Pancreas Cancer, Pancreas Cancers, Ala-Arg-Val-Tyr-Ile-His-Pro, CHAMPIGNON, Pancreas Neoplasm, Pancreatic Neoplasm, Human, TUBULIN FOLDING COFACTOR D, TITAN 1, Homo sapiens, cho, Pancreatic Cancer, Neoplasm, Pancreatic Acinar, Cell., pancreatic carcinoma, TFC D, Pancreatic, Cancer of the Pancreas, Man, Pancreatic Carcinomas, Carcinomas, carcinoma of pancreas, Cancer of Pancreas, Man (Taxonomy), Pancreatic Carcinoma, Acinar Carcinoma, Exocrine pancreas carcinoma, Pancreatic carcinoma, Cancers, Pancreatic Cancers, man, Pancreas, EMBRYO DEFECTIVE 133, human, Pancreatic Acinar Carcinoma, signalling process, EMB133, Modern Man, Pancreas Neoplasms, Pancreatic Acinar Carcinomas, Acinar Carcinomas, single organism signaling, Cancer"],"data_synonyms":["Bru, IPP2A2, E 920, Raw, Hgfr, determination, AI326280, Taf60-2, 5730555F13Rik, CG10390, Sialic acid-binding Ig-like lectin 1, phosphorylation, Long Term, 5730420M11Rik, std, peptide, Polypeptides, MIA, Mia, srybeta, peptido, PACA, HGFR, skc35, phosphate deficiency response 2, sry-beta, Min, 2-amino-3-mercaptopropanoic acid, Cystein, Software Engineering, Effect, paca, WMS, Computer Program, DmelCG42273, C79691, Svc, SER, sry alpha, C, SET, DmelCG6127, Man (Taxonomy), peptides, PAGEN2, MUB3_18, K, TAF-I, cisteina, M, 2-amino-3-(4-hydroxyphenyl)propanoic acid, 3-(p-Hydroxyphenyl)alanine, Open, epsilon-diaminocaproic acid, Computer Programs and Programming, min, 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ATCMPG2, AU020952, sry-a, sry-b, Col4a-1, PRSS, diabetes mellitus, ensemble, 2-amino-3-sulfanylpropanoic acid, tyrosine-protein kinase Met, DmelCG7938, CC1, Engineering, Tripcellim, L-2-Amino-3-mercaptopropionic acid, CG5785, ana, (R)-2-amino-3-mercaptopropanoic acid, Rpw, 2-Amino-3-mercaptopropionic acid, Longterm Effects, Cdrap, ME-IV, Computer Programs, Trypure, sry-alpha, dSET/TAF-Ibeta, 2610030F17Rik, CT18858, Applications Softwares, Modern Man, SSKS, alpha-amino-gamma-methylmercaptobutyric acid, E920, PTF1-p48, Peptid, assay, Par4, DmelCG17957, variable, AA407739, 5730455C01Rik, sry, SF receptor"],"additional_accession":[]},"is_claimable":false,"name":"Shedding lights on the alamandine signaling in CHO-MrgD and human pancreatic carcinoma cells: an antiproliferative effect was unveiled","description":"Antiproliferative effect of ang-(1-7) has been further described and detailed, assessing its possibility as a therapeutic cancer control agent. Other endogenous peptides in this system have been studied and characterized, such as alamandine, a heptapeptide very similar to ang-(1-7) in terms of amino acid sequence and physiological effects. In this study, we described for the first time the anti-proliferative effect induced by alamandine treatment in human cancer cells (Mia Paca-2 and A-549) and its signaling in CHO-MrgD by phosphoproteomics. Our results showed that alamandine inhibited cancer cell growth in vitro assays, but did not in non-cancer cells. Our proteomics results revealed that alamandine reprogramed the energetic metabolism in Mia Paca-2, inhibited PI3K/AKT/mTOR pathways and translocated Fox01 to nucleus portion, not only but also is able to decrease cell growth and possibly migration regulating several proteins related to actin cytoskeleton and focal adhesion. Based in our phosphoproteomics results of alamandine signaling in CHO-MrgD, we have unveiled the anti-proliferative mechanism induced by alamandine/MrgD interaction.","dates":{"publication":"2022-06-07","submission":"2020-04-14"},"accession":"PXD018529","cross_references":{"TAXONOMY":["NEWT:330879","NEWT:377960","NEWT:1131","NEWT:2042546","NEWT:259447","NEWT:295546","NEWT:625351","NCBITaxon:1280","NEWT:112503","NEWT:1129","NEWT:309807","NEWT:59753","NEWT:89184","NEWT:309800","NEWT:281395","NEWT:1211601","NEWT:876138","NEWT:44271","NEWT:193516","NEWT:1073882","NEWT:6819","NEWT:475174","NEWT:1117","NEWT:498257","NEWT:10036","NEWT:1590","NEWT:10034","NEWT:33114","NEWT:661410","NEWT:638632","NEWT:224326","NEWT:376619","NCBITaxon:79857","NEWT:1096976","NEWT:3765","NEWT:1589","NEWT:135622","NEWT:35786","NEWT:1580","NEWT:399784","NEWT:96731","NEWT:656064","NEWT:1582","NEWT:1584","NEWT:36630","NEWT:383379","NEWT:418106","NCBITaxon:12721","NEWT:10029","NEWT:913645","NEWT:641809","NEWT:1392488","NEWT:38815","NEWT:317447","NEWT:4688","NEWT:7719","NEWT:868565","NEWT:135674","NEWT:79329","NEWT:30069","NEWT:12637","NEWT:59729","NEWT:2164133","NEWT:295105","NEWT:108061","NEWT:60711","NEWT:224308","NEWT:3347","NEWT:160621","NEWT:212790","NEWT:110368","NEWT:1310161","NEWT:77133","NEWT:145481","NEWT:1310165","NEWT:29058","NCBITaxon:79824","NEWT:410658","NEWT:44688","NEWT:44689","NEWT:498211","NEWT:347256","NEWT:5518","NEWT:398007","NEWT:1527468","NEWT:498217","NEWT:498216","NEWT:11320","NEWT:246196","NEWT:246197","NEWT:145458","NEWT:44685","NEWT:161934","NEWT:1148","NEWT:5508","NEWT:3329","NEWT:419481","NEWT:5507","NEWT:410661","NEWT:1140","NCBITaxon:2157","NEWT:1143","NEWT:1287689","NEWT:1094343","NEWT:1462472","NEWT:1336795","NEWT:644042","NEWT:150808","NEWT:1182590","NEWT:3712","NEWT:3711","NEWT:3714","NEWT:2065263","NEWT:177437","NEWT:10418","NEWT:118698","NEWT:1616117","NEWT:118696","NEWT:34865","NEWT:52283","NEWT:284812","NEWT:8175","NEWT:43330","NEWT:1603293","NEWT:44664","NEWT:43346","NEWT:3702","NEWT:1245466","NEWT:3704","NEWT:244366","NEWT:1246791","NEWT:176597","NEWT:118694","NEWT:2850","NEWT:118691","NEWT:34871","NEWT:33548","NEWT:52299","NEWT:8165","NEWT:96794","NEWT:3708","NEWT:332648","NEWT:44670","NEWT:536231","NEWT:376219","NEWT:219813","NEWT:1510","NEWT:460519","NEWT:1515","NEWT:572307","NEWT:1432138","NEWT:1424507","NEWT:1194599","NEWT:272844","NEWT:1348799","NEWT:33995","NEWT:55784","NEWT:1303443","NEWT:485","NEWT:56636","NEWT:2499525","NEWT:2853422","NEWT:487","NEWT:1538553","NEWT:1679718","NEWT:480","NEWT:67767","NEWT:46835","NEWT:109757","NEWT:582580","NEWT:1185650","NEWT:216778","NEWT:1502","NEWT:128017","NEWT:376686","NEWT:237610","NEWT:95486","NEWT:1883446","NEWT:1233435","NEWT:118223","NEWT:11757","NEWT:109760","NEWT:29031","NEWT:317047","NEWT:491","NEWT:460523","NEWT:45954","NEWT:235443","NEWT:1757312","NEWT:85694","NEWT:109786","NEWT:108458","NEWT:5936","NEWT:320637","NEWT:1078283","NEWT:3750","NEWT:983964","NEWT:11706","NEWT:32644","NEWT:527796","NEWT:499175","NEWT:109779","NEWT:3745","NEWT:1715989","NCBITaxon:4751","NEWT:3747","NEWT:1116234","NEWT:1255228","NEWT:410289","NEWT:373153","NEWT:1640278","NEWT:472","NEWT:940825","NEWT:529507","NEWT:1071661","NEWT:28128","NEWT:470","NEWT:5911","NEWT:748693","NCBITaxon:50557","NEWT:39251","NEWT:29491","NEWT:101841","NEWT:446","NEWT:153481","NEWT:2014887","NEWT:33952","NEWT:445","NEWT:153009","NEWT:261756","NEWT:166313","NEWT:63366","NEWT:63367","NEWT:215402","NEWT:1547","NEWT:906914","NEWT:28141","NEWT:9031","NEWT:27292","NEWT:1050722","NEWT:3728","NEWT:108931","NEWT:1293497","NEWT:1055524","NEWT:150475","NEWT:267872","NEWT:381666","NEWT:172269","NEWT:9534","NEWT:5180","NEWT:256737","NEWT:9541","NEWT:8694","NEWT:33936","NEWT:8692","NEWT:2903","NEWT:185579","NEWT:13076","NEWT:207340","NEWT:1006581","NEWT:8673","NEWT:33940","NEWT:550","NEWT:554","NEWT:451516","NEWT:552","NEWT:1325291","NEWT:42410","NEWT:36185","NEWT:1054211","NEWT:1225786","NEWT:771870","NEWT:51338","NEWT:575412","NEWT:28112","NEWT:6493","NEWT:10832","NEWT:6494","NEWT:6491","NEWT:507601","NEWT:520","NEWT:186441","NEWT:643680","NEWT:214092","NCBITaxon:6157","NEWT:13095","NEWT:162425","NEWT:104105","NEWT:216257","NEWT:9986","NEWT:8654","NEWT:8658","NEWT:1268063","NEWT:8657","NEWT:9983","NEWT:8655","NEWT:5147","NEWT:28108","NEWT:28104","NEWT:407821","NEWT:568703","NCBITaxon:2","NEWT:568708","NEWT:1613","NEWT:986","NEWT:52641","NEWT:28532","NEWT:353152","NEWT:298176","NEWT:353153","NEWT:227377","NEWT:1774284","NEWT:40674","NEWT:1194669","NEWT:443906","NEWT:519","NEWT:2510939","NEWT:7394","NEWT:6063","NEWT:1328388","NEWT:105487","NEWT:1548728","NEWT:667127","NEWT:9557","NEWT:377586","NEWT:300641","NEWT:39655","NEWT:9554","NEWT:475932","NEWT:256318","NEWT:206411","NCBITaxon:6191","NEWT:229533","NEWT:214053","NEWT:28550","NEWT:80863","NEWT:90675","NEWT:52639","NEWT:52638","NEWT:57075","NEWT:1666905","NEWT:8697","NEWT:8695","NEWT:884204","NEWT:1045775","NEWT:1123869","NEWT:9544","NEWT:9545","NEWT:979","NEWT:7370","NEWT:83906","NEWT:99488","NEWT:1134506","NEWT:255470","NEWT:38783","NEWT:6426","NEWT:33090","NEWT:9935","NEWT:287889","NEWT:305959","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