{"database":"Pride","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Txt":["ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/07/PXD042631/checksum.txt"],"Raw":["ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/07/PXD042631/Jschugrp_082318_ppixtmt_fxn_14.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/07/PXD042631/Jschugrp_082318_ppixtmt_fxn_10.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/07/PXD042631/Jschugrp_082318_ppixtmt_fxn_05.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/07/PXD042631/Jschugrp_082318_ppixtmt_fxn_06.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/07/PXD042631/Jschugrp_082318_ppixtmt_fxn_01.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/07/PXD042631/Jschugrp_082318_ppixtmt_fxn_15.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/07/PXD042631/Jschugrp_082318_ppixtmt_fxn_11.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/07/PXD042631/Jschugrp_082318_ppixtmt_fxn_02.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/07/PXD042631/Jschugrp_082318_ppixtmt_fxn_07.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/07/PXD042631/Jschugrp_082318_ppixtmt_fxn_12.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/07/PXD042631/Jschugrp_082318_ppixtmt_fxn_03.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/07/PXD042631/Jschugrp_082318_ppixtmt_fxn_08.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/07/PXD042631/Jschugrp_082318_ppixtmt_fxn_13.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/07/PXD042631/Jschugrp_082318_ppixtmt_fxn_04.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/07/PXD042631/Jschugrp_082318_ppixtmt_fxn_09.raw"],"Pepxml":["ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/07/PXD042631/Jschugrp_082318_ppixtmt_fxn_06.1.pepXML","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/07/PXD042631/Jschugrp_082318_ppixtmt_fxn_12.1.pepXML","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/07/PXD042631/Jschugrp_082318_ppixtmt_fxn_15.1.pepXML","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/07/PXD042631/Jschugrp_082318_ppixtmt_fxn_09.1.pepXML","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/07/PXD042631/Jschugrp_082318_ppixtmt_fxn_03.1.pepXML","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/07/PXD042631/Jschugrp_082318_ppixtmt_fxn_04.1.pepXML","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/07/PXD042631/Jschugrp_082318_ppixtmt_fxn_13.1.pepXML","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/07/PXD042631/Jschugrp_082318_ppixtmt_fxn_10.1.pepXML","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/07/PXD042631/Jschugrp_082318_ppixtmt_fxn_07.1.pepXML","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/07/PXD042631/Jschugrp_082318_ppixtmt_fxn_01.1.pepXML","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/07/PXD042631/Jschugrp_082318_ppixtmt_fxn_02.1.pepXML","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/07/PXD042631/Jschugrp_082318_ppixtmt_fxn_08.1.pepXML","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/07/PXD042631/Jschugrp_082318_ppixtmt_fxn_05.1.pepXML","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/07/PXD042631/Jschugrp_082318_ppixtmt_fxn_14.1.pepXML","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/07/PXD042631/Jschugrp_082318_ppixtmt_fxn_11.1.pepXML"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"labhead_mail":["John.Schuetz@stjude.org"],"submitter":["Zuo-Fei Yuan"],"technology_type":["Mass Spectrometry","Shotgun proteomics"],"software":["Not available"],"submitter_keywords":["Prdx3","Ferroptosis","Tmt","Reactive oxygen species.","Protoporphyrin ix"],"full_dataset_link":["https://www.ebi.ac.uk/pride/archive/projects/PXD042631"],"tissue":["Hepatocyte","Fibroblast"],"sample_protocol":["For each cell type analyzed, 500 µg of lysate were incubated with 40 nmol of PPB, or control probe, for 30 minutes, then precipitated with 50 µL of avidin beads in phosphate buffered saline with 0.1% Triton X100.  The beads were precipitated by centrifugation at 500 x g for 2 min and washed 8 times in 10 volumes of PBS/0.1% Triton X100. Each sample was evaluated by SDS-PAGE gel and digested. Then digested peptides from each sample were labeled with TMT-11 tags. The TMT labeled peptides were pooled and separated into 15 fractions by basic LC fractionation. Every fraction was further separated on a reverse phase column (20 cm X 75 µm, 1.7 μm C18 resin) during a 90 min gradient of 16-45% buffer B (buffer A: 0.2% formic acid, 3% DMSO; buffer B: buffer A plus 65% acetonitrile) and analyzed by Orbitrap Fusion (Thermo Scientific) with one MS scan and up to 20 data-dependent high-resolution MS/MS scans."],"repository":["Pride"],"quantification_method":[""],"modification":[""],"data_protocol":["The MS/MS raw files are processed using the JUMP searching engine against UniProt human and mouse database. Searches were performed using 15 ppm mass tolerance and allowing up to two missed trypsin cleavage sites. TMT tags on lysine residues and peptide N termini (+229.162932 Da) and carbamidomethylation of cysteine residues (+57.021 Da) were used for static modifications and the dynamic modifications include oxidation of methionine residues (+15.99492 Da). Proteins were quantified by summing reporter ion counts across all matched PSMs using our in-house software."],"omics_type":["Proteomics"],"labhead":["John Schuetz"],"instrument_platform":[""],"submission_type":["PARTIAL"],"labhead_affiliation":["Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN 38105, USA"],"species":["Homo Sapiens (human)","Mus Musculus (mouse)"],"publication":["37355765 Lynch J, Wang Y, Li Y, Kavdia K, Fukuda Y, Ranjit S, Robinson CG, Grace CR, Xia Y, Peng J, Schuetz JD. A PPIX-binding probe facilitates discovery of PPIX-induced cell death modulation by peroxiredoxin. Commun Biol. 2023 6(1):673 10.1038/s42003-023-05024-5"],"submitter_mail":["zuo-fei.yuan@stjude.org"],"submitter_affiliation":["St. Jude Children's Research Hospital"],"submitter_country":["United States"],"pubmed_abstract":["While heme synthesis requires the formation of a potentially lethal intermediate, protoporphyrin IX (PPIX), surprisingly little is known about the mechanism of its toxicity, aside from its phototoxicity. The cellular protein interactions of PPIX might provide insight into modulators of PPIX-induced cell death. Here we report the development of PPB, a biotin-conjugated, PPIX-probe that captures proteins capable of interacting with PPIX. Quantitative proteomics in a diverse panel of mammalian cell lines reveal a high degree of concordance for PPB-interacting proteins identified for each cell line. Most differences are quantitative, despite marked differences in PPIX formation and sensitivity. Pathway and quantitative difference analysis indicate that iron and heme metabolism proteins are prominent among PPB-bound proteins in fibroblasts, which undergo PPIX-mediated death determined to occur through ferroptosis. PPB proteomic data (available at PRIDE ProteomeXchange # PXD042631) reveal that redox proteins from PRDX family of glutathione peroxidases interact with PPIX. Targeted gene knockdown of the mitochondrial PRDX3, but not PRDX1 or 2, enhance PPIX-induced death in fibroblasts, an effect blocked by the radical-trapping antioxidant, ferrostatin-1. Increased PPIX formation and death was also observed in a T-lymphoblastoid ferrochelatase-deficient leukemia cell line, suggesting that PPIX elevation might serve as a potential strategy for killing certain leukemias."],"pubmed_title":["A PPIX-binding probe facilitates discovery of PPIX-induced cell death modulation by peroxiredoxin."],"pubmed_authors":["Lynch John J, Wang Yao Y, Li Yuxin Y, Kavdia Kanisha K, Fukuda Yu Y, Ranjit Sabina S, Robinson Camenzind G CG, Grace Christy R CR, Xia Youlin Y, Peng Junmin J, Schuetz John D JD"],"sample_synonyms":["sodium salt, Methane, ammonium formate, 13C-labeled, cadmium salt, MeCN, NCMe, zinc formate, lead salt, magnesium formate, Pi, zinc salt, prevention, Polypeptides, ammonium tetraformate, Triton, peptido, cobalt(II) formate dihydrate, CH3-C#N, B1, SDS-PAGE, DGS, Min, prevention and control, Nereid, Rheumabene, DmelCG42273, PPB, tetraoxophosphate(V), Divorced, Orthophosphate, Polyacrylamide, MS2., reference sample, SDS-PAGE electrophoresis, peptides, PHOSPHATE ION, tetraoxidophosphate(3-), dimethyl sulphoxide, min, mAPC, Phosphate, IBP, Divorces, copper, SCAN, AI047805, preventive measures, ppb, lithium salt, column, Dimethylsulfoxide, DmelCG1106, sample, D1, Bladder pain syndrome, Avidins, ammonium (2:1) salt, Inorganic, Dimethylsulfoxid, nickel salt, sulfinylbis-, DMSO, preventive therapy, BZRP, dimethyli sulfoxidum, dmso, cobalt (+2) salt, PPB familial tumor and dysplasia syndrome, methylsulfinylmethane, Dmel_CG7826, Thermo Scientific, PPB familial tumour and dysplasia syndrome, PBS, PBR, TPSG1, (CH3)2SO, S-adenosyl-L-methionine:thiol S-methyltransferase activity, sodium (4:1:1) salt, Dm1, magnesium salt, nickel (+2) salt, Sulfinylbis(methane), Dmel_CG7835, Rimso 50, Phosphates, Mnb, MNB, absence of, ammonium salt, Painful Bladder Syndrome, Sodium Dodecyl Sulfate-PAGE, Rimso50, MS/MS, PO4(3-), formate, cobaltous formate, SDS polyacrylamide gel electrophoresis, pooled, cromium (+3), AW124434, cell_type, HIS1, CG1106, Painful bladder syndrome, phosphate, phosphate ions, PRSS31, copper salt, ammonium (4:1) salt, Polypeptide, methyl cyanide, Sodium Dodecyl Sulfate-PAGEs, lead (+2) salt, TMT, Bladder Pain Syndrome, BPBS, Dimethyl, tetraoxophosphate(3-), nickel formate dihydrate, lead formate, aluminum salt, cesium salt, dimethylsulfoxyde, Rimso 100, Gel Electrophoresis, abdominal muscles, SDS polyacrylamide gel electrophoresis of proteins, CG7826, Buffer, formic acid, Sodium Dodecyl Sulfate PAGE, Sulphoxide, potassium salt, 14C-labeled, Polyacrylamide Gel Electrophoresis, CG7835, CG42273, Separated, S(O)Me2, sulfinylbis(methane), thallium (+1) salt, gel, Inorganic Phosphates, rubidium salt, pk18, calcium formate, methanoic acid, MBR, Rimso-50, dimetil sulfoxido, lysate, Rimso, Dimethylsulphinyl, PTBR, peptidos, cromium (+3) salt, sodium formate, thiol methyltransferase activity, PTHB1, Controlled, SDS PAGE, [PO4](3-), Controlling, DYRK1, nickel formate, 1-(14)C-labeled, DBI, 3H-labeled, strontium formate, potassium formate, copper (+2) salt, strontium salt, acetonitrile, buffer, Peptide, PKBS, Dimexide, C18, cupric formate, Dimethylsulphoxide, Dyrk1, eagle-Barrett syndrome, Sulfoxide, aluminum formate, ACETONITRILE, tandem MS, cyanomethane, Inorganic Phosphate, AU020952, Separation, 10^[-9], with urinary tract Abnormality and cryptorchidism, lithium formate, prophylaxis, sodium dodecyl sulphate–polyacrylamide gel electrophoresis, Separations, CC1, dimethyl sulfoxide, Sclerosol, Dimethyl Sulphoxide, ethanenitrile, mDRC, sample population, chromic formate, ME-IV, control, nmol, calcium salt, Peptid, phosphates, dimethyl sulfur oxide"],"name_synonyms":["Taf[[II]]250, Taf200, dTAF[[II]]230, TAF[[II]]250, d230, dTAF[[II]]250, TAF[[II]]230, TFIID TAF250, cel, cell, ligand, Proteins, TAF200, Gene, l(3)84Ab, dTAFII250, Taf1p, TAF[II]250, BG:DS00004.13, TAFII-250, CG17603, TAF250/230, TAF[[II]], EfW1, Cell, Protein Gene Products, dTAF230, Gene Proteins, dTAF250, dmTAF[[II]]230, TAFII250, DmelCG17603, TAF1., Taf250, dmTAF1, SR3-5, Taf230, p230, Protein, Gene Products, TAF[[II]]250/230, TFIID, TAF, TAF230, TAF250"],"data_synonyms":["Bru, human being, Cysteine Hydrochloride, E 920, 2-amino-4-(methylsulfanyl)butanoic acid, Raw, ion, Lysine Hydrochloride, Laboratory, Mus domesticus, cleavage, L-Zystein, L Isomer, FBN, Gene, Computer, House Mouse, Human, peptide, Polypeptides, L-Isomer Methionine, Lysine Acetate, Methionine, peptido, Homo sapiens, House, ECTOL1, Gene Products, Mus musculus domesticus, L-Methionine, 2, Del(8)44H, Lysine, 2-amino-3-mercaptopropanoic acid, Cystein, Software Engineering, Half-Cystine, Mice, Man, WMS, Pedameth, Computer Program, Application, L Lysine, Svc, Open Source Softwares, C, Man (Taxonomy), peptides, K, Swiss, cisteina, MS2, L Cysteine, M, iones, Software Application, E-920, Open, beta-Trypsin, epsilon-diaminocaproic acid, Open Source Software, Computer Programs and Programming, Swiss Mice, Hcys, ions, Computer Software Application, OCTD, LYS, 2-amino-4-(methylthio)butanoic acid, Tools, CYSTEINE, Lysin, FREE CYSTEINE, peptidos, house mouse, Half Cystine, (2R)-2-amino-3-mercaptopropanoic acid, GPHYSD2, metionina, Racemethionine, thiol methyltransferase activity, SGS, Applications Software, Open Source, Computer Software, Zinc Cysteinate, DL-Methionine, Modern, Proteins, mouse, 2-Amino-4-(methylthio)butyric acid, L-Isomer, Cys, Peptide, Source Softwares, Software Tools, Tool, ACMICD, Programs, polypeptide, Program, Computer Applications, TPSG1, S-adenosyl-L-methionine:thiol S-methyltransferase activity, Software Tool, Ionen, Mus, Acetate, Protein, Computer Applications Software, lysine, Computer Applications Softwares, MFS1, Methionin, Hmet, Softwares, (2R)-2-amino-3-sulfanylpropanoic acid, L-Lysine, Software, tandem MS, Zystein, Data Base, WMS2, Met, Mus musculus, Software Applications, Col4a-1, PRSS, MS/MS, 2-amino-3-sulfanylpropanoic acid, mice, Source Software, Swiss Mouse, Engineering, Tripcellim, L-2-Amino-3-mercaptopropionic acid, House Mice, L-Cysteine, (R)-2-amino-3-mercaptopropanoic acid, MASS, alpha, beta Trypsin, human, 2-Amino-3-mercaptopropionic acid, L-Cystein, domesticus, Laboratory Mice, Protein Gene Products, Computer Programs, Trypure, Gene Proteins, Applications, Applications Softwares, Ion, Computer Software Applications., Modern Man, SSKS, PRSS31, alpha-amino-gamma-methylmercaptobutyric acid, E920, Peptid, Mouse, Polypeptide, 6-diaminohexanoic acid, TMT, Liquimeth, Laboratory Mouse, Enisyl"],"description_synonyms":["4-d]imidazol-4-yl)pentanoic acid, anon-EST:fe2E2, Deacura, l(3)alpha-Spec, vitamin B7, determination, Biotine, alpha-Spect, Medebiotin, alpha-Spe, FBN, Gene, Vitamin H, alpha-Spc, l(3)04276, B-spec, Biotin, ECTOL1, betaspec, 4beta, klo, Gene Products, Line, 6aR)-Hexahydro-2-oxo-1H-thieno[3, alpha-Sp, CG1977, 6aalpha))-, Gelfert, WMS, alpha-spec, study, Biotin Hermes, kus, Coenzyme R, (3aS, cis-Hexahydro-2-oxo-1H-thieno(3, biotina, dre3, biotine, labeling, alpha-spectrin, OCTD, anon-EST:fe1B3, 4-d]imidazole-4-valeric acid, Hermes, SPEC8, (+)-cis-Hexahydro-2-oxo-1H-thieno[3, biotinum, CG5870, GPHYSD2, thiol methyltransferase activity, SGS, l(3)dre3, single organism signaling, Medobiotin, Spec-beta, alpha-Spectrin, Rombellin, 3A9, DmelCG1977, Proteins, Cell Lines, Roche, Biotin Gelfert, i168, 5-(2-oxohexahydro-1H-thieno[3, SpeC, 4]imidazole-4-valeric acid, Cell, L-ornithine carboxy-lyase (putrescine-forming), L-ornithine carboxy-lyase activity, 4S, 4-d)imidazole-4-pentanoic acid, (3aS-(3aalpha, ACMICD, TPSG1, alphaSpec, S-adenosyl-L-methionine:thiol S-methyltransferase activity, cis-Tetrahydro-2-oxothieno(3, 4]imidazoline-4-valeric acid, biotin, l(1)G0108, Protein, chemical analysis, Biotin Ratiopharm, betaSpec, MFS1, 4-d)imidazoline-4-valeric acid, alphaSp, b-Spec, spectrin, WMS2, D-Biotin, Biodermatin, Lines, Biotin-Ratiopharm, 1H-Thieno(3, DmelCG5870, l(1)G0074, Biotine Roche, l(1)G0198, Gabunat, hexahydro-2-oxo-, FCP-B, b spectrin, MASS, alpha, 4)imidazole-4-valeric acid, beta, Protein Gene Products, Gene Proteins, ligand., signalling process, beta-spec, l(3)62Bd, i6, PRSS31, SSKS, cis-(+)-Tetrahydro-2-oxothieno[3, alfa-Spec, assay, D-(+)-biotin, TMT, Biokur, Spec, Specbeta"],"pubmed_abstract_synonyms":["Networks, Anti Oxidants, deceased, Ghrfr, TDPX2, euthanisia, degree (angle), Kinship, single-organism developmental process, vitamin B7, prx3, NKEF-A, Activity, determination, D0Tohi1, Protoheme ferro-lyase, postnatal development, prx1, growth and development, protein, Progress Reports, Cardiac Death, Gene Knock-Down, End-Of-Life, Techniques, protoporphyrin, Biotin, tdpx2, Summary Report, Murder, gamma-L-Glutamyl-L-cysteinyl-glycine, Line, Life Cycle, 6aR)-Hexahydro-2-oxo-1H-thieno[3, Protoheme Ferro Lyase, 26Fe, protein aggregate, Summary Reports, multicellular organismal biosynthetic process, Family Life Cycle, aop1, PPB, Anti Oxidant, increased, single-organism biosynthetic process, heme synthesis, prxi, Kinship Network, Progress Report, Gene Knock Downs, Glycine, Reduced, (3aS, PrdxI, 5-L-Glutamyl-L-cysteinylglycine, cis-Hexahydro-2-oxo-1H-thieno(3, biotina, Gene Knock-Downs, Tdpx2, Leucocythemias, End Of Life, PrxI, biotine, PRXI, Glutathione, Reduced glutathione, prx-III, allergic reaction, Progress, TPxA, ppb, Wrongful Death, Field Reports, Hermes, Antioxidant, Anti-Oxidant Effect, iron-dependent programmed cell death, Murders, Homicides, heme formation, necrosis, biotinum, Family Life Cycles, PAG, heme metabolism, Prx3, Wrongful Deaths, PRX1, Medobiotin, prx-3, prx-1, OSF-3, Rombellin, NKEFA, Paga, PPB familial tumor and dysplasia syndrome, Aop1, Antioxidants, AOP1, Knock Downs, Endogenous, gamma-L-Glu-L-Cys-Gly, Gene Knockdown Technique, lit, pag, Killings, Anti-Oxidants, PPB familial tumour and dysplasia syndrome, 4S, 4-d)imidazole-4-pentanoic acid, Gene Knockdowns, death status type, (3aS-(3aalpha, Gene Knock-Down Techniques, AW822249, Zinc Chelatase, Protoheme, Iron 56, haem biosynthesis, Investigative Report, ATP synthase D chain, PAGB, aop-1, PAGA, margin of safety, Biotin Ratiopharm, Near-Death Experience, haem metabolic process, 4-d)imidazoline-4-valeric acid, pagb, Filiation, D-Biotin, NkefA, little, Lines, AOP-1, paga, 1H-Thieno(3, Mitochondrial, Leucocythemia, antioxidants, Biotine Roche, Iron, Determination of Death, disodium salt, Field, haem biosynthetic process, Ef2l, GSH, HIS1, Knock-Downs, Fe, Life Cycles, haem metabolism, Endogenous Antioxidants, Report, Eisen, Chelatase, Specificity and Sensitivity, Knockdown Techniques, cis-(+)-Tetrahydro-2-oxothieno[3, Knockdown, iron, D-(+)-biotin, Biokur, protoporphyrin IX dihydride, Femicide, Fibroblast, accessory, heme biosynthesis, Knockdown Technique, 4-d]imidazol-4-yl)pentanoic acid, SP-22, Deacura, Family Member, PPIX, Peptidomics, Endogenous Antioxidant, Biotine, antoxidant, number, Medebiotin, Porphyrin Metal Chelatase, Gene, antioxydant, gamma-L-Glutamyl-L-Cysteinylglycine, Network, Vitamin H, protein-containing complex, mitochondrial, presence, Gene Knock Down, supernumerary, gene knock-down, N-(N-L-gamma-glutamyl-L-cysteinyl)-, Cardiac, Investigative, Porphyrin-Metal Chelatase, sensitive, Anti-Oxidant, 4beta, Gene Products, leukaemia NOS, Leucocythaemias., Leucocythaemia, Anti-Oxidant Effects, sp-22, 6aalpha))-, Gelfert, sensitivity, Technique, Knockdowns, TDXM, nkefa, Biotin Hermes, hierro, MSP23, Coenzyme R, Research, blocked, N-(N-gamma-L-Glutamyl-L-cysteinyl)glycine, HBC189, Heme, Msp23, Deaths, heme anabolism, gamma L Glutamyl L Cysteinylglycine, Killing, 4-d]imidazole-4-valeric acid, Wrongful, Porphyrin-Metal, PRO1748, sp22, (+)-cis-Hexahydro-2-oxo-1H-thieno[3, Knock-Down Technique, TDX2, Antioxidant Activity, accidental cell death, gamma L Glu L Cys Gly, Zinc, Sensitivity, Hbp23, toxic potential, Femicides, Heme Synthetase, Kinship Networks, Investigative Reports, Family, SP22, msp23, protoporphyrin IX, Family Research, Oxytosis, protein complex, Gene Knock-Down Technique, Proteins, life termination, Cell Lines, fer, Roche, Biotin Gelfert, 5-(2-oxohexahydro-1H-thieno[3, Gene Knock Down Techniques, Cell, 4]imidazole-4-valeric acid, Anti Oxidant Effect, Leukemias, Mer5, MER5, Family Members, development, count in organism, cis-Tetrahydro-2-oxothieno(3, 4]imidazoline-4-valeric acid, biotin, native protein, mer5, sacrifice, Antioxidant Effect, Protein, Research Reports, chemical analysis, post-mortem, Synthetase, OSF3, Death, Reduced Glutathione, Gene Knockdown, Knock-Down Techniques, Biodermatin, Knock Down, Biotin-Ratiopharm, Anti Oxidant Effects, ferrum, death, 10^[-9], Gabunat, Ovoperoxidase, increased number, Ferro-Lyase, postnatal growth, hexahydro-2-oxo-, Specificity, arc degree, Iron-56, 4)imidazole-4-valeric acid, Protein Gene Products, Gene Proteins, Antioxidant Effects, present in greater numbers in organism, Reports, Protoheme Ferro-Lyase, Families, Knock-Down, Glutathione-SH, assay, Summary, growth, Relatives, Field Report"],"pubmed_title_synonyms":["necrosis, Death, accidental cell death., Cell, ligand"],"additional_accession":[]},"is_claimable":false,"name":"Proteomic Profiling of PPIX-binding proteins between cell types","description":"To use a probe connecting PPIX with biotin to affinity purify interacting proteins in various cell lines.  Then to use TMT labeling of the purified proteins, as well as those from controls, to construct data sets of proteins identified with mass spec, together with biostatistical analysis, to distinguish valid interactions for further study.  These data may cumulatively allow us to delineate trafficking, signaling, or metabolic pathways related to PPIX binding.","dates":{"publication":"2023-07-20","submission":"2023-06-01"},"accession":"PXD042631","cross_references":{"TAXONOMY":["NEWT:68239","NEWT:108018","NEWT:377960","NEWT:1131","NEWT:190486","NEWT:2042546","NEWT:148942","NEWT:295546","NEWT:258594","NEWT:1126","NEWT:1129","NEWT:89187","NEWT:309807","NEWT:89184","NEWT:309800","NEWT:1323429","NEWT:876138","NEWT:44271","NEWT:193516","NEWT:2315688","NEWT:592321","NEWT:1073882","NEWT:6819","NEWT:428386","NEWT:1117","NEWT:498257","NEWT:10036","NEWT:32264","NEWT:10034","NEWT:661410","NEWT:488003","NEWT:224326","NEWT:376619","NEWT:3765","NEWT:3767","NEWT:433727","NEWT:135622","NEWT:672127","NEWT:656061","NEWT:37965","NEWT:656064","NEWT:3760","NEWT:36630","NEWT:381198","NEWT:418106","NEWT:10029","NEWT:913645","NEWT:2492962","NEWT:641809","NEWT:44250","NEWT:317447","NEWT:5530","NEWT:868565","NEWT:135674","NEWT:1562698","NEWT:12637","NEWT:2164133","NEWT:2767846","NEWT:1343074","NEWT:314344","NEWT:108061","NEWT:224308","NEWT:49928","NEWT:160621","NEWT:110368","NEWT:1916073","NEWT:1310161","NEWT:1230383","NEWT:77133","NEWT:1310165","NEWT:114727","NEWT:5516","NEWT:498211","NEWT:347256","NEWT:5518","NEWT:398007","NEWT:1527468","NEWT:498217","NEWT:498216","NEWT:11320","NEWT:1310173","NEWT:37919","NEWT:161934","NEWT:156587","NEWT:1148","NEWT:5508","NEWT:419481","NEWT:5507","NEWT:1140","NCBITaxon:2157","NEWT:2066563","NEWT:1143","NEWT:1462472","NEWT:1336795","NEWT:644042","NEWT:709964","NEWT:3712","NEWT:3711","NEWT:3714","NEWT:65121","NEWT:3715","NEWT:2065263","NEWT:1549675","NEWT:177437","NEWT:9014","NEWT:10891","NEWT:34869","NEWT:226126","NEWT:1616117","NEWT:34865","NEWT:28174","NEWT:550537","NEWT:284812","NEWT:3701","NEWT:3702","NEWT:1245466","NEWT:3704","NEWT:1246791","NEWT:34875","NEWT:9005","NEWT:34871","NEWT:9006","NEWT:33548","NEWT:1883426","NEWT:657321","NEWT:10886","NEWT:3708","NEWT:536231","NEWT:219813","NEWT:215451","NEWT:460519","NEWT:272843","NEWT:272844","NEWT:1348799","NEWT:55784","NEWT:485","NEWT:2709072","NEWT:2499525","NEWT:142786","NEWT:2853422","NEWT:487","NEWT:1679718","NEWT:480","NEWT:67767","NEWT:46835","NEWT:216778","NEWT:376686","NEWT:237610","EFO:0001352","NEWT:219809","NEWT:219808","NEWT:119562","NEWT:1883446","NEWT:1233435","NEWT:118223","NEWT:141469","NEWT:272831","NEWT:987059","NEWT:491","NEWT:460523","NEWT:85694","NEWT:85692","NEWT:911045","NEWT:3750","NEWT:291146","NEWT:29466","NEWT:233271","NEWT:3745","NEWT:1715989","NCBITaxon:4751","NEWT:3747","NEWT:278161","NEWT:415978","NEWT:410289","NEWT:191701","NEWT:9054","NEWT:472","NEWT:29459","NEWT:1380096","NEWT:28128","NEWT:470","NEWT:41122","NEWT:1328300","NEWT:748693","NCBITaxon:50557","NEWT:3735","NEWT:29491","NEWT:911022","NEWT:446","NEWT:153481","NEWT:445","NEWT:2003758","NEWT:63366","NEWT:63367","NEWT:29488","NEWT:215402","NEWT:3726","NEWT:30455","NEWT:28141","NEWT:9030","NEWT:9031","NEWT:3728","NEWT:108931","NEWT:219799","NEWT:219798","NEWT:548","NEWT:150475","NEWT:256737","NEWT:51350","NEWT:8694","NEWT:8692","NEWT:542","NEWT:394503","NEWT:13076","NEWT:219785","NEWT:451515","NEWT:8673","NEWT:550","NEWT:10804","NEWT:554","NEWT:451516","NEWT:552","NEWT:1325291","NEWT:42410","NEWT:1225786","NEWT:771870","NEWT:8665","NEWT:51338","NEWT:9995","NEWT:28112","NEWT:49012","NEWT:28110","NEWT:10832","NEWT:311339","NEWT:507601","NEWT:520","NEWT:64657","NEWT:186441","NEWT:2585209","NEWT:643680","NEWT:214092","NEWT:40697","NEWT:13095","NEWT:162425","NEWT:242124","NEWT:9986","NEWT:8654","NEWT:8658","NEWT:1268063","NEWT:8657","NEWT:9983","NEWT:8655","NEWT:595495","NEWT:80833","NEWT:479096","NEWT:28108","NEWT:28104","NEWT:1114957","NEWT:568703","NEWT:568708","NEWT:52641","NEWT:353152","NEWT:353153","NEWT:227377","NEWT:1774284","NEWT:27689","NEWT:207769","NEWT:40674","NEWT:51329","NCBITaxon:1763","NEWT:443906","NEWT:13037","NEWT:519","NEWT:941638","NEWT:7394","NEWT:6063","NEWT:404330","NEWT:1328388","NEWT:13064","NEWT:300641","NEWT:39655","NEWT:38323","NEWT:206411","NEWT:80869","NEWT:214053","NEWT:80863","NEWT:665890","NEWT:52639","NEWT:52638","NEWT:8697","NEWT:861109","NEWT:8695","NEWT:1196866","NEWT:6039","NEWT:510516","NEWT:1045775","NEWT:1123869","NCBITaxon:1335626","NEWT:7370","NEWT:280406","NEWT:83906","NEWT:99488","NEWT:1134506","NEWT:255470","NEWT:762903","NEWT:27697","NEWT:86185","NEWT:9935","NEWT:266940","NEWT:287889","NEWT:1028307","NEWT:52603","NEWT:92867","NEWT:92866","NEWT:1344414","NEWT:202950","NEWT:741158","NEWT:1293091","NEWT:202956","NEWT:315750","NEWT:632957","NEWT:9925","NCBITaxon:9606","NEWT:1436183","NEWT:1479235","NEWT:4232","NEWT:9922","NEWT:416348","NEWT:105812","NEWT:11298","NEWT:4233","NEWT:4236","NEWT:398031","NEWT:196627","NEWT:523840","NEWT:1076878","NEWT:200308","NEWT:200302","NEWT:9913","NEWT:9915","NEWT:105841","NEWT:1170227","NEWT:2666255","NEWT:999810","NEWT:28995","NEWT:1392998","NEWT:1150621","NEWT:1085791","NEWT:745531","NEWT:226900","NEWT:231490","NEWT:590651","NEWT:449239","NEWT:244704","NEWT:9909","NEWT:9902","NEWT:430615","NEWT:563041","NEWT:36599","NEWT:41949","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