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 Li"],"technology_type":["Mass Spectrometry","Data-independent acquisition"],"software":[""],"submitter_keywords":["Human","Ms","Pipline"],"full_dataset_link":["https://www.ebi.ac.uk/pride/archive/projects/PXD047657"],"tissue":["Brain","Blood Plasma","Cerebrospinal Fluid","Cell Culture","Embryonic Stem Cell"],"sample_protocol":["The sample preparation for mass spectrometry (MS)-based proteomics was performed on our previously published fully automated pipeline (Reilly et al., 2021). The resulting peptides were measured and normalized using an automated colorimetric assay on a Bravo (Agilent Technologies) robot. The final resulting tryptic peptides were separated on a nano column (75 μm × 500 mm, 2 μm C18 particle) using a 2-h efficient linear gradient (Phase B, 2-35% ACN) on an UltiMate 3000 nano-HPLC system. We used data independent acquisition (DIA) discovery proteomics on a hybrid Orbitrap Eclipse mass spectrometer. Specifically, MS1 resolution was set to 120K, and MS2 resolution was set to 30K. For DIA isolation, the precursor range was set to 400–1000 m/z, and the isolation window was 8 m/z, resulting in 75 windows for each scan cycle (3 s). High collision dissociation was used for fragmentation with 30% collision energy. The AGC target was set to 800% for MS2 scan (improve MS2 spectra quality). The MS2 scan range was defined as 145–1450 m/z, which covers the majority of fragment ions of typical tryptic peptides."],"repository":["Pride"],"quantification_method":["Not available"],"modification":[""],"data_protocol":["The database search was performed at the protein level by Spectronaut software 16.0. We used a library-free module (i.e., direct DIA), which does not require a preconstructed high-quality project-specific spectral library but only uses a proteome sequence file. Specifically, the MS/MS spectra were searched against a proteome reference database containing 17,125 proteins (reviewed) mapped to the mouse reference genome obtained via the UniProt Consortium. All spectra were allowed ‘‘trypsin and lysC’’ enzyme specificity, with up to two missed cleavages. Allowed fixed modifications included carbamidomethylation of cysteine and the allowed variable modifications for whole proteome datasets were acetylation of protein N-termini, oxidized methionine. The false discovery rates of peptide and protein were all set as 1%. Three replicate MS analyses were done from each sample. Further analysis was performed on the mean values of the replicate MS analyses. DESeq2 was implemented to analyze the differential expression between sample types. R software was used to analyze and visualize data."],"omics_type":["Proteomics"],"labhead":["Andy Qi"],"instrument_platform":[""],"labhead_affiliation":["Center for Alzheimer’s Disease and Related Dementias (CARD) National Institute on Aging (NIA) National Institutes of Health (NIH)"],"submission_type":["PARTIAL"],"species":["Homo Sapiens (human)"],"publication":["38168437 Li Z, Weller CA, Shah S, Johnson N, Hao Y, Roberts J, Bereda C, Klaisner S, Machado P, Fratta P, Petrucelli L, Prudencio M, Oskarsson B, Staff NP, Dickson DW, Cookson MR, Ward ME, Singleton AB, Nalls MA, Qi YA. ProtPipe: A Multifunctional Data Analysis Pipeline for Proteomics and Peptidomics. bioRxiv. 2023:2023.12.12.571327 10.1101/2023.12.12.571327"],"submitter_mail":["liz36@nih.gov"],"submitter_affiliation":["NIH"],"submitter_country":["United States"],"pubmed_abstract":["Mass spectrometry (MS) is a technique widely employed for the identification and characterization of proteins, personalized medicine, systems biology and biomedical applications. By combining MS with different proteomics approaches such as immunopurification MS, immunopeptidomics, and total protein proteomics, researchers can gain insights into protein-protein interactions, immune responses, cellular processes, and disease mechanisms. The application of MS-based proteomics in these areas continues to advance our understanding of protein function, cellular signaling, and complex biological systems. Data analysis for mass spectrometry is a critical process that includes identifying and quantifying proteins and peptides and exploring biological functions for these proteins in downstream analysis. To address the complexities associated with MS data analysis, we developed ProtPipe to streamline and automate the processing and analysis of high-throughput proteomics and peptidomics datasets. The pipeline facilitates data quality control, sample filtering, and normalization, ensuring robust and reliable downstream analysis. ProtPipe provides downstream analysis including identifying differential abundance proteins and peptides, pathway enrichment analysis, protein-protein interaction analysis, and MHC1-peptide binding affinity. ProtPipe generates annotated tables and diagnostic visualizations from statistical postprocessing and computation of fold-changes across pairwise conditions, predefined in an experimental design. ProtPipe is well-documented open-source software and is available at https://github.com/NIH-CARD/ProtPipe , accompanied by a web interface."],"pubmed_title":["ProtPipe: A Multifunctional Data Analysis Pipeline for Proteomics and Peptidomics."],"pubmed_authors":["Li Ziyi Z, Weller Cory A CA, Shah Syed S, Johnson Nicholas N, Hao Ying Y, Roberts Jessica J, Bereda Colleen C, Klaisner Sydney S, Machado Pedro P, Fratta Pietro P, Petrucelli Leonard L, Prudencio Mercedes M, Oskarsson Björn B, Staff Nathan P NP, Dickson Dennis W DW, Cookson Mark R MR, Ward Michael E ME, Singleton Andrew B AB, Nalls Mike A MA, Qi Yue A YA"],"description_synonyms":["Experimental Designs, Research Technique, Problem Formulations, Product, Adjustments, determination, CG 1618, Individualized Medicine, Ass-1, Addresses, Design, Error Sources, DEIH-BOX RNA/DNA HELICASE, dNSF, protein, Technic, Polypeptides, Techniques, Readability, peptido, DmNSF, diseases, Method, Biological, AA408052, fold, dNSF1, dNsf1, diseases and disorders, Software Engineering, Analysis, Biological Product, protein aggregate, Computer Program, Experimental Design, Mass Spectrum Analysis, Group, Immune Responses, human disease, Biologic Drugs, peptides, Analyses, Biology, Personnel, Natural, Matched Group, Open, Designs, Matched, Computer Programs and Programming, Groups, Biological Drugs, experimental design, ASS, Biological Medicine, Methodological Studies, Reporting, sample, Medicine, Research Techniques, Homo sapiens disease, Medicines, Biologic Drug, single organism signaling, Data Reporting, Cellular Immunity, anatomical protrusion, Biologic Products, Research Technic, Research Methodology, Immunity, Research Proposals, Procedure, Spectrum Analysis, Source Softwares, Research Proposal, Software Tools, Programs, Spectroscopy, Program, Computer Applications, Experimental, Personalized Medicine, Qualities, Biopharmaceuticals, Computer Applications Software, Diseases, Computer Applications Softwares, Cellular, Biologic Product, Cell-Mediated, Technics, Problem Formulation, Softwares, Problem, Cell-Mediated Immunities, dnsf1, Clinical Investigator, Software Applications, Biological Medicines, Source Software, Biological Drug, Spectrometry, Researcher, Biologics, Quality, Methodological, Methodological Study, Formulations, disease, data analysis, Applications, Cell-Mediated Immunity, Immunities, spine, Theranostics, NSF-1, Polypeptide, Data Adjustments, Computer Software Applications, other disease, F12K11.4, Procedures, Cellular Immunities, Biologic Pharmaceuticals, Peptidomics, Accuracies, Matched Groups, Comt, Gene, NSF1, Scoring Method, Spectrum Analyses, Computer, protein-containing complex, Data Qualities, protrusion, NSF, Nsf, method, Adjustment, CG1618, Scoring Methods, nuclear DEIH-boxhelicase, method used in an experiment, Sources, Mass, Studies, Gene Products, disease or disorder, Survey, F12K11_4, Precision, Technique, Mass Spectroscopy, Application, Biologicals, Drugs, Open Source Softwares, Methodology, Individualized, Clinical, Scoring, Research, Proposals, Software Application, Investigators, Natural Product, Clinical Investigators, Open Source Software, Research Strategy, Computer Software Application, non-neoplastic, Study, Table, Immune Response, data processing, Tools, Error Source, DmelCG1618, disorder, peptidos, Predictive, Strategies, Biologic, Pharmaceuticals, Applications Software, com, Products, Data Accuracies, Open Source, disorders of sex development (DSD)., Computer Software, Predictive Medicine, protein complex, Biologic Medicines, Investigator, Proteins, disorders, Formulation, medical condition, function, Personalized, Peptide, Cellular Immune, Tool, Research Strategies, Software Tool, MS, native protein, Protein, Systems, chemical analysis, Biopharmaceutical, condition, Data Quality, dNSF-1, Software, Mass Spectrum Analyses, Proposal, Methods, Survey Personnel, Mass Spectrum, Source, Engineering, Accuracy, Research Designs, Theranostic, Research Technics, Understanding, sample population, plan specification, Protein Gene Products, Drug, Computer Programs, Gene Proteins, Data Adjustment, Applications Softwares, signalling process, P-Health, Error, Data, Cellular Immune Response, Response, Cellular Immune Responses, Natural Products, P Health, Researchers, Cell Mediated Immunity, Peptid, assay, Strategy, Data Analyses"],"data_synonyms":["CDF, IPP2A2, Cysteine Hydrochloride, 2-amino-4-(methylsulfanyl)butanoic acid, determination, Laboratory, Biocatalysts, Mus domesticus, L Isomer, Gene, protein, Computer, protein-containing complex, House Mouse, PHAPII, 5730420M11Rik, peptide, Polypeptides, L-Isomer Methionine, POF, Methionine, peptido, House, DmelCG1768, Gene Products, HILDA, Mus musculus domesticus, L-Methionine, AGAMOUS-like 61, Software Engineering, Half-Cystine, protein aggregate, Mice, Computer Program, Pedameth, Application, DiA, Open Source Softwares, SET, l(2)k07135, peptides, Genomes, TAF-I, Swiss, Software Application, MS2, L Cysteine, M, Open, ipp2a2, Open Source Software, Computer Programs and Programming, Acetylations, 2pp2a, Swiss Mice, DIASP, DIA, Dia, CG10574, Computer Software Application, DmelCG4299, 4-(4-dihexadecylaminostyryl)N-methylpyridium iodide, IGAAD, set, Enzyme, 2-amino-4-(methylthio)butanoic acid, 2PP2A, Tools, DmelCG10574, taf-ibeta, sample, 38E.16, dSET, dSet, Sensitivity, peptidos, DIA2, house mouse, Half Cystine, metionina, Racemethionine, Applications Software, phapii, Open Source, Computer Software, Zinc Cysteinate, DL-Methionine, protein complex, Desmoplastic astrocytoma of infancy, Proteins, acetylation, mouse, 2-Amino-4-(methylthio)butyric acid, igaad, total expressed protein, StF-IT-1, CG1768, DRF2, L-Isomer, Source Softwares, Peptide, Software Tools, Tool, group, Programs, polypeptide, Program, Computer Applications, ms(2)04138, Software Tool, Desmoplastic infantile astrocytoma, native protein, Mus, I-2PP2A, Protein, Computer Applications Software, MLPLI, Dm I-2, chemical analysis, I2PP2A, Computer Applications Softwares, sequence, Methionin, Softwares, Hmet, Dias, Software, Library, tandem MS, Data Base, Met, Mus musculus, Software Applications, HLA-DR-associated protein II, ensemble, DI-2, MS/MS, Source Software, mice, POF2, I-2Dm, F27C12_24, Engineering, F27C12.24, Swiss Mouse, Specificity, House Mice, L-Cysteine, whole genome, CG4299, primary structure of sequence macromolecule, sample population, domesticus, Laboratory Mice, Protein Gene Products, I-2PP1, Computer Programs, Gene Proteins, dSET/TAF-Ibeta, Applications, 2610030F17Rik, Applications Softwares, TAF-IBETA, Specificity and Sensitivity, Computer Software Applications., DIANA, Biocatalyst, alpha-amino-gamma-methylmercaptobutyric acid, Peptid, Mouse, TAF-Ibeta, Polypeptide, assay, AA407739, Liquimeth, i2pp2a, Proteomes, Laboratory Mouse, Computer Software Applications"],"pubmed_title_synonyms":["Peptidomics., data analysis, Analysis, data processing, Data, Analyses, Peptidomics, Data Analyses"],"sample_synonyms":["CDF, IPP2A2, Disorders, ion, determination, Dissociative Reactions, fond, CycEI, 5730420M11Rik, Hysteria, Polypeptides, POF, peptido, Ccne, BANF, B1, High Performance Liquid Chromatography, AGAMOUS-like 61, Analysis, CDPS, DiA, Mass Spectrum Analysis, 3-hydroxy-5-estrane-17-carbonitrile, SET, Divorced, C79325, l(2)k07135, peptides, Analyses, TAF-I, 2610036I19Rik, 2610510L13Rik, E430039A18Rik, Divorces, purification, T6G21.3, DIASP, SCAN, DIA, Dia, HPLC, DmelCG4299, isolation and purification, 4-(4-dihexadecylaminostyryl)N-methylpyridium iodide, IGAAD, set, fSAP152, High-Performance, column, DmelCG10574, scientific observation, ACN, Reaction, D1, Acn, Chromatography, 38E.16, High-Performance Liquid, High Speed Liquid, mKIAA0343, CANPS, phapii, Stars, Liquid Chromatography, StF-IT-1, Th, Cyc E, br37, Spectrum Analysis, Spectroscopy, ms(2)04138, Desmoplastic infantile astrocytoma, BG:DS07108.3, Ionen, CSS1, l(2)05206, CANP, parent ion, HLA-DR-associated protein II, DI-2, MS/MS, POF2, I-2Dm, F27C12_24, F27C12.24, Spectrometry, CG4299, Dissociation, I-2PP1, TAF-IBETA, l35Dd, precursor ion, hydroxychlorothalonil, DIANA, chlorothalonil, Liquid, TAF-Ibeta, Polypeptide, STARS, i2pp2a, Hybrids, cycline, Peptidomics, Dissociative Reaction, DmcyclinE, CAPN4, cycE, Spectrum Analyses, ACINUS, precursor, thomson, 17alpha)-isomer, l(2)br37, PHAPII, CYCLE, mass-to-charge ratio, cdi7, cyclinE, Ms1, isolation, DmelCG1768, Mass, HILDA, Cdi7, CDI7, C030017F07Rik, Separated, Mass Spectroscopy, anatomical systems, CYCE, Acinus, MS1, MS2, DmelCG3938, iones, CyclE, ipp2a2, C130076O07Rik, Dissociative Hysteria, 3938, 2pp2a, DmcycE, ions, Chimeras, High-Performance Liquid Chromatographies, CG10574, CD156, acinusL, l(2)k05007, dm-cycE, 2PP2A, acinusS, taf-ibeta, male sterility 1, Disorder, dSET, dSet, Ultra Performance Liquid Chromatography, peptidos, UPLC, DIA2, PTHB1, High-Performance Liquid Chromatography, measuring, Dissociative, 30K, Desmoplastic astrocytoma of infancy, igaad, CG1768, DRF2, Peptide, mKIAA0670, group, MS, l(2)k02514, Hybrid, DmCycE, I-2PP2A, CALPAIN4, C18, Hysterias, chemical analysis, MLPLI, Dm I-2, I2PP2A, 5alpha, CyeE, Dias, (3alpha, Mass Spectrum Analyses, tandem MS, Bravo, Mass Spectrum, Separation, l(2)k02602, Reactions, ensemble, MALE STERILITY 1 PROTEIN, Separations, Striated muscle activator of Rho-dependent signaling, l(2)35Dd, CD156a, D-CycE, dSET/TAF-Ibeta, High Pressure, 2610030F17Rik, Ion, Dissociative Disorder, Peptid, High Performance Liquid, assay, SCH, AA407739, Fugue, CG3938, Peptide., Daconil, 3-OHECN"],"pubmed_abstract_synonyms":["Experimental Designs, Research Technique, Problem Formulations, Product, Adjustments, determination, CG 1618, Individualized Medicine, Ass-1, Addresses, Design, Error Sources, DEIH-BOX RNA/DNA HELICASE, dNSF, protein, Technic, Polypeptides, Techniques, Readability, peptido, DmNSF, diseases, Method, Biological, AA408052, fold, dNSF1, dNsf1, diseases and disorders, Software Engineering, Analysis, Biological Product, protein aggregate, Computer Program, Experimental Design, Mass Spectrum Analysis, Group, Immune Responses, human disease, Biologic Drugs, peptides, Analyses, Biology, Personnel, Natural, Matched Group, Open, Designs, Matched, Computer Programs and Programming, Groups, Biological Drugs, experimental design, ASS, Biological Medicine, Methodological Studies, Reporting, sample, Medicine, Research Techniques, Homo sapiens disease, Medicines, Biologic Drug, single organism signaling, Data Reporting, Cellular Immunity, anatomical protrusion, Biologic Products, Research Technic, Research Methodology, Immunity, Research Proposals, Procedure, Spectrum Analysis, Source Softwares, Research Proposal, Software Tools, Programs, Spectroscopy, Program, Computer Applications, Experimental, Personalized Medicine, Qualities, Biopharmaceuticals, Computer Applications Software, Diseases, Computer Applications Softwares, Cellular, Biologic Product, Cell-Mediated, Technics, Problem Formulation, Softwares, Problem, Cell-Mediated Immunities, dnsf1, Clinical Investigator, Software Applications, Biological Medicines, Source Software, Biological Drug, Spectrometry, Researcher, Biologics, Quality, Methodological, Methodological Study, Formulations, disease, data analysis, Applications, Cell-Mediated Immunity, Immunities, spine, Theranostics, NSF-1, Polypeptide, Data Adjustments, Computer Software Applications, other disease, F12K11.4, Procedures, Cellular Immunities, Biologic Pharmaceuticals, Peptidomics, Accuracies, Matched Groups, Comt, Gene, NSF1, Scoring Method, Spectrum Analyses, Computer, protein-containing complex, Data Qualities, protrusion, NSF, Nsf, method, Adjustment, CG1618, Scoring Methods, nuclear DEIH-boxhelicase, method used in an experiment, Sources, Mass, Studies, Gene Products, disease or disorder, Survey, F12K11_4, Precision, Technique, Mass Spectroscopy, Application, Biologicals, Drugs, Open Source Softwares, Methodology, Individualized, Clinical, Scoring, Research, Proposals, Software Application, Investigators, Natural Product, Clinical Investigators, Open Source Software, Research Strategy, Computer Software Application, non-neoplastic, Study, Table, Immune Response, data processing, Tools, Error Source, DmelCG1618, disorder, peptidos, Predictive, Strategies, Biologic, Pharmaceuticals, Applications Software, com, Products, Data Accuracies, Open Source, disorders of sex development (DSD)., Computer Software, Predictive Medicine, protein complex, Biologic Medicines, Investigator, Proteins, disorders, Formulation, medical condition, function, Personalized, Peptide, Cellular Immune, Tool, Research Strategies, Software Tool, MS, native protein, Protein, Systems, chemical analysis, Biopharmaceutical, condition, Data Quality, dNSF-1, Software, Mass Spectrum Analyses, Proposal, Methods, Survey Personnel, Mass Spectrum, Source, Engineering, Accuracy, Research Designs, Theranostic, Research Technics, Understanding, sample population, plan specification, Protein Gene Products, Drug, Computer Programs, Gene Proteins, Data Adjustment, Applications Softwares, signalling process, P-Health, Error, Data, Cellular Immune Response, Response, Cellular Immune Responses, Natural Products, P Health, Researchers, Cell Mediated Immunity, Peptid, assay, Strategy, Data Analyses"],"name_synonyms":["Peptidomics., data analysis, Analysis, data processing, Data, Analyses, Peptidomics, Data Analyses"],"additional_accession":[]},"is_claimable":false,"name":"ProtPipe: A Multifunctional Data Analysis Pipeline for Proteomics and Peptidomics","description":"Mass spectrometry (MS) is a technique widely employed for the identification and characterization of proteins, personalized medicine, systems biology and biomedical applications. By combining MS with different proteomics approaches such as immunopurification MS, immunopeptidomics, and total protein proteomics, researchers can gain insights into protein-protein interactions, immune responses, cellular processes, and disease mechanisms. The application of MS-based proteomics in these areas continues to advance our understanding of protein function, cellular signaling, and complex biological systems. Data analysis for mass spectrometry is a critical process that includes identifying and quantifying proteins and peptides and exploring biological functions for these proteins in downstream analysis. To address the complexities associated with MS data analysis, we developed ProtPipe to streamline and automate the processing and analysis of high-throughput proteomics and peptidomics datasets. The pipeline facilitates data quality control, sample filtering, and normalization, ensuring robust and reliable downstream analysis. ProtPipe provides downstream analysis including identifying differential abundance proteins and peptides, pathway enrichment analysis, protein-protein interaction analysis, and MHC1-peptide binding affinity. ProtPipe generates annotated tables and diagnostic visualizations from statistical postprocessing and computation of fold-changes across pairwise conditions, predefined in an experimental design. ProtPipe is well-documented open-source software and is available at https://github.com/NIH-CARD/ProtPipe, accompanied by a web interface.","dates":{"publication":"2024-09-03","submission":"2023-12-08"},"accession":"PXD047657","cross_references":{"TAXONOMY":["NEWT:330879","NEWT:377960","NEWT:1131","NEWT:35795","NEWT:2042546","NEWT:259447","NEWT:295546","NCBITaxon:2719036","NEWT:1334565","NEWT:625351","NEWT:258594","NCBITaxon:1280","NEWT:112503","NEWT:1129","NEWT:309807","NEWT:59753","NEWT:89184","NEWT:309800","NEWT:281395","NEWT:57577","NEWT:247480","NEWT:1211601","NEWT:876138","NEWT:44271","NEWT:193516","NEWT:2315688","NEWT:592321","NEWT:1073882","NEWT:6819","NEWT:77173","NEWT:112509","NEWT:475174","NEWT:111205","NEWT:1599","NEWT:428386","NEWT:1117","NEWT:498257","NEWT:10036","NEWT:32264","NEWT:12215","NEWT:1590","NEWT:10034","NEWT:33114","NEWT:1596","NEWT:661410","NEWT:638632","NEWT:224326","NEWT:294671","NEWT:376619","NEWT:1748418","NCBITaxon:79857","NEWT:1096976","NEWT:3765","NEWT:3767","NEWT:1589","NEWT:1907535","NEWT:135622","NEWT:4615","NEWT:67352","NEWT:672127","NEWT:35786","NEWT:1580","NEWT:399784","NEWT:96731","NEWT:656064","NEWT:1582","NEWT:3760","NEWT:1584","NEWT:2086595","NEWT:36630","NEWT:1585","NEWT:383379","NEWT:381198","NEWT:418106","NCBITaxon:12721","NEWT:166340","NEWT:10029","NEWT:913645","NEWT:2492962","NEWT:641809","NEWT:1392488","NEWT:38815","NEWT:317447","NEWT:4688","NEWT:3357","NEWT:111225","NEWT:7719","NEWT:29073","NEWT:5530","NEWT:868565","NEWT:135674","NEWT:1562698","NEWT:79329","NEWT:30069","NEWT:12637","NEWT:59729","NEWT:2164133","NEWT:295105","NEWT:29064","NEWT:108061","NEWT:60711","NEWT:2020713","NEWT:224308","NEWT:273791","NEWT:3347","NEWT:49928","NEWT:3349","NEWT:160621","NEWT:2502409","NEWT:212790","NEWT:110368","NEWT:55350","NEWT:1916073","NEWT:1310161","NEWT:77133","NEWT:145481","NEWT:1310165","NEWT:29058","NCBITaxon:79824","NEWT:1912919","NEWT:410658","NEWT:5516","NEWT:44688","NEWT:44689","NEWT:370038","NEWT:498211","NEWT:345076","NEWT:347256","NEWT:5518","NEWT:398007","NEWT:1527468","NEWT:498217","NEWT:498216","NEWT:11320","NEWT:33554","NEWT:246196","NEWT:246197","NEWT:145458","NEWT:1310173","NEWT:200795","NEWT:37919","NEWT:2579791","NEWT:171719","NEWT:44685","NEWT:161934","NEWT:156587","NEWT:1148","NEWT:5508","NEWT:3329","NEWT:419481","NEWT:5507","NEWT:260499","NEWT:410661","NEWT:329854","NEWT:1140","NCBITaxon:2157","NEWT:2066563","NEWT:2649329","NEWT:1143","NEWT:1287689","NEWT:1094343","NEWT:1462472","NEWT:1336795","NEWT:644042","NEWT:150808","NEWT:1182590","NEWT:3712","NEWT:3711","NEWT:3714","NCBITaxon:37162","NEWT:270643","NEWT:3715","NEWT:1538","NEWT:2065263","NEWT:199225","NEWT:177437","NEWT:717966","NEWT:10891","NEWT:10418","NEWT:118698","NEWT:1616117","NEWT:118696","NEWT:34865","NEWT:52283","NEWT:28174","NEWT:284812","NEWT:8175","NEWT:43330","NEWT:980415","NEWT:1603293","NEWT:44664","NEWT:43346","NEWT:3702","NEWT:66440","NEWT:1245466","NEWT:3704","NEWT:244366","NEWT:1246791","NEWT:176597","NEWT:118694","NEWT:2850","NEWT:118691","NEWT:34871","NEWT:9006","NEWT:33548","NEWT:52299","NEWT:8165","NEWT:96794","NEWT:34878","NEWT:10886","NEWT:3708","NEWT:332648","NEWT:44670","NEWT:926571","NEWT:536231","NEWT:376219","NEWT:219813","NEWT:1510","NEWT:1955249","NEWT:460519","NEWT:1515","NEWT:572307","NEWT:1432138","NEWT:2714896","NEWT:1424507","NEWT:1194599","NEWT:272844","NEWT:1348799","NEWT:1608994","NEWT:33995","NEWT:55784","NEWT:1303443","NEWT:9483","NEWT:485","NEWT:56636","NEWT:2709072","NEWT:2499525","NEWT:1122981","NEWT:2853422","NEWT:1122984","NEWT:487","NEWT:1538553","NEWT:1679718","NEWT:480","NEWT:67767","NEWT:45972","NEWT:46835","NEWT:109757","NEWT:582580","NEWT:1185650","NEWT:216778","NEWT:294607","NEWT:1502","NEWT:128017","NEWT:2836","NEWT:376686","NEWT:237610","NEWT:95486","EFO:0001352","NEWT:1385720","NEWT:119562","NEWT:1883446","NEWT:31345","NEWT:1233435","NEWT:118223","NEWT:11757","NEWT:987059","NEWT:109760","NEWT:29031","NEWT:1945864","NEWT:317047","NEWT:1509","NEWT:491","NEWT:460523","NEWT:45954","NEWT:235443","NEWT:1579","NEWT:133894","NEWT:1757312","NEWT:85694","NEWT:109786","NEWT:1922344","NEWT:108458","NEWT:5936","NEWT:85692","NEWT:321967","NEWT:320637","NEWT:1078283","NEWT:3750","NEWT:983964","NEWT:11706","NEWT:32644","NEWT:527796","NEWT:279010","NEWT:499175","NEWT:109779","NEWT:3745","NEWT:1715989","NCBITaxon:4751","NEWT:3747","NEWT:1116234","NEWT:415978","NEWT:235455","NEWT:1255228","NEWT:410289","NEWT:191701","NEWT:373153","NEWT:1640278","NEWT:9054","NEWT:472","NEWT:940825","NEWT:29459","NEWT:529507","NEWT:1071661","NEWT:1380096","NEWT:28128","NEWT:470","NEWT:41122","NEWT:5911","NEWT:1328300","NEWT:748693","NCBITaxon:50557","NEWT:39251","NEWT:29491","NEWT:101841","NEWT:446","NEWT:153481","NEWT:2014887","NEWT:717989","NEWT:33952","NEWT:11723","NEWT:445","NEWT:153009","NEWT:261756","NEWT:166314","NEWT:166313","NEWT:63366","NEWT:63367","NEWT:29488","NEWT:1871049","NEWT:215402","NEWT:1547","NEWT:1290454","NEWT:3726","NEWT:906914","NEWT:81231006","NEWT:30455","NEWT:28141","NEWT:9031","NEWT:27292","NEWT:1050722","NEWT:3728","NEWT:108931","NEWT:1293497","NEWT:1055524","NEWT:548","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