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Enzlein"],"technology_type":["mass spectrometry imaging","Mass Spectrometry"],"disease":["Alzheimer's Disease"],"software":[""],"submitter_keywords":["Alzheimer’s disease","Maldi ms imaging","Machine learning","Amyloid-β","Gangliosides"],"full_dataset_link":["https://www.ebi.ac.uk/pride/archive/projects/PXD049325"],"tissue":["Brain"],"sample_protocol":["Patient samples and Tissue sectioning  Brains were donated with the full, informed consent to the Queen Square Brain Bank for neurological disorders (UCL Queen Square Institute of Neurology). Accompanying clinical and demographic data of all cases used in this study were stored electronically in compliance with the 1998 data protection act.  All cases underwent pathological diagnosis for AD, according to current consensus criteria, regardless of clinical symptoms 53–55. The cohort included pathologically diagnosed cases of AD and AP-CU with varying degrees of underlying pathology as documented by Braak and Braak stages, Thal Phase and CERAD score. ApoE genotype was also determined. Frozen frontal cortices (Brodmann area 9) from all cases were mounted onto a cork block and sectioned on a Bright Cryostat (Bright Instruments Ltd, Huntingdon, UK) at 10 µm and onto ITO slides for MSI analysis.   MALDI MS imaging   Tissue sections on ITO slides (from the -80 °C freezer) were thawed in a desiccator for 20 min. Slides were washed with three dips in 8 °C 50 nM ammonium formate (pH 6.4) and dried in the desiccator (1 h). An optical image was recorded using an Aperio CS2 digital slide scanner (Leica Biosystems GmbH), before 1,5-DAN was deposited on the tissue using an HTX M5 (HTX Technologies, Chapel Hill, USA) sprayer with the following settings: Matrix solution: 18 mg/mL1,5-DAN in 70 % ACN, flowrate 0.1 mL/min, speed 2250 mm/min, nozzle height 40 mm, nozzle temperature 70 °C, plate temperature 30 °C, track spacing 3 mm, layers 15. MSI of lipids was done on a timsTOF FleX instrument (Bruker Daltonics) using the following parameters: Mass range 300-2100 m/z, negative polarity, laser intensity 25%, number of shots 300 at laser frequency of 2 kHz, laser spot size 20 x 20 µm, raster size 20 x 20 µm, tims-mode default. Instrument calibration was performed in ESI mode with ESI tuning mix (Agilent Technologies, Santa Clara, USA). The obtained mass resolving power was 40,000 at 400 m/z, and the mass accuracy was better than 5 ppm.  MSI of peptides was performed as previously described31. Briefly, after lipid MSI the matrix was removed by submerging the slide into 100 % ethanol for 60 s at RT. Tissue sections were delipidated and sDHB matrix applied before being measured on a Bruker Rapiflex MALDI-TOF MS (Bruker Daltonics) in positive linear mode in the range between 2,000-10,000 m/z with a spot size of 20 x 20 µm, as previously described in Enzlein, et. al., 2020."],"repository":["Pride"],"quantification_method":["Not available"],"modification":[""],"data_protocol":["Raw data was imported into SCiLS Lab (Bruker Daltonic, TIC normalized and the top 500 peaks were exported to imzML."],"omics_type":["Proteomics"],"labhead":["Carsten Hopf"],"instrument_platform":[""],"labhead_affiliation":["Center for Mass Spectrometry and Optical Spectroscopy (CeMOS), Mannheim University of Applied Sciences, Paul-Wittsack Str. 10, 68163, Mannheim, Germany.  Mannheim Center for Translational Neuroscience (MCTN), Medical Faculty Mannheim, Heidelberg University, 69120 Heidelberg, Germany.  Medical Faculty, Heidelberg University, 69120 Heidelberg, Germany."],"submission_type":["PARTIAL"],"species":["Homo Sapiens (human)"],"publication":["10.1021/ACS.ANALCHEM.3C05557"],"submitter_mail":["t.enzlein@hs-mannheim.de"],"submitter_affiliation":["Center for Mass Spectrometry and Optical Spectroscopy (CeMOS), Mannheim University of Applied Sciences, Paul-Wittsack Str. 10, 68163, Mannheim, Germany."],"submitter_country":["Germany"],"name_synonyms":["the brain, lipids, synganglion, assay, suprasegmental structures, suprasegmental levels of nervous system, determination, encephalon, Encephalon., chemical analysis, Lipid"],"data_synonyms":["Svc, Gestural Tic, Bru, data, Chorea, Col4a-1, bHLHe5, Raw, Habit Chorea, Habituation, Vocal Tic, Brain and muscle ARNT-like 1, Transient Tics, Spasm, Transient, Habituation Spasms, Transient Tic, MOP3, Tics, Motor Tics, Choreas, Motor, BMAL1., Motor Tic, Habit Choreas, Tic, Spasms, TIC, Vocal Tics, Habit, Habituation Spasm, Gestural Tics, BMAL1c, Del(8)44H, Habit Spasm, Habit Spasms, PASD3, Gestural, JAP3, Vocal"],"description_synonyms":["the brain, biochemical pathways, lipids, deceased, other disease, Metabolic Process, Biochemical Process, chemical properties, CG5099, GM1, determination, GM1a Monosialoganglioside, Processes, regulation by symbiont of host system process, Metabolic Concepts, positive regulation by symbiont of host non-apoptotic programmed cell death, Biochemical, Monosialoganglioside, Neurologic Diseases, Degenerative Neurologic Disorders, Amyloid Fibril, Neurologic Degenerative Condition, Cardiac Death, Ceramide, Metabolic Processes, Biochemical Concepts, dIKK-gamma, cerebral degeneration disease, Neurodegenerative Diseases, Readability, systemic amyloidosis, diseases, induction by organism of non-apoptotic programmed cell death in other organism during symbiotic interaction, Neurologic Disorders, Metabolism, DmIKK-gamma, symptoms, disease or disorder, Concepts, pathogenesis, amyloid, diseases and disorders, synganglion, cytopathology, dmIKKgamma, Metabolism Concept, Transfer, IKK[[gamma]], Phenomenon, Metabolism Phenomena, IKKg, KEY, Key, Nervous System Degenerative Diseases, study, Transfer Learning, amyloidosis, induction of non-apoptotic programmed cell death by other organism, modification by symbiont of host biological process, Nervous System, human disease, Degenerative Condition, stimulation by symbiont of host programmed cell death, catabolism, Machine, amyloidosis (disease), SIDNA, Metabolic Concept, metabolic process resulting in cell growth, causes, Substance, suprasegmental levels of nervous system, Amyloid, Neurodegenerative Disorder, chemical composition., Neurodegenerative Disorders, non-neoplastic, Msi, Neurologic, Neurologic Degenerative Diseases, IKK, Degenerative Neurologic Disease, Biochemical Concept, heterogeneity, Pathologies, Monosialosyl, causality, Degenerative Neurologic Diseases, Neurologic Degenerative Disease, Tetraglycosyl Ceramide, disorder, biotransformation, Homo sapiens disease, Biochemical Processes, Spinal Cord, associated, GM1 Ganglioside, Catabolism, chemical structure, screening, data, suprasegmental structures, Neurologic Disorder, findings, activation by organism of non-apoptotic programmed cell death in other organism, disruption by symbiont of host cell, clone 2.35, chemical characterization, degradation, Process, hemolysin activity, Ganglioside GM1, metabolism resulting in cell growth, Learning, disorders, Monosialosyl Tetraglycosyl Ceramide, medical condition, GM1a, DmelCG5099, encephalon, feature_extraction, Concept, Metabolic Phenomena, Degenerative Neurologic Disorder, Amyloid Fibrils, Metabolism Concepts, IKKgamma, DmIKKgamma, dIKK, Lipid, chemical analysis, post-mortem, Diseases, Phenomena, Kenny, modulation by symbiont of host system process, condition, secretion, Ganglioside, Biochemical Phenomenon, DMSIDNA, Death, metabolism, amyloid disease, Metabolic Phenomenon, Fibril, Degenerative Conditions, multicellular organism metabolic process, Amyloid Substance, amyloidoses, histopathology, distinct, biodegradation, Metabolic, Degenerative Diseases, Dmikkgamma, Monosialosyl Tetraglycosyl, Encephalon, IKK-gamma, signs, Neurologic Degenerative Conditions, Understanding, Neurologic Disease, chemical content, CG16910, induction by organism of programmed cell death in other organism during symbiotic interaction, modification by symbiont of host morphology or physiology, disease, single-organism metabolic process, Fibrils, DmelCG16910, Degenerative, activation by symbiont of host programmed cell death, Neurodegenerative Disease, Central Nervous System, assay, anon-EST:Liang-2.35, biopsy, Anabolism"],"sample_synonyms":["sodium salt, APO-E, mucolipidosis type 1, type 1, ammonium formate, 13C-labeled, Laser Desorption-Ionization Mass Spectrometry, cadmium salt, formiate, 2410041A17Rik, Bright, FEZL, Consent, Lasers, SDH, fs(1)M34, magnesium formate, K22G18.10, Diagnosis, zinc salt, DmelCG12051, Polypeptides, cobalt(II) formate dihydrate, type I, azanium, K22G18_10, symptoms, HEL-176, 1, CG4601, HCO2 anion, myoclonus--cherry Red spot syndrome, WMS, ASD2, A, DAND1, C, Grain, cyt5C, C79325, CANDF6, DHO, mKIAA4134, Tissue, Isoproteins, CG18572, MS-MALD, HardwareType, cherry Red spot--myoclonus syndrome, suprasegmental levels of nervous system, AI047805, Matrix Assisted Laser Desorption Ionization, DLPFC, Dehydrated ethanol, Area 46, ACN, Acn, AD2, Apo-E, ACT, Homo sapiens disease, Act, D1S1733E, Diagnose, Ammonium(1+), nickel salt, SGS, spiritus vini, frontal, Brodmann's, screening, Ito, suprasegmental structures, CG11849, Actin/BAP47, cobalt (+2) salt, CTE-II, AACT, CTE-IIa, act, Ach1, hBACH, ACH1, GASP, act42A, Diagnoses, AI255918, ACMICD, Absolute Alcohol, GIG25, sodium (4:1:1) salt, Postmortem, Dm1, magnesium salt, Su(b), sialidase deficiency, AFFX-Dros-ACTIN_M_r_at, GIG24, actin, simple tissue, LACH, [OEtH], Sensor, Q-Switched Laser, DmelCG4027, HTX1, instrument, HTX, OSA2, formate, signs, cromium (+3), Pulsed Laser, surveillance, alcohol etilico, Methylcarbinol, Speed, actin5C, Area 9, ammonium (4:1) salt, lead (+2) salt, BACH, DmelCG3283, l(1)Ab, Act5c, lipids, Brodmann Area 46, nickel formate dihydrate, lead formate, aluminum salt, etanol, number, ACT5C, formylate, IMAGE, D4H1S1733E, thomson, Bach, Chalk, ZNF203, 17alpha)-isomer, CG7826, Brodmanns Area 46, mass-to-charge ratio, ammonium cation, SPOT, APOEA, IP, Neug deficiency, TOF, Consensus, Brodmann's Area 9, CG7835, disease or disorder, Screening, CG42273, Cell growth-inhibiting gene 24|25 protein, Dorsolateral, E2FBP1, Antemortem, spot, ZNF312, Ip, Pulsed Lasers, Acinus, thallium (+1) salt, occurrence, ethanol, 0710008N11Rik, BRWS2, rubidium salt, prevalence, Diagnoses and Examinations, Matrix Assisted, methanoic acid, ESI, Genotypes, CSTN2, fs(1)829, acinusL, anon-EST:fe2D2, C2H5OH, Continuous Wave Laser, Q-Switched Lasers, 6A3-5, acinusS, DmelCG18572, Cst-2, peptidos, T11, Act-5C, MALD-MS, Antemortem Diagnoses, 42A, CPS, findings, Brodmann's Areas 9 and 46, ELD/OSA1, DRX, disorders, dJ393D12.2, Matrix-Assisted Laser Desorption-Ionization Mass Spectrometry, ion(1-), NH4+, aminate, potassium formate, copper (+2) salt, encephalon, mKIAA0670, DmelCG11849, Incontinentia pigmenti type 1 (formerly), Cs2, Cortex, Temperatures, ARID domain-containing protein 3A, beta-actin, CG3283, CWS2, cupric formate, chemical analysis, bA325O24.3., M32055, alcool ethylique, A530094C12Rik, condition, Act42, 5alpha, MFS1, NB, MIXL, aluminum formate, PGL4, outbreaks, AU020952, Dead ringer-like protein 1, MRD12, CS2, BAF250B, lithium formate, PYR1, ML 1, Matrix-Assisted Laser Desorption-Ionization, ME-IV, Genogroups, ZFP312, 2900042C18Rik, AVIEF, Calibration, Apo E, DRORUD, MEI2-like protein 1, epidemics, BAP47, ACTSG, biopsy, Bap47, formerly, Apo E Isoproteins, WAP3, Antemortem Diagnosis, glycoprotein neuraminidase deficiency, Grain Alcohol, lipomucopolysaccharidosis, Meth, Dorsolateral Prefrontal, determination, ACTG, ACTE, instrument configuration, Matrix Assisted Laser Desorption Ionization Mass Spectrometry, zinc formate, lead salt, Imaging, Model Calibration, 1-hydroxyethane, csp2, Act5, AI451642, ELD|OSA1, height, l(1)G0420, alcohol, BANK, Ethanol, ammonium tetraformate, peptido, diseases, BANF, alcagamma, Alkohol, diseases and disorders, Min, synganglion, cytopathology, Dri1, Surface Enhanced Laser Desorption Ionization Mass Spectrometry, DmelCG42273, MIX, neuraminidase 1 deficiency, portion of tissue, 3-hydroxy-5-estrane-17-carbonitrile, human disease, Maser, peptides, TACHD, bA325O24.3, Ethyl, 2610036I19Rik, 2610510L13Rik, SIDNA, apo-E, min, mAPC, Mass Spectrometry, MALDI MS, Dorsolateral Prefrontal Cortices, C6orf207, copper, Aethanol, ApoE, APOE, [CH2Me(OH)], WFDC14, Continuous Wave, Brodmann Area 9, fSAP152, lithium salt, Ice, act 42A, ppm, Pathologies, Ac5C, CG4027, ML1, Consensus Development, Apolipoprotein E Isoproteins, GPHYSD2, VACTERLX, ammonium (2:1) salt, l(1)G0330, DAN15, Alcohol, sialidosis, AML1, frequency, Dmel_CG7826, Q Switched Lasers, NO3, Th, Ethyl alcohol, LACH1, Laser Desorption Ionization Mass Spectrometry, LDLCQ5, Spectroscopy, NH4(+), Screenings, batch, Alpha-1-antichymotrypsin His-Pro-less, Examinations and Diagnoses, Lipid, tissue portion, DFNA26, bA325O24.4, Postmortem Diagnosis, DMSIDNA, nickel (+2) salt, CDHR13, ETHANOL, GAT, DFNA20, Dmel_CG7835, Crystal, Mnb, MNB, Diagnoses and Examination, MILD1, ammonium salt, Postmortem Diagnoses, histopathology, EtOH, l(1)G0117, Encephalon, TSEPA, cobaltous formate, Actin, Brodmanns Area 9, MASS, AW124434, 5-DAN, beta-actin/Bap47, morbidity, SDH1, SDH2, sdhB, l(1)G0486, l(1)G0245, Neu deficiency, disease, type II, Q-Switched, l(1)G0009, Patient, ACTL3, Lach1, Sensor Calibration, copper salt, Sensor Calibrations, Polypeptide, anon-EST:Liang-2.35, Laser, the brain, Ammonium, other disease, l(1)G0010, C6orf190, CG5099, MALDI-MS, Brodmann's Area 46, SDHb, cesium salt, FBN, CG12051, NEU 1 deficiency, Serpin A3, Development, ACINUS, SDH-IP, [NH4](+), hydrogen carboxylate, hardware, formic acid, l(1)G0025, Aethylalkohol, potassium salt, ECTOL1, os frontale, 14C-labeled, Pulsed, Tina, Mass, Dana, Masers, mucolipidosis 1, SDH-Ip, Mass Spectroscopy, 1200003I18Rik, study, LPG, act5C, Glass, Incontinentia pigmenti achromians, Absolute, ammonium ion, calcium formate, Brodmann Area 9 and 46, E2F-binding protein 1, non-neoplastic, SELDI-TOF-MS, OCTD, Act42a, Msi, 1700027G07Rik, 10^[-6], Informed, Clients, DAN, Dan, disorder, cromium (+3) salt, Model, FEZ, Cte-II, sodium formate, incidence, Apoproteins E, l(1)G0177, data, DYRK1, Neu1 deficiency, clone 2.35, nickel formate, cork, P250R, Continuous Wave Lasers, fer, strontium formate, medical condition, strontium salt, Client, DmelCG5099, Examination and Diagnoses, Peptide, light amplification by the stimulated emission of radiation, CAD, ML-1, Genogroup, Mass Screenings, Brodmann, Model Calibrations, Dyrk1, ACTA3, (3alpha, WMS2, ALC-GAMMA, BRIGHT, Ethyl Alcohol, l(1)G0079, VSD1, AI448973, DRIL1, DRIL3, ammonium, Matrix-Assisted, VSCM, Apoprotein (E), SDHIP, CC1, act 5C, neuraminidase deficiency, Apolipoprotein E, patient, chromic formate, endemics, methanoate, Brodmann's Area 9 and 46, Incontinentia pigmenti, IL-17F, hydroxyethane, HMI, MALDI, SSKS, cardinality, Prefrontal Cortex, Calibrations, calcium salt, glycoproteinosis, Dril1, Peptid, assay, B-cell regulator of IgH transcription, Brodmann Areas 9 and 46, SCH, IPA, Actin5C, 3-OHECN"],"additional_accession":[]},"is_claimable":false,"name":"Integrative single-plaque analysis reveals signature Aβ and lipid profiles in the Alzheimer’s brain","description":"Utilizing multimodal mass spectrometry imaging (MSI) combined with machine learning techniques, this study investigates the molecular heterogeneity of amyloid-β (Aβ) plaques and associated lipid profiles in post-mortem brain samples from Alzheimer’s disease (AD) and amyloid-positive cognitively unaffected (AP-CU) individuals. Our analytical approach permitted single-plaque level investigation, revealing distinct populations of amyloid plaques characterized by differential Aβ and lipid compositions. Notably, the integration of MSI data with machine learning based feature extraction enabled the identification of Aβ38 and ganglioside GM1 as significant molecular markers differentiating AD from AP-CU pathology. These findings suggest that the heterogeneity in Aβ metabolism and lipid homeostasis, as revealed through precise analysis, is a key factor in the pathogenesis of AD and implies that total amyloid burden alone is an insufficient marker for the disease. The application of MSI and machine learning based feature extraction in this context exemplifies a progressive analytic strategy to unravel complex biochemical phenomena, offering potential pathways for the refinement of diagnostic tools and deepening the understanding of neurodegenerative diseases from an analytical chemistry perspective.","dates":{"publication":"2024-06-06","submission":"2024-02-12"},"accession":"PXD049325","cross_references":{"TAXONOMY":["NEWT:330879","NEWT:108018","NEWT:377960","NEWT:1131","NEWT:35795","NEWT:2042546","NEWT:259447","NEWT:295546","NEWT:1334565","NEWT:625351","NEWT:258594","NCBITaxon:1280","NEWT:112503","NEWT:1129","NEWT:309807","NEWT:59753","NEWT:89184","NEWT:309800","NEWT:281395","NEWT:247480","NEWT:1211601","NEWT:876138","NEWT:44271","NEWT:193516","NEWT:2315688","NEWT:592321","NEWT:1073882","NEWT:6819","NEWT:475174","NEWT:1599","NEWT:428386","NEWT:1117","NEWT:498257","NEWT:10036","NEWT:32264","NEWT:12215","NEWT:1590","NEWT:10034","NEWT:33114","NEWT:1596","NEWT:2736291","NEWT:661410","NEWT:638632","NEWT:224326","NEWT:294671","NEWT:376619","NEWT:1748418","NCBITaxon:79857","NEWT:1096976","NEWT:3765","NEWT:3767","NEWT:1589","NEWT:135622","NEWT:4615","NEWT:672127","NEWT:35786","NEWT:1580","NEWT:399784","NEWT:96731","NEWT:656064","NEWT:1582","NEWT:3760","NEWT:1584","NEWT:2086595","NEWT:36630","NEWT:1585","NEWT:383379","NEWT:381198","NCBITaxon:12721","NEWT:10029","NEWT:913645","NEWT:641809","NEWT:1392488","NEWT:38815","NEWT:317447","NEWT:4688","NEWT:3357","NEWT:7719","NEWT:29073","NEWT:5530","NEWT:868565","NEWT:135674","NEWT:1562698","NEWT:79329","NEWT:30069","NEWT:12637","NEWT:59729","NEWT:2164133","NEWT:295105","NEWT:2767846","NEWT:108061","NEWT:60711","NEWT:2020713","NEWT:224308","NEWT:3347","NEWT:49928","NEWT:3349","NEWT:160621","NEWT:2502409","NEWT:212790","NEWT:110368","NEWT:1916073","NEWT:1310161","NEWT:77133","NEWT:145481","NEWT:1310165","NEWT:29058","NCBITaxon:79824","NEWT:468822","NEWT:410658","NEWT:5516","NEWT:44688","NEWT:44689","NEWT:370038","NEWT:498211","NEWT:345076","NEWT:347256","NEWT:5518","NEWT:398007","NEWT:1527468","NEWT:498217","NEWT:498216","NEWT:11320","NEWT:246196","NEWT:246197","NEWT:145458","NEWT:1310173","NEWT:200795","NEWT:342808","NEWT:2579791","NEWT:44685","NEWT:161934","NEWT:1148","NEWT:5508","NEWT:3329","NEWT:419481","NEWT:5507","NEWT:260499","NEWT:410661","NEWT:329854","NEWT:1140","NCBITaxon:2157","NEWT:2066563","NEWT:2649329","NEWT:1143","NEWT:1287689","NEWT:1094343","NEWT:1462472","NEWT:1336795","NEWT:644042","NEWT:150808","NEWT:709964","NEWT:1182590","NEWT:3712","NEWT:3711","NEWT:156974","NEWT:3714","NCBITaxon:37162","NEWT:3715","NEWT:2065263","NEWT:199225","NEWT:177437","NEWT:717966","NEWT:10891","NEWT:10418","NEWT:118698","NEWT:1616117","NEWT:118696","NEWT:34865","NEWT:52283","NEWT:284812","NEWT:8175","NEWT:43330","NEWT:1603293","NEWT:29022","NEWT:44664","NEWT:43346","NEWT:3702","NEWT:1245466","NEWT:3704","NEWT:244366","NEWT:1246791","NEWT:176597","NEWT:118694","NEWT:2850","NEWT:118691","NEWT:34871","NEWT:9006","NEWT:33548","NEWT:52299","NEWT:1883426","NEWT:8165","NEWT:96794","NEWT:10401","NEWT:10886","NEWT:3708","NEWT:332648","NEWT:44670","NEWT:926571","NEWT:536231","NEWT:376219","NEWT:219813","NEWT:1510","NEWT:1955249","NEWT:460519","NEWT:1515","NEWT:572307","NEWT:1432138","NEWT:2714896","NEWT:1424507","NEWT:1194599","NEWT:272844","NEWT:1348799","NEWT:1608994","NEWT:33995","NEWT:55784","NEWT:1303443","NEWT:485","NEWT:56636","NEWT:2499525","NEWT:1122981","NEWT:2853422","NEWT:1122984","NEWT:487","NEWT:1538553","NEWT:1679718","NEWT:480","NEWT:67767","NEWT:45972","NEWT:46835","NEWT:109757","NEWT:582580","NEWT:1185650","NEWT:216778","NEWT:1502","NEWT:128017","NEWT:2836","NEWT:376686","NEWT:237610","NEWT:95486","EFO:0001352","NEWT:219809","NEWT:219808","NEWT:119562","NEWT:1883446","NEWT:31345","NEWT:1233435","NEWT:118223","NEWT:11757","NEWT:141469","NEWT:987059","NEWT:109760","NEWT:29031","NEWT:317047","NEWT:1509","NEWT:491","NEWT:460523","NEWT:45954","NEWT:235443","NEWT:1579","NEWT:1757312","NEWT:85694","NEWT:109786","NEWT:1922344","NEWT:108458","NEWT:5936","NEWT:85692","NEWT:321967","NEWT:320637","NEWT:1078283","NEWT:3750","NEWT:983964","NEWT:11706","NEWT:32644","NEWT:527796","NEWT:279010","NEWT:291146","NEWT:499175","NEWT:109779","NEWT:3745","NEWT:1715989","NCBITaxon:4751","NEWT:3747","NEWT:1116234","NEWT:415978","NEWT:235455","NEWT:1255228","NEWT:410289","NEWT:191701","NEWT:373153","NEWT:1640278","NEWT:9054","NEWT:472","NEWT:940825","NEWT:29459","NEWT:529507","NEWT:1071661","NEWT:28128","NEWT:470","NEWT:41122","NEWT:5911","NEWT:1328300","NEWT:748693","NCBITaxon:50557","NEWT:39251","NEWT:29491","NEWT:911022","NEWT:101841","NEWT:446","NEWT:153481","NEWT:2014887","NEWT:717989","NEWT:33952","NEWT:1255232","NEWT:11723","NEWT:445","NEWT:153009","NEWT:1004879","NEWT:261756","NEWT:166314","NEWT:166313","NEWT:63366","NEWT:63367","NEWT:29488","NEWT:1871049","NEWT:215402","NEWT:1547","NEWT:1290454","NEWT:3726","NEWT:906914","NEWT:81231006","NEWT:156981","NEWT:30455","NEWT:28141","NEWT:9031","NEWT:27292","NEWT:1050722","NEWT:3728","NEWT:108931","NEWT:1293497","NEWT:1055524","NEWT:219799","NEWT:219798","NEWT:548","NEWT:150475","NEWT:267872","NEWT:381666","NEWT:172269","NEWT:9534","NEWT:2126348","NEWT:5180","NEWT:256737","NEWT:299467","NEWT:9541","NEWT:51350","NEWT:8694","NE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