{"database":"Pride","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Txt":["ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD053016/AEP_TiD_proteinGroups.txt","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD053016/HEK293_Control_vs_MVO_proteinGroups.txt","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD053016/HEK293_Control_vs_MVO_peptides.txt"],"Raw":["ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD053016/Hek293_1_1.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD053016/Hek293_3_2.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD053016/AEP_TiD_2.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD053016/Hek293_2_1.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD053016/Hek293_MVO_1_1.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD053016/AEP_TiD_3.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD053016/Hek293_MVO_2_1.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD053016/Hek293_3_1.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD053016/Hek293_MVO_3_1.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD053016/AEP_TiD_1.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD053016/Hek293_MVO_1_2.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD053016/Hek293_2_2.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD053016/Hek293_MVO_2_2.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD053016/Hek293_MVO_3_2.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD053016/Hek293_1_2.raw"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"labhead_mail":["jmartinez9@us.es"],"submitter":["Jonathan Martinez Fabregas"],"technology_type":["Mass Spectrometry","Top-down proteomics"],"software":[""],"submitter_keywords":["Hek293","Lc-ms/ms","Label-free"],"full_dataset_link":["https://www.ebi.ac.uk/pride/archive/projects/PXD053016"],"tissue":["Epithelial Cell"],"sample_protocol":["HEK293 cells were treated with MVO for 24 hours and proteins prepared for Mass Spec analysis. Proteins were digested with Trypsin and analysed on a LTQ Orbitrap HEK293 cells were transfected with TurboID, treated with biotin with 100 uM for 10 minutes. Proteins were digested with trypsin and analysed on a LTQ Orbitrap."],"repository":["Pride"],"quantification_method":[""],"modification":[""],"data_protocol":["MaxQuant software with all settings in default mode was used to analyse the raw files, using a human library obtained from Uniprot"],"omics_type":["Proteomics"],"labhead":["Jonathan Martinez Fabregas"],"instrument_platform":[""],"labhead_affiliation":["University of Seville Andalusian Molecular Biology and Regenerative Medicine"],"submission_type":["PARTIAL"],"species":["Homo Sapiens (human)"],"submitter_mail":["jmartinez9@us.es"],"publication":["40012043 Morillo-Huesca M, G López-Cepero I, Conesa-Bakkali R, Tomé M, Watts C, Huertas P, Moreno-Bueno G, Durán RV, Martínez-Fábregas J. Radiotherapy resistance driven by Asparagine endopeptidase through ATR pathway modulation in breast cancer. J Exp Clin Cancer Res. 2025 44(1):74 10.1186/s13046-025-03334-6"],"submitter_affiliation":["Andalusian Molecular Biology and Regenerative Medicine Centre, University of Seville"],"submitter_country":["Spain"],"pubmed_abstract":["<h4>Background</h4>Tumor resistance represents a major challenge in the current oncology landscape. Asparagine endopeptidase (AEP) overexpression correlates with worse prognosis and reduced overall survival in most human solid tumors. However, the underlying mechanisms of the connection between AEP and reduced overall survival in cancer patients remain unclear.<h4>Methods</h4>High-throughput proteomics, cellular and molecular biology approaches and clinical data from breast cancer (BC) patients were used to identify novel, biologically relevant AEP targets. Immunoblotting and qPCR analyses were used to quantify protein and mRNA levels. Flow cytometry, confocal microscopy, chemical inhibitors, siRNA- and shRNA-silencing and DNA repair assays were used as functional assays. In-silico analyses using the TCGA BC dataset and immunofluorescence assays in an independent cohort of invasive ductal (ID) BC patients were used to validate the clinical relevance of our findings.<h4>Results</h4>Here we showed a dual role for AEP in genomic stability and radiotherapy resistance in BC patients by suppressing ATR and PPP1R10 levels. Reduced ATR and PPP1R10 levels were found in BC patients expressing high AEP levels and correlated with worst prognosis. Mechanistically, AEP suppresses ATR levels, reducing DNA damage-induced cell death, and PPP1R10 levels, promoting Chek1/P53 cell cycle checkpoint activation, allowing BC cells to efficiently repair DNA. Functional studies revealed AEP-deficiency results in genomic instability, increased DNA damage signaling, reduced Chek1/P53 activation, impaired DNA repair and cell death, with phosphatase inhibitors restoring the DNA damage response in AEP-deficient BC cells. Furthermore, AEP inhibition sensitized BC cells to the chemotherapeutic reagents cisplatin and etoposide. Immunofluorescence assays in an independent cohort of IDBC patients showed increased AEP levels in ductal cells. These analyses showed that higher AEP levels in radioresistant IDBC patients resulted in ATR nuclear eviction, revealing AEPhigh/ATRlow protein levels as an efficient predictive biomarker for the stratification of radioresistant patients.<h4>Conclusion</h4>The newly identified AEP/ATR/PPP1R10 axis plays a dual role in genomic stability and radiotherapy resistance in BC. Our work provides new clues to the underlying mechanisms of tumor resistance and strong evidence validating the AEP/ATR axis as a novel predictive biomarker and therapeutic target for the stratification and treatment of radioresistant BC patients."],"pubmed_title":["Radiotherapy resistance driven by Asparagine endopeptidase through ATR pathway modulation in breast cancer."],"pubmed_authors":["Morillo-Huesca Macarena M, G López-Cepero Ignacio I, Conesa-Bakkali Ryan R, Tomé Mercedes M, Watts Colin C, Huertas Pablo P, Moreno-Bueno Gema G, Durán Raúl V RV, Martínez-Fábregas Jonathan J"],"sample_synonyms":["293T Cell, 293 Cells, 4-d]imidazol-4-yl)pentanoic acid, anon-EST:fe2E2, Deacura, l(3)alpha-Spec, vitamin B7, determination, Biotine, alpha-Spect, Human Embryonic Kidney Cell Line 293, alpha-Spe, Medebiotin, FBN, Gene, HEK293 Cell, Vitamin H, alpha-Spc, 293T, l(3)04276, B-spec, Biotin, ECTOL1, betaspec, 4beta, klo, Gene Products, 6aR)-Hexahydro-2-oxo-1H-thieno[3, alpha-Sp, HEK 293, CG1977, 6aalpha))-, Gelfert, WMS, alpha-spec, Biotin Hermes, kus, Coenzyme R, (3aS, beta-Trypsin, cis-Hexahydro-2-oxo-1H-thieno(3, biotina, dre3, biotine, alpha-spectrin, OCTD, anon-EST:fe1B3, 4-d]imidazole-4-valeric acid, Hermes, SPEC8, (+)-cis-Hexahydro-2-oxo-1H-thieno[3, 293T Cells, CG5870, biotinum, GPHYSD2, 293 Cell, SGS, l(3)dre3, Spec-beta, Medobiotin, alpha-Spectrin, Rombellin, 3A9, DmelCG1977, Proteins, Human Kidney Cell Line 293, Roche, Biotin Gelfert, i168, 5-(2-oxohexahydro-1H-thieno[3, HEK 293 Cell, SpeC, Cell, L-ornithine carboxy-lyase (putrescine-forming), L-ornithine carboxy-lyase activity, 4]imidazole-4-valeric acid, 4S, 4-d)imidazole-4-pentanoic acid, ACMICD, (3aS-(3aalpha, alphaSpec, cis-Tetrahydro-2-oxothieno(3, 4]imidazoline-4-valeric acid, biotin, l(1)G0108, Protein, chemical analysis, betaSpec, Biotin Ratiopharm, MFS1, 4-d)imidazoline-4-valeric acid, alphaSp, b-Spec, spectrin, WMS2, D-Biotin, Biodermatin, beta Trypsin., Biotin-Ratiopharm, 1H-Thieno(3, DmelCG5870, l(1)G0074, l(1)G0198, PRSS, Biotine Roche, Gabunat, HEK293, FCP-B, Tripcellim, hexahydro-2-oxo-, b spectrin, MASS, alpha, 4)imidazole-4-valeric acid, beta Trypsin, beta, Protein Gene Products, HEK 293 Cell Line, Gene Proteins, Trypure, HEK 293 Cells, beta-spec, l(3)62Bd, i6, Cells, SSKS, HEK, cis-(+)-Tetrahydro-2-oxothieno[3, alfa-Spec, assay, D-(+)-biotin, Biokur, Spec, Specbeta"],"name_synonyms":["antagonists, inhibitors, 293T Cell, AI746452, ATP-dependent helicase IGHMBP2, 293 Cells, LGMN1, Human Embryonic Kidney Cell Line 293, PRSC1, HEK293, Human Kidney Cell Line 293, inhibiteur, inhibitor, HEK293 Cell, Antifreeze enhancer-binding protein ortholog, antagonists and inhibitors., HEK 293 Cell, Cell, 293T, HEK 293 Cell Line, Prsc1, AU022324, inhibidor, HEK 293 Cells, AEP, 3.6.4.12, Cells, 3.6.4.13, HEK, 293T Cells, HEK 293, 293 Cell"],"data_synonyms":["Applications Software, Svc, Open Source Softwares, Open Source, Bru, Library., Software Applications, Col4a-1, human being, Computer Software, Man (Taxonomy), Raw, Source Software, Software Application, Open, Modern, Engineering, Open Source Software, Computer Programs and Programming, Computer, Source Softwares, human, Software Tools, Computer Software Application, Tool, Programs, Human, Computer Programs, Program, Computer Applications, Applications, Software Tool, Applications Softwares, Tools, Homo sapiens, Modern Man, Computer Applications Software, Computer Applications Softwares, Software Engineering, Del(8)44H, Softwares, Software, Man, Computer Program, Application, Computer Software Applications"],"description_synonyms":["antagonists, inhibitors, AI746452, Prsc1, ATP-dependent helicase IGHMBP2, LGMN1, AU022324, inhibidor, AEP, 3.6.4.12, 3.6.4.13, PRSC1, inhibiteur, inhibitor, Antifreeze enhancer-binding protein ortholog, antagonists and inhibitors."],"pubmed_abstract_synonyms":["Laser Scanning Confocal Microscopy, Immunoelectroblotting, dp53, Eto GRY, Surrogate Endpoints, cis-Dichlorodiammineplatinum(II), 9beta(R*)))-, Laboratory, Phosphatase, Antibody Technics, Randa, (5a alpha)-Isomer, Radiation Therapies, fs(1)M37, (SP-4-2)-, AtrII, Tumor, Vépéside Sandoz, Repeat Associated siRNA, Small, sckl1, Cell Cycle-Transition Points, (-)-etoposide, Fb19, Immunofluorescence Technics, Method, Biological, bbl, ARABIDOPSIS THALIANA ATAXIA TELANGIECTASIA-MUTATED AND RAD3-RELATED, symptoms, Peyrone's chloride, Cell Cycle Transition Points, cancer of the breast, 8, Cell Sortings, Non Polyadenylated, BC, treatment, thymus nucleic acid, BCC7, Chk1, Molecular, cis-diamminedichloridoplatinum(II), cis-DDP, C2, beta-Tub6D, dmp53, Dmmei41, NSC 141540, Radiotherapies, T, 1422/04, procedures, R111, Briplatin, Phosphomonoesterases, asparagine endopeptidase, chk1, Etopophos, Repeat-Associated, cancer of breast, Dp53, Ataxia telangiectasia-mutated and RAD3-related, Role Concepts, (SP-4-2)-diamminedichloroplatinum, 3-dioxol-6(5aH)-one, CHK1, Cell Cycle, GAPO, CG17117, phosphatase, Breast Malignant Neoplasms, p50/tubulin, single organism signaling, Tumors, Etopos, Cell Sorting, screening, (5a alpha, X-ray therapy, CG10873, Furo(3', Fluorescent Antibody, Radiation, Viral, Data Set, Targeted Radiation, Polyadenylated, 4-demethylepipodophyllotoxin beta-D-ethylideneglucoside, TGF-beta, Fluorescent, response to DNA damage stimulus, 9-((4, Procedure, Toposar, cis Platinum, meiP41, CG7904, Short, 2610025H06Rik, alpha D Glucopyranosyl Isomer, Benign, Role Concept, Atr88CD, Playthings and Play, Marker, AEP, Radiotherapy, Coons Technic, Role, CDDP, Etoposide Pierre Fabre, Technics, bfy, l(3)10460, desoxyribose nucleic acid, activation, HTH, Hth, mus(1)103, Scanning Laser, 4'':6, Carcinomas, Reverse Immunoblottings, Polyadenylated Messenger RNA, mus(1)104, Non Polyadenylated mRNA, protein_coding_transcript, End Points, 6-O-ethylidene-beta-D-glucopyranosyl)oxy)-5, Dichlorodiammineplatinum, [PtCl2(NH3)2], signs, CG3401, Benign Neoplasms, beta3Tub, beta3TUB, reagent, Methodological, Immunologic, Repeat Associated, \"mammary neoplasm\" RELATED [], Controls, Laboratory Marker, Fluorescence-Activated Cell, Teva, human, Non-Polyadenylated mRNA, Genomic, Etoposido, Malignant Neoplasms, DTB3, Cycle-Transition Point, mus-104, mus-103, Phosphohydrolase, Etoposide, breast cancer, antagonists and inhibitors, Reverse Immunoblotting, Fluorescent Antinuclear Antibody Test, Breast Tumors, Phosphoric, (5R-(5alpha, 3.6.4.12, ds DNA, Indicator, 3.6.4.13, etoposidum, Breast Malignant Tumors, bhy, cisplatinum, DNA, 4':6, other neoplasm, cancer, Poly(A) RNA, CG31325, DmelCG4252, Laser Microscopy, beta[[3]]-Tub, Radiation Treatments, DmelCG17117, DNS, Immunoblotting, (Deoxyribonucleotide)n, Peptidomics, Scanning Microscopy, Fluorescent Protein, 6-O-Ethylidine-beta-D-glucopyranosyl)oxy)-5, Clinical Marker, Neoplasms, Cell Cycle Control, asparaginyl endopeptidase, Mammary Cancers, stalk, Prognostic Factors, 143391_i_at, Immunofluorescence Technic, beta3 TU, protein-containing complex, Genomic Stability, LFS1, l(3)05745, Human, Fluorescence-Activated, Breast Malignant Tumor, Fluorescence-Activated Cell Sortings, Microfluorometry, Dot, Deoxyribonucleic Acid, Breast Tumor, mei-195, Small Scan RNA, Genomic Instabilities, Gene Products, Eto-GRY, breast tumor, anon-EST:Liang-2.13, Clinical Significance, Riboposid, Man, Technique, Genome Instabilities, Mei-41, Cytofluorometry, Toy, Vepesid, ATP-dependent helicase IGHMBP2, scnRNA, Injury, Clinical, Eposin, cis-Diamminedichloroplatinum, 5abeta, Playthings, Flow Cytofluorometries, Mammary Neoplasm, Mammary Carcinoma, NSC141540, messenger RNA, Double Stranded, Deoxyribonucleic acid, Lederplatin, culm, Phosphoric Monoester Hydrolase, Platamine, Short Hairpin, Neoplasias, Study, G1/S transition checkpoint, MHK7_5, template RNA, Puppets, Malignant Tumor of Breast, Trans Acting siRNA, accidental cell death, Flow, Flow Microfluorometries, Cytometry, Checkpoint, Coon's, Immunoelectroblottings, beta[[3]]-tubulin, (Deoxyribonucleotide)m, cob, Immunofluorescence Techniques, tasiRNA, Biologic, Puppet, Sortings, Cancer, inhibitors, Molecular Genetics, Breast Carcinoma, Human Mammary Neoplasm, 4252, l(3)j5A5, RNA, Trans-Acting, Dmbeta3, Breast Carcinomas, findings, Malignant Neoplasm, Tgf-r, Coon's Technic, Targeted Radiation Therapies, Cell Cycle-Transition Point, Cismaplat, DNAn+1, Proteins, prac, Serum Markers, beta3t, Messenger RNA, shRNA, Factor, Flow Cytometries, 4'-Demethylepipodophyllotoxin 9-(4, Genetics, \"breast tumor\" EXACT [NCI2004_11_17:C2910], Cell, Vépéside-Sandoz, Small Hairpin RNA, Immune Marker, Short Interfering, Concept, MT, Checkpoints, Dot Immunoblottings, native protein, CG4252, VP 16, Surrogate End Point, Poly(A)+ mRNA, p53/tubulin, Antinuclear Antibody Test, Neoplasm, INSDC_feature:mRNA, Human Mammary Carcinoma, VP 16 213, Flow Microfluorometry, Cell Cycle Arrests, Death, cis-diamminedichloroplatinum, Biologic Markers, Genotoxic Stress, CG33336, cis-platin, primary cancer, 4-dimethyloxyphenyl)furo(3', Small Interfering RNA, Q-PCR, cis-diamminedichloroplatinum(II), underdeveloped, mRNA, Coons Technique, Biochemical Genetic, Surrogate, Neoplatin, Endpoints, D-p53, cis Diamminedichloroplatinum, Dm-P53, Platinum, cisplatine, Cancers, beta3, Etoposide Teva, cblB, malignant tumor, cisplatin, dtl, Cell Cycle Checkpoint, cisplatino, Tub, Gene Proteins, Antibody Technic, Genome Instability, signalling process, TGF-B, siRNA, betatub60D, Point, Stress, Biocisplatinum, Radiation Therapy, Desoxyribonukleinsaeure, Cancer of Breast, STK-C, Polyadenylated mRNA, Instability, MEI41/FRP1, Neoplasia, Immunofluorescence, breast, Repeat-Associated siRNA, Immune Markers, malignant tumor of the breast, Reverse, Biological Markers, Viral Marker, Laser Scanning Microscopies, Platinol, G1/S checkpoint, cis-Diamminedichloroplatinum(II), kinetic polymerase chain reaction, Small Hairpin, SCKL1, PRSC1, Biochemical, mammary neoplasm, alpha-D-Glucopyranosyl Isomer, Endpoint, Human Mammary Neoplasms, Act-r, 6-O-(R)-ethylidene-beta-D-glucopyranoside), protein, Genome Stability, Serum, Technic, betaTub3, FCTCS, Tp53, Arrests, mei41, ATRAD3, Phosphatases, Techniques, Hydrolase, Laboratory Markers, Electroimmunoblotting, DMP53, Trans Acting, \"neoplasm of breast (disorder)\" EXACT [SNOMEDCT_2005_07_31:126926005], Roles, Celltop, DmelCG7904, Concepts, Dmp53, Flow Microfluorimetry, protein aggregate, Peyrone's salt, Laser Scanning, Mammary Neoplasms, malignant neoplasm of breast, 1323/07, Prognoses, Man (Taxonomy), Protein Tracings, Biology, Fluorescence Activated Cell Sorting, D17Ertd808e, Immunoblottings, Coon Technic, Pnuts, Polyadenylated Messenger, hypoplasia, Human Mammary Carcinomas, Clinical Importance, DmP53, VP 16213, Antifreeze enhancer-binding protein ortholog, PNUTS, NSC-141540, legumain, Scanning Microscopies, INSDC_feature:ncRNA, Laser Microscopies, B3t, DmelCG3401, Immune, Markers, Methodological Studies, malignant neoplasm, Viral Markers, Cisplatin, disease management, Therapies, Mei-41/DATR, atrII, Malignancies, Double-Stranded DNA, necrosis, deoxyribonucleic acids, DNAn, Reagents, VP16, mammary cancer, Cell Cycle Arrest, Flow Cytofluorometry, reagents, Atr, ATR, Therapy, Interfering RNA, Fluorescent Antibody Techniques, Carcinoma, Confocal Microscopies, Fluorescence-Activated Cell Sorting, Trans-Acting siRNA, \"breast neoplasm\" EXACT [MTH:120], Surrogate Endpoint, Punt, NSC-119875, Modern, Biochemical Markers, Double-Stranded, qPCR, Confocal Laser Scanning Microscopy, Biologic Marker, diamminedichloro-, VP 16-213, Significance, atr, Microfluorimetry, 3t, (Deoxyribonucleotide)n+m, Atr-II, Small Scan, PUNT, Plaything, NOS, Antibody Techniques, Short Interfering RNA, reactif, 8aalpha, Malignant Neoplasm of Breast, Hairpin RNA, Scan, Tub60D, Protein Tracing, DNA Injury, AI746452, DNA Injuries, beta-tub, Arrest, Cytofluorometries, DmATR, Factors, Prognostic, Relevance, DmelCG33336, Control, Toys, Platinum Diamminodichloride, 5-dimethoxyphenyl)-, radioisotope therapy, G2/M transition checkpoint, ATATR, Lastet, Methodological Study, Treatments, Prsc1, hth1, delta secretase, Genotoxic, hth2, Patient, Coon's Technique, Biochemical Marker, mus103, Platidiam, Put, Fluorescent Protein Tracings, mus104, P53, p44, Fluorescent Protein Tracing, Etomedac, Microscopy, Laser, VP-16, Genomic Stabilities, Hydrolases, Confocal Microscopy, quantitative real time polymerase chain reaction, betaTub, Prognostic Factor, alpha-D-Glucopyranosyl Isomer Etoposide, protein levels, primary breast cancer, LGMN1, Etoposido Ferrer Farma, Plays, human being, pun, Procedures, Targeted Radiation Therapy, Cat53, p50, Confocal, Clinical Markers, Reagent, XATR, p53, Importance, Benign Neoplasm, Dot Immunoblotting, Gene, Exitop, Monoester Hydrolase, CAT53, Malignant, Deoxyribonucleic acids, Surrogate End Points, PP1R10, Stability, Surrogate Markers, Short Hairpin RNA, Eposide, AU022324, Client., reduced, Homo sapiens, 8a, Messenger, Scan RNA, Instabilities, Studies, DNA Damage Response, \"mammary tumor\" EXACT [CSP2005:2016-0671], tiny, etoposide, Tracing, Reagents and Indicators, Biomarker, Human Mammary, Genetic, clone 2.13, reactivo, Demethyl Epipodophyllotoxin Ethylidine Glucoside, Malignancy, dlhC, 7)naphtho(2, D.m.BETA-60D, Microfluorometries, Onkoposid, Biological Marker, MHK7.5, 7)naptho-(2, cis-Platinum, inhibiteur, Targeted Radiotherapies, Indicators, Cancer of the Breast, Trp53, Immunologic Markers, inhibidor, 9-tetrahydro-5-(4-hydroxy-3, LGMN protein, Clients, Mammary, Mammary Cancer, rad27, betaTub60C, Play, beta3-tubulin, biological marker, Cell Cycle-Transition, Targeted Radiotherapy, TRP53, Breast, mammary tumor, Immunologic Marker, Cytometries, small, beta-Tub60D, Tracings, sckl, Dm-HTH, Microscopies, protein complex, FRP1, axis, Molecular Genetic, BETA 60D, 9 alpha)-Isomer, p99, beta3-Tub, Targeted, End Point, inhibitor, Fluorescent Antibody Technics, SCKL, TEM8, Client, Fluorescent Antibody Technic, (5S)-Isomer, Xp53, Breast Malignant Neoplasm, Stabilities, Phosphomonoesterase, Mammary Carcinomas, 3-d)-1, Protein, (SP-4-2)-diamminedichloridoplatinum, Laser Scanning Microscopy, MEI41, Immunofluorescence Technique, techniques, Polyadenylated RNA, radiation therapy, beta[[3]] tubulin, ds-DNA, Antibody Technique, G2/M checkpoint, Genome Stabilities, frp1, cis-diammineplatinum(II) dichloride, antagonists, MEC1, Electroimmunoblottings, Phosphoric Monoester, FB19, cis-[PtCl2(NH3)2], Breast Neoplasm, Poly(A)+ RNA, Serum Marker, cis-dichlorodiammineplatinum(II), Poly(A) Tail, Cell Cycle Controls, Diamminodichloride, Non-Polyadenylated, DNA Lesion, beta60C, l(3)86Ca, phosphoric monoester hydrolase activity, Radiation Treatment, Coon Technique, Surrogate Marker, CFAP23, Protein Gene Products, Phosphohydrolases, DNA Lesions, Meis1, Therapeutic, Modern Man, Breast Cancer, Sorting, Platino, C85740, Treatment, Biochemical Genetics, mec1, Genome, methodology, Platinex, trans-Etoposide"],"pubmed_title_synonyms":["Radiation Treatments, primary breast cancer, malignant tumor of the breast, pun, Targeted Radiation Therapy, Neoplasms, XATR, asparaginyl endopeptidase, SCKL1, Radiation Therapies, fs(1)M37, mammary neoplasm, Mammary Cancers, AtrII, Act-r, Human Mammary Neoplasms, Tumor, FCTCS, Human, mei41, ATRAD3, sckl1, Breast Malignant Tumor, \"neoplasm of breast (disorder)\" EXACT [SNOMEDCT_2005_07_31:126926005], Breast Tumor, mei-195, DmelCG7904, ARABIDOPSIS THALIANA ATAXIA TELANGIECTASIA-MUTATED AND RAD3-RELATED, \"mammary tumor\" EXACT [CSP2005:2016-0671], breast tumor, cancer of the breast, Mei-41, BC, Mammary Neoplasms, malignant neoplasm of breast, Human Mammary, dlhC, Mammary Neoplasm, Mammary Carcinoma, MHK7.5, Dmmei41, Human Mammary Carcinomas, Radiotherapies, Targeted Radiotherapies, legumain, asparagine endopeptidase, Cancer of the Breast, MHK7_5, LGMN protein, cancer of breast, Ataxia telangiectasia-mutated and RAD3-related, Malignant Tumor of Breast, Mammary, Mammary Cancer, Therapies, Mei-41/DATR, atrII, Targeted Radiotherapy, cob, GAPO, Breast, mammary cancer, mammary tumor, Atr, ATR, Tumors, Cancer, Therapy, X-ray therapy, 4252, l(3)j5A5, Breast Carcinoma, Human Mammary Neoplasm, Carcinoma, sckl, Radiation, Breast Carcinomas, Tgf-r, \"breast neoplasm\" EXACT [MTH:120], Targeted Radiation, Targeted Radiation Therapies, FRP1, Punt, Targeted, TGF-beta, SCKL, \"breast tumor\" EXACT [NCI2004_11_17:C2910], TEM8, meiP41, CG7904, atr, Breast Malignant Neoplasm, Atr88CD, CG4252, Mammary Carcinomas, Radiotherapy, Atr-II, PUNT, Neoplasm, Human Mammary Carcinoma, MEI41, NOS, l(3)10460, radiation therapy, Malignant Neoplasm of Breast, frp1, mus(1)103, Carcinomas, mus(1)104, MEC1, Breast Neoplasm, DmATR, radioisotope therapy, Radiation Treatment, ATATR, Cancers, Breast Malignant Neoplasms., \"mammary neoplasm\" RELATED [], cblB, human, CFAP23, mus-104, mus-103, delta secretase, TGF-B, breast cancer, mus103, Breast Tumors, Breast Cancer, Put, mus104, Radiation Therapy, Breast Malignant Tumors, Treatment, Cancer of Breast, mec1, STK-C, MEI41/FRP1, cancer, DmelCG4252, breast"],"additional_accession":[]},"is_claimable":false,"name":"AEP targets HEK293 cells using specific inhibitor and TurboID approaches","description":"Characterisation of AEP physiological targets using specific inhibitors and TurboID approaches","dates":{"publication":"2025-05-07","submission":"2024-06-11"},"accession":"PXD053016","cross_references":{"TAXONOMY":["NEWT:330879","NEWT:377960","NEWT:2042546","NEWT:259447","NEWT:295546","NCBITaxon:2719036","NEWT:625351","NCBITaxon:1280","NEWT:112503","NEWT:1129","NEWT:309807","NEWT:59753","NEWT:89184","NEWT:309800","NEWT:281395","NEWT:1211601","NEWT:876138","NEWT:44271","NEWT:193516","NEWT:1073882","NEWT:6819","NEWT:475174","NEWT:111205","NEWT:1117","NEWT:498257","NEWT:10036","NEWT:1590","NEWT:10034","NEWT:33114","NEWT:661410","NEWT:638632","NEWT:224326","NEWT:376619","NCBITaxon:79857","NEWT:1096976","NEWT:3765","NEWT:1589","NEWT:135622","NEWT:35786","NEWT:1580","NEWT:399784","NEWT:96731","NEWT:656064","NEWT:1582","NEWT:36630","NEWT:383379","NEWT:418106","NCBITaxon:12721","NEWT:10029","NEWT:913645","NEWT:641809","NEWT:1392488","NEWT:38815","NEWT:317447","NEWT:4688","NEWT:111225","NEWT:7719","NEWT:868565","NEWT:135674","NEWT:79329","NEWT:30069","NEWT:12637","NEWT:59729","NEWT:2164133","NEWT:295105","NEWT:108061","NEWT:60711","NEWT:224308","NEWT:3347","NEWT:160621","NEWT:212790","NEWT:110368","NEWT:1310161","NEWT:77133","NEWT:145481","NEWT:1310165","NEWT:29058","NCBITaxon:79824","NEWT:1912919","NEWT:410658","NEWT:44688","NEWT:44689","NEWT:498211","NEWT:347256","NEWT:5518","NEWT:398007","NEWT:1527468","NEWT:498217","NEWT:498216","NEWT:11320","NEWT:246196","NEWT:246197","NEWT:145458","NEWT:44685","NEWT:161934","NEWT:156587","NEWT:1148","NEWT:5508","NEWT:3329","NEWT:419481","NEWT:5507","NEWT:410661","NEWT:1140","NCBITaxon:2157","NEWT:1143","NEWT:1287689","NEWT:1094343","NEWT:1462472","NEWT:1336795","NEWT:644042","NEWT:150808","NEWT:1182590","NEWT:3712","NEWT:3711","NEWT:3714","NEWT:270643","NEWT:2065263","NEWT:177437","NEWT:10418","NEWT:118698","NEWT:1616117","NEWT:118696","NEWT:34865","NEWT:52283","NEWT:28174","NEWT:284812","NEWT:8175","NEWT:43330","NEWT:1603293","NEWT:44664","NEWT:43346","NEWT:3702","NEWT:1245466","NEWT:3704","NEWT:244366","NEWT:1246791","NEWT:176597","NEWT:118694","NEWT:2850","NEWT:118691","NEWT:34871","NEWT:33548","NEWT:52299","NEWT:8165","NEWT:96794","NEWT:3708","NEWT:332648","NEWT:44670","NEWT:536231","NEWT:376219","NEWT:219813","NEWT:1510","NEWT:460519","NEWT:1515","NEWT:572307","NEWT:1432138","NEWT:1424507","NEWT:1194599","NEWT:272844","NEWT:1348799","NEWT:33995","NEWT:55784","NEWT:1303443","NEWT:9483","NEWT:485","NEWT:56636","NEWT:2709072","NEWT:2499525","NEWT:2853422","NEWT:487","NEWT:1538553","NEWT:1679718","NEWT:480","NEWT:67767","NEWT:46835","NEWT:109757","NEWT:582580","NEWT:1185650","NEWT:216778","NEWT:294607","NEWT:1502","NEWT:128017","NEWT:376686","NEWT:237610","NEWT:95486","NEWT:1883446","NEWT:1233435","NEWT:118223","NEWT:11757","NEWT:109760","NEWT:29031","NEWT:317047","NEWT:491","NEWT:460523","NEWT:45954","NEWT:235443","NEWT:1757312","NEWT:85694","NEWT:109786","NEWT:108458","NEWT:5936","NEWT:320637","NEWT:1078283","NEWT:3750","NEWT:983964","NEWT:11706","NEWT:32644","NEWT:527796","NEWT:499175","NEWT:109779","NEWT:3745","NEWT:1715989","NCBITaxon:4751","NEWT:3747","NEWT:1116234","NEWT:1255228","NEWT:410289","NEWT:373153","NEWT:1640278","NEWT:472","NEWT:940825","NEWT:529507","NEWT:1071661","NEWT:28128","NEWT:470","NEWT:5911","NEWT:748693","NCBITaxon:50557","NEWT:39251","NEWT:29491","NEWT:101841","NEWT:446","NEWT:153481","NEWT:2014887","NEWT:33952","NEWT:445","NEWT:153009","NEWT:261756","NEWT:166313","NEWT:63366","NEWT:63367","NEWT:215402","NEWT:1547","NEWT:906914","NEWT:9031","NEWT:27292","NEWT:1050722","NEWT:3728","NEWT:108931","NEWT:1293497","NEWT:1055524","NEWT:150475","NEWT:267872","NEWT:381666","NEWT:172269","NEWT:9534","NEWT:5180","NEWT:256737","NEWT:9541","NEWT:8694","NEWT:33936","NEWT:8692","NEWT:2903","NEWT:185579","NEWT:13076","NEWT:207340","NEWT:1006581","NEWT:8673","NEWT:33940","NEWT:550","NEWT:554","NEWT:451516","NEWT:552","NEWT:1325291","NEWT:36185","NEWT:1054211","NEWT:1225786","NEWT:771870","NEWT:51338","NEWT:575412","NEWT:28112","NEWT:6493","NEWT:10832","NEWT:6494","NEWT:6491","NEWT:507601","NEWT:520","NEWT:186441","NEWT:643680","NEWT:214092","NCBITaxon:6157","NEWT:13095","NEWT:162425","NEWT:104105","NEWT:216257","NEWT:9986","NEWT:8654","NEWT:8658","NEWT:1268063","NEWT:8657","NEWT:9983","NEWT:8655","NEWT:5147","NEWT:28108","NEWT:28104","NEWT:407821","NEWT:568703","NCBITaxon:2","NEWT:568708","NEWT:1613","NEWT:986","NEWT:52641","NEWT:28532","NEWT:353152","NEWT:298176","NEWT:353153","NEWT:227377","NEWT:1774284","NEWT:40674","NEWT:1194669","NEWT:51329","NEWT:443906","NEWT:519","NEWT:2510939","NEWT:7394","NEWT:6063","NEWT:1328388","NEWT:105487","NEWT:1548728","NEWT:667127","NEWT:9557","NEWT:377586","NEWT:300641","NEWT:39655","NEWT:9554","NEWT:38323","NEWT:475932","NEWT:256318","NEWT:206411","NCBITaxon:6191","NEWT:229533","NEWT:214053","NEWT:28550","NEWT:80863","NEWT:90675","NEWT:52639","NEWT:52638","NEWT:57075","NEWT:1666905","NEWT:8697","NEWT:8695","NEWT:884204","NEWT:510516","NEWT:1045775","NEWT:1123869","NEWT:9544","NEWT:9545","NEWT:979","NEWT:7370","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