{"database":"Pride","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD055744/20211207_SINTEF_DDA_sample-A3-3.d.tar","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD055744/20211207_SINTEF_DDA_sample-B3-2.d.tar","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD055744/20211207_SINTEF_DDA_sample-B2-2.d.tar","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD055744/20211207_SINTEF_DDA_sample-A1-5.d.tar","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD055744/20211207_SINTEF_DDA_sample-A1-3.d.tar","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD055744/20211207_SINTEF_DDA_sample-B3-5.d.tar","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD055744/20211207_SINTEF_DDA_sample-B1-2.d.tar","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD055744/20211207_SINTEF_DDA_sample-A2-3.d.tar","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD055744/20211207_SINTEF_DDA_sample-B1-5.d.tar","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD055744/20211207_SINTEF_DDA_sample-A3-1.d.tar","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD055744/20211207_SINTEF_DDA_sample-B2-5.d.tar","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD055744/20211207_SINTEF_DDA_sample-A2-1.d.tar","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD055744/20211207_SINTEF_DDA_sample-A3-4.d.tar","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD055744/20211207_SINTEF_DDA_sample-A1-1.d.tar","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD055744/20211207_SINTEF_DDA_sample-B2-3.d.tar","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD055744/20211207_SINTEF_DDA_sample-B3-3.d.tar","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD055744/20211207_SINTEF_DDA_sample-B1-3.d.tar","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD055744/20211207_SINTEF_DDA_sample-A1-4.d.tar","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD055744/20211207_SINTEF_DDA_sample-B3-1.d.tar","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD055744/20211207_SINTEF_DDA_sample-A2-4.d.tar","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD055744/20211207_SINTEF_DDA_sample-B2-1.d.tar","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD055744/20211207_SINTEF_DDA_sample-A2-2.d.tar","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD055744/20211207_SINTEF_DDA_sample-A3-2.d.tar","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD055744/20211207_SINTEF_DDA_sample-A1-2.d.tar","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD055744/20211207_SINTEF_DDA_sample-B1-1.d.tar","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD055744/20211207_SINTEF_DDA_sample-B3-4.d.tar","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD055744/txt.tgz","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD055744/20211207_SINTEF_DDA_sample-B1-4.d.tar","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD055744/20211207_SINTEF_DDA_sample-A2-5.d.tar","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD055744/20211207_SINTEF_DDA_sample-B2-4.d.tar","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD055744/20211207_SINTEF_DDA_sample-A3-5.d.tar"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"labhead_mail":["francesca.dibartolomeo@sintef.no"],"submitter":["Animesh Sharma"],"technology_type":["Mass Spectrometry","Bottom-up proteomics"],"software":[""],"submitter_keywords":["Antibiotic challenge","Label-free quantitative proteomics","Pseudomonas aeruginosa","Imipenem .","Antimicrobial resistance"],"full_dataset_link":["https://www.ebi.ac.uk/pride/archive/projects/PXD055744"],"sample_protocol":["The bacteria were grown in cation-adjusted Mueller-Hinton broth (Becton Dickinson, Sparks, MD, USA) at 37°C with shaking (120 rpm) to optical density OD600 = 1.0. For antibiotic challenge, imipenem concentration of 0.1 x MIC, 0.25 x MIC, 0.5 x MIC and 1 x MIC of the strain was used in a volume of 5 ml. Bacterial cultures without the antibiotic were considered as untreated controls, see Table 1. Challenged bacterial cultures were then incubated with shaking (120 rpm) for 5 hours at 35°C±2°C. Each experiment was performed three times for both, clinical and reference strains (3 biological replicates) with two technical replicates for each condition (antibiotic concentration). After incubation the bacterial cell pellets were harvested in pre-cooled Falcon tubes by centrifugation (5 min at 3,000 × g below 0 °C). Then the cell pellets were washed twice with ice-cold 1 x PBS (Sigma-Aldrich, Life Science, St. Louis, MO, USA). Finally, cell pellets were collected by centrifugation (5 min at 3,000 × g below 0 °C), snap-frozen, and stored at −80°C until further testing (Ref. 3, 4, 5)."],"repository":["Pride"],"quantification_method":[""],"modification":[""],"data_protocol":["Proteins were quantified by processing the timsTOF-pro DDA MS-data using MaxQuant v2.0.3.0 (Ref:https://www.nature.com/articles/nprot.2016.136 ). Namely, the following search parameters were used: enzyme specified as trypsin with a maximum of two missed cleavages allowed; minimum peptide length of 7; acetylation of protein N-terminal, oxidation of methionine, and deamidation of asparagine/glutamine as dynamic post-translational modification. These were imported in MaxQuant which uses m/z and retention time (RT) values to align each run against each other sample with a minute window match-between-run function and 20 mins overall sliding window using a clustering-based technique. These were further queried against the reference-proteome of Pseudomonas aeruginosa downloaded from Uniprot (https://www.uniprot.org/proteomes/UP000002438) in May 2022 and MaxQuant’s internal contaminants database using Andromeda built into MaxQuant. Both Protein and peptide identifications false discovery rate (FDR) was set to 1%, only unique peptides with high confidence were used for final protein group identification. Peak abundances were extracted by integrating the area under the peak curve. Each protein group abundance was normalized by the total abundance of all identified peptides for each run and protein by calculated median summing all unique peptide-ion abundances for each protein using label-free quantification (LFQ) algorithm (Ref:https://doi.org/10.1074/mcp.M113.031591) with minimum unique peptide(s) ≥ 1."],"omics_type":["Proteomics"],"labhead":["Francesca Di Bartolomeo"],"instrument_platform":[""],"submission_type":["PARTIAL"],"labhead_affiliation":["Department of Biotechnology and Nanomedicine, SINTEF Industry, Trondheim 7034, Norway"],"species":["Pseudomonas Aeruginosa Atcc 700888"],"publication":["41181332 Eidsaa M, Sharma A, Janasch M, Kuch A, Skoczyńska A, Di Bartolomeo F. Proteomic landscape of imipenem resistance in &lt;i&gt;Pseudomonas aeruginosa&lt;/i&gt;: a comparative investigation between clinical and control strains. Front Cell Infect Microbiol. 2025 15:1623154 10.3389/fcimb.2025.1623154"],"submitter_mail":["sharma.animesh@gmail.com"],"submitter_affiliation":["Engineer at NTNU, Norway"],"submitter_country":["India"],"pubmed_abstract":["The increasing prevalence of antimicrobial resistance (AMR) poses a significant challenge to global health, particularly with bacterial pathogens such as <i>Pseudomonas aeruginosa</i>, a notorious cause of nosocomial infections. This study focuses on the comparative proteomic analysis of an imipenem-resistant strain of <i>P. aeruginosa</i>, a representative of world epidemic clone ST235, and a wildtype control strain, <i>P. aeruginosa</i> ATCC 27853, in response to varying concentrations of imipenem. Using label-free quantification (LFQ) and gene ontology (GO) enrichment analyses, we identified significant differences in the proteomic responses between the two strains. The clinical strain exhibited a stable proteomic profile across the imipenem gradient, suggesting pre-established and efficient resistance mechanisms that do not require extensive reconfiguration under antibiotic pressure. In contrast, the control strain showed a broader, more reactive proteomic response, particularly in proteins associated with membrane transport, stress response, and biofilm formation. Notably, uncharacterized proteins were significantly upregulated in the clinical strain, indicating potential novel resistance mechanisms. These findings highlight the distinct strategies employed by the two strains, with the clinical strain's stable resistance mechanisms contrasting sharply with the control strain's reactive approach. The study underscores the importance of further research into the uncharacterized proteins that may play crucial roles in antibiotic resistance, potentially leading to new therapeutic targets in the fight against AMR."],"pubmed_title":["Proteomic landscape of imipenem resistance in &lt;i&gt;Pseudomonas aeruginosa&lt;/i&gt;: a comparative investigation between clinical and control strains."],"pubmed_authors":["Eidsaa Marius M, Sharma Animesh A, Janasch Markus M, Kuch Alicja A, Skoczyńska Anna A, Di Bartolomeo Francesca F"],"additional_accession":[]},"is_claimable":false,"name":"Unravelling the Proteomic Landscape of Imipenem Resistance in Pseudomonas aeruginosa: A Comparative Investigation between Clinical and Control Strains","description":"The proteomic landscape of Pseudomonas aeruginosa under the influence of Imipenem, a commonly used antibiotic, has been the subject of investigation in this study. Our comparative analysis between the world epidemic clinical strain (6378/09) and the control strain (ATCC 27853)has revealed results highlighting the proteomic changes that occur in response to varying Imipenem concentrations. Utilizing label-free quantification (LFQ) intensity scores, protein-level t-tests, and Gene Ontology (GO) enrichment analysis, we have been able to delve deeper into the molecular mechanisms that underpin Imipenem resistance.","dates":{"publication":"2026-04-13","submission":"2024-09-09"},"accession":"PXD055744","cross_references":{"TAXONOMY":["NEWT:3555","NEWT:71647","NEWT:330879","NEWT:35554","NCBITaxon:12939","NEWT:32046","NEWT:544496","NEWT:2042546","NEWT:32049","NEWT:1392696","NEWT:259447","NEWT:295546","NEWT:45351","NEWT:445974","NEWT:43179","NEWT:180454","NEWT:5722","NCBITaxon:1280","NEWT:1129","NEWT:309807","NEWT:10245","NEWT:55153","NEWT:309800","NEWT:281395","NEWT:1211601","NEWT:876138","NEWT:44271","NEWT:193516","NEWT:351581","NEWT:43186","NEWT:428146","NEWT:498257","NEWT:10036","NEWT:1590","NEWT:498019","NEWT:1351","NEWT:1438992","NEWT:1352","NEWT:2649997","NEWT:1147161","NEWT:661410","NEWT:638632","NEWT:263737","NEWT:224326","NEWT:1333499","NCBITaxon:79857","NEWT:1096976","NEWT:5702","NEWT:95648","NEWT:1589","NEWT:135622","NEWT:1349","NEWT:35786","NEWT:1580","NEWT:399784","NEWT:96731","NEWT:383379","NEWT:1401257","NEWT:418106","NEWT:10029","NEWT:913645","NEWT:44491","NEWT:641809","NEWT:27933","NEWT:556484","NEWT:317447","NEWT:4688","NEWT:7955","NEWT:7719","NEWT:7959","NEWT:2261","NEWT:868565","NEWT:31156","NEWT:3112","NEWT:79329","NEWT:4442","NEWT:192875","NEWT:12637","NEWT:59729","NEWT:2164133","NEWT:295105","NEWT:108061","NEWT:60711","NEWT:1316931","NEWT:224308","NEWT:3347","NEWT:511145","NEWT:160621","NEWT:212790","NEWT:931281","NEWT:4432","NEWT:5762","NEWT:5763","NEWT:658457","NEWT:1310161","NEWT:77133","NEWT:295358","NEWT:145481","NCBITaxon:79824","NEWT:2246","NEWT:2652724","NEWT:5757","NCBITaxon:4563","NEWT:5755","NEWT:44689","NEWT:44447","NEWT:752555","NEWT:498211","NEWT:5759","NEWT:347256","NEWT:1736231","NEWT:5518","NEWT:398007","NEWT:1527468","NEWT:1392","NEWT:498217","NEWT:498216","NEWT:2242","NEWT:11320","NEWT:286","NEWT:391619","NEWT:246196","NEWT:287","NEWT:246197","NEWT:145458","NEWT:633149","NEWT:1149786","NEWT:10239","NEWT:68895","NEWT:44685","NEWT:161934","NEWT:4897","NEWT:1148","NEWT:5744","NEWT:5508","NEWT:3329","NEWT:5507","NEWT:410661","NEWT:55571","NEWT:35500","NEWT:1140","NCBITaxon:2157","NEWT:1143","NEWT:4896","NEWT:1287689","NEWT:1390","NEWT:11557","NEWT:1094343","NEWT:1462472","NEWT:1336795","NEWT:644042","NEWT:294","NEWT:1773","NEWT:1182590","NEWT:3712","NEWT:82380","NEWT:3711","NEWT:935293","NEWT:375146","NEWT:2065263","NEWT:1772","NEWT:118698","NEWT:1616117","NEWT:263","NEWT:118696","NEWT:52283","NEWT:11988","NEWT:284812","NEWT:8175","NEWT:400667","NEWT:43330","NEWT:1603293","NEWT:408169","NEWT:44664","NEWT:47946","NEWT:3702","NEWT:1245466","NEWT:243277","NEWT:1246791","NEWT:7067","NEWT:118694","NEWT:586722","NEWT:2850","NEWT:118691","NEWT:33548","NEWT:274","NEWT:7070","NCBITaxon:287","NEWT:408172","NEWT:408170","NEWT:96794","NEWT:3708","NEWT:332648","NEWT:44670","NEWT:536231","NEWT:376219","NEWT:219813","NEWT:1510","NEWT:1436733","NEWT:460519","NEWT:1247411","NEWT:1515","NEWT:572307","NEWT:1432138","NEWT:1424507","NEWT:1194599","NEWT:272844","NEWT:333760","NEWT:56636","NEWT:1513458","NEWT:1233681","NCBITaxon:40559","NEWT:506599","NEWT:2853422","NEWT:81077","NEWT:84588","NEWT:1679718","NEWT:480","NEWT:65349","NEWT:67767","NEWT:46835","NEWT:109757","NEWT:582580","NEWT:300852","NEWT:1502","NEWT:128017","NEWT:376686","NEWT:95486","NEWT:508771","NEWT:1883446","NEWT:253","NCBITaxon:2759","NEWT:1233435","NEWT:93061","NEWT:93062","NEWT:34613","NCBITaxon:4932","NEWT:109760","NEWT:943274","NEWT:644223","NEWT:235443","NEWT:108458","NEWT:5936","NEWT:272623","NEWT:272624","NEWT:320637","NEWT:886559","NEWT:55521","NEWT:983964","NEWT:118499","NEWT:11706","NEWT:32644","NEWT:527796","NEWT:1130798","NEWT:55529","NEWT:499175","NEWT:109779","NEWT:3745","NEWT:1715989","NCBITaxon:4751","NEWT:476272","NEWT:3747","NEWT:195051","NEWT:3988","NEWT:1116234","NEWT:1255228","NEWT:649908","NEWT:410289","NEWT:373153","NEWT:3983","NEWT:203696","NEWT:352472","NEWT:1071661","NEWT:1202532","NEWT:360094","NEWT:470","NEWT:41364","NEWT:5911","NEWT:1313","NEWT:1218097","NCBITaxon:50557","NEWT:39251","NEWT:39491","NEWT:212142","NCBITaxon:5811","NEWT:29491","NEWT:101841","NEWT:2014887","NEWT:33952","NEWT:153009","NEWT:261756","NEWT:571256","NEWT:40483","NEWT:63366","NEWT:63367","NEWT:688333","NEWT:215402","NCBITaxon:548681","NEWT:318586","NCBITaxon:5820","NEWT:1547","NEWT:272634","NEWT:198107","NEWT:9031","NEWT:1872122","NEWT:1308","NEWT:7091","NEWT:1034015","NEWT:760568","NEWT:141262","NEWT:108931","NEWT:1055524","NEWT:4087","NEWT:9778","NEWT:306","NEWT:150475","NEWT:303","NEWT:267872","NEWT:97477","NEWT:7111","NEWT:347515","NEWT:172269","NEWT:9534","NEWT:6269","NEWT:5180","NEWT:256737","NEWT:4090","NEWT:4092","NEWT:9541","NEWT:8694","NEWT:4093","NEWT:4096","NEWT:8692","NEWT:2903","NEWT:185579","NEWT:941442","NEWT:536088","NEWT:13076","NEWT:1226408","NEWT:7108","NEWT:40479","NEWT:43989","NEWT:4076","NEWT:142615","NEWT:317","NEWT:1006581","NEWT:885318","NEWT:39488","NEWT:550","NEWT:4081","NEWT:273068","NEWT:554","NEWT:98334","NEWT:451516","NEWT:4084","NEWT:63577","NEWT:36185","NEWT:1225786","NEWT:7574","NEWT:1715256","NEWT:30640","NEWT:575412","NEWT:929793","NEWT:29204","NEWT:28112","NEWT:114155","NEWT:6494","NEWT:6491","NEWT:507601","NEWT:520","NEWT:186441","NEWT:634955","NEWT:643680","NEWT:214092","NCBITaxon:6157","NEWT:6239","NEWT:13095","NEWT:162425","NEWT:216257","NEWT:102169","NEWT:208893","NEWT:9986","NEWT:4054","NEWT:8654","NEWT:8658","NEWT:1268063","NEWT:8657","NEWT:8655","NEWT:5147","NEWT:98351","NEWT:1263854","NEWT:118503","NEWT:2059687","NEWT:160488","NEWT:28104","NEWT:207559","NEWT:407821","NCBITaxon:2","NEWT:85057","NEWT:985076","NEWT:568708","NEWT:1215323","NEWT:986","NEWT:52641","NEWT:7159","NEWT:267671","NEWT:28532","NEWT:353152","NEWT:8496","NEWT:7165","NEWT:1257118","NEWT:27448","NEWT:40674","NEWT:1194669","NEWT:243230","NEWT:443906","NEWT:1080772","NEWT:519","NEWT:8479","NEWT:8485","NEWT:6063","NEWT:49240","NEWT:1328388","NEWT:9557","NEWT:6289","NEWT:377586","NEWT:6287","NEWT:300641","NEWT:727","NEWT:9796","NEWT:9554","NEWT:725","NEWT:7137","NEWT:469008","NEWT:256318","NEWT:9321","NEWT:206411","NCBITaxon:6191","NEWT:596153","NEWT:229533","NEWT:1836","NEWT:214053","NCBITaxon:10298","NEWT:80863","NEWT:90675","NEWT:105231","NEWT:104385","NEWT:74649","NEWT:52638","NEWT:57075","NEWT:206672","NEWT:4097","NEWT:8697","NEWT:8695","NEWT:884204","NEWT:71139","NEWT:9785","NEWT:6279","NEWT:1123869","NEWT:9544","NEWT:9545","NEWT:7370","NEWT:9793","NEWT:83906","NCBITaxon:780","NCBITaxon:1502","NEWT:6282","NEWT:1134506","NEWT:255470","NEWT:27457","NEWT:38783","NEWT:4006","NEWT:6426","NCBITaxon:5476","NEWT:113208","NEWT:33090","NEWT:6669","NEWT:9935","NEWT:89453","NEWT:287889","NEWT:1114301","NEWT:51515","NEWT:588596","NEWT:51511","NEWT:8845","NEWT:92867","NEWT:92866","NEWT:419610","NEWT:5334","NEWT:51750","NEWT:202950","NEWT:382352","NEWT:413071","NCBITaxon:10239","NCBITaxon:714","NEWT:295027","NCBITaxon:11320","NEWT:632957","NEWT:11051","NEWT:9925","NEWT:89462","NCBITaxon:9606","NEWT:452680","NEWT:8839","NEWT:90690","NEWT:1436183","NEWT:4232","NEWT:2758385","NEWT:416348","NEWT:11298","NEWT:171101","NEWT:714","NEWT:5322","NEWT:421932","NEWT:312017","NEWT:196627","NEWT:200308","NEWT:553470","NEWT:200302","NEWT:870435","NEWT:284593","NEWT:100392","NEWT:655819","NEWT:5315","NEWT:9913","NEWT:265872","NEWT:105841","NEWT:337330","NEWT:2666255","NEWT:2285","NEWT:2287","NEWT:999810","NCBITaxon:5693","NEWT:28995","NEWT:1392998","NEWT:380394","NEWT:981087","NEWT:180066","NEWT:226900","NEWT:1266738","NEWT:231490","NEWT:244704","NEWT:7725","NEWT:430615","NEWT:72664","NEWT:174633","NEWT:326423","NEWT:452467","NEWT:198822","NEWT:36111","NEWT:326424","NEWT:1416333","NEWT:35024","NEWT:135461","NEWT:1678078","NEWT:7962","NEWT:749906","NEWT:418985","NEWT:1817808","NEWT:749907","NEWT:145262","NEWT:145263","NEWT:431947","NEWT:69014","NEWT:142809","NEWT:694569","NEWT:27606","NEWT:9739","NEWT:59202","NEWT:9975","NEWT:8643","NEWT:51953","NEWT:502780","NEWT:57267","NEWT:3197","NEWT:860688","NEWT:13443","NEWT:8644","NEWT:36329","NEWT:62615","NEWT:5141","NEWT:46360","NCBITaxon:3044782","NEWT:1333550","NEWT:160235","NEWT:72407","NEWT:8639","NEWT:1928434","NEWT:8637","NEWT:349741","NEWT:1114970","NEWT:409859","NEWT:157295","NEWT:2096","NEWT:509169","NEWT:192222","NEWT:9721","NEWT:137221","NEWT:9963","NEWT:1617910","NEWT:565050","NEWT:409860","NEWT:2785785","NEWT:411901","NEWT:8626","NEWT:105884","NCBITaxon:9615","NEWT:8621","NEWT:58334","NEWT:452659","NEWT:1193501","NEWT:58331","NEWT:6689","NEWT:8624","NEWT:5116","NEWT:8623","NEWT:5597","NEWT:298315","NEWT:8618","NEWT:70448","NEWT:9704","NEWT:698936","NEWT:1009874","NEWT:8855","NEWT:9940","NEWT:3168","NEWT:1247190","NEWT:521001","NEWT:192011","NEWT:1813887","NEWT:118702","NEWT:118700","NEWT:2126719","NEWT:224911","NEWT:118705","NCBITaxon:11552","NEWT:334249","NEWT:6945","NEWT:184922","NEWT:6703","NEWT:2104","NEWT:6943","NEWT:2","NEWT:157546","NEWT:35670","NEWT:870726","NEWT:474186","NEWT:38942","NEWT:1493","NEWT:307972","NEWT:1496","NEWT:2102","NEWT:3674","NEWT:660469","NEWT:1365186","NEWT:38949","NEWT:45474","NEWT:1299114","NEWT:1590841","NEWT:2282334","NEWT:4513","NEWT:1247","NEWT:70667","NEWT:869728","NEWT:5843","NEWT:6938","NCBITaxon:39054","NCBITaxon:10407","NEWT:1736309","NEWT:4751","NEWT:10360","NEWT:47664","NEWT:317548","NEWT:15819","NEWT:3654","NEWT:237561","NEWT:1085956","NEWT:5833","NEWT:3659","NEWT:6928","NEWT:1239","NEWT:36745","NEWT:499229","NEWT:31298","NEWT:400727","NEWT:1204162","NEWT:272563","NEWT:11009","NEWT:82688","NEWT:5823","NEWT:3885","NEWT:3888","NEWT:5821","NEWT:44139","NEWT:649408","NCBITaxon:4895","NCBITaxon:4896","NEWT:315393","NEWT:6915","NEWT:3649","NEWT:101510","NEWT:28903","NEWT:3880","NEWT:272559","NEWT:216816","NEWT:28909","NEWT:515849","NEWT:3641","NEWT:10141","NEWT:466585","NEWT:1000589","NEWT:85963","NEWT:85962","NEWT:42197","NEWT:143361","NCBITaxon:5796","NEWT:12993","NEWT:398580","NEWT:4565","NEWT:1264690","NEWT:515619","NEWT:1299","NEWT:316407","NEWT:34305","NCBITaxon:183674","NEWT:167387","NEWT:84645","NEWT:44586","NEWT:1123294","NEWT:626528","NEWT:139927","NEWT:4558","NEWT:209285","NEWT:5888","NEWT:211586","NEWT:747078","NEWT:1282","NEWT:1283","NEWT:431241","NEWT:4550","NEWT:1000561","NEWT:2133","NEWT:4555","NEWT:294381","NEWT:197","NEWT:1390363","NEWT:35889","NEWT:406072","NEWT:144030","NEWT:288705","NEWT:29176","NEWT:4787","NEWT:3217","NEWT:113549","NEWT:4547","NEWT:3218","NEWT:556182","NEWT:1270","NEWT:374990","NEWT:1432059","NEWT:154293","NEWT:156471","NEWT:4784","NEWT:3694","NEWT:360106","NEWT:156476","NEWT:4543","NEWT:4785","NEWT:210007","NEWT:360104","NEWT:1857017","NEWT:10117","NEWT:10359","NEWT:10116","NEWT:1280","NEWT:10358","NEWT:83333","NEWT:1735272","NEWT:83334","NEWT:83332","NEWT:317513","NEWT:580240","NEWT:294128","NEWT:11676","NEWT:100226","NEWT:718308","NEWT:4530","NEWT:176299","NEWT:54126","NEWT:75058","NEWT:13616","NEWT:296543","NEWT:173","NEWT:316435","NEWT:42157","NEWT:1895","NEWT:1034304","NEWT:105023","NEWT:866628","NEWT:64152","NEWT:4924","NEWT:749200","NEWT:2748","NEWT:8049","NEWT:33892","NEWT:9378","NEWT:990346","NEWT:145953","NEWT:257309","NEWT:100816","NEWT:203124","NEWT:192952","NEWT:230741","NEWT:8296","NEWT:117008","NCBITaxon:1313","NEWT:167748","NEWT:44544","NEWT:529818","NEWT:400540","NEWT:4911","NEWT:645463","NEWT:152480","NEWT:129249","NEWT:1077286","NEWT:943129","NEWT:1221594","NEWT:990119","NEWT:77216","NEWT:1111708","NEWT:227321","NEWT:493760","NEWT:281677","NEWT:106590","NEWT:260710","NEWT:257313","NEWT:3827","NEWT:400772","NEWT:128161","NEWT:930945","NEWT:1162296","NEWT:106592","NEWT:46704","NEWT:482428","NEWT:1187947","NEWT:269796","NEWT:10312","NCBITaxon:1773","NEWT:54571","NEWT:9598","NEWT:8030","NEWT:1423772","NEWT:53232","NEWT:1235987","NEWT:1639","NEWT:188229","NEWT:246437","NEWT:3818","NEWT:4909","NEWT:759272","NEWT:432359","NEWT:1182263","NEWT:943146","NEWT:2711","NEWT:537457","NEWT:479249","NEWT:9103","NEWT:715877","NEWT:862238","NEWT:29159","NEWT:10306","NEWT:9595","NEWT:8022","NEWT:145943","NEWT:595536","NEWT:240906","NEWT:593117","NEWT:89920","NEWT:29158","NEWT:3633","NEWT:3635","NEWT:5811","NEWT:3879","NEWT:180923","NEWT:1328881","NEWT:411483","NEWT:76336","NEWT:3870","NEWT:884019","NEWT:198215","NEWT:411490","NEWT:200298","NEWT:169963","NEWT:587","NEWT:588","NEWT:585","NEWT:343","NEWT:225117","NEWT:746128","NEWT:5801","NEWT:43665","NEWT:212035","NEWT:5802","NCBITaxon:1653394","NEWT:1266464","NEWT:1205","NEWT:367830","NEWT:178616","NEWT:95145","NEWT:375451","NEWT:357","NEWT:9172","NEWT:2770979","NEWT:2010198","NEWT:1277351","NEWT:1594786","NEWT:457428","NEWT:411469","NEWT:84023","NEWT:1679","NEWT:559292","NEWT:569","NEWT:411464","NEWT:411460","NEWT:2762","NEWT:1174673","NEWT:1328426","NEWT:562","NEWT:28035","NEWT:411470","NEWT:2094720","NCBITaxon:2697049","NCBITaxon:138","NEWT:28038","NEWT:1663","NEWT:62141","NEWT:1423","NEWT:4932","NEWT:3603","NEWT:2756","NEWT:2759","NEWT:3848","NEWT:3847","NEWT:38293","NEWT:1428","NEWT:339","NEWT:327159","NEWT:178876","NEWT:1660","NEWT:2751","NEWT:327160","NEWT:573","NEWT:571","NEWT:12922","NEWT:29595","NEWT:1306413","NEWT:241368","NEWT:518766","NEWT:42528","NEWT:2664373","NEWT:190802","NEWT:9417","NEWT:1216979","NEWT:7237","NEWT:264483","NEWT:509924","NEWT:28450","NEWT:115104","NEWT:1121114","NEWT:663","NEWT:8570","NEWT:1081927","NEWT:1238993","NEWT:67825","NEWT:187878","NEWT:220668","NEWT:1821314","NEWT:1249668","NEWT:426430","NEWT:9407","NEWT:9646","NEWT:5286","NEWT:7227","NEWT:7469","NEWT:9402","NEWT:9644","NEWT:415540","NEWT:675060","NEWT:334542","NEWT:313625","NEWT:27592","NEWT:426428","NEWT:227289","NEWT:63459","NEWT:40324","NEWT:588858","NEWT:9638","NEWT:9639","NCBITaxon:11071","NEWT:242231","NEWT:197221","NEWT:7215","NEWT:2172103","NCBITaxon:59201","NEWT:7460","NEWT:504457","NEWT:434271","NEWT:747679","NEWT:66712","NEWT:42752","NEWT:103372","NEWT:746360","NEWT:862751","NEWT:89764","NEWT:470150","NEWT:9627","NEWT:543734","NEWT:1009714","NEWT:73239","NEWT:38018","NEWT:226186","NEWT:9870","NEWT:8782","NEWT:115357","NEWT:435590","NEWT:1902","NEWT:1908","NEWT:1169740","NEWT:13164","NEWT:216129","NEWT:2664179","NEWT:623","NEWT:7038","NEWT:6192","NCBITaxon:1639","NCBITaxon:38727","NEWT:74790","NEWT:2829","NEWT:366581","NEWT:216599","NEWT:405534","NEWT:216595","NEWT:40559","NEWT:51208","NEWT:216597","NEWT:9689","NEWT:8355","NEWT:633","NEWT:1607839","NEWT:9685","NEWT:7029","NEWT:6182","NEWT:1283300","NEWT:9694","NEWT:186990","NEWT:632","NEWT:1204551","NEWT:6183","NEWT:99586","NEWT:630","NCBITaxon:11019","NEWT:334747","NEWT:61235","NEWT:392021","NEWT:343691","NEWT:1457551","NEWT:15368","NEWT:1491466","NEWT:436486","NEWT:340188","NEWT:51655","NEWT:170187","NEWT:260707","NEWT:121845","NEWT:8595","NEWT:7263","NEWT:186763","NEWT:185431","NEWT:216591","NEWT:29760","NEWT:260704","NEWT:1719","NEWT:703612","NEWT:260705","NEWT:692672","NEWT:2697049","NEWT:1505907","NEWT:1216981","NEWT:1109443","NEWT:1249885","NEWT:7004","NEWT:9669","NCBITaxon:6073","NEWT:1089448","NEWT:1415167","NEWT:1329349","NEWT:607699","NEWT:208963","NEWT:208964","NEWT:27337","NEWT:575584","NEWT:185687","NEWT:3039","NEWT:669202","NEWT:2706014","NEWT:8727","NEWT:8726","NEWT:10090","NEWT:8729","NEWT:4120","NEWT:8720","NEWT:5693","NEWT:2186","NEWT:8724","NEWT:8723","NEWT:283166","NEWT:37334","NEWT:5697","NEWT:6544","NCBITaxon:10357","NCBITaxon:10114","NCBITaxon:10359","NEWT:1685931","NEWT:1203258","NEWT:242619","NEWT:49317","NEWT:557722","NEWT:160791","NEWT:1353008","NEWT:34073","NEWT:696811","NEWT:402042","NEWT:373995","NEWT:8715","NEWT:5689","NEWT:839","NEWT:544404","NEWT:92519","NEWT:2173","NEWT:943925","NEWT:37349","NEWT:4113","NEWT:837","NEWT:640459","NEWT:36015","NEWT:1232801","NEWT:81866","NEWT:5691","NEWT:48479","NEWT:61435","NEWT:627025","NEWT:1097677","NEWT:375939","NEWT:61674","NEWT:2072580","NEWT:669465","NEWT:1117957","NEWT:6526","NEWT:8709","NEWT:4100","NEWT:1159556","NEWT:5671","NEWT:1076","NEWT:4102","NEWT:4101","NEWT:6763","NEWT:8700","NEWT:803","NEWT:29722","NEWT:1692259","NEWT:1486917","NEWT:468911","NEWT:13373","NEWT:7604","NEWT:818","NEWT:135588","NEWT:1843183","NEWT:5661","NEWT:157592","NEWT:51866","NEWT:29719","NEWT:58002","NEWT:5665","NEWT:6754","NEWT:1179777","NEWT:6997","NEWT:452589","NEWT:509068","NEWT:5666","NEWT:4577","NEWT:813","NEWT:5664","NEWT:2157","NEWT:146479","NEWT:1042986","NEWT:1911079","NEWT:69373","NEWT:1843192","NEWT:206189","NEWT:427577","NEWT:264203","NEWT:1480154","NEWT:1274414","NEWT:9612","NEWT:38626","NEWT:1286640","NEWT:38865","NEWT:3077","NEWT:9615","NEWT:10299","NEWT:6100","NEWT:713604","NEWT:112273","NEWT:1147787","NEWT:1440772","NEWT:1355477","NEWT:8759","NEWT:9605","NEWT:9606","NEWT:90371","NEWT:641501","NEWT:4153","NEWT:9601","NEWT:278839","NEWT:35128","NEWT:39966","NEWT:7668","NEWT:8756","NEWT:915099","NEWT:74940","NEWT:13551","NEWT:10041","NEWT:9600","NEWT:1450511","NEWT:1143193","NEWT:1122233","NEWT:890382","NEWT:174934","NEWT:179392","NEWT:2823525","NEWT:115778","NEWT:9838","NEWT:9839","NEWT:546414","NEWT:227086","NEWT:3055","NEWT:11167","NEWT:9835","NEWT:7650","NEWT:4146","NEWT:5478","NEWT:6326","NEWT:7656","NEWT:5476","NEWT:1450520","NEWT:1042311","NEWT:1123352","NEWT:1882945","NEWT:746707","NEWT:299767","NEWT:235909","NEWT:28835","NEWT:47311","NEWT:1274432","NEWT:2053667","NEWT:1274426","NEWT:104660","NEWT:9825","NEWT:1274423","NEWT:393765","NEWT:652611","NEWT:39946","NEWT:9823","NEWT:95602","NEWT:8732","NEWT:39947","NEWT:1274420","NEWT:578458","NEWT:60520"],"pubmed":["41181332"],"ORCID":["0000-0002-8791-4635"]}}