{"database":"Pride","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Raw":["ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/10/PXD055872/HC-I2.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/10/PXD055872/SI2.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/10/PXD055872/HC-U1.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/10/PXD055872/SUN2.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/10/PXD055872/HC-U3.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/10/PXD055872/HC-I1.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/10/PXD055872/SI1.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/10/PXD055872/HC-I3.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/10/PXD055872/HC-U2.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/10/PXD055872/SUN1.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/10/PXD055872/SI3.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/10/PXD055872/SUN3.raw"],"Other":["ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/10/PXD055872/2D_ABDUL_HASAN_ICGEB_ANALYSIS_201021.pdResult","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/10/PXD055872/3D_ABDUL_HASAN_ICGEB_ANALYSIS_13052022.pdResult"]},"type":"primary"},"statusCodeValue":200,"statusCode":"OK"}],"scores":null,"additional":{"labhead_mail":["sujatha@icgeb.res.in"],"submitter":["Sujatha Sunil"],"technology_type":["Mass Spectrometry","Bottom-up proteomics"],"software":[""],"submitter_keywords":["2-dimension (2d) monolayer","Proteomics","Chondrocytes","3-dimension (3d) spheroid cell culture","Chikungunya virus (chikv)"],"full_dataset_link":["https://www.ebi.ac.uk/pride/archive/projects/PXD055872"],"sample_protocol":["25 ug of protein sample was used for digestion and reduced with 5 mM TCEP and further alkylated with 50 mM iodoacetamide and then digested with Trypsin (1:50, Trypsin/lysate ratio) for 16 h at 37 °C. Digests were cleaned using a C18 silica cartridge to remove the salt and dried using a speed vac. The dried pellet was resuspended in buffer A (2% acetonitrile, 0.1% formic acid)."],"repository":["Pride"],"quantification_method":[""],"modification":[""],"data_protocol":["All samples were processed and RAW files generated were analyzed with Proteome Discoverer (v2.4) against the Uniprot reference database. For Sequest and Amanda search, the precursor and fragment mass tolerances were set at 10 ppm and 0.02 Da, respectively. The protease used to generate peptides, i.e. enzyme specificity was set for trypsin/P (cleavage at the C terminus of “K/R: unless followed by “P”) along with maximum missed cleavages value of two. Carbamidomethyl on cysteine as fixed modification and oxidation of methionine were considered as Variable modifications for database search. Both peptide spectrum match and protein false discovery rate were set to 0.01 FDR. Identified proteins were also listed in separate tab labelled with Sample name in result excel sheet."],"omics_type":["Proteomics"],"labhead":["Dr. Sujatha Sunil"],"instrument_platform":[""],"labhead_affiliation":["Group Leader, Vector Borne Diseases Group, ICGEB, New Delhi, India"],"submission_type":["PARTIAL"],"species":["Homo Sapiens (human)"],"publication":["41018649 Hasan A, Sharma G, Majumder N, Chaudhary S, Mehta D, Vaishya R, Ghosh S, Sunil S. Global Proteome Analysis of a Three-Dimensional Human Chondrocyte Cell Culture System Infected with Chikungunya Virus (CHIKV) Reveals Distinct Immune and Inflammatory Signatures. ACS Omega. 2025 10(37):42480-42493 10.1021/acsomega.5c02832"],"submitter_mail":["sujatha@icgeb.res.in"],"submitter_affiliation":["International Centre for Genetic Engineering and Biotechnology"],"submitter_country":["India"],"pubmed_abstract":["Chikungunya disease (CHIKD) presents as an acute viral fever with severe joint pain, which may progress into a chronic arthritic condition that can last for months or even years. The cell tropism of chikungunya virus (CHIKV) infection is well studied; however, the mechanisms underlying the pathogenesis of chronicity, especially in the joints, remain poorly understood. Primary chondrocytes were isolated from human joint samples, characterized and grown both as monolayers and as 3D spheroids. These cultures were infected with chikungunya virus (CHIKV) at different multiplicity of infections(MOIs), and a temporal analysis of infection in these distinct types of culture systems was conducted. Further, the global proteome was obtained from these two kinds of culture systems upon infection, and the proteomes were analyzed in detail to understand the impact of CHIKV on these culture systems. Chondrocytes grown as 3D spheroids were able to sustain CHIKV for extended periods of time, i.e., as long as 168 h, without compromising cellular integrity. Proteomic analysis revealed distinct protein regulation patterns during CHIKV infection, with the changes in 3D spheroids closely resembling those in the natural joint tissue microenvironment. Our study has, for the first time, presented a bird's-eye view of the global proteome changes in human chondrocytes in response to CHIKV infection and further established the usefulness of the 3D chondrocyte culture system in understanding CHIKV infection."],"pubmed_title":["Global Proteome Analysis of a Three-Dimensional Human Chondrocyte Cell Culture System Infected with Chikungunya Virus (CHIKV) Reveals Distinct Immune and Inflammatory Signatures."],"pubmed_authors":["Hasan Abdul A, Sharma Geetika G, Majumder Nilotpal N, Chaudhary Sakshi S, Mehta Divya D, Vaishya Raju R, Ghosh Sourabh S, Sunil Sujatha S"],"additional_accession":[]},"is_claimable":false,"name":"Global proteome characterization of a three-dimensional human chondrocyte cell culture system during chikungunya virus (CHIKV) infection reveals distinct immune and inflammatory signatures","description":"Chikungunya virus (CHIKV) belongs to alphavirus infections which often tend to deliberate musculoskeletal disorders affecting joints, muscles, and bones. Primary cells isolated from patients undergoing total knee replacement were utilized to perceive the effect of virus infection on it, upon isolation and characterization. A well-characterized set of cells was utilized to set the model system in a 2D monolayer and a 3D spheroidal model which was used to evaluate the infection profile of primary chondrocyte cells to CHIKV, the model systems were infected at different multiplicity of infection (MOI) of 0.1, 1 over number of days. Viral titers were determined by plaque assay. We further obtained the global proteome of the infected chondrocytes in its 2D and 3D architecture and analysed various pathways and perturbed proteins in two model systems. Gene expression studies were conducted using total RNA of isolated from cells to study the articular genes upon infection. Our study demonstrates that human chondrocyte cells are permissive to CHIKV infection which is evaluated in both 2D model system and 3D model systems, a comparative study of the proteomes of the chondrocytes was obtained from both 2D and 3D cultures in which distinct protein signatures attributing to cell architecture and immune system were 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