{"database":"Pride","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Xlsx":["ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD059345/M_2_protein_view.xlsx","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD059345/M_1_modification_site.xlsx","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD059345/M_1_peptide_view.xlsx","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD059345/M_2_modification_site.xlsx","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD059345/2E_peptide_view.xlsx","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD059345/2E_protein_view.xlsx","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD059345/M_1_protein_view.xlsx","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD059345/2E_modificaition_site.xlsx","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD059345/M_2_peptide_view.xlsx"],"Txt":["ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD059345/checksum.txt"],"Raw":["ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD059345/M_2.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD059345/M_1.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD059345/2E.raw"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"labhead_mail":["yankg@sustech.edu.cn"],"submitter":["Ruifang Ma"],"technology_type":["Data-dependent acquisition","Mass Spectrometry"],"software":[""],"submitter_keywords":["Phosphorylation sites，phk"],"full_dataset_link":["https://www.ebi.ac.uk/pride/archive/projects/PXD059345"],"tissue":["Cell Suspension Culture"],"sample_protocol":["Phosphorylated PhK proteins were first reduced and alkylated, and then digested with trypsin (Promega) in solution. The peptides were loaded to an analytical column (100 μm i.d ×20 cm) packed with 1.9 μm and 120 Å ReproSil-Pur C18 resins (Dr. Maisch GmbH, Ammerbuch, Germany). Mobile phase A consisted of 0.1% formic acid (FA) in water, and mobile phase B consisted of 0.1% FA in acetonitrile (ACN). Gradients were run from 7% to 22% mobile phase B for 50 min followed by 22%-35% mobile phase B for 10 min. The full mass scan was acquired from m/z 350 to 1550 with resolution 120,000 at a target of 2e5 ions, and the MS/MS spectra were obtained in a data dependent acquisition in the top speed mode with higher-energy collision dissociation (target 5e4 ions, max ion injection time 40 ms, isolation window 1.6 m/z, normalized collision energy 30%). The dynamic exclusion time was set to 30 s. Precursor ions with unassigned charge state as well as charge state of 1+ or superior to 6+ were excluded from fragmentation."],"repository":["Pride"],"quantification_method":["Not available"],"modification":[""],"data_protocol":["The LC-MS/MS data were subsequently analyzed by searching against the UniProt-Homo sapiens database utilizing Proteome Discoverer 2.4.1.15 (Thermo). The search parameters were set with a mass tolerance of 10 ppm for the first-order mass spectrum and 0.02 Da for the second-order mass spectrum. During the enzymatic digestion process, a maximum of 2 missed cleavages were permitted, and the peptide lengths ranged from 4 to 144 amino acids. The carbamidomethylation of cysteine (C) was considered as a fixed modification, while the variable modifications encompassed oxidation of methionine (M), phosphorylation of serine, threonine, or tyrosine (S/T/Y), and farnesylation on the C-terminal cysteine (C). The experiment was repeated three times, and the phosphorylation sites that were present in all three trials were selected for subsequent analysis."],"omics_type":["Proteomics"],"labhead":["Kaige Yan"],"instrument_platform":[""],"labhead_affiliation":["School of Life Sciences, Southern University of Science and Technology, Shenzhen 518055, Guangdong, China"],"submission_type":["PARTIAL"],"species":["Homo Sapiens (human)"],"publication":["40148320 Ma R, Du B, Shi C, Wang L, Zeng F, Han J, Guan H, Wang Y, Yan K. Molecular basis for the regulation of human phosphorylase kinase by phosphorylation and Ca&lt;sup&gt;2&lt;/sup&gt;. Nat Commun. 2025 16(1):3020 10.1038/s41467-025-58363-8"],"submitter_mail":["marf@sustech.edu.cn"],"submitter_affiliation":["Southern University of Science and Technology"],"submitter_country":["China"],"pubmed_abstract":["Phosphorylase kinase (PhK) regulates the degradation of glycogen by integrating diverse signals, providing energy to the organism. Dysfunctional mutations may directly lead to Glycogen Storage Disease type IX (GSD IX), whereas the abnormal expression of PhK is also associated with tumors. Here, we use cryo-electron microscopy (cryo-EM) to resolve its near-atomic structures in the inactive and active states. These structures reveal the interactions and relative locations of the four subunits (αβγδ) within the PhK complex. Phosphorylated α and β subunits induce PhK to present a more compact state, while Ca<sup>2+</sup> causes sliding of the δ subunit along the helix of the γ subunit. Both actions synergistically activate PhK by enabling the de-inhibition of the γ subunit. We also identified different binding modes between PhK and its substrate, glycogen phosphorylase (GP), in two distinct states, using cross-linking mass spectrometry (XL-MS). This study provides valuable insights into the regulatory mechanisms of PhK, thereby enhancing our understanding of GSD IX and its implications in tumorigenesis."],"pubmed_title":["Molecular basis for the regulation of human phosphorylase kinase by phosphorylation and Ca&lt;sup&gt;2&lt;/sup&gt;."],"pubmed_authors":["Ma Ruifang R, Du Bowen B, Shi Chen C, Wang Lei L, Zeng Fuxing F, Han Jie J, Guan Huiyi H, Wang Yong Y, Yan Kaige K"],"pubmed_title_synonyms":["Regulations, Phosphorylase b, human being, Man (Taxonomy), Formal Social Control, FON1, Modern, ATP:phosphorylase-b phosphotransferase, Phosphorylase Kinase, Bdr, Control, Phosphorylations, SUPERMAN, FLO10, FLORAL DEFECTIVE 10., Synaptosomal-associated 25 kDa protein, Controls, Super protein, FLORAL ORGAN NUMBER 1, HERP, man, Glycogen Phosphorylase Kinase, human, phosphorylation, sp, Social Controls, SNAP-25, Social, Human, Mif1, Glycogen, Homo sapiens, Social Control, SNAP, Modern Man, Phosphorylase, SUP, b Kinase, GENA70, regulation, phosphorylation enrichment, Phosphorylase b Kinase, Kinase, Glycogen Phosphorylase, Regulation, Formal Social Controls, Man, FLORAL DEFECTIVE 10"],"data_synonyms":["liquid chromatography tandem mass spectroscopy, IPP2A2, para Tyrosine, human being, Cysteine Hydrochloride, E 920, 2-amino-4-(methylsulfanyl)butanoic acid, determination, Aminosaeure, Aminocarbonsaeure, L-Zystein, L Isomer, FBN, Amino acid, L-Threonine, alpha-amino acid, phosphorylation, PHAPII, LC-MS-MS, Human, protrusion, 2-Amino-3-hydroxypropionic acid, 5730420M11Rik, peptide, Polypeptides, L-Isomer Methionine, Methionine, peptido, Homo sapiens, ECTOL1, LC-MSMS, L-Methionine, 2-amino-3-mercaptopropanoic acid, Cystein, Half-Cystine, Man, WMS, Pedameth, Threonin, farnesylation, SET, C, LCMSMS, amino acids, Man (Taxonomy), peptides, TAF-I, cisteina, L Cysteine, M, E-920, 2-amino-3-(4-hydroxyphenyl)propanoic acid, 3-(p-Hydroxyphenyl)alanine, ipp2a2, chemical analysis., 2pp2a, Hcys, L Threonine, Y, man, CG10574, DmelCG4299, OCTD, IGAAD, set, 2PP2A, 2-amino-4-(methylthio)butanoic acid, 10^[-6], 2-amino-3-hydroxypropanoic acid, DmelCG10574, CYSTEINE, L Tyrosine, taf-ibeta, ppm, Tyr, dSET, dSet, FREE CYSTEINE, s, peptidos, Half Cystine, Tyrosin, (2R)-2-amino-3-mercaptopropanoic acid, GPHYSD2, metionina, Racemethionine, SGS, LC-MS2, phapii, data, Farnesylation, anatomical protrusion, Zinc Cysteinate, DL-Methionine, Geranylgeranylation, Aminokarbonsaeure, Modern, LC-MS/MS, igaad, 2-Amino-4-(methylthio)butyric acid, 2-Amino-3-(p-hydroxyphenyl)propionic acid, Phosphorylations, StF-IT-1, alpha-amino acids, para-Tyrosine, L-Isomer, Cys, Peptide, alpha-amino carboxylic acids, group, ACMICD, Tyrosine, polypeptide, Serin, LC/MS/MS, Experiment, 3-Hydroxyalanine, I-2PP2A, tirosina, Dm I-2, I2PP2A, MFS1, Methionin, phosphorylation enrichment, Hmet, (2R)-2-amino-3-sulfanylpropanoic acid, Zystein, Data Base, WMS2, Met, Amino Acid, Acid, HLA-DR-associated protein II, Amino acids, ensemble, DI-2, 2-amino-3-sulfanylpropanoic acid, I-2Dm, L-isomer, L-2-Amino-3-mercaptopropionic acid, L-Cysteine, (R)-2-amino-3-mercaptopropanoic acid, CG4299, MASS, Amino, human, 2-Amino-3-mercaptopropionic acid, L-Cystein, L isomer, I-2PP1, dSET/TAF-Ibeta, 2610030F17Rik, TAF-IBETA, spine, liquid chromatography-tandem mass spectroscopy, Modern Man, SSKS, alpha-amino-gamma-methylmercaptobutyric acid, liquid chromatography tandem mass spectrometry, E920, Peptid, L Serine, TAF-Ibeta, Acids, L-Tyrosine, Polypeptide, assay, AA407739, L-Serine, i2pp2a, Liquimeth, Isoprenylation"],"pubmed_abstract_synonyms":["biochemical pathways, single-organism catabolic process, multicellular organismal catabolic process, Cryomicroscopies, Cognitive Function, atypia, Tumorigeneses, multi-cellular organism, STK17, FON1, Neoplasms, GSD9A, PYKL, Benign Neoplasm, phosphorylase B kinase activity, Pb, dephosphophosphorylase kinase activity, SUPERMAN, Spectrum Analyses, Gsdix, Tumor, FLORAL ORGAN NUMBER 1, Malignant, cellular catabolism, Cryo-electron Microscopy, Mutations, Tumorigenesis., Readability, utilization, SUP, Mass, pathogenesis, cellular degradation, 4, Kinase, atypical, Analysis, 3/[a2122h-1a_1-5]/1-1-1-1/a4-b1_b4-c1_b6-d1, animal, phosphorylase kinase, Glycogenosis due to phosphorylase kinase deficiency, GSD type IX, Glycogenosis type IX, Gsd Ix, Mass Spectroscopy, phosphorylase kinase (phosphorylating) activity, Mass Spectrum Analysis, study, Phosphorylase Kinase Deficiency, Malignancy, Analyses, breakdown of chemical, catabolism, ligand, Bdr, PHK, Phk, animal starch, WURCS=2.0/1, Oncogeneses, Glycogen storage disease due to PhK deficiency, causes, Super protein, sp, SNAP-25, Cognitive Functions, Neoplasias, PYK, Glycogen storage disease type IX, Mif1, Glycogen, Cognitions, Functions, glycogen, lead, causality, biotransformation, Malignancies, Cryoelectron, Phosphorylase b Kinase, species, Glycogen storage disease type 9, Cancer, Tumors, cellular breakdown, use, plomo, Malignant Neoplasm, D330034O08, Glycogenosis type 9, Microscopies, Cryo electron Microscopy, degradation, aberrant, body, statistics and numerical data, Blei, Cryo-electron, whole body, plomb, XLG2, 82Pb, defective, Synaptosomal-associated 25 kDa protein, Phosphorylase B Kinase Deficiency, Insight, Spectrum Analysis, Spectroscopy, Insights, organism, GSD due to phosphorylase kinase deficiency, MS, Benign, 6330505C01Rik, Cryomicroscopy, Gycogenosis due to PhK deficiency, Electron Cryomicroscopy, b Kinase, Neoplasm, numerical data, GENA70, secretion, glycogen phosphorylase kinase activity, Cryoelectron Microscopies, Glycogen Phosphorylase, intrinsic catalyst activity, Phk Deficiency, Mass Spectrum Analyses, breakdown of molecule, Mass Spectrum, Phosphorylase b, breakdown, whole organism, biodegradation, Electron Cryomicroscopies, plumbum, ATP:phosphorylase-b phosphotransferase, Phosphorylase Kinase, Phosphorylase ab, Function, Carcinogeneses, XLG, Spectrometry, Benign Neoplasms, FLO10, Cancers, Electron, Understanding, HERP, Cognitive, Glycogen Phosphorylase Kinase, Malignant Neoplasms, breakdown of substance, liver starch, ATP:phosphorylase-b phosphotransferase activity, Oncogenesis, SNAP, Phosphorylase, Koerper, GSD type 9, Microscopy, Cryo-electron Microscopies, Neoplasia, FLORAL DEFECTIVE 10"],"name_synonyms":["human being, Man (Taxonomy), STK17, D330034O08, Modern, GSD9A, PYKL, Phosphorylations, phosphorylase B kinase activity, PHK, XLG, Phk, dephosphophosphorylase kinase activity, XLG2, man, phosphorylation, human, Human, PYK, ATP:phosphorylase-b phosphotransferase activity, Homo sapiens, 6330505C01Rik, Modern Man, phosphorylation enrichment, glycogen phosphorylase kinase activity, phosphorylase kinase (phosphorylating) activity., intrinsic catalyst activity, phosphorylase kinase, Man"],"description_synonyms":["glycogen synthase kinase activity, Cryomicroscopies, Cognitive Function, 6353, Dmel_CG3263, protein kinase A activity, Activity, Tandem, GSD9A, phosphorylase B kinase activity, dephosphophosphorylase kinase activity, Mass Spectrometry Mass Spectrometry, phosphorylation, CG18677, CG12452, Prp4 protein kinase activity, ATP-protein transphosphorylase activity, cAMP-dependent protein kinase, ATP:protein phosphotransferase (non-specific) activity, Dpck, mitogen-activated protein kinase activity, establishment and maintenance of substrate location, RI, phosphorylase kinase (phosphorylating) activity, treatment, C, Man (Taxonomy), CALCIUM ION, CG4379, Pk72A, 3', 5' cAMP-dependent protein kinase complex, Mass Spectrometry, CG15862, Raf kinase activity, serine kinase activity, Cognitions, DmelCG6117, 5' cAMP-dependent protein kinase activity, atypical protein kinase C activity, Functions, disease management, Therapies, mitogen-activated S6 kinase activity, protein-aspartyl kinase activity, Cryoelectron, p82 kinase activity, Therapy, establishment and maintenance of substance location, D330034O08, Modern, betaIIPKC, cyclic AMP-dependent protein kinase complex, Cryo-electron, CG42341, XLG2, Insight, pka-C1, doubly charged positive ion, M phase-specific cdc2 kinase activity, Wee-kinase activity, single organism localization, pka-R1, Cryomicroscopy, MAPK, 5'-cAMP-dependent protein kinase complex, Electron Cryomicroscopy, Cos-1, RII[[DR]], glycogen phosphorylase kinase activity, Cryoelectron Microscopies, pka-c1, serine protein kinase activity, activation, 5-23, PKA C, phosphorylase B kinase kinase activity, protein glutamyl kinase activity, MS/MS, CG6117, non-specific serine/threonine protein kinase activity, Dmel_CG12452, pka-RII, Electron, Ca(2+), Treatments, human, calcium, hydroxyalkyl-protein kinase activity, WEE1Hu, DmelCG4379, ATP:protein phosphotransferase (cAMP-dependent) activity, PKA RII, serine-specific protein kinase activity, dPKA, epsilon PKC, PkaC1, PKAcA, HIPK2, cytidine 3', RII, Microscopy, Epa, Wee 1-like kinase activity, Dcpk, adenosine 3', PKAC1, establishment and maintenance of cellular component location, ribosomal S6 protein kinase activity, calcium/phospholipid-dependent protein kinase activity, human being, STK17, glycogen synthase A kinase activity, PYKL, glycogen synthase kinase 3 activity, Pk?5, PKA-C3, PKA-C-3, PKA-C1, BcDNA:GM01761, phosphorylase b kinase kinase activity, Cryo-electron Microscopy, Human, Ca2+, Homo sapiens, Pka-RI, l(2)cos[[1]], establishment and maintenance of position, serine(threonine) protein kinase activity, BG02142, AMPK, ribosomal protein S6 kinase II activity, phosphorylase kinase, Man, 18304, T-antigen kinase activity, galactosyltransferase-associated kinase activity, protein-serine kinase activity, Pka-C, PKAR, PkaR, MS2, STK32, PHK, Phk, PKa-R2, PKa-R1, PKAc, man, Cognitive Functions, PYK, protein kinase (phosphorylating) activity, PKA-R1, DmelCG15862, 5'-cyclophosphate-dependent protein kinase activity, PKA-R2, Cos, CdkA, protein-cysteine kinase activity, Raf-1, Hpr kinase activity, Dc0, STK22, casein kinase (phosphorylating) activity, DRI, PKA-RI, PKA Cl, Microscopies, Cryo electron Microscopy, Cos1, 5'-cyclophosphate-dependent protein kinase complex, l(2)s4402, DC0, Phosphorylations, DC2, dPKA-RI, CG3263, CdkR, protein serine kinase activity, protein phosphokinase activity, Insights, cos1, twitchin kinase activity, PKAi, cyclic AMP-dependent protein kinase activity, pkA, PKA, Pka, PKAr, PKC, 6330505C01Rik, AP50 kinase activity, dcO, DCO, Dco, phosphorylation enrichment, establishment and maintenance of localization, intrinsic catalyst activity, protein kinase p58 activity, tandem MS, Pka-RII, serine/threonine protein kinase activity, threonine-specific protein kinase activity, pka, pka C1, pKA, dr[[1]], PKA C3, Electron Cryomicroscopies, Function, dco, XLG, Mass Spectrometry-Mass Spectrometry, single-organism localization, 5'-cAMP-dependent protein kinase activity, Cognitive, dsk1, PKA-RII, 5'-cyclic monophosphate-responsive protein kinase activity, atypical PKC activity, DmelCG42341, PKA CI, ATP:phosphorylase-b phosphotransferase activity, localisation, Therapeutic, Modern Man, l(2)01272, Treatment, phosphorylase kinase (phosphorylating) activity., Cryo-electron Microscopies, General activity, protein serine-threonine kinase activity, A-kinase activity"],"sample_synonyms":["sodium salt, Water, l(2)06475, IPP2A2, ammonium formate, 13C-labeled, cadmium salt, MeCN, Disorders, l(2)00255, Meth, dmMOF, NCMe, ion, Dissociative Reactions, GSD9A, leg, H(2)O, phosphorylase B kinase activity, zinc formate, dephosphophosphorylase kinase activity, lead salt, BOUND WATER, magnesium formate, DmelCG42281, oxidane, zinc salt, vinyl polysiloxane polymer, Long Term, WATER, HOH, l(1)AA33, Hysteria, DmelCG9648, 5730420M11Rik, Polypeptides, ammonium tetraformate, peptido, BANF, cobalt(II) formate dihydrate, CH3-C#N, dMOF, B1, 1, Tsc22, 2, Min, Effect, DmelCG42273, phosphorylase kinase (phosphorylating) activity, 3-hydroxy-5-estrane-17-carbonitrile, SET, MACH 2 dental impression material, C79325, peptides, TAF-I, dMax, 2610036I19Rik, 2610510L13Rik, hypoplasia, min, mAPC, proteins, purification, l(2)02687, copper, Bun, AI047805, DmelCG4299, isolation and purification, IGAAD, set, fSAP152, lithium salt, column, affinis, l(1)B2/13.1, DmelCG10574, RUN, Run, Ice, ACN, Reaction, D1, Acn, dihydridooxygen, dihydrogen oxide, z, ammonium (2:1) salt, Long-Term Effects, nickel salt, phapii, l(1)LB9, D330034O08, cobalt (+2) salt, vinyl siloxane, aqua, Dmel_CG7826, CG9648, Longterm Effect, StF-IT-1, Th, XLG2, not genetically inherited, AA33, bHLHd7, bHLHd6, bHLHd9, bHLHd8, H2O, sodium (4:1:1) salt, bHLHd5, bHLHd4, magnesium salt, Dm1, Ionen, polyvinyl siloxane, dmax, glycogen phosphorylase kinase activity, Dm_2L:60722, nickel (+2) salt, l(2)k02903, Dmel_CG7835, Hydrogen Oxide, shs, Crystal, Mnb, MNB, parent ion, ammonium salt, HLA-DR-associated protein II, polyvinyl siloxane polymer, DI-2, MS/MS, I-2Dm, formate, cobaltous formate, hydrogen hydroxide, cromium (+3), CG4299, AW124434, beta Trypsin, Dissociation, acqua, I-2PP1, Speed, MOF, Mof, l(2)05479, TAF-IBETA, precursor ion, copper salt, Dmel_CG31857, ammonium (4:1) salt, TAF-Ibeta, z., Polypeptide, Wasser, methyl cyanide, lead (+2) salt, i2pp2a, CG1849, STK17, nickel formate dihydrate, lead formate, Dissociative Reaction, Effects, TSC-22, PYKL, aluminum salt, cesium salt, Z-350, Gene, ACINUS, precursor, polyvinylxiloxane, thomson, Chalk, 17alpha)-isomer, CG7826, PHAPII, agua, formic acid, 4-(3-(4-(1-(4-methylphenyl)-3-(4-(2-methoxyphenyl)piperazine-1-yl)propoxy)benzoyl)indole-1-yl)butyric acid, mass-to-charge ratio, ghenesil, potassium salt, DmelCG3025, reduced, isolation, 14C-labeled, Tina, Gene Products, CG7835, CG42273, tiny, phosphorylase kinase, Pro-Mega, MAX, MACH-2, Glass, Acinus, thallium (+1) salt, Longterm, iones, MS2, Runt, ipp2a2, beta-Trypsin, rubidium salt, PHK, Phk, Dissociative Hysteria, 2pp2a, eau, Long-Term, calcium formate, methanoic acid, BunA, ions, CG10574, Solution, acinusL, PYK, max, 2PP2A, acinusS, taf-ibeta, Disorder, dSET, dSet, peptidos, cromium (+3) salt, Long-Term Effect, sodium formate, PTHB1, LB5, small, DYRK1, data, 5E4, nickel formate, 1-(14)C-labeled, 3H-labeled, Dissociative, Proteins, DmelCG1849, CG3025, igaad, Reprosil, strontium formate, bnc, potassium formate, CG31857, copper (+2) salt, Rnt, strontium salt, acetonitrile, Peptide, mKIAA0670, group, AI875693, lLB5, 1550, CG5461, 6330505C01Rik, I-2PP2A, C18, EP(2)0488, Hysterias, cupric formate, water, Protein, Long Term Effects, Dm I-2, I2PP2A, 5alpha, Dyrk1, intrinsic catalyst activity, aluminum formate, (3alpha, ACETONITRILE, tandem MS, cyanomethane, AU020952, l(2)rI043, MACH-2 dental impression material, Dmel_CG5461, lithium formate, PRSS, Reactions, underdeveloped, ensemble, CC1, XLG, Tripcellim, CG42281, l(1)19Ea, ethanenitrile, chromic formate, Longterm Effects, ME-IV, Protein Gene Products, P235, Gene Proteins, Trypure, dSET/TAF-Ibeta, 2610030F17Rik, ATP:phosphorylase-b phosphotransferase activity, exafine, Ion, Dissociative Disorder, AA960152, calcium salt, Peptid, [OH2], SCH, Fugue, AA407739, 3-OHECN"],"additional_accession":[]},"is_claimable":false,"name":"Confirmation of the phosphorylation sites of human PhK","description":"The activity of PhK is regulated by phosphorylation, and we utilized single-particle cryo-electron microscopy to solve the high-resolution structures of human PhK under phosphorylation and calcium ion activation. To gain a deeper insight into the phosphorylation sites following PKA treatment, we employed tandem mass spectrometry for precise localization of the phosphorylation sites within PhK.","dates":{"publication":"2025-05-07","submission":"2025-01-01"},"accession":"PXD059345","cross_references":{"TAXONOMY":["NEWT:330879","NEWT:377960","NEWT:1131","NEWT:35795","NEWT:2042546","NEWT:259447","NEWT:295546","NEWT:1334565","NEWT:625351","NEWT:258594","NCBITaxon:1280","NEWT:112503","NEWT:1129","NEWT:309807","NEWT:59753","NEWT:89184","NEWT:309800","NEWT:281395","NEWT:247480","NEWT:1211601","NEWT:876138","NEWT:44271","NEWT:193516","NEWT:2315688","NEWT:1073882","NEWT:6819","NEWT:475174","NEWT:428386","NEWT:1117","NEWT:498257","NEWT:10036","NEWT:32264","NEWT:12215","NEWT:1590","NEWT:10034","NEWT:33114","NEWT:1596","NEWT:661410","NEWT:638632","NEWT:224326","NEWT:376619","NCBITaxon:79857","NEWT:1096976","NEWT:3765","NEWT:3767","NEWT:1589","NEWT:135622","NEWT:4615","NEWT:672127","NEWT:35786","NEWT:1580","NEWT:399784","NEWT:96731","NEWT:656064","NEWT:1582","NEWT:3760","NEWT:1584","NEWT:36630","NEWT:1585","NEWT:383379","NEWT:418106","NCBITaxon:12721","NEWT:10029","NEWT:913645","NEWT:641809","NEWT:1392488","NEWT:38815","NEWT:317447","NEWT:4688","NEWT:7719","NEWT:5530","NEWT:868565","NEWT:135674","NEWT:79329","NEWT:30069","NEWT:12637","NEWT:59729","NEWT:2164133","NEWT:295105","NEWT:108061","NEWT:60711","NEWT:224308","NEWT:3347","NEWT:49928","NEWT:3349","NEWT:160621","NEWT:212790","NEWT:110368","NEWT:1310161","NEWT:77133","NEWT:145481","NEWT:1310165","NEWT:29058","NCBITaxon:79824","NEWT:410658","NEWT:5516","NEWT:44688","NEWT:44689","NEWT:498211","NEWT:345076","NEWT:347256","NEWT:5518","NEWT:398007","NEWT:1527468","NEWT:498217","NEWT:498216","NEWT:11320","NEWT:246196","NEWT:246197","NEWT:145458","NEWT:1310173","NEWT:200795","NEWT:2579791","NEWT:44685","NEWT:161934","NEWT:1148","NEWT:5508","NEWT:3329","NEWT:419481","NEWT:5507","NEWT:260499","NEWT:410661","NEWT:1140","NCBITaxon:2157","NEWT:2066563","NEWT:1143","NEWT:1287689","NEWT:1094343","NEWT:1462472","NEWT:1336795","NEWT:644042","NEWT:150808","NEWT:1182590","NEWT:3712","NEWT:3711","NEWT:3714","NCBITaxon:37162","NEWT:2065263","NEWT:177437","NEWT:717966","NEWT:10891","NEWT:10418","NEWT:118698","NEWT:1616117","NEWT:118696","NEWT:34865","NEWT:52283","NEWT:28174","NEWT:284812","NEWT:8175","NEWT:43330","NEWT:1603293","NEWT:44664","NEWT:43346","NEWT:3702","NEWT:1245466","NEWT:3704","NEWT:244366","NEWT:1246791","NEWT:176597","NEWT:118694","NEWT:2850","NEWT:118691","NEWT:34871","NEWT:33548","NEWT:52299","NEWT:8165","NEWT:96794","NEWT:3708","NEWT:332648","NEWT:44670","NEWT:926571","NEWT:536231","NEWT:376219","NEWT:219813","NEWT:1510","NEWT:460519","NEWT:1515","NEWT:572307","NEWT:1432138","NEWT:1424507","NEWT:1194599","NEWT:272844","NEWT:1348799","NEWT:33995","NEWT:55784","NEWT:1303443","NEWT:9483","NEWT:485","NEWT:56636","NEWT:2499525","NEWT:2853422","NEWT:487","NEWT:1538553","NEWT:1679718","NEWT:480","NEWT:67767","NEWT:45972","NEWT:46835","NEWT:109757","NEWT:582580","NEWT:1185650","NEWT:216778","NEWT:1502","NEWT:128017","NEWT:2836","NEWT:376686","NEWT:237610","NEWT:95486","EFO:0001352","NEWT:119562","NEWT:1883446","NEWT:1233435","NEWT:118223","NEWT:11757","NEWT:987059","NEWT:109760","NEWT:29031","NEWT:317047","NEWT:1509","NEWT:491","NEWT:460523","NEWT:45954","NEWT:235443","NEWT:1579","NEWT:1757312","NEWT:85694","NEWT:109786","NEWT:108458","NEWT:5936","NEWT:321967","NEWT:320637","NEWT:1078283","NEWT:3750","NEWT:983964","NEWT:11706","NEWT:32644","NEWT:527796","NEWT:499175","NEWT:109779","NEWT:3745","NEWT:1715989","NCBITaxon:4751","NEWT:3747","NEWT:1116234","NEWT:1255228","NEWT:410289","NEWT:191701","NEWT:373153","NEWT:1640278","NEWT:472","NEWT:940825","NEWT:29459","NEWT:529507","NEWT:1071661","NEWT:28128","NEWT:470","NEWT:5911","NEWT:748693","NCBITaxon:50557","NEWT:39251","NEWT:29491","NEWT:101841","NEWT:446","NEWT:153481","NEWT:2014887","NEWT:33952","NEWT:11723","NEWT:445","NEWT:153009","NEWT:261756","NEWT:166313","NEWT:63366","NEWT:63367","NEWT:29488","NEWT:215402","NEWT:1547","NEWT:1290454","NEWT:3726","NEWT:906914","NEWT:81231006","NEWT:28141","NEWT:9031","NEWT:27292","NEWT:1050722","NEWT:3728","NEWT:108931","NEWT:1293497","NEWT:1055524","NEWT:548","NEWT:150475","NEWT:267872","NEWT:381666","NEWT:172269","NEWT:9534","NEWT:2126348","NEWT:5180","NEWT:256737","NEWT:9541","NEWT:8694","NEWT:33936","NEWT:8692","NEWT:542","NEWT:2903","NEWT:185579","NEWT:872227","NEWT:13076","NEWT:2587410","NEWT:207340","NEWT:1006581","NEWT:8673","NEWT:33940","NEWT:2126337","NEWT:550","NEWT:33941","NEWT:554","NEWT:451516","NEWT:552","NEWT:1325291","NEWT:42410","NEWT:36185","NEWT:1054211","NEWT:1225786","NEWT:771870","NEWT:51338","NEWT:9995","NEWT:575412","NEWT:28112","NEWT:49012","NEWT:6493","NEWT:10832","NEWT:6494","NEWT:6491","NEWT:507601","NEWT:520","NEWT:64657","NEWT:186441","NEWT:643680","NEWT:214092","NCBITaxon:6157","NEWT:13095","NEWT:162425","NEWT:104105","NEWT:216257","NEWT:9986","NEWT:8654","NEWT:8658","NEWT:1268063","NEWT:8657","NEWT:9983","NEWT:8655","NEWT:5147","NEWT:28108","NEWT:28104","NEWT:407821","NEWT:568703","NCBITaxon:2","NEWT:568708","NEWT:1613","NEWT:986","NEWT:52641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