{"database":"Pride","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Tabular":["ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/08/PXD060283/Ecoli_Corra_report.pg_matrix.tsv","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/08/PXD060283/MTB_Corra_report.pg_matrix.tsv"],"Other":["ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/08/PXD060283/MTB_Corra_untreated.zip","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/08/PXD060283/Ecoli_Corra_treated.zip","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/08/PXD060283/MTB_Corra_treated.zip","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/08/PXD060283/Ecoli_Corra_untreated.zip"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"labhead_mail":["rolf.mueller@helmholtz-hips.de"],"submitter":["Timo Risch"],"technology_type":["Mass Spectrometry","Data-independent acquisition"],"software":[""],"submitter_keywords":["Mycobacterium tuberculosis","Escherichia coli","Corramycin","Mode of action"],"full_dataset_link":["https://www.ebi.ac.uk/pride/archive/projects/PXD060283"],"sample_protocol":["For Escherichia coli ATCC25922, a liquid overnight culture of was inoculated (1:100) in 5 mL fresh LB-media and treated with 0.125x MIC corramycin, or the respective amount of DMSO as negative control. The liquid cultures were incubated at 37°C, 180 rpm until they reached the early stationary growth phase. Subsequently, 1 mL sample was collected in an Eppendorf tube on ice, centrifuged (16900xg, 4°C, 5 min) and washed with 1 mL cold PBS, before storing the pellet at -80°C until further use. Mycobacterium tuberculosis H37Ra was grown until early log-phase (OD600 0.4) and diluted to OD600 of 0.2 in 5 mL fresh M7H9 medium (supplemented with 10% OADC) and treated with 0.125x MIC corramycin, or the respective amount of DMSO as negative control. The liquid cultures were incubated at 37 °C, 180 rpm for 5 d. Subsequently, 5 mL were transferred into a 15 mL falcon tube on ice, centrifuged (16900xg, 4 °C, 5 min), re-suspended in 1 mL cold PBS and transferred into a 1.5 mL centrifuge tube. The sample was centrifuged again and the pellet was stored at -80 °C until further use.  Collected samples were lysed by adding 210 µL 0.4% SDS in PBS and three rounds of sonication with an amplitude of 50% for 30 s (Bandelin Sonoplus). Subsequently, samples were centrifuged (16900xg, 20 min, RT) and the supernatant was used to determine the protein concentration using BCA assay (Thermo). Proteome concentrations of the samples were adjusted to 100 µg/200 µL per sample. Afterwards, the proteome was precipitated by adding 1 mL ice-cold acetone and incubation overnight at -20°C. Next, the samples were centrifuged (16900xg, 15 min, 4°C), and supernatant was discarded. Samples were washed two times with 1 mL ice-cold methanol. Preparation for protein digest was done by resuspension in 200 µL X-buffer (7 M urea, 2 M thiourea, 20 mM HEPES, pH = 7.5) followed by reduction of cysteine with 0.8 µL DTT (250 mM) (dithiothreitol) for 45 min at 25°C, capping with 2 µL IAA (550 mM) (iodoacetic acid) for 30 min at 25°C and adding additional 3.2 µL DTT (250 mM) for 30 min at 25°C. The protein digest was performed by adding 600 µL ammonium bicarbonate buffer (pH = 8.5) and trypsin (1 µg) (MS grade, Promega) and incubation overnight at 37°C, 400 rpm shaking. Digestion was stopped by adding 8 µL formic acid. Peptide samples were desalted on SepPak C18 columns (Waters) using the following protocol. Columns were primed by adding 1 mL 100% and 80% acetonitrile (ACN) with 0.5% FA, followed by equilibration with 3x 1 mL H2O + 0.1% TFA, before samples were loaded and washed with 3x 1 mL 0.1% TFA and 1x 0.5 mL 0.5% FA. Subsequently, samples were eluted into 2 mL LoBind (Eppendorf) by adding 3x 250 µL 80% ACN + 0.5% FA under slight vacuum and dried using speedVac before solving in 1% FA with a proteome concentration of 1 µg/µL. Samples were filtered through 0.22 µm membrane (Merck Millipore, UFC30GVNB) and transferred to QuanRecovery autosampler vials (Waters)."],"repository":["Pride"],"quantification_method":["Not available"],"modification":[""],"data_protocol":["Sample analysis was done by using nanoElute nano flow liquid chromatography system (Bruker, Germany) coupled with a timsTOF Pro (Bruker, Germany). Samples were loaded to the trap column (Thermo Trap Cartridge 5 mm) and washed with 6 µL 0.1% FA with a flow rate of 10 µL/min. Peptides were then transferred to the analytical column (Aurora Ultimate CSI 25 cm x 75 µm ID, 1.6 µm FSC C18, IonOpticks) and separated by a gradient elution (eluent A: H2O + 0.1% FA, B: ACN + 0.1% FA; 0% to 3% in 1 min, 3% to 17% in 57 min, 17% to 25% in 21 min, 25% to 34% in 13 min, 34% to 85% in 1 min, 85% kept for 8 min) with a flow rate of 400 nL/min. Captive Spray nanoESI source (Bruker, Germany) was used to ionize the peptides at 1.5 kV with 180°C dry temperature at 3 L/min gas flow. timsTOF Pro (Bruker, Germany) was operated in default dia-PASEF long gradient mode with TIMS set to 1/K0 start at 0.6 Vs/cm2, end at 1.6 Vs/cm2 with a ramp and accumulation time of 100 ms each and a ramp rate of 9.43 Hz. Mass range was set from 100.0 Da to 1700 Da with positive ion polarity. Dia-PASEF mass range was set to 400.0 Da to 1201.0 Da with a mobility range of 0.60 1/K0 to 1.43 1/K0 and a cycle time of 1.80 s. Collision energy for 0.60 1/K0 was set to 20.00 eV and for 1.6 1/K0 to 59.00 eV. Tuning MIX ESI-TOF (Agilent) was used for calibration of m/z and mobility. Data were processed using DIA-NN (version 1.8.1), and proteins were identified using Uniprot E. coli K12 reference proteome (Proteome ID: UP000000625, downloaded 13/04/2023) or Mycobacterium tuberculosis H37Rv (Proteome ID: UP000001584, downloaded 17/12/2022). Settings were used as default except precursor charge range was from 2 to 4. C carbamidomethylation was set as fixed modification. “--relaxed-prot-inf” was added in additional options to allow further data processing with Perseus Software. In Perseus (version 2.0.7.0) the values were transformed to their log2-value and the replicates were grouped. The results were filtered by valid values in 3 out of 4 in at least one group. Missing values were imputed by default settings and the differential protein abundances between different conditions were evaluated using two-tailed student’s t-test. Cut-off for –log10 p-value was set to 1.3 (p-value = 0.05) and t-test difference >1.5. Proteins fitting these thresholds were identified as significantly over- or under-expressed compared to the controls."],"omics_type":["Proteomics"],"labhead":["Prof. Dr. Rolf Mueller"],"instrument_platform":[""],"labhead_affiliation":["Helmholtz-Institute for Pharmaceutical Research Saarland"],"submission_type":["PARTIAL"],"species":["Escherichia Coli","Mycobacterium Tuberculosis H37rv"],"publication":["42573571 Fries F, Herrmann J, Dal Molin M, Wormser Y, Risch T, Gao Y, Prosser G, Gubellini F, Mechaly A, Wallach JB, Castro A, Banerjee A, Rasheed S, Horn A, Müsken M, Kurz M, Sonnenkalb L, Dreyer V, Niemann S, Andres S, Schnappinger D, Kazmaier U, Reiling N, Müller R, Rybniker J, Petrella S. The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis. Adv Sci (Weinh). 2026:e76832 10.1002/advs.76832"],"submitter_mail":["timo.risch@helmholtz-hips.de"],"submitter_affiliation":["Helmholtz-Institute for Pharmaceutical Research"],"submitter_country":["Germany"],"pubmed_abstract":["Despite significant advancements in drug development and discovery, tuberculosis remains one of the world's deadliest infectious diseases. The rise and global spread of multidrug-resistant strains underscore a critical need for new antibiotics with distinct mechanisms of action. Screening of a myxobacterial extract library uncovered the previously unrecognized antitubercular activity of corramycin, a natural product with potent bactericidal activity against both drug-sensitive and -resistant Mycobacterium tuberculosis. Corramycin enters the bacterial cell by exploiting multiple transport systems, and induces DNA double-strand breaks through a novel form of DNA gyrase poisoning. The cryo-electron microscopy structure of M. tuberculosis gyrase in complex with corramycin reveals that the natural product targets a site overlapping with the binding site of synthetic fluoroquinolones, thereby locking the gyrase in an inactive conformation and preventing re-ligation of DNA. Importantly, its unique mode of binding allows corramycin to overcome fluoroquinolone resistance, highlighting its promise as a novel antibiotic scaffold to address the antimicrobial resistance crisis."],"pubmed_title":["The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis."],"pubmed_authors":["Fries Franziska F, Herrmann Jennifer J, Dal Molin Michael M, Wormser Yaëlle Y, Risch Timo T, Gao Yunsheng Y, Prosser Gareth G, Gubellini Francesca F, Mechaly Ariel A, Wallach Joshua B JB, Castro Anthony A, Banerjee Arka A, Rasheed Sari S, Horn Alexander A, Müsken Mathias M, Kurz Michael M, Sonnenkalb Lindsay L, Dreyer Viola V, Niemann Stefan S, Andres Sönke S, Schnappinger Dirk D, Kazmaier Uli U, Reiling Norbert N, Müller Rolf R, Rybniker Jan J, Petrella Stéphanie S"],"additional_accession":[]},"is_claimable":false,"name":"Corramycin mode of action in Escherichia coli and mycobacterium tuberculosis","description":"Corramycin mode of action in Escherichia coli and mycobacterium tuberculosis. Proteome comparison of corramycin treated vs untreated bacterial protein expression","dates":{"publication":"2026-08-13","submission":"2025-01-28"},"accession":"PXD060283","cross_references":{"TAXONOMY":["NEWT:330879","NEWT:377960","NEWT:1131","NEWT:35795","NEWT:2042546","NEWT:259447","NEWT:295546","NCBITaxon:2719036","NEWT:1334565","NEWT:625351","NEWT:258594","NCBITaxon:1280","NEWT:112503","NEWT:1129","NEWT:309807","NEWT:59753","NEWT:89184","NEWT:309800","NEWT:281395","NEWT:57577","NEWT:247480","NEWT:1211601","NEWT:876138","NEWT:44271","NEWT:193516","NEWT:2315688","NEWT:1073882","NEWT:6819","NEWT:112509","NEWT:475174","NEWT:111205","NEWT:1599","NEWT:428386","NEWT:1117","NEWT:498257","NEWT:10036","NEWT:32264","NEWT:12215","NEWT:1590","NEWT:10034","NEWT:33114","NEWT:1596","NEWT:661410","NEWT:638632","NEWT:224326","NEWT:376619","NCBITaxon:79857","NEWT:1096976","NEWT:3765","NEWT:3767","NEWT:1589","NEWT:135622","NEWT:4615","NEWT:67352","NEWT:672127","NEWT:35786","NEWT:1580","NEWT:399784","NEWT:96731","NEWT:656064","NEWT:1582","NEWT:3760","NEWT:1584","NEWT:36630","NEWT:1585","NEWT:383379","NEWT:381198","NEWT:418106","NCBITaxon:12721","NEWT:10029","NEWT:913645","NEWT:2492962","NEWT:641809","NEWT:1392488","NEWT:38815","NEWT:317447","NEWT:4688","NEWT:111225","NEWT:7719","NEWT:5530","NEWT:868565","NEWT:135674","NEWT:79329","NEWT:30069","NEWT:12637","NEWT:59729","NEWT:2164133","NEWT:295105","NEWT:29064","NEWT:108061","NEWT:60711","NEWT:224308","NEWT:273791","NEWT:3347","NEWT:49928","NEWT:3349","NEWT:160621","NEWT:212790","NEWT:110368","NEWT:55350","NEWT:1310161","NEWT:77133","NEWT:145481","NEWT:1310165","NEWT:29058","NCBITaxon:79824","NEWT:1912919","NEWT:410658","NEWT:5516","NEWT:44688","NEWT:44689","NEWT:370038","NEWT:498211","NEWT:345076","NEWT:347256","NEWT:5518","NEWT:398007","NEWT:1527468","NEWT:498217","NEWT:498216","NEWT:11320","NEWT:33554","NEWT:246196","NEWT:246197","NEWT:145458","NEWT:1310173","NEWT:200795","NEWT:37919","NEWT:2579791","NEWT:171719","NEWT:44685","NEWT:161934","NEWT:156587","NEWT:1148","NEWT:5508","NEWT:3329","NEWT:419481","NEWT:5507","NEWT:260499","NEWT:410661","NEWT:1140","NCBITaxon:2157","NEWT:2066563","NEWT:2649329","NEWT:1143","NEWT:1287689","NEWT:1094343","NEWT:1462472","NEWT:1336795","NEWT:644042","NEWT:150808","NEWT:1182590","NEWT:3712","NEWT:3711","NEWT:3714","NCBITaxon:37162","NEWT:270643","NEWT:3715","NEWT:2065263","NEWT:177437","NEWT:717966","NEWT:10891","NEWT:10418","NEWT:118698","NEWT:1616117","NEWT:118696","NEWT:34865","NEWT:52283","NEWT:28174","NEWT:284812","NEWT:8175","NEWT:43330","NEWT:980415","NEWT:1603293","NEWT:44664","NEWT:43346","NEWT:3702","NEWT:66440","NEWT:1245466","NEWT:3704","NEWT:244366","NEWT:1246791","NEWT:176597","NEWT:118694","NEWT:2850","NEWT:118691","NEWT:34871","NEWT:9006","NEWT:33548","NEWT:52299","NEWT:8165","NEWT:96794","NEWT:34878","NEWT:3708","NEWT:332648","NEWT:44670","NEWT:926571","NEWT:536231","NEWT:376219","NEWT:219813","NEWT:1510","NEWT:460519","NEWT:1515","NEWT:572307","NEWT:1432138","NEWT:1424507","NEWT:1194599","NEWT:272844","NEWT:1348799","NEWT:33995","NEWT:55784","NEWT:1303443","NEWT:9483","NEWT:485","NEWT:56636","NEWT:2709072","NEWT:2499525","NEWT:2853422","NEWT:487","NEWT:1538553","NEWT:1679718","NEWT:480","NEWT:67767","NEWT:45972","NEWT:46835","NEWT:109757","NEWT:582580","NEWT:1185650","NEWT:216778","NEWT:294607","NEWT:1502","NEWT:128017","NEWT:2836","NEWT:376686","NEWT:237610","NEWT:95486","EFO:0001352","NEWT:119562","NEWT:1883446","NEWT:1233435","NEWT:118223","NEWT:11757","NEWT:987059","NEWT:109760","NEWT:29031","NEWT:317047","NEWT:1509","NEWT:491","NEWT:460523","NEWT:45954","NEWT:235443","NEWT:1579","NEWT:133894","NEWT:1757312","NEWT:85694","NEWT:109786","NEWT:108458","NEWT:5936","NEWT:321967","NEWT:320637","NEWT:1078283","NEWT:3750","NEWT:983964","NEWT:11706","NEWT:32644","NEWT:527796","NEWT:499175","NEWT:109779","NEWT:3745","NEWT:1715989","NCBITaxon:4751","NEWT:3747","NEWT:1116234","NEWT:415978","NEWT:1255228","NEWT:410289","NEWT:191701","NEWT:373153","NEWT:1640278","NEWT:472","NEWT:940825","NEWT:29459","NEWT:529507","NEWT:1071661","NEWT:28128","NEWT:470","NEWT:41122","NEWT:5911","NEWT:748693","NCBITaxon:50557","NEWT:39251","NEWT:29491","NEWT:101841","NEWT:446","NEWT:153481","NEWT:2014887","NEWT:33952","NEWT:11723","NEWT:445","NEWT:153009","NEWT:261756","NEWT:166313","NEWT:63366","NEWT:63367","NEWT:29488","NEWT:215402","NEWT:1547","NEWT:1290454","NEWT:3726","NEWT:906914","NEWT:81231006","NEWT:28141","NEWT:9031","NEWT:27292","NEWT:1050722","NEWT:3728","NEWT:108931","NEWT:1293497","NEWT:1055524","NEWT:548","NEWT:150475","NEWT:267872","NEWT:381666","NEWT:172269","NEWT:9534","NEWT:2126348","NEWT:5180","NEWT:256737","NEWT:9541","NEWT:8694","NEWT:33936","NEWT:8692","NEWT:542","NEWT:2903","NEWT:185579","NEWT:872227","NEWT:13076","NEWT:2587410","NEWT:207340","NEWT:172271","NEWT:1006581","NEWT:8673","NEWT:33940","NEWT:2126337","NEWT:550","NEWT:33941","NEWT:554","NEWT:451516","NEWT:552","NEWT:1325291","NEWT:42410","NEWT:36185","NEWT:1054211","NEWT:1225786","NEWT:771870","NEWT:51338","NEWT:9995","NEWT:575412","NEWT:28112","NEWT:49012","NEWT:6493","NEWT:10832","NEWT:6494","NEWT:6491","NEWT:507601","NEWT:520","NEWT:64657","NEWT:186441","NEWT:643680","NEWT:214092","NCBITaxon:6157","NEWT:13095","NEWT:162425","NEWT:104105","NEWT:216257","NEWT:9986","NEWT:8654","NEWT:8658","NEWT:1268063","NEWT:8657","NEWT:9983","NEWT:8655","NEWT:5147","NEWT:595495","NEWT:28108","NEWT:28104","NEWT:407821","NEWT:568703","NCBITaxon:2","NEWT:568708","NEWT:1613","NEWT:8247","NEWT:986","NEWT:52641","NEWT:28532","NEWT:353152","NEWT:298176","NEWT:353153","NEWT:227377","NEWT:1774284","NEWT:27689","NEWT:40674","NEWT:1194669","NEWT:51329","NEWT:74426","NEWT:443906","NEWT:13037","NEWT:519","NEWT:30871","NEWT:2510939","NEWT:7394","NEWT:6063","NEWT:1328388","NEWT:105487","NEWT:1548728","NEWT:667127","NEWT:9557","NEWT:377586","NEWT:7375","NEWT:300641","NEWT:39655","NEWT:9554","NEWT:38323","NEWT:475932","NEWT:256318","NEWT:206411","NCBITaxon:6191","NEWT:229533","NEWT:2925","NEWT:214053","NEWT:28550","NEWT:80863","NEWT:90675","NEWT:52639","NEWT:52638","NEWT:57075","NEWT:367774","NEWT:1666905","NEWT:8697","NEWT:861109","NEWT:8695","NEWT:75736","NEWT:884204","NEWT:510516","NEWT:1045775","NEWT:1123869","NEWT:9544","NEWT:9545","NEWT:979","NEWT:7370","NEWT:30850","NEWT:83906","NEWT:99488","NEWT:1134506","NEWT:255470","NEWT:38783","NEWT:6426","NEWT:33090","NEWT:9935","NEWT:287889","NEWT:305959","NEWT:1028307","NEWT:13489","NEWT:29829","NEWT:92867","NEWT:92866","NCBITaxon:3055","NEWT:51750","NEWT:202950","NEWT:441772","NEWT:1293091","NEWT:1867051","NEWT:48106","NEWT:202956","NEWT:295027","NEWT:315750","NCBITaxon:11320","NEWT:99490","NEWT:632957","NEWT:9925","NCBITaxon:9606","NEWT:90690","NEWT:1436183","NEWT:300273","NEWT:4232","NEWT:9922","NEWT:416348","NEWT:11298","NEWT:4236","NEWT:7742","NEWT:196627","NEWT:63737","NEWT:1076878","NEWT:200308","NEWT:941279","NEWT:242507","NEWT:200302","NEWT:870435","NEWT:9917","NEWT:95912","NEWT:58370","NEWT:9913","NEWT:9915","NEWT:105841","NEWT:2666255","NEWT:57047","NEWT:999810","NCBITaxon:5693","NEWT:28995","NEWT:2144189","NEWT:1392998","NEWT:380394","NEWT:114796","NEWT:1150621","NEWT:226900","NEWT:1266738","NEWT:231490","NEWT:244704","NEWT:7725","NEWT:9909","NEWT:883796","NEWT:9902","NEWT:430615","NEWT:563041","NEWT:72664","NEWT:36599","NEWT:41949","NEWT:249161","NEWT:326423","NEWT:452467","NEWT:198822","NEWT:283035","NEWT:36111","NEWT:326424","NEWT:1156395","NEWT:1678078","NEWT:749906","NEWT:418985","NEWT:749907","NEWT:150847","NEWT:2023717","NEWT:29835","NEWT:1229733","NEWT:431947","NEWT:69014","NEWT:142809","NEWT:1095183","NEWT:302409","NEWT:89252","NEWT:130821","NEWT:27606","NEWT:290610","NEWT:1519788","NEWT:59202","NEWT:9975","NEWT:8643","NEWT:1801631","NEWT:1159899","NEWT:502780","NEWT:860688","NEWT:13443","NEWT:35231","NEWT:1774208","NEWT:33059","NEWT:8644","NEWT:1125630","NEWT:5141","NEWT:46360","NCBITaxon:3044782","NEWT:202914","NEWT:160235","NEWT:502779","NEWT:297246","NEWT:103690","NEWT:8639","NEWT:1928434","NEWT:8637","NEWT:1114970","NEWT:2096","NEWT:285272","NEWT:192222","NEWT:9963","NEWT:1617910","NEWT:197911","NEWT:197912","NEWT:637379","NEWT:12107","NEWT:701504","NEWT:2785785","NEWT:411901","NEWT:1298722","NEWT:8626","NEWT:186801","NEWT:105884","NCBITaxon:9615","NEWT:219334","NEWT:8621","NEWT:58334","NEWT:58331","NEWT:6446","NEWT:33038","NEWT:8624","NEWT:5116","NEWT:6447","NEWT:8623","NEWT:5597","NCBITaxon:3077","NEWT:33035","NEWT:194439","NCBITaxon:12637","NEWT:38727","NEWT:218496","NEWT:420850","NEWT:8618","NEWT:70448","NEWT:9946","NEWT:103695","NEWT:300251","NEWT:9945","NEWT:9940","NEWT:13451","NEWT:1247190","NEWT:118702","NEWT:118700","NEWT:2126719","NEWT:118705","NEWT:1079921","NEWT:1145230","NEWT:6945","NEWT:72859","NEWT:3435","NEWT:2104","NEWT:2627626","NEWT:6943","NEWT:157546","NEWT:870726","NEWT:91374","NEWT:91373","NEWT:1414448","NEWT:27804","NEWT:474186","NEWT:54195","NEWT:10136","NEWT:321803","NEWT:38942","NEWT:4762","NEWT:6941","NEWT:307972","NEWT:2102","NEWT:34","NEWT:38949","NEWT:1299114","NEWT:1590841","NEWT:60876","NCBITaxon:5518","NEWT:1276473","NEWT:2282334","NEWT:1247","NEWT:70667","NEWT:869728","NEWT:6938","NCBITaxon:6854","NCBITaxon:39054","NEWT:1885322","NEWT:1736309","NEWT:4751","NEWT:36774","NEWT:194963","NEWT:860918","NEWT:2005482","NEWT:77298","NEWT:15819","NEWT:109461","NEWT:1085956","NEWT:3899","NEWT:1136157","NEWT:6928","NEWT:1239","NEWT:272568","NEWT:36745","NEWT:400727","NEWT:272560","NEWT:272563","NEWT:11009","NEWT:913998","NEWT:68335","NEWT:3885","NEWT:3888","NEWT:649408","NEWT:6915","NEWT:101510","NEWT:3880","NEWT:272559","NEWT:216816","NEWT:153151","NEWT:2681598","NEWT:1220","NEWT:515849","NEWT:10141","NEWT:95767","NEWT:466585","NEWT:1000589","NEWT:42192","NEWT:85963","NEWT:29","NEWT:85962","NEWT:42197","NEWT:6918","NEWT:681196","NEWT:143361","NEWT:1223501","NEWT:5658","NEWT:5659","NEWT:5656","NEWT:1292","NEWT:1295","NEWT:1085537","NEWT:1299","NEWT:424718","NEWT:316407","NEWT:1794699","NCBITaxon:183674","NEWT:167387","NEWT:84645","NEWT:1123294","NEWT:6978","NEWT:209285","NEWT:211586","NEWT:747078","NEWT:30195","NEWT:1282","NEWT:1283","NEWT:1000561","NEWT:253836","NEWT:2133","NEWT:6973","NEWT:176279","NEWT:294381","NEWT:197","NEWT:1390363","NEWT:35889","NEWT:406072","NEWT:1454958","NEWT:351660","NEWT:29176","NEWT:201319","NEWT:1073569","NEWT:4787","NEWT:751585","NEWT:113549","NEWT:46503","NEWT:180788","NEWT:159749","NEWT:1270","NEWT:388919","NEWT:130081","NEWT:4784","NEWT:360106","NEWT:4785","NEWT:360104","NEWT:85517","NEWT:10117","NEWT:401614","NEWT:10116","NEWT:1280","NEWT:83333","NEWT:2501646","NEWT:83334","NEWT:242718","NEWT:83332","NEWT:161","NEWT:242715","NEWT:2951803","NEWT:46515","NEWT:563924","NEWT:100226","NEWT:1263","NEWT:176299","NEWT:1654360","NEWT:1450134","NEWT:54126","NEWT:75058","NEWT:13616","NEWT:13613","NEWT:2852005","NEWT:35869","NEWT:172","NEWT:296543","NEWT:173","NEWT:316435","NEWT:42157","NEWT:165179","NEWT:1034304","NEWT:105023","NEWT:866628","NEWT:535026","NEWT:749200","NEWT:1036967","NEWT:266264","NEWT:272942","NEWT:272943","NEWT:1882682","NEWT:537209","NEWT:145953","NEWT:257309","NEWT:33658","NEWT:33657","NEWT:203124","NEWT:306254","NEWT:230741","NEWT:8296","NEWT:117008","NEWT:167748","NEWT:1163394","NEWT:2972","NEWT:645463","NEWT:749696","NEWT:986075","NEWT:320549","NEWT:990119","NEWT:77216","NEWT:29137","NEWT:1111708","NEWT:11855","NEWT:998086","NEWT:228410","NEWT:493760","NEWT:93163","NEWT:257313","NEWT:3827","NEWT:400772","NEWT:257310","NEWT:128161","NEWT:930945","NEWT:332521","NEWT:106350","NEWT:1966486","NEWT:455045","NEWT:29170","NEWT:269796","NEWT:1208370","NEWT:54571","NEWT:412754","NEWT:9598","NEWT:1867944","NEWT:52389","NEWT:2665964","NEWT:1423772","NEWT:51056","NEWT:35815","NEWT:78534","NEWT:53232","NEWT:1235987","NEWT:257329","NEWT:632138","NCBITaxon:2509511","NEWT:1639","NEWT:188229","NEWT:3818","NEWT:432359","NCBITaxon:37296","NEWT:12721","NEWT:9103","NEWT:715877","NEWT:862238","NEWT:29159","NEWT:1155748","NEWT:9593","NEWT:8260","NEWT:9595","NEWT:2665958","NEWT:246200","NEWT:6087","NEWT:145943","NEWT:595536","NEWT:1134822","NEWT:240906","NEWT:89920","NEWT:3809","NEWT:65699","NEWT:29158","NEWT:44745","NEWT:44744","NEWT:3879","NEWT:1328881","NEWT:1219","NEWT:411483","NEWT:76336","NEWT:3871","NEWT:3870","NEWT:479437","NEWT:884019","NEWT:411490","NEWT:169963","NEWT:587","NEWT:588","NEWT:585","NCBITaxon:43925","NEWT:746128","NEWT:3864","NEWT:212035","NCBITaxon:1653394","NEWT:1205","NEWT:3682081","NEWT:214693","NEWT:1207","NEWT:45609","NEWT:239935","NEWT:1680","NEWT:280148","NEWT:9172","NEWT:2770979","NEWT:310713","NEWT:112","NEWT:423477","NEWT:1277351","NEWT:1594786","NEWT:40366","NEWT:3854","NEWT:214687","NEWT:1080228","NEWT:411469","NEWT:1679","NEWT:333849","NEWT:214684","NEWT:1758543","NEWT:569","NEWT:411464","NEWT:525283","NEWT:411460","NEWT:1328426","NEWT:562","NEWT:411470","NEWT:10515","NEWT:2094720","NEWT:2545266","NCBITaxon:2697049","NEWT:294750","NEWT:1663","NEWT:214675","NEWT:62141","NEWT:65651","NEWT:3848","NEWT:3847","NEWT:198466","NEWT:2806551","NEWT:327159","NEWT:1045010","NEWT:178876","NEWT:1660","NEWT:327160","NEWT:573","NEWT:1131757","NEWT:571","NEWT:142479","NEWT:29595","NEWT:241368","NEWT:42528","NEWT:1969471","NEWT:9657","NEWT:150596","NEWT:9659","NEWT:30540","NEWT:264483","NEWT:439733","NEWT:76777","NEWT:30545","NEWT:76773","NEWT:9662","NEWT:1121114","NEWT:663","NEWT:1081927","NEWT:1238993","NEWT:126479","NEWT:67825","NEWT:187878","NEWT:1504802","NEWT:633528","NEWT:1821314","NEWT:103351","NEWT:40354","NEWT:1249668","NEWT:300558","NEWT:426430","NEWT:223926","NEWT:38033","NEWT:37181","NEWT:929439","NEWT:9646","NEWT:1808362","NEWT:5286","NEWT:7469","NEWT:37189","NEWT:9643","NEWT:9644","NEWT:1580596","NEWT:426428","NEWT:63459","NCBITaxon:446","NEWT:2652157","NEWT:2652158","NEWT:40353","NEWT:1276815","NEWT:40324","NEWT:588858","NEWT:9638","NEWT:9639","NCBITaxon:11071","NEWT:693977","NEWT:242231","NEWT:197221","NEWT:528354","NEWT:51453","NEWT:1279085","NEWT:28231","NEWT:7460","NEWT:504457","NEWT:392227","NEWT:1920175","NEWT:1004024","NEWT:103372","NEWT:862751","NEWT:470150","NEWT:9627","NEWT:1009714","NEWT:73239","NEWT:38018","NEWT:226186","NEWT:381518","NEWT:659","NEWT:30532","NEWT:633513","NEWT:8782","NEWT:30538","NEWT:115357","NEWT:5270","NEWT:63436","NEWT:28229","NEWT:63433","NEWT:13164","NEWT:1601067","NEWT:943311","NEWT:129554","NEWT:40302","NEWT:1249615","NEWT:343232","NEWT:343237","NEWT:2664179","NEWT:623","NEWT:217219","NEWT:7038","NEWT:6192","NCBITaxon:1639","NEWT:767468","NEWT:3915","NEWT:1581419","NCBITaxon:3570232","NEWT:3065436","NEWT:405534","NEWT:9689","NEWT:8355","NEWT:633","NEWT:9685","NEWT:1218948","NEWT:7029","NEWT:9688","NEWT:6182","NEWT:9693","NEWT:9694","NEWT:604162","NEWT:1046723","NEWT:9695","NEWT:186990","NEWT:8364","NEWT:6185","NEWT:632","NEWT:6183","NEWT:1423800","NEWT:9690","NEWT:630","NCBITaxon:11019","NEWT:9691","NEWT:334747","NEWT:3907","NEWT:3906","NEWT:27315","NEWT:61235","NEWT:393595","NEWT:343691","NEWT:1457551","NEWT:15368","NEWT:76717","NEWT:13180","NEWT:9678","NEWT:1491466","NEWT:340188","NEWT:170187","NEWT:1755437","NEWT:1042399","NEWT:9681","NEWT:9680","NEWT:1718","NEWT:1719","NEWT:692672","NEWT:2697049","NEWT:568813","NEWT:1109443","NEWT:267566","NEWT:58042","NEWT:7004","NEWT:9668","NEWT:9669","NCBITaxon:6073","NEWT:1089448","NEWT:615","NEWT:1329349","NEWT:1089444","NEWT:607699","NEWT:6161","NEWT:206542","NEWT:27337","NEWT:575584","NEWT:186536","NEWT:257771","NEWT:185687","NEWT:3039","NEWT:2706014","NEWT:6549","NEWT:8727","NEWT:8726","NEWT:8725","NEWT:10090","NEWT:8729","NEWT:8720","NEWT:5692","NEWT:5693","NEWT:2186","NEWT:8724","NEWT:8723","NEWT:283166","NEWT:439334","NEWT:8722","NEWT:5697","NEWT:6544","NEWT:218192","NCBITaxon:10114","NEWT:2190","NEWT:1685931","NEWT:242619","NEWT:557723","NEWT:557722","NEWT:160791","NEWT:1353008","NEWT:34073","NEWT:402042","NEWT:373995","NEWT:5689","NEWT:8715","NEWT:3040162","NEWT:544404","NEWT:287535","NEWT:1547922","NEWT:2172","NEWT:2173","NEWT:2175","NEWT:6535","NEWT:1232801","NEWT:5691","NEWT:563192","NEWT:61674","NEWT:2072580","NEWT:669465","NEWT:1117957","NEWT:6526","NEWT:8709","NEWT:1064539","NEWT:8707","NEWT:1306274","NEWT:5671","NEWT:13146","NEWT:6523","NEWT:8700","NEWT:3498","NEWT:1692259","NEWT:1486917","NEWT:3062780","NEWT:2636997","NEWT:1843183","NEWT:5661","NEWT:157592","NEWT:3482","NEWT:52714","NEWT:51866","NEWT:58002","NEWT:13136","NEWT:3483","NEWT:5660","NEWT:5665","NEWT:1179777","NEWT:6997","NEWT:5666","NEWT:1746091","NEWT:5664","NEWT:2157","NEWT:70125","NEWT:146479","NEWT:905079","NEWT:1843192","NEWT:206189","NEWT:2160","NEWT:295139","NEWT:27779","NEWT:181214","NEWT:6108","NEWT:1720309","NEWT:9612","NEWT:1286640","NEWT:38865","NEWT:3077","NEWT:9615","NEWT:6100","NEWT:713604","NEWT:3076","NEWT:2250255","NEWT:112273","NEWT:13563","NEWT:33178","NEWT:1147787","NEWT:39717","NEWT:62977","NEWT:2562269","NEWT:1440772","NEWT:45157","NEWT:10040","NEWT:8759","NEWT:9605","NEWT:9606","NEWT:27717","NEWT:641501","NEWT:9601","NEWT:8752","NEWT:34038","NEWT:9604","NEWT:8756","NEWT:74940","NEWT:13551","NEWT:10041","NEWT:9600","NEWT:1450511","NEWT:439375","NEWT:1857323","NEWT:211508","NEWT:890382","NEWT:174934","NEWT:179392","NEWT:2823525","NEWT:115778","NEWT:1538186","NEWT:82996","NEWT:1659668","NEWT:227086","NEWT:3055","NEWT:195883","NEWT:1450520","NEWT:1042311","NEWT:1123352","NEWT:741258","NEWT:82525","NEWT:29920","NEWT:82528","NEWT:235909","NEWT:47311","NCBITaxon:813","NEWT:127785","NEWT:708248","NEWT:47314","NEWT:104660","NEWT:652611","NEWT:1417983","NEWT:94993","NEWT:6550","NEWT:10068","NEWT:8732","NEWT:763037","NEWT:1250232","NEWT:669041","NEWT:1052588","NEWT:1377","NEWT:3555","NEWT:71647","NEWT:260201","NEWT:35554","NCBITaxon:12939","NEWT:935692","NEWT:1322343","NEWT:32046","NEWT:2222","NEWT:59523","NEWT:544496","NEWT:1736657","NEWT:59529","NEWT:32049","NEWT:59528","NEWT:1392696","NEWT:762376","NEWT:45351","NEWT:445974","NEWT:43179","NEWT:180454","NEWT:3544","NEWT:1142745","NEWT:5722","NEWT:7901","NEWT:32051","NEWT:10245","NEWT:55153","NEWT:2944139","NEWT:10243","NEWT:10244","NEWT:351581","NEWT:43186","NEWT:70779","NEWT:428146","NEWT:889247","NEWT:498019","NEWT:1351","NEWT:1438992","NEWT:1352","NEWT:32025","NEWT:2649997","NEWT:1147161","NEWT:1645733","NEWT:43150","NEWT:69781","NEWT:85831","NEWT:263737","NEWT:1333499","NEWT:5702","NEWT:95648","NEWT:1349","NEWT:67593","NEWT:866555","NEWT:100787","NEWT:1263054","NEWT:1401257","NEWT:44491","NEWT:27933","NEWT:556484","NEWT:94328","NEWT:7956","NEWT:7955","NEWT:7959","NEWT:645159","NEWT:2261","NEWT:94323","NEWT:31156","NEWT:3112","NEWT:8801","NEWT:4442","NEWT:31155","NEWT:192875","NEWT:1214915","NEWT:1214916","NEWT:284218","NEWT:169683","NEWT:1316931","NEWT:45796","NEWT:511145","NEWT:213401","NEWT:931281","NEWT:4432","NEWT:5762","NEWT:5763","NEWT:118099","NEWT:32019","NEWT:658457","NEWT:420247","NEWT:35525","NEWT:1424337","NEWT:295358","NEWT:2246","NEWT:2652724","NEWT:5757","NEWT:68415","NCBITaxon:4563","NEWT:5755","NEWT:44447","NEWT:752555","NEWT:39097","NEWT:347495","NEWT:5759","NEWT:1736231","NEWT:1392","NEWT:35974","NEWT:2242","NEWT:1396","NEWT:1324588","NEWT:286","NEWT:391619","NEWT:470921","NEWT:287","NEWT:1367269","NEWT:633149","NEWT:1149786","NEWT:10239","NEWT:68895","NEWT:3567","NEWT:68888","NEWT:4897","NEWT:5744","NEWT:72901","NEWT:213863","NEWT:1905158","NEWT:55571","NEWT:35500","NEWT:1235816","NEWT:2041044","NEWT:3562","NEWT:4896","NEWT:5740","NEWT:1262161","NEWT:343904","NEWT:1314781","NEWT:1390","NEWT:11557","NEWT:562716","NEWT:294","NEWT:1773","NEWT:82380","NEWT:63186","NEWT:935293","NEWT:375146","NEWT:471876","NEWT:1772","NEWT:1090134","NEWT:264","NEWT:263","NEWT:525338","NEWT:11988","NEWT:400667","NEWT:408169","NEWT:36809","NEWT:47946","NEWT:459758","NEWT:105135","NEWT:1764","NEWT:39087","NEWT:109974","NEWT:413996","NEWT:243277","NEWT:7067","NEWT:243275","NEWT:586722","NEWT:243273","NEWT:1986198","NEWT:274","NEWT:7070","NCBITaxon:287","NEWT:408172","NEWT:59919","NEWT:408170","NEWT:283734","NEWT:7074","NEWT:64495","NEWT:1436733","NEWT:42229","NEWT:85431","NEWT:1247411","NEWT:9238","NEWT:13708","NEWT:333760","NEWT:34607","NEWT:35938","NEWT:1451139","NEWT:1513458","NEWT:1233681","NEWT:2212966","NCBITaxon:40559","NEWT:506599","NEWT:81077","NEWT:84588","NEWT:1279007","NEWT:85433","NEWT:572545","NEWT:65349","NEWT:300852","NEWT:3920","NEWT:84595","NEWT:564933","NEWT:508771","NEWT:1121405","NEWT:580165","NEWT:1736604","NEWT:253","NCBITaxon:2759","NEWT:93061","NEWT:93062","NEWT:1284813","NEWT:34613","NEWT:548470","NEWT:7054","NCBITaxon:4932","NEWT:1748","NEWT:108673","NEWT:2764168","NEWT:943274","NEWT:1488406","NEWT:644223","NEWT:1263082","NEWT:64471","NEWT:272623","NEWT:1288389","NEWT:272624","NEWT:2719099","NEWT:886559","NEWT:55521","NEWT:118499","NEWT:1130798","NEWT:385388","NEWT:55529","NEWT:1089176","NEWT:272621","NEWT:256136","NEWT:476272","NEWT:195051","NEWT:3988","NEWT:561007","NEWT:649908","NEWT:1001135","NEWT:147828","NEWT:3981","NEWT:3983","NEWT:203696","NEWT:223283","NEWT:352472","NEWT:235","NEWT:505235","NEWT:55518","NEWT:97441","NEWT:1154756","NEWT:1202531","NCBITaxon:12066","NEWT:1202532","NEWT:360094","NEWT:1408223","NEWT:1408224","NEWT:29695","NEWT:41364","NEWT:1311","NEWT:1313","NEWT:1218097","NEWT:1080348","NEWT:1314","NEWT:39491","NEWT:212142","NCBITaxon:5811","NEWT:3972","NEWT:1499105","NEWT:55986","NEWT:686","NEWT:192812","NEWT:408188","NEWT:571256","NEWT:40483","NEWT:688333","NEWT:1119529","NEWT:1303","NCBITaxon:548681","NEWT:318586","NCBITaxon:5820","NEWT:272634","NEWT:198107","NEWT:1979401","NEWT:9267","NEWT:155892","NEWT:691","NEWT:637910","NEWT:28384","NEWT:167879","NEWT:1872122","NEWT:1308","NEWT:7091","NEWT:1034015","NEWT:760568","NEWT:141262","NCBITaxon:118655","NEWT:1737068","NEWT:1813","NEWT:4087","NEWT:9778","NEWT:306","NEWT:505693","NEWT:303","NEWT:97477","NEWT:8443","NEWT:7111","NEWT:113287","NEWT:347515","NEWT:79923","NEWT:435258","NEWT:6269","NEWT:412133","NEWT:4090","NEWT:4092","NEWT:9783","NEWT:4093","NEWT:786","NEWT:4096","NEWT:208895","NEWT:184485","NEWT:941442","NEWT:536088","NEWT:311553","NEWT:1226408","NEWT:43984","NEWT:7108","NEWT:367110","NEWT:40479","NEWT:43989","NEWT:4076","NEWT:142615","NEWT:316","NEWT:317","NEWT:885319","NEWT:293939","NEWT:497515","NEWT:885318","NEWT:39488","NEWT:1268285","NEWT:4081","NEWT:273068","NEWT:1316582","NEWT:227166","NEWT:98334","NEWT:231663","NEWT:4084","NEWT:63577","NEWT:7574","NEWT:1715256","NEWT:30640","NEWT:348824","NEWT:929793","NEWT:1507179","NEWT:29204","NEWT:114155","NEWT:4072","NEWT:1337056","NEWT:4073","NEWT:634955","NEWT:148364","NEWT:6239","NEWT:102169","NEWT:208893","NEWT:4054","NEWT:301301","NEWT:98351","NEWT:1263854","NEWT:118503","NEWT:2059687","NEWT:160488","NEWT:63558","NEWT:61376","NEWT:207559","NEWT:107401","NEWT:85057","NEWT:985076","NEWT:1215323","NCBITaxon:565995","NEWT:7159","NEWT:267671","NEWT:72491","NEWT:198618","NEWT:7160","NEWT:8496","NEWT:7165","NEWT:1257118","NEWT:1387333","NEWT:8010","NEWT:1315282","NEWT:7162","NEWT:1859","NEWT:27448","NEWT:2708","NEWT:38111","NEWT:405416","NEWT:235612","NEWT:243232","NEWT:243230","NEWT:243231","NEWT:936053","NEWT:1080772","NEWT:8479","NEWT:8485","NEWT:119856","NEWT:72000","NEWT:119857","NEWT:49240","NEWT:161398","NEWT:89426","NEWT:2893330","NEWT:89427","NCBITaxon:3707","NEWT:391295","NEWT:1170828","NEWT:1249515","NEWT:2049433","NEWT:104395","NEWT:93934","NEWT:1833","NEWT:9315","NEWT:6289","NEWT:38568","NEWT:6287","NEWT:38569","NEWT:727","NEWT:9796","NEWT:118562","NEWT:725","NEWT:7137","NEWT:469008","NEWT:9321","NEWT:596153","NEWT:8472","NEWT:1836","NEWT:3064004","NCBITaxon:10298","NEWT:1652998","NEWT:573039","NEWT:49212","NEWT:105231","NEWT:104385","NEWT:74649","NEWT:1037924","NEWT:206672","NEWT:9788","NEWT:4097","NEWT:9305","NEWT:436113","NEWT:71139","NEWT:9785","NEWT:6279","NEWT:1195774","NEWT:9793","NCBITaxon:780","NCBITaxon:1502","NEWT:6282","NEWT:69298","NEWT:27457","NEWT:4006","NEWT:1872635","NCBITaxon:5476","NEWT:113208","NEWT:6669","NEWT:1215360","NEWT:89453","NEWT:1114301","NEWT:51515","NEWT:13249","NEWT:1566338","NEWT:588596","NEWT:51511","NEWT:8845","NEWT:7998","NEWT:419610","NEWT:5334","NEWT:382352","NEWT:413071","NCBITaxon:10239","NEWT:332097","NCBITaxon:714","NEWT:1076620","NEWT:11051","NEWT:1565494","NEWT:89462","NEWT:452680","NEWT:8839","NEWT:4472","NEWT:2758385","NEWT:171101","NEWT:714","NEWT:5322","NEWT:34199","NEWT:568996","NEWT:421932","NEWT:312017","NEWT:576131","NEWT:553470","NCBITaxon:10243","NEWT:284593","NEWT:100392","NEWT:655819","NEWT:5315","NEWT:11082","NEWT:265872","NEWT:59463","NEWT:337330","NEWT:2285","NEWT:2287","NEWT:6645","NEWT:251229","NEWT:981087","NEWT:180066","NEWT:46147","NCBITaxon:6312","NEWT:11072","NEWT:174633","NEWT:52830","NEWT:1416333","NEWT:35024","NEWT:135461","NEWT:7962","NEWT:99287","NEWT:1817808","NEWT:145262","NEWT:145263","NEWT:296587","NEWT:694569","NEWT:9739","NEWT:111069","NEWT:1379791","NEWT:51953","NEWT:57267","NEWT:3197","NEWT:13686","NEWT:2750454","NEWT:264561","NEWT:1402135","NEWT:36329","NEWT:62615","NEWT:1555636","NEWT:46124","NEWT:1333550","NEWT:646099","NEWT:72407","NEWT:180498","NEWT:352914","NEWT:349741","NEWT:409859","NEWT:157295","NEWT:6211","NEWT:1263871","NEWT:509169","NEWT:6210","NEWT:3051137","NEWT:9720","NEWT:9721","NEWT:137221","NEWT:565050","NEWT:409860","NEWT:9719","NEWT:92683","NEWT:1298968","NEWT:5353","NEWT:1034809","NEWT:452659","NEWT:1193501","NEWT:51930","NEWT:1193502","NEWT:8867","NEWT:6689","NEWT:194675","NEWT:12374","NEWT:43075","NEWT:298315","NEWT:392547","NEWT:46105","NEWT:104782","NEWT:10181","NEWT:9704","NEWT:1049056","NEWT:698936","NEWT:13216","NEWT:1009874","NEWT:4498","NEWT:8855","NEWT:11034","NEWT:3168","NEWT:10185","NEWT:78168","NEWT:521001","NEWT:192011","NEWT:340912","NEWT:1813887","NEWT:224911","NEWT:1090946","NCBITaxon:11552","NEWT:267608","NEWT:334249","NEWT:184922","NEWT:6703","NEWT:1498","NEWT:2","NEWT:35670","NEWT:511693","NEWT:5855","NEWT:4528","NEWT:6706","NEWT:1232659","NEWT:35677","NEWT:1492","NEWT:136841","NEWT:1493","NEWT:10376","NEWT:1496","NEWT:3674","NEWT:5851","NEWT:660469","NEWT:935568","NEWT:1365186","NEWT:1813019","NEWT:45474","NEWT:48500","NEWT:4513","NEWT:5843","NEWT:110205","NEWT:1117645","NEWT:376741","NEWT:310915","NCBITaxon:10407","NEWT:35688","NEWT:1000364","NEWT:1736548","NEWT:10360","NEWT:1403536","NEWT:1427524","NEWT:47664","NEWT:260799","NEWT:557436","NEWT:317548","NEWT:106198","NEWT:2323","NEWT:3654","NEWT:237561","NEWT:5833","NEWT:70415","NEWT:3659","NEWT:59620","NEWT:499229","NEWT:31298","NEWT:1204162","NEWT:1532734","NEWT:635003","NEWT:79220","NEWT:82688","NEWT:5823","NEWT:5821","NEWT:44139","NCBITaxon:4895","NEWT:570417","NCBITaxon:4896","NEWT:675512","NEWT:315393","NEWT:3649","NEWT:28903","NEWT:325176","NEWT:910263","NEWT:1211705","NEWT:13894","NEWT:28909","NEWT:3641","NEWT:79698","NEWT:28901","NCBITaxon:5796","NEWT:137732","NEWT:12993","NEWT:398580","NEWT:4565","NEWT:1264690","NEWT:515619","NEWT:170721","NEWT:34305","NEWT:77020","NEWT:10335","NEWT:1908323","NEWT:648794","NEWT:83558","NEWT:44586","NEWT:626528","NEWT:139927","NEWT:4558","NEWT:5888","NEWT:1736582","NEWT:431241","NEWT:4550","NEWT:4555","NEWT:443226","NEWT:144036","NEWT:144030","NEWT:288705","NEWT:392815","NEWT:3217","NEWT:4547","NEWT:3218","NEWT:556182","NEWT:374990","NEWT:36941","NEWT:1432059","NEWT:154293","NEWT:156471","NEWT:3694","NEWT:5875","NEWT:156476","NEWT:4543","NEWT:210007","NEWT:1857017","NEWT:10359","NEWT:1358430","NEWT:10358","NEWT:1381693","NEWT:1735272","NEWT:109298","NEWT:317513","NEWT:707678","NEWT:580240","NEWT:294128","NEWT:11676","NEWT:1917265","NEWT:55210","NEWT:718308","NEWT:4530","NEWT:5861","NEWT:44577","NEWT:1895","NEWT:2558360","NEWT:215358","NEWT:64152","NEWT:4924","NEWT:2748","NEWT:8049","NEWT:33892","NEWT:99931","NEWT:9378","NEWT:527640","NEWT:990346","NEWT:100816","NEWT:192952","NEWT:1640346","NCBITaxon:1313","NEWT:29385","NEWT:44544","NEWT:529818","NEWT:400540","NEWT:382","NEWT:4911","NEWT:152480","NEWT:1886","NEWT:129249","NEWT:1888","NEWT:1077286","NEWT:943129","NEWT:131567","NEWT:1221594","NEWT:10760","NEWT:1077281","NEWT:1524260","NEWT:227321","NEWT:192944","NEWT:492670","NEWT:281677","NEWT:106590","NEWT:260710","NEWT:4918","NEWT:1162296","NEWT:106592","NEWT:596645","NEWT:46704","NEWT:42345","NEWT:482428","NEWT:1187947","NEWT:4903","NEWT:10312","NCBITaxon:1773","NEWT:323848","NEWT:190304","NEWT:1432499","NEWT:8030","NEWT:10319","NEWT:246432","NEWT:246437","NEWT:36909","NEWT:4909","NEWT:443256","NEWT:1279365","NEWT:759272","NEWT:1182263","NEWT:943146","NEWT:646532","NEWT:2711","NEWT:537457","NEWT:479249","NEWT:435623","NEWT:33889","NCBITaxon:131567","NEWT:10306","NEWT:12967","NEWT:8022","NEWT:12966","NEWT:42353","NEWT:593117","NEWT:3633","NEWT:319761","NEWT:3635","NEWT:5811","NEWT:86662","NEWT:43658","NEWT:180923","NEWT:2050920","NEWT:1451","NEWT:198215","NEWT:200298","NEWT:12916","NEWT:1400870","NEWT:343","NEWT:178606","NEWT:84005","NEWT:225117","NEWT:34708","NEWT:8090","NEWT:537012","NEWT:5801","NEWT:43665","NEWT:5802","NEWT:4952","NEWT:1266464","NEWT:367830","NEWT:1093790","NEWT:267386","NEWT:178616","NEWT:95145","NEWT:358","NEWT:375451","NEWT:53468","NEWT:54788","NEWT:357","NEWT:74381","NEWT:2010198","NEWT:167539","NCBITaxon:186538","NEWT:457428","NEWT:106178","NEWT:316275","NEWT:84023","NEWT:589904","NEWT:559292","NEWT:316273","NEWT:48092","NEWT:2762","NEWT:1174673","NEWT:28035","NEWT:1313166","NEWT:28034","NEWT:690307","NEWT:323","NEWT:518753","NCBITaxon:138","NEWT:29365","NEWT:28038","NEWT:1422","NEWT:84030","NEWT:1423","NEWT:4932","NEWT:1205903","NEWT:3603","NEWT:2756","NEWT:2759","NEWT:38293","NEWT:1428","NEWT:339","NEWT:2751","NEWT:330","NEWT:139077","NEWT:391904","NEWT:12922","NEWT:316277","NEWT:163159","NEWT:1306413","NEWT:2813599","NEWT:518766","NEWT:2664373","NEWT:190802","NEWT:1213463","NEWT:9899","NEWT:7234","NEWT:9417","NEWT:9894","NEWT:1216979","NEWT:9895","NEWT:7237","NEWT:5059","NEWT:9897","NEWT:2608663","NEWT:55601","NEWT:31631","NEWT:509924","NEWT:28450","NEWT:115104","NEWT:5061","NEWT:7240","NEWT:8570","NEWT:127569","NEWT:5062","NEWT:1408434","NEWT:1241935","NEWT:220668","NEWT:3428464","NEWT:9407","NEWT:7227","NEWT:193079","NEWT:679895","NEWT:9402","NEWT:415540","NEWT:336722","NEWT:675060","NEWT:416870","NEWT:334542","NEWT:313625","NEWT:51240","NEWT:27592","NEWT:5052","NEWT:227289","NEWT:31646","NEWT:1985738","NEWT:7215","NEWT:196139","NEWT:9874","NEWT:5037","NEWT:651182","NEWT:2172103","NCBITaxon:59201","NEWT:7220","NEWT:1876254","NEWT:434271","NEWT:1915","NEWT:747679","NEWT:66712","NEWT:42752","NEWT:746360","NEWT:89764","NEWT:543734","NEWT:53408","NEWT:49390","NEWT:9870","NEWT:256648","NEWT:1261557","NEWT:4182","NEWT:1125722","NEWT:435590","NEWT:1902","NEWT:208526","NEWT:1908","NEWT:1169740","NEWT:217459","NEWT:216129","NEWT:1245012","NEWT:171250","NEWT:347834","NEWT:528135","NEWT:198732","NEWT:8128","NEWT:1637254","NCBITaxon:38727","NEWT:176946","NEWT:74790","NEWT:254472","NEWT:2829","NEWT:126279","NEWT:1228997","NEWT:1428006","NEWT:62335","NEWT:366581","NEWT:757417","NEWT:216599","NEWT:84096","NEWT:216595","NEWT:40559","NEWT:51208","NEWT:216597","NEWT:42736","NEWT:1607839","NEWT:194366","NEWT:1283300","NEWT:1218707","NEWT:198726","NEWT:1204551","NEWT:99586","NEWT:228577","NEWT:2060328","NEWT:48038","NEWT:392021","NEWT:436486","NEWT:51655","NEWT:1933298","NEWT:260707","NEWT:121845","NEWT:8595","NEWT:7263","NEWT:280754","NEWT:225058","NEWT:186763","NEWT:447135","NEWT:185431","NEWT:216591","NEWT:29760","NEWT:260704","NEWT:703612","NEWT:260705","NEWT:1202347","NEWT:1295743","NEWT:546805","NEWT:1505907","NEWT:1216981","NEWT:1249885","NEWT:1972855","NEWT:853","NEWT:7244","NEWT:1415167","NEWT:36036","NCBITaxon:662","NEWT:9430","NEWT:851","NEWT:71251","NEWT:426688","NEWT:208963","NEWT:208964","NEWT:181088","NEWT:48498","NEWT:669202","NEWT:1193806","NEWT:6306","NEWT:1250006","NEWT:4120","NEWT:820","NEWT:821","NEWT:7634","NEWT:137772","NEWT:37334","NCBITaxon:10357","NEWT:2040765","NCBITaxon:10358","NCBITaxon:10359","NEWT:1203258","NEWT:49317","NEWT:1899318","NEWT:696811","NEWT:9808","NEWT:839","NEWT:9809","NEWT:9803","NEWT:1097670","NEWT:9805","NEWT:92519","NEWT:37347","NEWT:943925","NEWT:4111","NEWT:37349","NEWT:4113","NEWT:837","NEWT:640459","NEWT:72568","NEWT:8954","NEWT:36015","NEWT:51641","NEWT:35168","NEWT:81866","NEWT:334147","NEWT:1262469","NEWT:555778","NEWT:277944","NEWT:48479","NEWT:61435","NEWT:627025","NEWT:1097677","NEWT:375939","NEWT:712938","NEWT:3258","NEWT:112018","NEWT:1906951","NEWT:101364","NEWT:52945","NEWT:4100","NEWT:1159556","NEWT:1076","NEWT:4102","NEWT:1028688","NEWT:4101","NEWT:6763","NEWT:803","NEWT:29722","NEWT:37319","NEWT:419947","NEWT:2847306","NEWT:184545","NEWT:468911","NEWT:13373","NEWT:36470","NEWT:266834","NEWT:817","NEWT:7604","NEWT:6756","NEWT:818","NEWT:135588","NEWT:1061","NEWT:4571","NEWT:29719","NEWT:6754","NEWT:452589","NEWT:509068","NEWT:2794344","NEWT:4577","NEWT:813","NEWT:1365218","NEWT:337677","NEWT:2086510","NEWT:1042986","NEWT:1911079","NEWT:69373","NEWT:427577","NCBITaxon:620","NEWT:264203","NEWT:1480154","NEWT:9858","NEWT:9859","NEWT:512623","NEWT:1274414","NEWT:2907833","NEWT:38626","NEWT:10298","NEWT:10299","NEWT:9850","NEWT:1087439","NEWT:9852","NEWT:357231","NEWT:9860","NEWT:660025","NEWT:61408","NEWT:1355477","NEWT:90371","NEWT:55194","NEWT:2907829","NEWT:4153","NEWT:11137","NEWT:1320353","NEWT:9844","NEWT:278839","NEWT:59552","NEWT:35128","NEWT:39966","NEWT:7668","NEWT:2929635","NEWT:58228","NEWT:915099","NEWT:8996","NEWT:1143193","NEWT:681376","NEWT:687914","NEWT:1122233","NEWT:277988","NEWT:1199150","NEWT:859313","NEWT:59540","NEWT:52904","NEWT:9837","NEWT:9838","NEWT:9839","NEWT:546414","NEWT:11167","NEWT:9835","NEWT:7650","NEWT:4146","NEWT:5478","NEWT:37751","NEWT:6326","NEWT:7656","NEWT:5476","NEWT:5477","NEWT:322159","NEWT:1882945","NEWT:746707","NEWT:299767","NEWT:28835","NEWT:1206781","NEWT:5480","NEWT:1274432","NEWT:222863","NEWT:2053667","NEWT:859321","NEWT:1274426","NEWT:105751","NEWT:9825","NEWT:1274423","NEWT:393765","NEWT:104421","NEWT:39946","NEWT:9823","NEWT:95602","NEWT:6313","NEWT:314539","NEWT:39947","NEWT:382641","NEWT:718274","NEWT:1274420","NEWT:859314","NEWT:578458","NEWT:60520"],"pubmed":["42573571"]}}