{"database":"Pride","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Txt":["ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD063105/proteinGroups.txt"],"Xml":["ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD063105/mqpar.xml"],"Raw":["ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD063105/240524_organoid_EV_iTRAQ_26mM_2_1.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD063105/240604_organoid_EV_iTRAQ_28mM_3_1.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD063105/240524_organoid_EV_iTRAQ_30mM_1_1.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD063105/240524_organoid_EV_iTRAQ_1000mM_1_2.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD063105/240524_organoid_EV_iTRAQ_20mM_1_2.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD063105/240524_organoid_EV_iTRAQ_100mM_1_1.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD063105/240604_organoid_EV_iTRAQ_100mM_3_2.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD063105/240604_organoid_EV_iTRAQ_28mM_3_2.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD063105/240524_organoid_EV_iTRAQ_26mM_2_2.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD063105/240524_organoid_EV_iTRAQ_60mM_2_2.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD063105/240604_organoid_EV_iTRAQ_30mM_3_2.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD063105/240604_organoid_EV_iTRAQ_24mM_3_2.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD063105/240524_organoid_EV_iTRAQ_20mM_1_1.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD063105/240524_organoid_EV_iTRAQ_1000mM_1_1.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD063105/240524_organoid_EV_iTRAQ_60mM_2_1.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD063105/240524_organoid_EV_iTRAQ_1000mM_2_1.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD063105/240524_organoid_EV_iTRAQ_100mM_2_1.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD063105/240604_organoid_EV_iTRAQ_60mM_3_2.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD063105/240604_organoid_EV_iTRAQ_30mM_3_1.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD063105/240524_organoid_EV_iTRAQ_26mM_1_2.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD063105/240524_organoid_EV_iTRAQ_28mM_2_2.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD063105/240604_organoid_EV_iTRAQ_60mM_3_1.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD063105/240524_organoid_EV_iTRAQ_60mM_1_2.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD063105/240524_organoid_EV_iTRAQ_30mM_1_2.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD063105/240524_organoid_EV_iTRAQ_100mM_1_2.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD063105/240524_organoid_EV_iTRAQ_26mM_1_1.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD063105/240604_organoid_EV_iTRAQ_1000mM_3_2.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD063105/240524_organoid_EV_iTRAQ_30mM_2_2.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD063105/240604_organoid_EV_iTRAQ_26mM_3_2.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD063105/240524_organoid_EV_iTRAQ_24mM_2_2.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD063105/240604_organoid_EV_iTRAQ_0mM_3_2.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD063105/240524_organoid_EV_iTRAQ_60mM_1_1.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD063105/240524_organoid_EV_iTRAQ_28mM_1_2.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD063105/240524_organoid_EV_iTRAQ_0mM_1_2.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD063105/240524_organoid_EV_iTRAQ_30mM_2_1.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD063105/240604_organoid_EV_iTRAQ_26mM_3_1.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD063105/240524_organoid_EV_iTRAQ_24mM_2_1.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD063105/240524_organoid_EV_iTRAQ_1000mM_2_2.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD063105/240524_organoid_EV_iTRAQ_20mM_2_2.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD063105/240524_organoid_EV_iTRAQ_28mM_2_1.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD063105/240604_organoid_EV_iTRAQ_0mM_3_1.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD063105/240524_organoid_EV_iTRAQ_100mM_2_2.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD063105/240524_organoid_EV_iTRAQ_0mM_1_1.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD063105/240604_organoid_EV_iTRAQ_1000mM_3_1.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD063105/240524_organoid_EV_iTRAQ_20mM_2_1.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD063105/240604_organoid_EV_iTRAQ_24mM_3_1.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD063105/240604_organoid_EV_iTRAQ_20mM_3_2.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD063105/240604_organoid_EV_iTRAQ_100mM_3_1.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD063105/240524_organoid_EV_iTRAQ_0mM_2_2.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD063105/240604_organoid_EV_iTRAQ_20mM_3_1.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD063105/240524_organoid_EV_iTRAQ_24mM_1_1.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD063105/240524_organoid_EV_iTRAQ_0mM_2_1.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD063105/240524_organoid_EV_iTRAQ_28mM_1_1.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD063105/240524_organoid_EV_iTRAQ_24mM_1_2.raw"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"labhead_mail":["djkang@kriss.re.kr"],"submitter":["Young Eun Kim"],"technology_type":["Data-dependent acquisition","Mass Spectrometry"],"software":[""],"submitter_keywords":["Exosome","Cerebral organoids","Proteome"],"full_dataset_link":["https://www.ebi.ac.uk/pride/archive/projects/PXD063105"],"tissue":["Brain"],"sample_protocol":["Each fraction of exosomes obtained from cerebral organoids were resuspended in lysis buffer consisting of 8 M urea, 75 mM NaCl, 50 mM Tris-HCl (pH 8.0], and protease inhibitors, and homogenized using an ultrasonic homogenizer. The lysates were centrifuged at 14,000 xg for 15 min at 4 °C, and the supernatants containing exosomal proteins were collected for further analysis. Protein concentrations were measured using a bicinchoninic acid (BCA) assay. Equal amounts of protein (50 μg) from each sample were reduced by incubation with 10 mM dithiothreitol (DTT) for 2 h at 37 °C, followed by alkylation with 20 mM iodoacetamide (IAA) for 30 min at room temperature in the dark. The alkylation reaction was quenched by adding 20 mM L-cysteine. The urea concentration was then diluted to 1 M with 50 mM ammonium bicarbonate buffer, proteins were digested with sequencing-grade modified trypsin (1/50, enzyme/protein) for 18 h at 37 °C. After digestion, the peptide mixtures were acidified with 1% formic acid (v/v) to terminate the reaction and desalted using Oasis HLB SPE cartridges. The eluted peptides were then dried in a centrifugal vacuum concentrator. The resulting digests from each sample were labeled using 8-plex iTRAQ reagents, following the manufacturer’s instructions. The labeled peptides were then pooled, desalted using OASIS HLB cartridges, and dried under vacuum. Subsequently, the dried peptides were reconstituted in 0.1% (v/v) formic acid and subjected to two-dimensional nanoflow liquid chromatography-tandem mass spectrometry (2D-nLC-MS/MS) analysis. For each condition, three biological replicates were prepared and analyzed in duplicate using 2D-nLC-MS/MS."],"repository":["Pride"],"quantification_method":[""],"modification":[""],"data_protocol":["The MS raw files were analyzed using MaxQuant software version 1.6.6.0 (Max Planck Institute, Munich, Germany) with the Andromeda search engine, against a UniProt Homo sapiens database (March 2021 release, containing 78,120 entries). The analysis was performed with the “Reporter ion MS2” search type, with 8-plex iTRAQ for isobaric label quantification. The iTRAQ tags used were as follows: 113-tag for F1, 114-tag for F2, 119-tag for F3 and 121-tag for F4. The following search parameters were applied: trypsin was chosen as the enzyme, with a maximum of two missed cleavages allowed; precursor ion mass tolerance was set to 4.5 ppm, and fragment ion mass tolerance was set to 20 ppm; carbamidomethylation of cysteine (C) was specified as a fixed modification; oxidation of methionine (M) and acetylation of the N-terminus were set as variable modifications. The false discovery rate (FDR) threshold was set to 1% for both peptide and protein levels. Proteins identified only by site and reverse hits were excluded, and only proteins with a minimum of two unique peptides were included for further analysis."],"omics_type":["Proteomics"],"labhead":["Dukjin Kang"],"instrument_platform":[""],"labhead_affiliation":["Group for Biometrology, Korea Research Institute of Standards and Science (KRISS), 267 Gajeong-ro, Yuseong-gu, Daejeon 34113, Republic of Korea"],"submission_type":["PARTIAL"],"species":["Homo Sapiens (human)"],"submitter_mail":["yekim1125@gmail.com"],"publication":["41918234 Kim YE, Kim SS, Lee J, Park SB, Jo JH, Cho HJ, Choi KJ, Im J, Seo WR, Park Y, Kim S, Bae MA, Kim KY, Cho SH, Kang D, Koh B. Comparative Multiomics Analysis of Cerebral Organoid-Derived Exosomes during Organoid Maturation. Nano Lett. 2026 26(14):4554-4563 10.1021/acs.nanolett.5c04673"],"submitter_affiliation":["Center for Bioanalysis, Division of Chemical and Medical Metrology, Korea Research Institute of Standards and Science, Daejeon 34113, Republic of Korea"],"submitter_country":["South Korea"],"pubmed_abstract":["Cerebral organoids derived from human pluripotent stem cells recapitulate key features of early brain development and provide a physiologically relevant model for neurogenesis. Exosomes secreted by these organoids carry bioactive cargo and offer a noninvasive means to monitor maturation and intercellular communication. We performed comprehensive multiomics profiling of exosomes collected from cerebral organoids at defined developmental stages to evaluate their utility as biomarkers of neuronal differentiation. Metabolomic analysis revealed a progressive decline in amino acids, including glutamic acid, consistent with increased metabolic demand during neurogenesis. Lipidomic and neurosteroid profiling showed dynamic increases in phosphatidylethanolamine and pregnenolone, reflecting synaptic membrane formation and signaling. Transcriptomic and proteomic analyses identified stage-specific neurodevelopmental signatures, with key markers mirroring those of parent organoids. Collectively, cerebral organoid-derived exosomes faithfully reflect organoid maturation and provide a robust platform for tracking in vitro brain development."],"pubmed_title":["Comparative Multiomics Analysis of Cerebral Organoid-Derived Exosomes during Organoid Maturation."],"pubmed_authors":["Kim Young Eun YE, Kim Seong Soon SS, Lee Jangjae J, Park Sung Bum SB, Jo Jeong Hyeon JH, Cho Hye Jin HJ, Choi Kyoung Jin KJ, Im Jeonghui J, Seo Woo Rin WR, Park Yeonji Y, Kim Sunghwan S, Bae Myung-Ae MA, Kim Ki Young KY, Cho Sung-Hee SH, Kang Dukjin D, Koh Byumseok B"],"additional_accession":[]},"is_claimable":false,"name":"Proteomic analysis of Cerebral organoid-derived exsome","description":"In this study, we provides a comprehensive analysis of proteomic changes in exosomes derived from cerebral organoids during neuronal differentiation.","dates":{"publication":"2026-04-27","submission":"2025-04-18"},"accession":"PXD063105","cross_references":{"TAXONOMY":["NEWT:3555","NEWT:71647","NEWT:330879","NEWT:260201","NEWT:35554","NCBITaxon:12939","NEWT:32046","NEWT:544496","NEWT:59529","NEWT:2042546","NEWT:32049","NEWT:1392696","NEWT:259447","NEWT:295546","NEWT:45351","NEWT:445974","NEWT:43179","NEWT:180454","NEWT:5722","NCBITaxon:1280","NEWT:112503","NEWT:1129","NEWT:309807","NEWT:10245","NEWT:55153","NEWT:89184","NEWT:309800","NEWT:281395","NEWT:1211601","NEWT:876138","NEWT:44271","NEWT:193516","NEWT:351581","NEWT:43186","NEWT:428146","NEWT:1117","NEWT:498257","NEWT:10036","NEWT:1590","NEWT:498019","NEWT:1351","NEWT:1438992","NEWT:1352","NEWT:2649997","NEWT:1147161","NEWT:661410","NEWT:638632","NEWT:43150","NEWT:263737","NEWT:224326","NEWT:1333499","NEWT:376619","NCBITaxon:79857","NEWT:1096976","NEWT:5702","NEWT:95648","NEWT:1589","NEWT:135622","NEWT:1349","NEWT:35786","NEWT:1580","NEWT:399784","NEWT:96731","NEWT:383379","NEWT:1401257","NEWT:418106","NEWT:10029","NEWT:913645","NEWT:44491","NEWT:641809","NEWT:27933","NEWT:556484","NEWT:317447","NEWT:4688","NEWT:7955","NEWT:7719","NEWT:7959","NEWT:2261","NEWT:868565","NEWT:135674","NEWT:94323","NEWT:31156","NEWT:3112","NEWT:79329","NEWT:4442","NEWT:192875","NEWT:30069","NEWT:12637","NEWT:59729","NEWT:2164133","NEWT:284218","NEWT:295105","NEWT:108061","NEWT:60711","NEWT:1316931","NEWT:224308","NEWT:3347","NEWT:511145","NEWT:160621","NEWT:212790","NEWT:931281","NEWT:4432","NEWT:5762","NEWT:5763","NEWT:658457","NEWT:1310161","NEWT:77133","NEWT:295358","NEWT:145481","NEWT:1310165","NEWT:29058","NCBITaxon:79824","NEWT:2246","NEWT:2652724","NEWT:5757","NEWT:68415","NCBITaxon:4563","NEWT:5755","NEWT:44688","NEWT:44689","NEWT:44447","NEWT:752555","NEWT:498211","NEWT:5759","NEWT:347256","NEWT:1736231","NEWT:5518","NEWT:398007","NEWT:1527468","NEWT:1392","NEWT:498217","NEWT:498216","NEWT:2242","NEWT:11320","NEWT:286","NEWT:391619","NEWT:246196","NEWT:287","NEWT:246197","NEWT:145458","NEWT:633149","NEWT:1149786","NEWT:10239","NEWT:68895","NEWT:44685","NEWT:161934","NEWT:4897","NEWT:1148","NEWT:5744","NEWT:72901","NEWT:213863","NEWT:5508","NEWT:3329","NEWT:5507","NEWT:410661","NEWT:55571","NEWT:35500","NEWT:1140","NCBITaxon:2157","NEWT:1143","NEWT:4896","NEWT:1287689","NEWT:1390","NEWT:11557","NEWT:1094343","NEWT:1462472","NEWT:1336795","NEWT:644042","NEWT:294","NEWT:1773","NEWT:1182590","NEWT:3712","NEWT:82380","NEWT:3711","NEWT:935293","NEWT:375146","NEWT:2065263","NEWT:177437","NEWT:1772","NEWT:10418","NEWT:118698","NEWT:1616117","NEWT:263","NEWT:118696","NEWT:34865","NEWT:52283","NEWT:11988","NEWT:284812","NEWT:8175","NEWT:400667","NEWT:43330","NEWT:1603293","NEWT:408169","NEWT:44664","NEWT:47946","NEWT:3702","NEWT:1245466","NEWT:243277","NEWT:1246791","NEWT:7067","NEWT:118694","NEWT:586722","NEWT:2850","NEWT:118691","NEWT:34871","NEWT:33548","NEWT:274","NEWT:7070","NCBITaxon:287","NEWT:408172","NEWT:408170","NEWT:96794","NEWT:3708","NEWT:332648","NEWT:44670","NEWT:536231","NEWT:376219","NEWT:219813","NEWT:1510","NEWT:1436733","NEWT:460519","NEWT:1247411","NEWT:1515","NEWT:572307","NEWT:1432138","NEWT:1424507","NEWT:1194599","NEWT:272844","NEWT:1303443","NEWT:333760","NEWT:485","NEWT:34607","NEWT:56636","NEWT:1513458","NEWT:1233681","NCBITaxon:40559","NEWT:506599","NEWT:2853422","NEWT:81077","NEWT:84588","NEWT:1679718","NEWT:480","NEWT:65349","NEWT:67767","NEWT:46835","NEWT:109757","NEWT:582580","NEWT:300852","NEWT:1502","NEWT:128017","NEWT:376686","NEWT:95486","NEWT:508771","NEWT:1883446","NEWT:253","NCBITaxon:2759","NEWT:1233435","NEWT:93061","NEWT:93062","NEWT:34613","NCBITaxon:4932","NEWT:109760","NEWT:29031","NEWT:943274","NEWT:644223","NEWT:1263082","NEWT:235443","NEWT:108458","NEWT:5936","NEWT:272623","NEWT:272624","NEWT:320637","NEWT:886559","NEWT:3750","NEWT:55521","NEWT:983964","NEWT:118499","NEWT:11706","NEWT:32644","NEWT:527796","NEWT:1130798","NEWT:55529","NEWT:499175","NEWT:109779","NEWT:3745","NEWT:1715989","NCBITaxon:4751","NEWT:476272","NEWT:3747","NEWT:195051","NEWT:3988","NEWT:1116234","NEWT:561007","NEWT:1255228","NEWT:649908","NEWT:410289","NEWT:373153","NEWT:3983","NEWT:203696","NEWT:472","NEWT:352472","NEWT:97441","NEWT:1071661","NEWT:1202531","NEWT:1202532","NEWT:360094","NEWT:1408223","NEWT:470","NEWT:1408224","NEWT:41364","NEWT:5911","NEWT:1313","NEWT:1218097","NEWT:1080348","NCBITaxon:50557","NEWT:1314","NEWT:39251","NEWT:39491","NEWT:212142","NCBITaxon:5811","NEWT:29491","NEWT:101841","NEWT:153481","NEWT:2014887","NEWT:33952","NEWT:445","NEWT:153009","NEWT:261756","NEWT:571256","NEWT:40483","NEWT:63366","NEWT:63367","NEWT:688333","NEWT:215402","NCBITaxon:548681","NEWT:318586","NCBITaxon:5820","NEWT:1547","NEWT:272634","NEWT:198107","NEWT:9031","NEWT:27292","NEWT:1872122","NEWT:1308","NEWT:7091","NEWT:1034015","NEWT:760568","NEWT:141262","NEWT:108931","NEWT:1293497","NEWT:1055524","NEWT:4087","NEWT:9778","NEWT:306","NEWT:150475","NEWT:303","NEWT:267872","NEWT:97477","NEWT:7111","NEWT:347515","NEWT:172269","NEWT:9534","NEWT:6269","NEWT:5180","NEWT:256737","NEWT:4090","NEWT:4092","NEWT:9541","NEWT:8694","NEWT:4093","NEWT:33936","NEWT:4096","NEWT:8692","NEWT:2903","NEWT:185579","NEWT:941442","NEWT:536088","NEWT:13076","NEWT:1226408","NEWT:7108","NEWT:40479","NEWT:43989","NEWT:4076","NEWT:142615","NEWT:317","NEWT:1006581","NEWT:33940","NEWT:885318","NEWT:39488","NEWT:550","NEWT:4081","NEWT:273068","NEWT:554","NEWT:98334","NEWT:451516","NEWT:552","NEWT:231663","NEWT:4084","NEWT:1325291","NEWT:63577","NEWT:36185","NEWT:1225786","NEWT:7574","NEWT:1715256","NEWT:30640","NEWT:575412","NEWT:929793","NEWT:1507179","NEWT:29204","NEWT:28112","NEWT:114155","NEWT:6494","NEWT:6491","NEWT:507601","NEWT:520","NEWT:186441","NEWT:634955","NEWT:643680","NEWT:214092","NCBITaxon:6157","NEWT:6239","NEWT:13095","NEWT:162425","NEWT:104105","NEWT:216257","NEWT:102169","NEWT:208893","NEWT:9986","NEWT:4054","NEWT:8654","NEWT:8658","NEWT:1268063","NEWT:8657","NEWT:8655","NEWT:5147","NEWT:98351","NEWT:1263854","NEWT:118503","NEWT:2059687","NEWT:160488","NEWT:28104","NEWT:207559","NEWT:407821","NCBITaxon:2","NEWT:85057","NEWT:985076","NEWT:568708","NEWT:1215323","NEWT:986","NEWT:52641","NEWT:7159","NEWT:267671","NEWT:28532","NEWT:7160","NEWT:353152","NEWT:8496","NEWT:7165","NEWT:1257118","NEWT:1387333","NEWT:27448","NEWT:40674","NEWT:1194669","NEWT:235612","NEWT:243230","NEWT:443906","NEWT:1080772","NEWT:519","NEWT:8479","NEWT:8485","NEWT:6063","NEWT:49240","NEWT:1328388","NEWT:1548728","NEWT:667127","NEWT:9557","NEWT:9315","NEWT:6289","NEWT:377586","NEWT:6287","NEWT:38569","NEWT:300641","NEWT:727","NEWT:39655","NEWT:9796","NEWT:9554","NEWT:725","NEWT:7137","NEWT:469008","NEWT:256318","NEWT:9321","NEWT:206411","NCBITaxon:6191","NEWT:596153","NEWT:229533","NEWT:1836","NEWT:214053","NCBITaxon:10298","NEWT:80863","NEWT:90675","NEWT:105231","NEWT:104385","NEWT:74649","NEWT:52638","NEWT:57075","NEWT:206672","NEWT:4097","NEWT:8697","NEWT:8695","NEWT:884204","NEWT:71139","NEWT:9785","NEWT:6279","NEWT:1123869","NEWT:9544","NEWT:9545","NEWT:979","NEWT:7370","NEWT:9793","NEWT:83906","NCBITaxon:780","NCBITaxon:1502","NEWT:6282","NEWT:1134506","NEWT:255470","NEWT:27457","NEWT:38783","NEWT:4006","NEWT:6426","NCBITaxon:5476","NEWT:113208","NEWT:33090","NEWT:6669","NEWT:9935","NEWT:89453","NEWT:287889","NEWT:1114301","NEWT:305959","NEWT:51515","NEWT:13249","NEWT:588596","NEWT:51511","NEWT:8845","NEWT:92867","NEWT:92866","NEWT:419610","NEWT:5334","NEWT:51750","NEWT:202950","NEWT:382352","NEWT:413071","NCBITaxon:10239","NCBITaxon:714","NEWT:295027","NCBITaxon:11320","NEWT:632957","NEWT:11051","NEWT:9925","NEWT:89462","NCBITaxon:9606","NEWT:452680","NEWT:8839","NEWT:90690","NEWT:1436183","NEWT:4232","NEWT:2758385","NEWT:416348","NEWT:11298","NEWT:171101","NEWT:714","NEWT:5322","NEWT:421932","NEWT:312017","NEWT:196627","NEWT:576131","NEWT:200308","NEWT:553470","NEWT:200302","NEWT:870435","NEWT:284593","NEWT:100392","NEWT:655819","NEWT:5315","NEWT:11082","NEWT:9913","NEWT:265872","NEWT:9915","NEWT:105841","NEWT:337330","NEWT:2666255","NEWT:2285","NEWT:2287","NEWT:6645","NEWT:999810","NCBITaxon:5693","NEWT:28995","NEWT:1392998","NEWT:380394","NEWT:981087","NEWT:180066","NEWT:226900","NEWT:1266738","NEWT:231490","NEWT:244704","NEWT:7725","NCBITaxon:6312","NEWT:11072","NEWT:430615","NEWT:72664","NEWT:174633","NEWT:326423","NEWT:452467","NEWT:198822","NEWT:36111","NEWT:326424","NEWT:1416333","NEWT:35024","NEWT:135461","NEWT:1678078","NEWT:7962","NEWT:749906","NEWT:418985","NEWT:1817808","NEWT:749907","NEWT:150847","NEWT:145262","NEWT:145263","NEWT:431947","NEWT:69014","NEWT:142809","NEWT:694569","NEWT:130821","NEWT:27606","NEWT:9739","NEWT:1519788","NEWT:59202","NEWT:9975","NEWT:8643","NEWT:1159899","NEWT:51953","NEWT:502780","NEWT:57267","NEWT:3197","NEWT:13686","NEWT:2750454","NEWT:860688","NEWT:13443","NEWT:8644","NEWT:1402135","NEWT:36329","NEWT:62615","NEWT:5141","NEWT:46360","NCBITaxon:3044782","NEWT:202914","NEWT:1333550","NEWT:160235","NEWT:502779","NEWT:297246","NEWT:72407","NEWT:8639","NEWT:1928434","NEWT:8637","NEWT:349741","NEWT:1114970","NEWT:409859","NEWT:157295","NEWT:2096","NEWT:1263871","NEWT:509169","NEWT:192222","NEWT:9721","NEWT:137221","NEWT:9963","NEWT:1617910","NEWT:565050","NEWT:409860","NEWT:2785785","NEWT:411901","NEWT:8626","NEWT:105884","NCBITaxon:9615","NEWT:8621","NEWT:58334","NEWT:452659","NEWT:1193501","NEWT:58331","NEWT:6689","NEWT:8624","NEWT:5116","NEWT:8623","NEWT:5597","NCBITaxon:12637","NEWT:298315","NEWT:46105","NEWT:8618","NEWT:70448","NEWT:9704","NEWT:1049056","NEWT:698936","NEWT:1009874","NEWT:4498","NEWT:8855","NEWT:9940","NEWT:3168","NEWT:10185","NEWT:1247190","NEWT:521001","NEWT:192011","NEWT:1813887","NEWT:118702","NEWT:118700","NEWT:2126719","NEWT:224911","NEWT:118705","NCBITaxon:11552","NEWT:334249","NEWT:6945","NEWT:184922","NEWT:6703","NEWT:2104","NEWT:6943","NEWT:2","NEWT:157546","NEWT:35670","NEWT:511693","NEWT:870726","NEWT:4528","NEWT:91374","NEWT:91373","NEWT:474186","NEWT:10136","NEWT:38942","NEWT:35677","NEWT:1493","NEWT:10376","NEWT:307972","NEWT:1496","NEWT:2102","NEWT:3674","NEWT:660469","NEWT:935568","NEWT:34","NEWT:1365186","NEWT:38949","NEWT:45474","NEWT:1299114","NEWT:1590841","NEWT:2282334","NEWT:4513","NEWT:1247","NEWT:70667","NEWT:869728","NEWT:5843","NEWT:6938","NCBITaxon:39054","NCBITaxon:10407","NEWT:1736309","NEWT:4751","NEWT:10360","NEWT:194963","NEWT:47664","NEWT:260799","NEWT:317548","NEWT:15819","NEWT:109461","NEWT:3654","NEWT:237561","NEWT:1085956","NEWT:5833","NEWT:3659","NEWT:6928","NEWT:1239","NEWT:59620","NEWT:36745","NEWT:499229","NEWT:31298","NEWT:400727","NEWT:1204162","NEWT:272563","NEWT:11009","NEWT:82688","NEWT:5823","NEWT:3885","NEWT:3888","NEWT:5821","NEWT:44139","NEWT:649408","NCBITaxon:4895","NCBITaxon:4896","NEWT:315393","NEWT:6915","NEWT:3649","NEWT:101510","NEWT:28903","NEWT:3880","NEWT:272559","NEWT:216816","NEWT:153151","NEWT:28909","NEWT:515849","NEWT:3641","NEWT:10141","NEWT:95767","NEWT:466585","NEWT:1000589","NEWT:85963","NEWT:85962","NEWT:42197","NEWT:143361","NCBITaxon:5796","NEWT:12993","NEWT:398580","NEWT:4565","NEWT:1264690","NEWT:515619","NEWT:1299","NEWT:316407","NEWT:34305","NEWT:1794699","NCBITaxon:183674","NEWT:83558","NEWT:167387","NEWT:84645","NEWT:44586","NEWT:1123294","NEWT:626528","NEWT:139927","NEWT:4558","NEWT:209285","NEWT:5888","NEWT:211586","NEWT:747078","NEWT:1282","NEWT:1283","NEWT:431241","NEWT:4550","NEWT:1000561","NEWT:2133","NEWT:4555","NEWT:294381","NEWT:197","NEWT:1390363","NEWT:35889","NEWT:406072","NEWT:144030","NEWT:288705","NEWT:29176","NEWT:392815","NEWT:4787","NEWT:751585","NEWT:3217","NEWT:113549","NEWT:4547","NEWT:3218","NEWT:180788","NEWT:556182","NEWT:1270","NEWT:374990","NEWT:1432059","NEWT:154293","NEWT:388919","NEWT:156471","NEWT:4784","NEWT:3694","NEWT:360106","NEWT:156476","NEWT:4543","NEWT:4785","NEWT:210007","NEWT:360104","NEWT:1857017","NEWT:10117","NEWT:10359","NEWT:10116","NEWT:1280","NEWT:10358","NEWT:83333","NEWT:1735272","NEWT:83334","NEWT:109298","NEWT:83332","NEWT:317513","NEWT:580240","NEWT:294128","NEWT:11676","NEWT:100226","NEWT:718308","NEWT:1263","NEWT:4530","NEWT:176299","NEWT:5861","NEWT:54126","NEWT:75058","NEWT:13616","NEWT:296543","NEWT:173","NEWT:316435","NEWT:42157","NEWT:1895","NEWT:1034304","NEWT:105023","NEWT:866628","NEWT:64152","NEWT:4924","NEWT:749200","NEWT:2748","NEWT:8049","NEWT:33892","NEWT:9378","NEWT:990346","NEWT:145953","NEWT:257309","NEWT:100816","NEWT:203124","NEWT:192952","NEWT:1640346","NEWT:230741","NEWT:8296","NEWT:117008","NCBITaxon:1313","NEWT:167748","NEWT:1163394","NEWT:44544","NEWT:529818","NEWT:400540","NEWT:4911","NEWT:645463","NEWT:152480","NEWT:129249","NEWT:1077286","NEWT:943129","NEWT:1221594","NEWT:990119","NEWT:77216","NEWT:1524260","NEWT:1111708","NEWT:227321","NEWT:493760","NEWT:93163","NEWT:281677","NEWT:106590","NEWT:260710","NEWT:257313","NEWT:3827","NEWT:400772","NEWT:128161","NEWT:930945","NEWT:1162296","NEWT:106592","NEWT:106350","NEWT:46704","NEWT:482428","NEWT:1187947","NEWT:269796","NEWT:10312","NCBITaxon:1773","NEWT:54571","NEWT:190304","NEWT:412754","NEWT:9598","NEWT:8030","NEWT:1423772","NEWT:53232","NEWT:1235987","NCBITaxon:2509511","NEWT:1639","NEWT:188229","NEWT:246437","NEWT:3818","NEWT:4909","NEWT:759272","NEWT:432359","NEWT:1182263","NEWT:943146","NEWT:2711","NEWT:537457","NEWT:479249","NEWT:9103","NEWT:715877","NEWT:862238","NEWT:29159","NEWT:1155748","NEWT:10306","NEWT:9595","NEWT:8022","NEWT:6087","NEWT:145943","NEWT:595536","NEWT:240906","NEWT:593117","NEWT:89920","NEWT:29158","NEWT:3633","NEWT:319761","NEWT:3635","NEWT:5811","NEWT:3879","NEWT:180923","NEWT:1328881","NEWT:411483","NEWT:76336","NEWT:3870","NEWT:884019","NEWT:198215","NEWT:411490","NEWT:200298","NEWT:169963","NEWT:1400870","NEWT:587","NEWT:588","NEWT:585","NEWT:343","NEWT:84005","NEWT:225117","NEWT:746128","NEWT:8090","NEWT:5801","NEWT:43665","NEWT:212035","NEWT:5802","NCBITaxon:1653394","NEWT:1266464","NEWT:1205","NEWT:214693","NEWT:367830","NEWT:178616","NEWT:95145","NEWT:358","NEWT:375451","NEWT:357","NEWT:9172","NEWT:2770979","NEWT:2010198","NEWT:1277351","NEWT:1594786","NEWT:457428","NEWT:411469","NEWT:84023","NEWT:1679","NEWT:559292","NEWT:214684","NEWT:569","NEWT:411464","NEWT:411460","NEWT:2762","NEWT:1174673","NEWT:1328426","NEWT:562","NEWT:28035","NEWT:411470","NEWT:1313166","NEWT:2094720","NCBITaxon:2697049","NCBITaxon:138","NEWT:28038","NEWT:294750","NEWT:1663","NEWT:62141","NEWT:1422","NEWT:1423","NEWT:4932","NEWT:3603","NEWT:2756","NEWT:2759","NEWT:3848","NEWT:3847","NEWT:38293","NEWT:1428","NEWT:198466","NEWT:339","NEWT:327159","NEWT:178876","NEWT:1660","NEWT:2751","NEWT:327160","NEWT:573","NEWT:571","NEWT:142479","NEWT:12922","NEWT:163159","NEWT:29595","NEWT:1306413","NEWT:241368","NEWT:2813599","NEWT:518766","NEWT:42528","NEWT:2664373","NEWT:190802","NEWT:1213463","NEWT:9417","NEWT:1216979","NEWT:7237","NEWT:264483","NEWT:509924","NEWT:28450","NEWT:115104","NEWT:1121114","NEWT:5061","NEWT:663","NEWT:8570","NEWT:1081927","NEWT:1238993","NEWT:1408434","NEWT:67825","NEWT:187878","NEWT:1241935","NEWT:220668","NEWT:1821314","NEWT:1249668","NEWT:426430","NEWT:9407","NEWT:37181","NEWT:9646","NEWT:5286","NEWT:7227","NEWT:7469","NEWT:9402","NEWT:9644","NEWT:415540","NEWT:336722","NEWT:675060","NEWT:416870","NEWT:334542","NEWT:313625","NEWT:51240","NEWT:27592","NEWT:5052","NEWT:426428","NEWT:227289","NEWT:63459","NEWT:2652157","NEWT:2652158","NEWT:40324","NEWT:588858","NEWT:9638","NEWT:9639","NCBITaxon:11071","NEWT:242231","NEWT:197221","NEWT:7215","NEWT:528354","NEWT:51453","NEWT:2172103","NCBITaxon:59201","NEWT:7460","NEWT:504457","NEWT:434271","NEWT:392227","NEWT:747679","NEWT:66712","NEWT:42752","NEWT:103372","NEWT:746360","NEWT:862751","NEWT:89764","NEWT:470150","NEWT:9627","NEWT:543734","NEWT:1009714","NEWT:73239","NEWT:38018","NEWT:226186","NEWT:9870","NEWT:8782","NEWT:115357","NEWT:435590","NEWT:1902","NEWT:63436","NEWT:1908","NEWT:1169740","NEWT:13164","NEWT:1601067","NEWT:216129","NEWT:1245012","NEWT:2664179","NEWT:623","NEWT:7038","NEWT:6192","NCBITaxon:1639","NCBITaxon:38727","NEWT:74790","NEWT:2829","NEWT:62335","NEWT:366581","NEWT:757417","NEWT:216599","NEWT:405534","NEWT:216595","NEWT:40559","NEWT:51208","NEWT:216597","NEWT:9689","NEWT:8355","NEWT:633","NEWT:1607839","NEWT:9685","NEWT:7029","NEWT:6182","NEWT:1283300","NEWT:9694","NEWT:1218707","NEWT:186990","NEWT:8364","NEWT:632","NEWT:1204551","NEWT:6183","NEWT:99586","NEWT:630","NCBITaxon:11019","NEWT:334747","NEWT:3907","NEWT:61235","NEWT:392021","NEWT:343691","NEWT:1457551","NEWT:15368","NEWT:1491466","NEWT:436486","NEWT:340188","NEWT:51655","NEWT:1933298","NEWT:170187","NEWT:260707","NEWT:121845","NEWT:8595","NEWT:7263","NEWT:186763","NEWT:185431","NEWT:216591","NEWT:29760","NEWT:260704","NEWT:1719","NEWT:703612","NEWT:260705","NEWT:692672","NEWT:2697049","NEWT:1505907","NEWT:1216981","NEWT:1109443","NEWT:1249885","NEWT:7004","NEWT:9669","NCBITaxon:6073","NEWT:1089448","NEWT:1415167","NEWT:1329349","NEWT:607699","NEWT:6161","NEWT:208963","NEWT:208964","NEWT:27337","NEWT:575584","NEWT:181088","NEWT:185687","NEWT:3039","NEWT:669202","NEWT:2706014","NEWT:8727","NEWT:8726","NEWT:6306","NEWT:10090","NEWT:8729","NEWT:4120","NEWT:8720","NEWT:5693","NEWT:2186","NEWT:8724","NEWT:8723","NEWT:283166","NEWT:37334","NEWT:5697","NEWT:6544","NCBITaxon:10357","NCBITaxon:10114","NCBITaxon:10359","NEWT:1685931","NEWT:1203258","NEWT:242619","NEWT:49317","NEWT:557722","NEWT:160791","NEWT:1353008","NEWT:34073","NEWT:696811","NEWT:402042","NEWT:9808","NEWT:373995","NEWT:8715","NEWT:5689","NEWT:839","NEWT:544404","NEWT:92519","NEWT:2173","NEWT:943925","NEWT:4111","NEWT:37349","NEWT:4113","NEWT:837","NEWT:640459","NEWT:72568","NEWT:36015","NEWT:51641","NEWT:1232801","NEWT:81866","NEWT:1262469","NEWT:5691","NEWT:48479","NEWT:61435","NEWT:627025","NEWT:1097677","NEWT:375939","NEWT:61674","NEWT:2072580","NEWT:669465","NEWT:3258","NEWT:1117957","NEWT:6526","NEWT:112018","NEWT:8709","NEWT:4100","NEWT:1159556","NEWT:5671","NEWT:1076","NEWT:4102","NEWT:4101","NEWT:6763","NEWT:8700","NEWT:803","NEWT:29722","NEWT:1692259","NEWT:1486917","NEWT:2847306","NEWT:468911","NEWT:13373","NEWT:7604","NEWT:6756","NEWT:818","NEWT:135588","NEWT:1843183","NEWT:5661","NEWT:157592","NEWT:1061","NEWT:51866","NEWT:29719","NEWT:58002","NEWT:13136","NEWT:5665","NEWT:6754","NEWT:1179777","NEWT:6997","NEWT:452589","NEWT:509068","NEWT:5666","NEWT:4577","NEWT:813","NEWT:5664","NEWT:2157","NEWT:146479","NEWT:1042986","NEWT:1911079","NEWT:69373","NEWT:1843192","NEWT:206189","NEWT:427577","NEWT:264203","NEWT:1480154","NEWT:9859","NEWT:1274414","NEWT:9612","NEWT:38626","NEWT:1286640","NEWT:38865","NEWT:3077","NEWT:9615","NEWT:10299","NEWT:6100","NEWT:713604","NEWT:112273","NEWT:1087439","NEWT:33178","NEWT:1147787","NEWT:61408","NEWT:1440772","NEWT:1355477","NEWT:8759","NEWT:9605","NEWT:9606","NEWT:90371","NEWT:641501","NEWT:4153","NEWT:9601","NEWT:278839","NEWT:35128","NEWT:39966","NEWT:7668","NEWT:8756","NEWT:915099","NEWT:74940","NEWT:13551","NEWT:10041","NEWT:9600","NEWT:1450511","NEWT:1143193","NEWT:1122233","NEWT:890382","NEWT:174934","NEWT:179392","NEWT:2823525","NEWT:115778","NEWT:59540","NEWT:9838","NEWT:9839","NEWT:546414","NEWT:227086","NEWT:3055","NEWT:11167","NEWT:9835","NEWT:7650","NEWT:4146","NEWT:5478","NEWT:6326","NEWT:7656","NEWT:5476","NEWT:1450520","NEWT:1042311","NEWT:1123352","NEWT:1882945","NEWT:746707","NEWT:299767","NEWT:235909","NEWT:28835","NEWT:1206781","NEWT:47311","NEWT:1274432","NEWT:127785","NEWT:708248","NEWT:2053667","NEWT:1274426","NEWT:104660","NEWT:9825","NEWT:1274423","NEWT:393765","NEWT:652611","NEWT:104421","NEWT:39946","NEWT:9823","NEWT:95602","NEWT:8732","NEWT:763037","NEWT:39947","NEWT:1274420","NEWT:578458","NEWT:60520"],"pubmed":["41918234"]}}