{"database":"Pride","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Tabular":["ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD063729/P3480_fractionated_peptide.tsv","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD063729/P3480_fractionated_psm.tsv","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD063729/P3480_fractionated_ion.tsv","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD063729/P3480_fractionated_protein.tsv"],"Txt":["ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD063729/log_2024-11-08_12-22-14.txt","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD063729/annotation.txt"],"Csv":["ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD063729/metadata.csv"],"Raw":["ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD063729/Zelda_241106_P3480_PH_CG_TMT6_60prc_R1_F12.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD063729/Zelda_241106_P3480_PH_CG_TMT6_60prc_R1_F03.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD063729/Zelda_241106_P3480_PH_CG_TMT6_60prc_R1_F05.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD063729/Zelda_241106_P3480_PH_CG_TMT6_60prc_R1_F10.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD063729/Zelda_241106_P3480_PH_CG_TMT6_60prc_R1_F09.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD063729/Zelda_241106_P3480_PH_CG_TMT6_60prc_R1_F07.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD063729/Zelda_241106_P3480_PH_CG_TMT6_60prc_R1_F02.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD063729/Zelda_241106_P3480_PH_CG_TMT6_60prc_R1_F11.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD063729/Zelda_241106_P3480_PH_CG_TMT6_60prc_R1_F04.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD063729/Zelda_241106_P3480_PH_CG_TMT6_60prc_R1_F08.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD063729/Zelda_241106_P3480_PH_CG_TMT6_60prc_R1_F06.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD063729/Zelda_241106_P3480_PH_CG_TMT6_60prc_R1_F01.raw"],"Fasta":["ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD063729/2024-11-08-decoys-contam-UP000005640_HomoSapiens_ID9606_20594entries_26102022_dl11012023.fasta.fas","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD063729/UP000005640_HomoSapiens_ID9606_20594entries_26102022_dl11012023.fasta"],"Other":["ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD063729/fragpipe-files.fp-manifest","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD063729/FragPipe_workflow.workflow"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"labhead_mail":["cgkogkas@bri.forth.gr"],"submitter":["Frank Stein"],"technology_type":["Data-dependent acquisition","Mass Spectrometry"],"disease":["Parkinson's Disease 1"],"software":[""],"submitter_keywords":["Parkinson's disease (pd)","Translational control","Snca"],"full_dataset_link":["https://www.ebi.ac.uk/pride/archive/projects/PXD063729"],"tissue":["Pluripotent Stem Cell","Cell Culture"],"sample_protocol":["D100 organoids were transferred from culture plates, briefly washed in ice-cold DPBS, centrifuged for 1 min at 600 × g at 4 °C, and DPBS was removed completely. Afterwards, organoids were lysed in a buffer consisting of 4% SDS, 0.1 M DTT,and 0.1 M Tris pH 7.4, supplemented with protease and phosphatase inhibitors. For each biological replicate, 3–4 organoids were pooled and lysed together. Samples were sonicated, heated at 95 °C for 3 min, and centrifuged for 15 min at 16,000 × g. Protein concentration was measured using tryptophan fluorescence. Albumin standards were prepared in a concentration range of 0–2000 μg/ml to generate a standard curve. For each sample, 10 μl of lysate was diluted into 490 μl of urea buffer (8 M urea in 10 mM HEPES pH 8.5) in a quartz cuvette, and absorbance was measured using a spectrofluorometer."],"repository":["Pride"],"quantification_method":[""],"modification":[""],"data_protocol":["For the proteomics data analysis the raw output files of FragPipe (protein.tsv files) were processed using the R programming environment (ISBN 3-900051-07-0). Initial data processing included filtering out contaminants and reverse proteins. Only proteins quantified with at least 2 razor peptides (with Razor.Peptides >= 2) were considered for further analysis. 6289 proteins passed the quality control filters. In order to correct for technical variability, batch effects were removed using the 'removeBatchEffect' function of the limma package (PMID: 25605792) on the log2 transformed raw TMT reporter ion intensities ('channel' columns). Subsequently, normalization was performed using the 'normalizeVSN' function of the limma package (VSN - variance stabilization normalization - PMID: 12169536). Differential expression analysis was performed using the moderated t-test provided by the limma package (PMID: 25605792). The model accounted for replicate information by including it as a factor in the design matrix passed to the 'lmFit' function. Proteins were annotated as hits if they had a false discovery rate (FDR) below 0.05 and an absolute fold change greater than 2. Proteins were considered candidates if they had an FDR below 0.2 and an absolute fold change greater than 1.5. Gene ontology (GO) enrichment analysis was performed using the 'compareCluster' function of the 'clusterProfiler' package (PMID: 22455463), which assesses over-representation of GO terms in the dataset relative to the background gene set. Enrichment was conducted for the following GO categories: Cellular Component (CC), Molecular Function (MF), and Biological Process (BP). The analysis was performed using 'org.Hs.eg.db' as the reference database. The odds ratio ('odds_ratio') for each GO term was calculated by comparing the proportion of genes associated with that term in the dataset ('GeneRatio') to the proportion in the background set ('BgRatio'). An odds ratio greater than 1 indicates that the GO term is enriched in the dataset compared to the expected background."],"omics_type":["Proteomics"],"labhead":["Christos G. Gkogkas"],"instrument_platform":[""],"labhead_affiliation":["Biomedical Research Institute, Foundation for Research and Technology-Hellas, Ioannina, Greece."],"submission_type":["PARTIAL"],"species":["Homo Sapiens (human)"],"submitter_mail":["frank.stein@embl.de"],"publication":["41698927 Statoulla E, Zafeiri M, Chalkiadaki K, Voudouri G, Gkika KS, Papazoglou C, Durcan TM, Khoutorsky A, Jafarnejad SM, Maguire S, Dityatev A, Gkogkas CG. SNCA triplication disrupts proteostasis and extracellular architecture prior to neurodegeneration in human midbrain organoids. NPJ Parkinsons Dis. 2026 12(1):81 10.1038/s41531-026-01292-0"],"submitter_affiliation":["EMBL"],"submitter_country":["Germany"],"additional_accession":[]},"is_claimable":false,"name":"SNCA triplication disrupts proteostasis and extracellular architecture prior to neurodegeneration in human midbrain organoids","description":"Synucleinopathies, including Parkinson’s disease, are characterized by α-synuclein aggregation and progressive neurodegeneration, yet the early molecular events linking SNCA gene dosage to disrupted proteostasis remain poorly understood. Here, we used human midbrain organoids carrying an SNCA triplication (SNCA Trip) and the isogenic corrected line (SNCA Isog) to dissect early pathogenic mechanisms in a 3D human model of synucleinopathy. We combined immunohistochemistry, immunoblotting, tandem mass tag proteomics, bulk RNA sequencing, and ribosome profiling to systematically characterize molecular alterations in SNCA Trip organoids at day 50 (D50) and day 100 (D100) of maturation. SNCA Trip organoids exhibited increased α-synuclein accumulation, neuromelanin deposition, and activation of mTORC1 (p-rpS6), ERK1/2, and p-eIF2α signalling pathways by D100. Proteomic and transcriptomic analyses revealed upregulation of cytoskeletal, synaptic, and axonal development pathways, alongside significant downregulation of extracellular matrix (ECM) components. Ribosome profiling showed minimal global translational changes but uncovered selective translational buffering of neuronal and ECM-associated transcripts. Confocal imaging confirmed progressive disorganization of pericellular and interstitial ECM structures around neurons in SNCA Trip organoids. Our findings demonstrate that SNCA triplication induces early proteostatic disruption and extracellular matrix remodelling prior to neurodegeneration, suggesting that altered translation and ECM homeostasis may contribute to disease initiation and progression. Targeting these early aberrant mechanisms may offer new therapeutic opportunities for synucleinopathies, such as Parkinson’s Disease.","dates":{"publication":"2026-04-06","submission":"2025-05-07"},"accession":"PXD063729","cross_references":{"TAXONOMY":["NEWT:3555","NEWT:71647","NEWT:35554","NEWT:32046","NEWT:544496","NEWT:2042546","NEWT:32049","NEWT:259447","NEWT:45351","NEWT:445974","NEWT:43179","NEWT:180454","NEWT:5722","NEWT:1129","NEWT:55153","NEWT:309800","NEWT:281395","NEWT:1211601","NEWT:876138","NEWT:44271","NEWT:10036","NEWT:498019","NEWT:1351","NEWT:1438992","NEWT:1352","NEWT:2649997","NEWT:1147161","NEWT:224326","NEWT:1333499","NCBITaxon:79857","NEWT:1096976","NEWT:95648","NEWT:1589","NEWT:135622","NEWT:383379","NEWT:10029","NEWT:913645","NEWT:556484","NEWT:317447","NEWT:4688","NEWT:7955","NEWT:7959","NEWT:2261","NEWT:31156","NEWT:4442","NEWT:192875","NEWT:59729","NEWT:2164133","NEWT:1316931","NEWT:224308","NEWT:3347","NEWT:511145","NEWT:931281","NEWT:658457","NEWT:77133","NEWT:145481","NCBITaxon:79824","NCBITaxon:4563","NEWT:5755","NEWT:44689","NEWT:44447","NEWT:5759","NEWT:1736231","NEWT:1392","NEWT:498217","NEWT:2242","NEWT:11320","NEWT:286","NEWT:391619","NEWT:246196","NEWT:287","NEWT:246197","NEWT:10239","NEWT:44685","NEWT:161934","NEWT:1148","NEWT:5508","NEWT:5507","NEWT:55571","NEWT:35500","NEWT:1140","NEWT:1143","NEWT:4896","NEWT:1390","NEWT:11557","NEWT:1094343","NEWT:1336795","NEWT:644042","NEWT:1773","NEWT:1182590","NEWT:3712","NEWT:82380","NEWT:935293","NEWT:375146","NEWT:263","NEWT:52283","NEWT:284812","NEWT:8175","NEWT:43330","NEWT:1603293","NEWT:408169","NEWT:47946","NEWT:3702","NEWT:243277","NEWT:7067","NEWT:2850","NEWT:408172","NEWT:408170","NEWT:3708","NEWT:332648","NEWT:536231","NEWT:1436733","NEWT:460519","NEWT:572307","NEWT:1432138","NEWT:1424507","NEWT:1194599","NEWT:272844","NEWT:1513458","NCBITaxon:40559","NEWT:84588","NEWT:480","NEWT:67767","NEWT:46835","NEWT:109757","NEWT:300852","NEWT:1502","NEWT:376686","NEWT:95486","NEWT:508771","NEWT:1883446","NEWT:253","NCBITaxon:2759","NEWT:1233435","NEWT:93061","NEWT:93062","NCBITaxon:4932","NEWT:644223","NEWT:235443","NEWT:108458","NEWT:272623","NEWT:272624","NEWT:983964","NEWT:118499","NEWT:32644","NEWT:527796","NEWT:499175","NEWT:109779","NEWT:3745","NEWT:1715989","NCBITaxon:4751","NEWT:476272","NEWT:3747","NEWT:195051","NEWT:3988","NEWT:1255228","NEWT:649908","NEWT:410289","NEWT:373153","NEWT:352472","NEWT:1071661","NEWT:360094","NEWT:470","NEWT:41364","NEWT:1313","NEWT:39491","NCBITaxon:5811","NEWT:29491","NEWT:2014887","NEWT:33952","NEWT:571256","NEWT:40483","NEWT:9031","NEWT:1872122","NEWT:7091","NEWT:141262","NEWT:108931","NEWT:1055524","NEWT:9778","NEWT:150475","NEWT:303","NEWT:267872","NEWT:7111","NEWT:347515","NEWT:9534","NEWT:5180","NEWT:256737","NEWT:9541","NEWT:185579","NEWT:941442","NEWT:13076","NEWT:40479","NEWT:317","NEWT:1006581","NEWT:885318","NEWT:39488","NEWT:550","NEWT:4081","NEWT:273068","NEWT:554","NEWT:98334","NEWT:451516","NEWT:36185","NEWT:1225786","NEWT:7574","NEWT:1715256","NEWT:575412","NEWT:929793","NEWT:29204","NEWT:28112","NEWT:6494","NEWT:6491","NEWT:507601","NEWT:643680","NEWT:214092","NCBITaxon:6157","NEWT:6239","NEWT:162425","NEWT:216257","NEWT:102169","NEWT:9986","NEWT:4054","NEWT:1268063","NEWT:1263854","NEWT:118503","NEWT:2059687","NEWT:160488","NEWT:28104","NEWT:407821","NCBITaxon:2","NEWT:985076","NEWT:1215323","NEWT:986","NEWT:52641","NEWT:7159","NEWT:28532","NEWT:353152","NEWT:27448","NEWT:1194669","NEWT:243230","NEWT:1080772","NEWT:519","NEWT:8479","NEWT:6063","NEWT:49240","NEWT:6289","NEWT:6287","NEWT:300641","NEWT:727","NEWT:9796","NEWT:725","NEWT:469008","NEWT:256318","NEWT:206411","NCBITaxon:6191","NEWT:596153","NEWT:1836","NEWT:80863","NEWT:105231","NEWT:52638","NEWT:4097","NEWT:884204","NEWT:9785","NEWT:6279","NEWT:1123869","NEWT:9544","NEWT:7370","NEWT:83906","NCBITaxon:780","NCBITaxon:1502","NEWT:6282","NEWT:1134506","NEWT:38783","NEWT:4006","NEWT:6426","NCBITaxon:5476","NEWT:6669","NEWT:9935","NEWT:89453","NEWT:51515","NEWT:51511","NEWT:8845","NEWT:92867","NEWT:92866","NEWT:5334","NEWT:51750","NEWT:202950","NEWT:382352","NEWT:413071","NEWT:632957","NEWT:9925","NEWT:89462","NEWT:8839","NEWT:4232","NEWT:2758385","NEWT:11298","NEWT:171101","NEWT:714","NEWT:421932","NEWT:312017","NEWT:196627","NEWT:870435","NEWT:284593","NEWT:100392","NEWT:5315","NEWT:9913","NEWT:265872","NEWT:105841","NEWT:337330","NEWT:2666255","NEWT:2285","NCBITaxon:5693","NEWT:1392998","NEWT:380394","NEWT:981087","NEWT:180066","NEWT:226900","NEWT:430615","NEWT:326423","NEWT:452467","NEWT:36111","NEWT:326424","NEWT:1416333","NEWT:1678078","NEWT:749906","NEWT:418985","NEWT:749907","NEWT:145263","NEWT:694569","NEWT:27606","NEWT:9739","NEWT:59202","NEWT:9975","NEWT:51953","NEWT:3197","NEWT:860688","NEWT:13443","NEWT:36329","NEWT:62615","NCBITaxon:3044782","NEWT:160235","NEWT:72407","NEWT:349741","NEWT:157295","NEWT:2096","NEWT:9721","NEWT:137221","NEWT:9963","NEWT:1617910","NEWT:565050","NEWT:2785785","NEWT:411901","NEWT:105884","NCBITaxon:9615","NEWT:58334","NEWT:1193501","NEWT:58331","NEWT:6689","NEWT:70448","NEWT:698936","NEWT:9940","NEWT:521001","NEWT:192011","NEWT:1813887","NEWT:224911","NCBITaxon:11552","NEWT:6945","NEWT:184922","NEWT:6703","NEWT:2104","NEWT:2","NEWT:157546","NEWT:474186","NEWT:38942","NEWT:307972","NEWT:1496","NEWT:2102","NEWT:4513","NEWT:1247","NEWT:6938","NCBITaxon:10407","NEWT:1736309","NEWT:10360","NEWT:47664","NEWT:317548","NEWT:15819","NEWT:3654","NEWT:237561","NEWT:5833","NEWT:6928","NEWT:36745","NEWT:272563","NEWT:82688","NEWT:3885","NEWT:3888","NEWT:5821","NEWT:44139","NCBITaxon:4896","NEWT:6915","NEWT:3649","NEWT:101510","NEWT:28903","NEWT:3880","NEWT:272559","NEWT:28909","NEWT:515849","NEWT:3641","NEWT:466585","NEWT:1000589","NEWT:85963","NEWT:85962","NEWT:143361","NEWT:398580","NEWT:4565","NEWT:1264690","NEWT:515619","NEWT:34305","NCBITaxon:183674","NEWT:167387","NEWT:84645","NEWT:44586","NEWT:626528","NEWT:139927","NEWT:4558","NEWT:209285","NEWT:5888","NEWT:211586","NEWT:747078","NEWT:1282","NEWT:1283","NEWT:431241","NEWT:4550","NEWT:1000561","NEWT:2133","NEWT:294381","NEWT:197","NEWT:1390363","NEWT:288705","NEWT:29176","NEWT:4787","NEWT:3218","NEWT:556182","NEWT:1270","NEWT:374990","NEWT:1432059","NEWT:156471","NEWT:4784","NEWT:360106","NEWT:156476","NEWT:4543","NEWT:360104","NEWT:10117","NEWT:10116","NEWT:1280","NEWT:10358","NEWT:1735272","NEWT:83334","NEWT:83332","NEWT:317513","NEWT:580240","NEWT:294128","NEWT:11676","NEWT:100226","NEWT:4530","NEWT:75058","NEWT:13616","NEWT:296543","NEWT:173","NEWT:316435","NEWT:42157","NEWT:1895","NEWT:1034304","NEWT:105023","NEWT:866628","NEWT:64152","NEWT:4924","NEWT:749200","NEWT:9378","NEWT:990346","NEWT:145953","NEWT:257309","NEWT:100816","NEWT:230741","NCBITaxon:1313","NEWT:44544","NEWT:4911","NEWT:645463","NEWT:129249","NEWT:1077286","NEWT:943129","NEWT:990119","NEWT:1111708","NEWT:227321","NEWT:493760","NEWT:106590","NEWT:260710","NEWT:257313","NEWT:3827","NEWT:400772","NEWT:128161","NEWT:930945","NEWT:106592","NEWT:46704","NEWT:1187947","NEWT:269796","NEWT:10312","NCBITaxon:1773","NEWT:54571","NEWT:9598","NEWT:8030","NEWT:1639","NEWT:188229","NEWT:3818","NEWT:4909","NEWT:759272","NEWT:432359","NEWT:1182263","NEWT:943146","NEWT:2711","NEWT:537457","NEWT:9103","NEWT:29159","NEWT:10306","NEWT:8022","NEWT:145943","NEWT:595536","NEWT:240906","NEWT:593117","NEWT:89920","NEWT:29158","NEWT:3635","NEWT:5811","NEWT:180923","NEWT:411483","NEWT:884019","NEWT:198215","NEWT:411490","NEWT:169963","NEWT:225117","NEWT:746128","NEWT:43665","NEWT:1266464","NEWT:367830","NEWT:178616","NEWT:375451","NEWT:357","NEWT:411469","NEWT:84023","NEWT:1679","NEWT:559292","NEWT:411464","NEWT:411460","NEWT:2762","NEWT:1174673","NEWT:1328426","NEWT:562","NEWT:411470","NEWT:2094720","NCBITaxon:2697049","NCBITaxon:138","NEWT:28038","NEWT:1663","NEWT:1423","NEWT:4932","NEWT:3603","NEWT:2759","NEWT:3847","NEWT:38293","NEWT:1428","NEWT:327159","NEWT:178876","NEWT:1660","NEWT:327160","NEWT:573","NEWT:571","NEWT:241368","NEWT:42528","NEWT:2664373","NEWT:190802","NEWT:9417","NEWT:1216979","NEWT:7237","NEWT:115104","NEWT:1121114","NEWT:663","NEWT:1081927","NEWT:1238993","NEWT:67825","NEWT:187878","NEWT:220668","NEWT:1821314","NEWT:1249668","NEWT:9646","NEWT:5286","NEWT:7227","NEWT:7469","NEWT:9402","NEWT:9644","NEWT:415540","NEWT:675060","NEWT:334542","NEWT:313625","NEWT:27592","NEWT:426428","NEWT:63459","NEWT:588858","NEWT:9639","NCBITaxon:11071","NEWT:242231","NEWT:197221","NEWT:7215","NEWT:2172103","NEWT:7460","NEWT:434271","NEWT:747679","NEWT:42752","NEWT:746360","NEWT:89764","NEWT:470150","NEWT:543734","NEWT:73239","NEWT:38018","NEWT:226186","NEWT:8782","NEWT:115357","NEWT:435590","NEWT:1902","NEWT:1908","NEWT:13164","NEWT:216129","NEWT:2664179","NEWT:623","NEWT:7038","NEWT:6192","NCBITaxon:38727","NEWT:2829","NEWT:366581","NEWT:216599","NEWT:216595","NEWT:40559","NEWT:8355","NEWT:633","NEWT:9685","NEWT:7029","NEWT:1283300","NEWT:186990","NEWT:632","NEWT:6183","NEWT:630","NEWT:334747","NEWT:61235","NEWT:343691","NEWT:15368","NEWT:1491466","NEWT:436486","NEWT:51655","NEWT:170187","NEWT:260707","NEWT:185431","NEWT:29760","NEWT:260704","NEWT:1719","NEWT:703612","NEWT:260705","NEWT:692672","NEWT:2697049","NEWT:7004","NCBITaxon:6073","NEWT:1089448","NEWT:1329349","NEWT:607699","NEWT:208963","NEWT:208964","NEWT:27337","NEWT:575584","NEWT:8727","NEWT:8726","NEWT:10090","NEWT:4120","NEWT:5693","NEWT:2186","NEWT:8724","NEWT:8723","NEWT:37334","NCBITaxon:10359","NEWT:1203258","NEWT:242619","NEWT:49317","NEWT:160791","NEWT:34073","NEWT:373995","NEWT:544404","NEWT:37349","NEWT:4113","NEWT:837","NEWT:5691","NEWT:48479","NEWT:61435","NEWT:627025","NEWT:1097677","NEWT:375939","NEWT:61674","NEWT:1117957","NEWT:6526","NEWT:8709","NEWT:4100","NEWT:1159556","NEWT:5671","NEWT:1076","NEWT:4101","NEWT:6763","NEWT:803","NEWT:29722","NEWT:1692259","NEWT:1486917","NEWT:468911","NEWT:7604","NEWT:818","NEWT:135588","NEWT:1843183","NEWT:5661","NEWT:29719","NEWT:58002","NEWT:6997","NEWT:452589","NEWT:4577","NEWT:5664","NEWT:2157","NEWT:146479","NEWT:1042986","NEWT:1911079","NEWT:69373","NEWT:206189","NEWT:264203","NEWT:1480154","NEWT:1274414","NEWT:9612","NEWT:38626","NEWT:38865","NEWT:3077","NEWT:9615","NEWT:10299","NEWT:112273","NEWT:1147787","NEWT:1440772","NEWT:1355477","NEWT:9605","NEWT:9606","NEWT:90371","NEWT:641501","NEWT:4153","NEWT:7668","NEWT:915099","NEWT:74940","NEWT:13551","NEWT:9600","NEWT:1450511","NEWT:1143193","NEWT:174934","NEWT:2823525","NEWT:9838","NEWT:9839","NEWT:3055","NEWT:4146","NEWT:5478","NEWT:6326","NEWT:5476","NEWT:1450520","NEWT:1042311","NEWT:299767","NEWT:28835","NEWT:1274432","NEWT:2053667","NEWT:1274426","NEWT:9825","NEWT:1274423","NEWT:393765","NEWT:39946","NEWT:9823","NEWT:95602","NEWT:8732","NEWT:39947","NEWT:1274420","NEWT:578458"],"pubmed":["41698927"]}}