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Redkar"],"software":[""],"tissue":["Knee","Chondrocyte"],"sample_protocol":["Rat knee joints were dissected, lyophilized for 24 h, and pulverized in 2 mL tubes containing 1.4 mm acid-washed zirconia beads using a bead beater (1200 GenoLyte, SPEX SamplePrep). The powder was resuspended in 50 mM ammonium bicarbonate (ABC), vortexed briefly, pulverized again, and centrifuged at 13,000 g for 5 min at 4 °C to remove the beads. Guanidine extraction buffer (4 M guanidine-HCl, 50 mM sodium acetate, Roche Cocktail, and DTT 0.1 M) was made up in each sample vial such that the final volume remaining was 800 µL and incubated for 24 hours in a cold room on an orbital shaker. The samples were centrifuged at 13,000 × g for 30 minutes at 4 °C, and the supernatant was collected. To the remaining pellet, 200 µL of 0.1% RapiGest extraction buffer (Waters) prepared in 50 mM ammonium bicarbonate (ABC) was added, followed by brief vortexing. The mixture was centrifuged again at 13,000 × g for 30 minutes at 4 °C, and the resulting supernatant was collected. Protein-containing supernatants were desalted using 3 kDa molecular weight cut-off (MWCO) filters (Amicon® Ultra-0.5 Centrifugal Filter Units, Millipore), and protein concentrations were determined using the BCA assay. A total of 100 µg of protein from each sample was digested with trypsin (0.4 µg/µL), and the resulting peptides were purified using C18 columns (Pierce™ C18 Spin Tips, Thermo Fisher Scientific). After speed-vacuum drying, the peptides were reconstituted in 100 µL of 0.1% formic acid prior to LC-MS analysis."],"repository":["Pride"],"labhead":["Vibin Ramakrishnan"],"instrument_platform":[""],"submission_type":["COMPLETE"],"labhead_affiliation":["Professor, Biosciences & Bioengineering. Associate Faculty: MF School of Data Science and Artificial Intelligence  Indian Institute of Technology Guwahati, Assam, India"],"publication":["10.1016/J.JEP.2026.122058"],"submitter_affiliation":["Indian Institute of Technology Guwahati"],"labhead_mail":["vibin@iitg.ac.in"],"technology_type":["Data-dependent acquisition","Mass Spectrometry","Bottom-up proteomics"],"disease":["Osteoarthritis"],"submitter_keywords":["withania somnifera","Knee joint","Data-dependent acquisition","Osteoarthritis; withania somnifera","Rattus norvegicus","Orbitrap eclipse","Lc-ms/ms","Osteoarthritis","Yogaraj guggulu","Label-free proteomics"],"full_dataset_link":["https://www.ebi.ac.uk/pride/archive/projects/PXD065118"],"quantification_method":[""],"modification":[""],"data_protocol":["Raw data files were analyzed using Proteome Discoverer version 2.5.0.400 (Thermo Fisher Scientific). Spectra were searched against the UniProt rat protein database retrieved on 24-01-05 using the Sequest HT search engine. The precursor mass tolerance was set to 20 ppm, and the fragment mass tolerance to 0.6 Da. Enzyme specificity was set to trypsin, allowing up to two missed cleavages, with a minimum peptide length of 6 and a maximum of 144 amino acids. Carbamidomethylation of cysteine (+57.021 Da) was specified as a static modification, while oxidation of methionine (+15.995 Da) and N-terminal acetylation (+42.011 Da) were set as dynamic modifications. Peptide identification was refined using the Percolator node, employing a target-decoy approach to control the false discovery rate (FDR). Strict and relaxed FDR thresholds were set at 1% and 5%, respectively. Peptides were further processed using the Minora Feature Detector node for label-free quantification, with a minimum trace length of 5, signal-to-noise threshold of 1, and a maximum isotope pattern retention time deviation of 0.2 minutes."],"omics_type":["Proteomics"],"species":["Rattus Norvegicus (rat)"],"submitter_mail":["amay@iitg.ac.in"],"submitter_country":["India"],"doi":["10.6019/PXD065118"],"additional_accession":[]},"is_claimable":false,"name":"Label-free quantitative proteomics of rat knee-joint tissue in a monosodium-iodoacetate osteoarthritis model treated with the Ayurvedic formulations","description":"Osteoarthritis (OA) causes progressive cartilage and bone degradation for which no disease-modifying therapy exists. Withania somnifera (WS) and Yogaraj Guggulu (YG) are centuries-old herbal formulation used in Ayurveda for joint disorders, but its molecular mode of action is poorly defined. We performed label-free LC-MS/MS proteomics on rat knee-joint tissue to uncover pathways modulated by oral WS and YG in an MIA-induced OA model. Eighty male Sprague-Dawley rats were randomised into normal control, vehicle, disease control, diclofenac (standard), three YG dose groups (low, medium, high) and three WS groups (low, medium, high). WS or YG or vehicle was given orally for 21 days after OA induction (5 mg MIA, intra-articular). Knee joints were harvested on Day 28, flash-frozen, pulverised and processed for LC-MS/MS. Each biological replicate was injected with three times, resulting in 12 replicates per group. WS and YG normalised multiple OA-dysregulated proteins, dampening NF-κB/IL-17 signalling and collagen-degradation cascades while restoring metabolic and cytoskeletal processes, congruent with micro-CT, histology and behavioural recovery.","dates":{"publication":"2026-06-19","submission":"2025-06-17"},"accession":"PXD065118","cross_references":{"TAXONOMY":["NEWT:3555","NEWT:71647","NEWT:330879","NEWT:35554","NCBITaxon:12939","NEWT:32046","NEWT:544496","NEWT:2042546","NEWT:32049","NEWT:1392696","NEWT:259447","NEWT:295546","NCBITaxon:2719036","NEWT:45351","NEWT:445974","NEWT:43179","NEWT:180454","NEWT:5722","NCBITaxon:1280","NEWT:1129","NEWT:309807","NEWT:10245","NEWT:55153","NEWT:309800","NEWT:281395","NEWT:1211601","NEWT:876138","NEWT:44271","NEWT:193516","NEWT:351581","NEWT:43186","NEWT:428146","NEWT:498257","NEWT:10036","NEWT:1590","NEWT:498019","NEWT:1351","NEWT:1438992","NEWT:1352","NEWT:2649997","NEWT:1147161","NEWT:661410","NEWT:638632","NEWT:263737","NEWT:224326","NEWT:1333499","NCBITaxon:79857","NEWT:1096976","NEWT:5702","NEWT:95648","NEWT:1589","NEWT:135622","NEWT:1349","NEWT:35786","NEWT:1580","NEWT:399784","NEWT:96731","NEWT:383379","NEWT:1401257","NEWT:418106","NEWT:10029","NEWT:913645","NEWT:44491","NEWT:641809","NEWT:27933","NEWT:556484","NEWT:317447","NEWT:4688","NEWT:7955","NEWT:7719","NEWT:7959","NEWT:2261","NEWT:868565","NEWT:31156","NEWT:3112","NEWT:79329","NEWT:4442","NEWT:192875","NEWT:1214915","NEWT:12637","NEWT:59729","NEWT:2164133","NEWT:295105","NEWT:108061","NEWT:60711","NEWT:1316931","NEWT:224308","NEWT:3347","NEWT:511145","NEWT:160621","NEWT:212790","NEWT:931281","NEWT:4432","NEWT:5762","NEWT:5763","NEWT:658457","NEWT:1310161","NEWT:77133","NEWT:295358","NEWT:145481","NCBITaxon:79824","NEWT:2246","NEWT:2652724","NEWT:5757","NCBITaxon:4563","NEWT:5755","NEWT:44689","NEWT:44447","NEWT:752555","NEWT:498211","NEWT:5759","NEWT:347256","NEWT:1736231","NEWT:5518","NEWT:398007","NEWT:1527468","NEWT:1392","NEWT:498217","NEWT:498216","NEWT:2242","NEWT:11320","NEWT:286","NEWT:391619","NEWT:246196","NEWT:287","NEWT:246197","NEWT:145458","NEWT:633149","NEWT:1149786","NEWT:10239","NEWT:68895","NEWT:44685","NEWT:161934","NEWT:4897","NEWT:1148","NEWT:5744","NEWT:5508","NEWT:3329","NEWT:5507","NEWT:410661","NEWT:55571","NEWT:35500","NEWT:1235816","NEWT:1140","NCBITaxon:2157","NEWT:1143","NEWT:4896","NEWT:1287689","NEWT:1390","NEWT:11557","NEWT:1094343","NEWT:1462472","NEWT:1336795","NEWT:644042","NEWT:294","NEWT:1773","NEWT:1182590","NEWT:3712","NEWT:82380","NEWT:3711","NEWT:935293","NEWT:375146","NEWT:270643","NEWT:2065263","NEWT:1772","NEWT:118698","NEWT:1616117","NEWT:263","NEWT:118696","NEWT:52283","NEWT:11988","NEWT:284812","NEWT:8175","NEWT:400667","NEWT:43330","NEWT:1603293","NEWT:408169","NEWT:44664","NEWT:47946","NEWT:459758","NEWT:3702","NEWT:1245466","NEWT:243277","NEWT:1246791","NEWT:7067","NEWT:118694","NEWT:586722","NEWT:2850","NEWT:118691","NEWT:33548","NEWT:274","NEWT:7070","NCBITaxon:287","NEWT:408172","NEWT:408170","NEWT:96794","NEWT:3708","NEWT:332648","NEWT:44670","NEWT:536231","NEWT:376219","NEWT:219813","NEWT:1510","NEWT:1436733","NEWT:460519","NEWT:1247411","NEWT:1515","NEWT:572307","NEWT:1432138","NEWT:1424507","NEWT:1194599","NEWT:272844","NEWT:9483","NEWT:333760","NEWT:56636","NEWT:1513458","NEWT:1233681","NCBITaxon:40559","NEWT:506599","NEWT:2853422","NEWT:81077","NEWT:84588","NEWT:1679718","NEWT:480","NEWT:65349","NEWT:67767","NEWT:46835","NEWT:109757","NEWT:582580","NEWT:300852","NEWT:1502","NEWT:128017","NEWT:376686","NEWT:95486","NEWT:508771","NEWT:1883446","NEWT:253","NCBITaxon:2759","NEWT:1233435","NEWT:93061","NEWT:93062","NEWT:34613","NCBITaxon:4932","NEWT:109760","NEWT:943274","NEWT:644223","NEWT:235443","NEWT:108458","NEWT:5936","NEWT:272623","NEWT:272624","NEWT:320637","NEWT:886559","NEWT:55521","NEWT:983964","NEWT:118499","NEWT:11706","NEWT:32644","NEWT:527796","NEWT:1130798","NEWT:55529","NEWT:499175","NEWT:109779","NEWT:3745","NEWT:1715989","NCBITaxon:4751","NEWT:476272","NEWT:3747","NEWT:195051","NEWT:3988","NEWT:1116234","NEWT:1255228","NEWT:649908","NEWT:410289","NEWT:373153","NEWT:3983","NEWT:203696","NEWT:352472","NEWT:1071661","NEWT:1202532","NEWT:360094","NEWT:470","NEWT:41364","NEWT:5911","NEWT:1313","NEWT:1218097","NCBITaxon:50557","NEWT:39251","NEWT:39491","NEWT:212142","NCBITaxon:5811","NEWT:29491","NEWT:101841","NEWT:2014887","NEWT:33952","NEWT:153009","NEWT:261756","NEWT:571256","NEWT:40483","NEWT:63366","NEWT:63367","NEWT:688333","NEWT:215402","NCBITaxon:548681","NEWT:318586","NCBITaxon:5820","NEWT:1547","NEWT:272634","NEWT:198107","NEWT:9031","NEWT:1872122","NEWT:1308","NEWT:7091","NEWT:1034015","NEWT:760568","NEWT:141262","NEWT:108931","NEWT:1055524","NEWT:4087","NEWT:9778","NEWT:306","NEWT:150475","NEWT:303","NEWT:267872","NEWT:97477","NEWT:7111","NEWT:347515","NEWT:172269","NEWT:9534","NEWT:6269","NEWT:5180","NEWT:256737","NEWT:4090","NEWT:4092","NEWT:9541","NEWT:8694","NEWT:4093","NEWT:4096","NEWT:8692","NEWT:2903","NEWT:185579","NEWT:941442","NEWT:536088","NEWT:13076","NEWT:1226408","NEWT:7108","NEWT:40479","NEWT:43989","NEWT:4076","NEWT:142615","NEWT:317","NEWT:1006581","NEWT:885318","NEWT:39488","NEWT:550","NEWT:4081","NEWT:273068","NEWT:554","NEWT:98334","NE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