Prideapplication/xmlftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD065122/report_keratinocyte.tsvftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD065122/report_melanocyte.tsvftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD065122/checksum.txtftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD065122/230825_HeBA_Evo_DIA_ADAR1_n1-9_siADAR1-highCa-5_S1-B11_1_605.d.7zftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD065122/240704_HeBA_nE_TTP_DIA_ADAR-mel_n1-6_sh_3_12192.d.7zftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD065122/230825_HeBA_Evo_DIA_ADAR1_n1-9_scr-lowCa-5_S1-A5_1_585.d.7zftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD065122/230825_HeBA_Evo_DIA_ADAR1_n1-9_scr-lowCa-2_S1-A2_1_582.d.7zftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD065122/240704_HeBA_nE_TTP_DIA_ADAR-mel_n1-6_scr_2_12197.d.7zftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD065122/Results_DIA-NN_keratinocyte.7zftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD065122/230825_HeBA_Evo_DIA_ADAR1_n1-9_scr-highCa-3_S1-B3_1_595.d.7zftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD065122/230825_HeBA_Evo_DIA_ADAR1_n1-9_siADAR1-lowCa-6_S1-A12_1_592.d.7zftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD065122/240704_HeBA_nE_TTP_DIA_ADAR-mel_n1-6_sh_5_12194.d.7zftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD065122/230825_HeBA_Evo_DIA_ADAR1_n1-9_siADAR1-highCa-3_S1-B9_1_601.d.7zftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD065122/240704_HeBA_nE_TTP_DIA_ADAR-mel_n1-6_scr_6_12201.d.7zftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD065122/230825_HeBA_Evo_DIA_ADAR1_n1-9_scr-highCa-2_S1-B2_1_594.d.7zftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD065122/230825_HeBA_Evo_DIA_ADAR1_n1-9_scr-highCa-5_S1-B5_1_597.d.7zftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD065122/230825_HeBA_Evo_DIA_ADAR1_n1-9_scr-lowCa-1_S1-A1_1_581.d.7zftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD065122/230825_HeBA_Evo_DIA_ADAR1_n1-9_siADAR1-highCa-1_S1-B7_1_599.d.7zftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD065122/230825_HeBA_Evo_DIA_ADAR1_n1-9_siADAR1-lowCa-5_S1-A11_1_591.d.7zftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD065122/230825_HeBA_Evo_DIA_ADAR1_n1-9_siADAR1-lowCa-3_S1-A9_1_589.d.7zftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD065122/230825_HeBA_Evo_DIA_ADAR1_n1-9_scr-lowCa-6_S1-A6_1_586.d.7zftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD065122/240704_HeBA_nE_TTP_DIA_ADAR-mel_n1-6_scr_1_12196.d.7zftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD065122/Results_DIA-NN_melanocyte.7zftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD065122/240704_HeBA_nE_TTP_DIA_ADAR-mel_n1-6_sh_4_12193.d.7zftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD065122/230825_HeBA_Evo_DIA_ADAR1_n1-9_scr-highCa-1_S1-B1_1_593.d.7zftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD065122/230825_HeBA_Evo_DIA_ADAR1_n1-9_scr-highCa-4_S1-B4_1_596.d.7zftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD065122/230825_HeBA_Evo_DIA_ADAR1_n1-9_scr-lowCa-3_S1-A3_1_583.d.7zftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD065122/230825_HeBA_Evo_DIA_ADAR1_n1-9_siADAR1-highCa-2_S1-B8_1_600.d.7zftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD065122/240704_HeBA_nE_TTP_DIA_ADAR-mel_n1-6_sh_2_12191.d.7zftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD065122/quant_kera.7zftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD065122/230825_HeBA_Evo_DIA_ADAR1_n1-9_siADAR1-lowCa-1_S1-A7_1_587.d.7zftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD065122/230825_HeBA_Evo_DIA_ADAR1_n1-9_scr-lowCa-4_S1-A4_1_584.d.7zftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD065122/quant_mela.7zftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD065122/230825_HeBA_Evo_DIA_ADAR1_n1-9_siADAR1-highCa-6_S1-B12_1_606.d.7zftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD065122/240704_HeBA_nE_TTP_DIA_ADAR-mel_n1-6_scr_3_12198.d.7zftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD065122/240704_HeBA_nE_TTP_DIA_ADAR-mel_n1-6_sh_1_12190.d.7zftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD065122/240704_HeBA_nE_TTP_DIA_ADAR-mel_n1-6_scr_5_12200.d.7zftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD065122/230825_HeBA_Evo_DIA_ADAR1_n1-9_siADAR1-lowCa-4_S1-A10_1_590.d.7zftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD065122/240704_HeBA_nE_TTP_DIA_ADAR-mel_n1-6_scr_4_12199.d.7zftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD065122/230825_HeBA_Evo_DIA_ADAR1_n1-9_siADAR1-lowCa-2_S1-A8_1_588.d.7zftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD065122/230825_HeBA_Evo_DIA_ADAR1_n1-9_scr-highCa-6_S1-B6_1_598.d.7zftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD065122/230825_HeBA_Evo_DIA_ADAR1_n1-9_siADAR1-highCa-4_S1-B10_1_602.d.7zprimaryOK200chiara.guerrera@inserm.frChiara guerreraMass SpectrometryBottom-up proteomicsData-independent acquisitionTimtof proMelanocyteKeratinocyteAdar1https://www.ebi.ac.uk/pride/archive/projects/PXD065122MelanocyteCell CultureKeratinocyteS-Trap digestion for keratinocyte S-TrapTM micro spin column (Protifi, Hutington, USA) digestion was performed on 25µg of keratinocytes whole lysates according to manufacturer’s instructions. Samples were reduced with 20mM TCEP (Tris(2-carboxyethyl) phosphine hydrochloride) and alkylated with 50mM CAA (chloroacetamide) for 5min at 95oC. Aqueous phosphoric acid was then added to a final concentration of 2.5% following by the addition of S-Trap binding buffer (90% aqueous methanol, 100mM TEAB, pH7.1). Mixtures were loaded on S-Trap columns by 30sec centrifugation at 4000xg and five washes with 150µl of binding buffer were performed for thorough SDS elimination. Samples were digested with 1.3µg of trypsin (Promega) at 47°C for 2h and the digested peptides were eluted by subsequent addition of 40µl of 50mM TEAB, 40µl of 0.2% formic acid and 35µl of 50% acetonitrile (ACN). After elution, peptides were vacuum dried and resuspended in 2% ACN, 0.1% formic acid in HPLC-grade water prior to MS analysis. LC-MS/MS analysis for keratinocyte The tryptic peptides were resuspended in 50µL and the concentration was measured using a NanoDrop spectrophotometer at 215nm. A volume corresponding to 400ng was injected on a nanoElute (Bruker Daltonics, Germany) HPLC (high-performance liquid chromatography) system coupled to a timsTOF Pro (Bruker Daltonics, Germany) mass spectrometer. HPLC separation (Solvent A: 0.1% formic acid in water, 2% acetonitrile; Solvent B: 0.1% formic acid in acetonitrile) was carried out at 250nl/min using a packed emitter column (C18, 25cm×75μm 1.6μm) (Ion Optics, Australia) and a 40min elution gradient (2 to 13% solvent B during 19min; 13 to 19% during 7min; 19% to 22% during 4min; 22% to 95% for 3min and finally 95% for 7min to wash the column). Mass-spectrometric data were acquired using the parallel accumulation serial fragmentation (PASEF) acquisition method in data-independent acquisition mode (DIA). The measurements were carried out over the m/z range from 475 to 1000. The range of ion mobilities values were from 0.85 to 1.27 V s/cm2(1/k0). The total cycle time was set to 0.95s and the number of PASEF MS/MS scans was set to 10. S-Trap tryptic digestion for melanocyte S-Trap™ 96-well plate S-TrapTM (Protifi, Hutington, USA) digestion was performed on 200µg of melanocytes whole lysates according to manufacturer’s instructions. Briefly, samples were reduced with 20mM TCEP (Tris(2-carboxyethyl) phosphine hydrochloride) and alkylated with 50mM CAA (chloroacetamide) for 5min at 95oC. Aqueous phosphoric acid was then added to a final concentration of 2.5% following by the addition of S-Trap binding buffer (90% aqueous methanol, 100mM TEAB, pH7.1). Mixtures were then loaded on S-Trap plate. Five washes were performed for thorough SDS elimination. Samples were digested with 10µg of trypsin (Promega) at 47°C for 2h. After elution, peptides were vacuum dried and resuspended in 40µl of 10% ACN, 2% TFA in HPLC-grade water. 2µl were diluted in 2% ACN, 0.1% formic acid in HPLC-grade water for the global proteomics analysis and the remaining 38µl were subjected to phosphopeptide enrichment by titanium dioxide (TiO2) and phosphopeptide purification by graphite carbon (GC). nanoLC-MS/MS analysis - global proteomics for melanocyte 400ng of tryptic peptides were injected on a nanoElute (Bruker Daltonics, Germany) HPLC (high-performance liquid chromatography) system coupled to a timsTOF Pro (Bruker Daltonics, Germany) mass spectrometer. HPLC separation (Solvent A: 0.1% formic acid in water, 2% acetonitrile; Solvent B : 0.1% formic acid in acetonitrile) was carried out at 250nL/min using a packed emitter column (C18, 25 cm×75μm 1.6μm) (Ion Optics, Australia) using a 40min gradient elution (2 to 13% solvent B during 19min; 13 to 19% during 7min; 19% to 22% during 4min; 22% to 95% for 3min and finally 95% for 7min to wash the column). Mass-spectrometric data were acquired using the parallel accumulation serial fragmentation (PASEF) acquisition method in DIA mode. The diaPASEF setting were: mass range from 475 to 1000 m/z, mobility ranges from 0.85 to 1.27 V s/cm2 1/k0, cycle time estimate of 0.95s, mass width of 25Da and 21 mass steps for cycle.PrideData analysis was performed using DIA-NN software (version 1.8.1)(1). A search against the Homo Sapiens database (20,428 entries) was performed using library free workflow. For this purpose, “FASTA digest for library free search/library generation” and “Deep learning spectra, RTs and IMs prediction” options were checked for precursor ion generation. A maximum of 1 trypsin missed cleavages was allowed and the maximum variable modification was set to 2. Carbamidomethylation (Cys) was set as the fixed modification, whereas protein N-terminal methionine excision, methionine oxidation and N-terminal acetylation were set as variable modifications. The peptide length range was set to 7–30 amino acids, precursor charge range 2–4, precursor m/z range 300–1300, and fragment ion m/z range 300–1300. To search the parent mass and fragment ions, accuracy was set to 10 ppm manually. The false discovery rates (FDRs) at the protein and peptide level were set to 1%. Match between runs was allowed. For the quantification strategy, Robust LC (high precision) was used as advised in the software documentation, whereas default settings were kept for the other algorithm parameters. Statistical and bioinformatic analysis were performed with MassDynamics software available at https://massdynamics.com.ProteomicsIda Chiara GuerreraPARTIALPlateforme protéomique Necker, Université Paris Cité - Structure Fédérative de Recherche Necker, INSERM US24/CNRS UAR3633, Paris 75015, France.Homo Sapiens (human)Not availablechiara.guerrera@inserm.frNecker proteomics, INSERMFrancefalseRare ADAR1 loss-of-function variants alter RNA editing and drive interferondependent inflammation in psoriasisIn 4 unrelated pedigrees, we report rare heterozygous loss-of-function ADAR1 mutations cosegregating with autosomal dominant, early onset psoriasis and increased type I interferon (IFN)-stimulated gene (ISG) transcripts in skin lesions and/or blood. We identified 6 additional variants in a psoriasis cohort. Skin single cell transcriptomics identified keratinocytes and melanocytes as key IFN sources. ADAR1 knockdown in keratinocytes and melanocytes, and transduction of ADAR1G1119R and ADAR1P3A alleles in keratinocytes, led to reduced A-to-I RNA editing and upregulation of ISG expression, reversed by JAK1 and TYK2 inhibition, mirroring their clinical benefit in these patients. This set of data defines a new IFN-dependent psoriasis subtype resulting from inborn errors of ADAR1-dependent RNA editing, leading to IFN constitutive dysregulation, and opens new avenues in precision medicine.2026-04-272025-06-17PXD065122NEWT:3555NEWT:71647NEWT:330879NEWT:35554NCBITaxon:12939NEWT:32046NEWT:544496NEWT:2042546NEWT:32049NEWT:1392696NEWT:259447NEWT:295546NEWT:45351NEWT:445974NEWT:43179NEWT:180454NEWT:5722NCBITaxon:1280NEWT:1129NEWT:309807NEWT:10245NEWT:55153NEWT:309800NEWT:281395NEWT:1211601NEWT:876138NEWT:44271NEWT:193516NEWT:351581NEWT:43186NEWT:428146NEWT:498257NEWT:10036NEWT:1590NEWT:498019NEWT:1351NEWT:1438992NEWT:1352NEWT:2649997NEWT:1147161NEWT:661410NEWT:638632NEWT:263737NEWT:224326NEWT:1333499NCBITaxon:79857NEWT:1096976NEWT:5702NEWT:95648NEWT:1589NEWT:135622NEWT:1349NEWT:35786NEWT:1580NEWT:399784NEWT:96731NEWT:383379NEWT:1401257NEWT:418106NEWT:10029NEWT:913645NEWT:44491NEWT:641809NEWT:27933NEWT:556484NEWT:317447NEWT:4688NEWT:7955NEWT:7719NEWT:7959NEWT:2261NEWT:868565NEWT:31156NEWT:3112NEWT:79329NEWT:4442NEWT:192875NEWT:12637NEWT:59729NEWT:2164133NEWT:295105NEWT:108061NEWT:60711NEWT:1316931NEWT:224308NEWT:3347NEWT:511145NEWT:160621NEWT:212790NEWT:931281NEWT:4432NEWT:5762NEWT:5763NEWT:658457NEWT:1310161NEWT:77133NEWT:295358NEWT:145481NCBITaxon:79824NEWT:2246NEWT:2652724NEWT:5757NCBITaxon:4563NEWT:5755NEWT:44689NEWT:44447NEWT:752555NEWT:498211NEWT:5759NEWT:347256NEWT:1736231NEWT:5518NEWT:398007NEWT:1527468NEWT:1392NEWT:498217NEWT:498216NEWT:2242NEWT:11320NEWT:286NEWT:391619NEWT:246196NEWT:287NEWT:246197NEWT:145458NEWT:633149NEWT:1149786NEWT:10239NEWT:68895NEWT:44685NEWT:161934NEWT:4897NEWT:1148NEWT:5744NEWT:5508NEWT:3329NEWT:5507NEWT:410661NEWT:55571NEWT:35500NEWT:1140NCBITaxon:2157NEWT:1143NEWT:4896NEWT:1287689NEWT:1390NEWT:11557NEWT:1094343NEWT:1462472NEWT:1336795NEWT:644042NEWT:294NEWT:1773NEWT:1182590NEWT:3712NEWT:82380NEWT:3711NEWT:935293NEWT:375146NEWT:2065263NEWT:1772NEWT:118698NEWT:1616117NEWT:263NEWT:118696NEWT:52283NEWT:11988NEWT:284812NEWT:8175NEWT:400667NEWT:43330NEWT:1603293NEWT:408169NEWT:44664NEWT:47946NEWT:3702NEWT:1245466NEWT:243277NEWT:1246791NEWT:7067NEWT:118694NEWT:586722NEWT:2850NEWT:118691NEWT:33548NEWT:274NEWT:7070NCBITaxon:287NEWT:408172NEWT:408170NEWT:96794NEWT:3708NEWT:332648NEWT:44670NEWT:536231NEWT:376219NEWT:219813NEWT:1510NEWT:1436733NEWT:460519NEWT:1247411NEWT:1515NEWT:572307NEWT:1432138NEWT:1424507NEWT:1194599NEWT:272844NEWT:333760NEWT:56636NEWT:1513458NEWT:1233681NCBITaxon:40559NEWT:506599NEWT:2853422NEWT:81077NEWT:84588NEWT:1679718NEWT:480NEWT:65349NEWT:67767NEWT:46835NEWT:109757NEWT:582580NEWT:300852NEWT:1502NEWT:128017NEWT:376686NEWT:95486NEWT:508771NEWT:1883446NEWT:253NCBITaxon:2759NEWT:1233435NEWT:93061NEWT:93062NEWT:34613NCBITaxon:4932NEWT:109760NEWT:943274NEWT:644223NEWT:235443NEWT:108458NEWT:5936NEWT:272623NEWT:272624NEWT:320637NEWT:886559NEWT:55521NEWT:983964NEWT:118499NEWT:11706NEWT:32644NEWT:527796NEWT:1130798NEWT:55529NEWT:499175NEWT:109779NEWT:3745NEWT:1715989NCBITaxon:4751NEWT:476272NEWT:3747NEWT:195051NEWT:3988NEWT:1116234NEWT:1255228NEWT:649908NEWT:410289NEWT:373153NEWT:3983NEWT:203696NEWT:352472NEWT:1071661NEWT:1202532NEWT:360094NEWT:470NEWT:41364NEWT:5911NEWT:1313NEWT:1218097NCBITaxon:50557NEWT:39251NEWT:39491NEWT:212142NCBITaxon:5811NEWT:29491NEWT:101841NEWT:2014887NEWT:33952NEWT:153009NEWT:261756NEWT:571256NEWT:40483NEWT:63366NEWT:63367NEWT:688333NEWT:215402NCBITaxon:548681NEWT:318586NCBITaxon:5820NEWT:1547NEWT:272634NEWT:198107NEWT:9031NEWT:1872122NEWT:1308NEWT:7091NEWT:1034015NEWT:760568NEWT:141262NEWT:108931NEWT:1055524NEWT:4087NEWT:9778NEWT:306NEWT:150475NEWT:303NEWT:267872NEWT:97477NEWT:7111NEWT:347515NEWT:172269NEWT:9534NEWT:6269NEWT:5180NEWT:256737NEWT:4090NEWT:4092NEWT:9541NEWT:8694NEWT:4093NEWT:4096NEWT:8692NEWT:2903NEWT:185579NEWT:941442NEWT:536088NEWT:13076NEWT:1226408NEWT:7108NEWT:40479NEWT:43989NEWT:4076NEWT:142615NEWT:317NEWT:1006581NEWT:885318NEWT:39488NEWT:550NEWT:4081NEWT:273068NEWT:554NEWT:98334NEWT:451516NEWT:4084NEWT:63577NEWT:36185NEWT:1225786NEWT:7574NEWT:1715256NEWT:30640NEWT:575412NEWT:929793NEWT:29204NEWT:28112NEWT:114155NEWT:6494NEWT:6491NEWT:507601NEWT:520NEWT:186441NEWT:634955NEWT:643680NEWT:214092NCBITaxon:6157NEWT:6239NEWT:13095NEWT:162425NEWT:216257NEWT:102169NEWT:208893NEWT:9986NEWT:4054NEWT:8654NEWT:8658NEWT:1268063NEWT:8657NEWT:8655NEWT:5147NEWT:98351NEWT:1263854NEWT:118503NEWT:2059687NEWT:160488NEWT:28104NEWT:207559NEWT:407821NCBITaxon:2NEWT:85057NEWT:985076NEWT:568708NEWT:1215323NEWT:986NEWT:52641NEWT:7159NEWT:267671NEWT:28532NEWT:353152NEWT:8496NEWT:7165NEWT:1257118NEWT:27448NEWT:40674NEWT:1194669NEWT:243230NEWT:443906NEWT:1080772NEWT:519NEWT:8479NEWT:8485NEWT:6063NEWT:49240NEWT:1328388NEWT:9557NEWT:9315NEWT:6289NEWT:377586NEWT:6287NEWT:300641NEWT:727NEWT:9796NEWT:9554NEWT:725NEWT:7137NEWT:469008NEWT:256318NEWT:9321NEWT:206411NCBITaxon:6191NEWT:596153NEWT:229533NEWT:1836NEWT:214053NCBITaxon:10298NEWT:80863NEWT:90675NEWT:105231NEWT:104385NEWT:74649NEWT:52638NEWT:57075NEWT:206672NEWT:4097NEWT:8697NEWT:8695NEWT:884204NEWT:71139NEWT:9785NEWT:6279NEWT:1123869NEWT:9544NEWT:9545NEWT:7370NEWT:9793NEWT:83906NCBITaxon:780NCBITaxon:1502NEWT:6282NEWT:1134506NEWT:255470NEWT:27457NEWT:38783NEWT:4006NEWT:6426NCBITaxon:5476NEWT:113208NEWT:33090NEWT:6669NEWT:9935NEWT:89453NEWT:287889NEWT:1114301NEWT:51515NEWT:588596NEWT:51511NEWT:8845NEWT:92867NEWT:92866NEWT:419610NEWT:5334NEWT:51750NEWT:202950NEWT:382352NEWT:413071NCBITaxon:10239NCBITaxon:714NEWT:295027NCBITaxon:11320NEWT:632957NEWT:11051NEWT:9925NEWT:89462NCBITaxon:9606NEWT:452680NEWT:8839NEWT:90690NEWT:1436183NEWT:4232NEWT:2758385NEWT:416348NEWT:11298NEWT:171101NEWT:714NEWT:5322NEWT:421932NEWT:312017NEWT:196627NEWT:200308NEWT:553470NEWT:200302NEWT:870435NEWT:284593NEWT:100392NEWT:655819NEWT:5315NEWT:9913NEWT:265872NEWT:105841NEWT:337330NEWT:2666255NEWT:2285NEWT:2287NEWT:999810NCBITaxon:5693NEWT:28995NEWT:1392998NEWT:380394NEWT:981087NEWT:180066NEWT:226900NEWT:1266738NEWT:231490NEWT:244704NEWT:7725NEWT:430615NEWT:72664NEWT:174633NEWT:326423NEWT:452467NEWT:198822NEWT:36111NEWT:326424NEWT:1416333NEWT:35024NEWT:135461NEWT:1678078NEWT:7962NEWT:749906NEWT:418985NEWT:1817808NEWT:749907NEWT:145262NEWT:145263NEWT:431947NEWT:69014NEWT:142809NEWT:694569NEWT:27606NEWT:9739NEWT:59202NEWT:9975NEWT:8643NEWT:51953NEWT:502780NEWT:57267NEWT:3197NEWT:860688NEWT:13443NEWT:8644NEWT:36329NEWT:62615NEWT:5141NEWT:46360NCBITaxon:3044782NEWT:1333550NEWT:160235NEWT:72407NEWT:8639NEWT:1928434NEWT:8637NEWT:349741NEWT:1114970NEWT:409859NEWT:157295NEWT:2096NEWT:509169NEWT:192222NEWT:9721NEWT:137221NEWT:9963NEWT:1617910NEWT:565050NEWT:409860NEWT:2785785NEWT:411901NEWT:8626NEWT:105884NCBITaxon:9615NEWT:8621NEWT:58334NEWT:452659NEWT:1193501NEWT:58331NEWT:6689NEWT:8624NEWT:5116NEWT:8623NEWT:5597NEWT:298315NEWT:8618NEWT:70448NEWT:9704NEWT:698936NEWT:1009874NEWT:8855NEWT:9940NEWT:3168NEWT:1247190NEWT:521001NEWT:192011NEWT:1813887NEWT:118702NEWT:118700NEWT:2126719NEWT:224911NEWT:118705NCBITaxon:11552NEWT:334249NEWT:6945NEWT:184922NEWT:6703NEWT:2104NEWT:6943NEWT:2NEWT:157546NEWT:35670NEWT:511693NEWT:870726NEWT:91374NEWT:91373NEWT:474186NEWT:38942NEWT:35677NEWT:1493NEWT:307972NEWT:1496NEWT:2102NEWT:3674NEWT:660469NEWT:1365186NEWT:38949NEWT:45474NEWT:1299114NEWT:1590841NEWT:2282334NEWT:4513NEWT:1247NEWT:70667NEWT:869728NEWT:5843NEWT:6938NCBITaxon:39054NCBITaxon:10407NEWT:1736309NEWT:4751NEWT:10360NEWT:47664NEWT:317548NEWT:15819NEWT:3654NEWT:237561NEWT:1085956NEWT:5833NEWT:3659NEWT:6928NEWT:1239NEWT:36745NEWT:499229NEWT:31298NEWT:400727NEWT:1204162NEWT:272563NEWT:11009NEWT:82688NEWT:5823NEWT:3885NEWT:3888NEWT:5821NEWT:44139NEWT:649408NCBITaxon:4895NCBITaxon:4896NEWT:315393NEWT:6915NEWT:3649NEWT:101510NEWT:28903NEWT:3880NEWT:272559NEWT:216816NEWT:28909NEWT:515849NEWT:3641NEWT:10141NEWT:466585NEWT:1000589NEWT:85963NEWT:85962NEWT:42197NEWT:143361NCBITaxon:5796NEWT:12993NEWT:398580NEWT:4565NEWT:1264690NEWT:515619NEWT:1299NEWT:316407NEWT:34305NCBITaxon:183674NEWT:167387NEWT:84645NEWT:44586NEWT:1123294NEWT:626528NEWT:139927NEWT:4558NEWT:209285NEWT:5888NEWT:211586NEWT:747078NEWT:1282NEWT:1283NEWT:431241NEWT:4550NEWT:1000561NEWT:2133NEWT:4555NEWT:294381NEWT:197NEWT:1390363NEWT:35889NEWT:406072NEWT:144030NEWT:288705NEWT:29176NEWT:4787NEWT:3217NEWT:113549NEWT:4547NEWT:3218NEWT:556182NEWT:1270NEWT:374990NEWT:1432059NEWT:154293NEWT:156471NEWT:4784NEWT:3694NEWT:360106NEWT:156476NEWT:4543NEWT:4785NEWT:210007NEWT:360104NEWT:1857017NEWT:10117NEWT:10359NEWT:10116NEWT:1280NEWT:10358NEWT:83333NEWT:1735272NEWT:83334NEWT:83332NEWT:317513NEWT:580240NEWT:294128NEWT:11676NEWT:100226NEWT:718308NEWT:4530NEWT:176299NEWT:5861NEWT:54126NEWT:75058NEWT:13616NEWT:296543NEWT:173NEWT:316435NEWT:42157NEWT:1895NEWT:1034304NEWT:105023NEWT:866628NEWT:64152NEWT:4924NEWT:749200NEWT:2748NEWT:8049NEWT:33892NEWT:9378NEWT:990346NEWT:145953NEWT:257309NEWT:100816NEWT:203124NEWT:192952NEWT:230741NEWT:8296NEWT:117008NCBITaxon:1313NEWT:167748NEWT:1163394NEWT:44544NEWT:529818NEWT:400540NEWT:4911NEWT:645463NEWT:152480NEWT:129249NEWT:1077286NEWT:943129NEWT:1221594NEWT:990119NEWT:77216NEWT:1111708NEWT:227321NEWT:493760NEWT:281677NEWT:106590NEWT:260710NEWT:257313NEWT:3827NEWT:400772NEWT:128161NEWT:930945NEWT:1162296NEWT:106592NEWT:46704NEWT:482428NEWT:1187947NEWT:269796NEWT:10312NCBITaxon:1773NEWT:54571NEWT:9598NEWT:8030NEWT:1423772NEWT:53232NEWT:1235987NEWT:1639NEWT:188229NEWT:246437NEWT:3818NEWT:4909NEWT:759272NEWT:432359NEWT:1182263NEWT:943146NEWT:2711NEWT:537457NEWT:479249NEWT:9103NEWT:715877NEWT:862238NEWT:29159NEWT:10306NEWT:9595NEWT:8022NEWT:145943NEWT:595536NEWT:240906NEWT:593117NEWT:89920NEWT:29158NEWT:3633NEWT:3635NEWT:5811NEWT:3879NEWT:180923NEWT:1328881NEWT:411483NEWT:76336NEWT:3870NEWT:884019NEWT:198215NEWT:411490NEWT:200298NEWT:169963NEWT:1400870NEWT:587NEWT:588NEWT:585NEWT:343NEWT:225117NEWT:746128NEWT:5801NEWT:43665NEWT:212035NEWT:5802NCBITaxon:1653394NEWT:1266464NEWT:1205NEWT:214693NEWT:367830NEWT:178616NEWT:95145NEWT:375451NEWT:357NEWT:9172NEWT:2770979NEWT:2010198NEWT:1277351NEWT:1594786NEWT:457428NEWT:411469NEWT:84023NEWT:1679NEWT:559292NEWT:569NEWT:411464NEWT:411460NEWT:2762NEWT:1174673NEWT:1328426NEWT:562NEWT:28035NEWT:411470NEWT:2094720NCBITaxon:2697049NCBITaxon:138NEWT:28038NEWT:1663NEWT:62141NEWT:1423NEWT:4932NEWT:3603NEWT:2756NEWT: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