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Tholey"],"technology_type":["Mass Spectrometry","Bottom-up proteomics"],"software":["Not available"],"submitter_keywords":["Lc-ms","Nematostella vectensis","Proteomics","Nematocomes","Label-free","Immunity","Phagocytosis","Microbiome"],"full_dataset_link":["https://www.ebi.ac.uk/pride/archive/projects/PXD065753"],"sample_protocol":["Samples of nematosomes extracted from one nematostella were received as a protein extract in a lysis buffer (5M Urea, 1% Triton-X-100, 5 mM DTT and 1x cOmplete) -80 °C. Samples were then processed according to SP3 beads digestion protocol (ref) as follows. After thawing, lysates were mixed each with 25 µL Alkylation buffer (50 mM borate buffer and 25 mM IAA) for 50 min at room temperature (RT). Then, 5 µL of resuspeneded SP3 beads (20 µg/µL A:B 1:1 mixture) were added to each sample followed by 150 µL ACN and mixed for 30 min at 800 rpm, RT. Then, beads were washed with 300 µL 70% EtOH, followed by 150 µL ACN. A 10 µL digestion buffer (4 ng/µL trypsin/Lys-C, 25 mM borate buffer and 0.01% DDOPM) was added to each sample followed by mixing on a shaker for 10 min at 800 rpm RT. Samples were mixed each by pipetting up and down and kept back on the shaker overnight. Next day, samples were centrifuged at 20,000 x g for 2 min and supernatant (ca. 10 µL) was transferred to LC-MS vials containing 1 µL of 5% FA."],"repository":["Pride"],"quantification_method":[""],"modification":[""],"data_protocol":["Chromatographic separation was performed on a Dionex U3000 nanoHPLC system equipped with an Acclaim pepmap100 C18 column (2 μm particle size, 75 μm × 500 mm) coupled online to a mass spectrometer.  The eluents used were; eluent A: 0.05% formic acid (FA), eluent B: 80% ACN + 0.04% FA. The separation was performed over a programmed 120 minutes run. Initial chromatographic conditions were 4% B for 2 minutes followed by linear gradients from 4% to 50% A over 90 minutes then 50 to 90% A over 5 minute, and 10 minutes at 90% A. Following this, an inter-run equilibration of the column was achieved by 16 minutes at 4% A.  A constant flow rate of 300 nl/min was employed. The sample was resuspended in 20-18 μl of 3% acetonitrile with 0.1% trifluoroacetic acid, and 2-4 μl of samples were injected for LC-MS analysis. Wash runs were performed between each sample.  Data acquisition following separation was performed on an QExactive Plus. Full scan MS acquisition was performed (350-1400 m/z, resolution 70,000). Subsequent data dependent MS/MS scans were collected for the 15 most intense ions (Top15) via HCD activation at NCE 27.5 (resolution 17,500); dynamic exclusion was enabled (20 sec duration)."],"omics_type":["Proteomics"],"labhead":["Prof. Dr. Andreas Tholey"],"instrument_platform":[""],"labhead_affiliation":["Institut für Experimentelle Medizin (IEM) Arbeitsgruppe Systematische Proteomforschung Christian-Albrechts-Universität zu Kiel Kiel, Germany"],"submission_type":["PARTIAL"],"species":["Nematostella Vectensis"],"submitter_mail":["a.tholey@iem.uni-kiel.de"],"publication":["10.1038/S41467-026-75511-W"],"submitter_affiliation":["Systematic Proteome Research & Bioanalytics, University of Kiel"],"submitter_country":["Germany"],"additional_accession":[]},"is_claimable":false,"name":"cJUN dependent innate immunity controls microbiome through selective phagocytosis in Nematostella","description":"Innate immunity, traditionally considered as a broad and non-specific defense system, is increasingly recognized for its capacity to selectively regulate microbial communities. Emerging evidence suggests that invertebrates can differentiate between closely related microorganisms, challenging the dichotomy between innate and adaptive immunity. This specificity is crucial for maintaining symbiotic relationships while preventing colonization by harmful microbes. In the sea anemone Nematostella vectensis, nematosomes—motile immune cells—play a key role in selective phagocytosis, preferentially engulfing foreign Vibrio isolates while sparing native bacterial colonizers. Here, wWe identifiedy the transcription factor cJUN as a crucial regulator of nematosome proliferation and function. CRISPR/Cas9-mediated knockout of cJUN resulted in a significant reduction of nematosome proliferation, impaired lysosomal activation, and an altered microbiome composition with increased colonization of non-native Vibrio strains. These findings demonstrate a direct link between host immune specificity and microbial community structure, challenging the traditional view of innate immunity as a non-specific defense. Our study highlights the evolutionary conservation of selective innate immune mechanisms and their role in maintaining microbial homeostasis in early-branching metazoans.","dates":{"publication":"2026-07-24","submission":"2025-07-03"},"accession":"PXD065753","cross_references":{"TAXONOMY":["NEWT:330879","NEWT:2042546","NEWT:259447","NEWT:295546","NCBITaxon:2719036","NCBITaxon:1280","NEWT:112503","NEWT:1129","NEWT:309807","NEWT:89184","NEWT:309800","NEWT:281395","NEWT:1211601","NEWT:876138","NEWT:44271","NEWT:193516","NEWT:111205","NEWT:1117","NEWT:498257","NEWT:10036","NEWT:1590","NEWT:661410","NEWT:638632","NEWT:224326","NEWT:376619","NCBITaxon:79857","NEWT:1096976","NEWT:1589","NEWT:135622","NEWT:67352","NEWT:35786","NEWT:1580","NEWT:399784","NEWT:96731","NEWT:383379","NEWT:418106","NEWT:10029","NEWT:913645","NEWT:641809","NEWT:317447","NEWT:4688","NEWT:111225","NEWT:7719","NEWT:868565","NEWT:135674","NEWT:79329","NEWT:30069","NEWT:12637","NEWT:59729","NEWT:2164133","NEWT:295105","NEWT:108061","NEWT:60711","NEWT:224308","NEWT:3347","NEWT:160621","NEWT:212790","NEWT:1310161","NEWT:77133","NEWT:145481","NEWT:1310165","NEWT:29058","NCBITaxon:79824","NEWT:1912919","NEWT:44688","NEWT:44689","NEWT:498211","NEWT:347256","NEWT:5518","NEWT:398007","NEWT:1527468","NEWT:498217","NEWT:498216","NEWT:11320","NEWT:246196","NEWT:246197","NEWT:145458","NEWT:44685","NEWT:161934","NEWT:1148","NEWT:5508","NEWT:3329","NEWT:5507","NEWT:410661","NEWT:1140","NCBITaxon:2157","NEWT:1143","NEWT:1287689","NEWT:1094343","NEWT:1462472","NEWT:1336795","NEWT:644042","NEWT:1182590","NEWT:3712","NEWT:3711","NEWT:270643","NEWT:2065263","NEWT:177437","NEWT:10418","NEWT:118698","NEWT:1616117","NEWT:118696","NEWT:34865","NEWT:52283","NEWT:284812","NEWT:8175","NEWT:43330","NEWT:980415","NEWT:1603293","NEWT:44664","NEWT:3702","NEWT:1245466","NEWT:1246791","NEWT:118694","NEWT:2850","NEWT:118691","NEWT:34871","NEWT:33548","NEWT:96794","NEWT:3708","NEWT:332648","NEWT:44670","NEWT:536231","NEWT:376219","NEWT:219813","NEWT:1510","NEWT:460519","NEWT:1515","NEWT:572307","NEWT:1432138","NEWT:1424507","NEWT:1194599","NEWT:272844","NEWT:1348799","NEWT:1303443","NEWT:9483","NEWT:485","NEWT:56636","NEWT:2709072","NEWT:2853422","NEWT:1679718","NEWT:480","NEWT:67767","NEWT:46835","NEWT:109757","NEWT:582580","NEWT:294607","NEWT:1502","NEWT:128017","NEWT:376686","NEWT:95486","NEWT:1883446","NEWT:1233435","NEWT:109760","NEWT:29031","NEWT:235443","NEWT:108458","NEWT:5936","NEWT:320637","NEWT:3750","NEWT:983964","NEWT:11706","NEWT:32644","NEWT:527796","NEWT:499175","NEWT:109779","NEWT:3745","NEWT:1715989","NCBITaxon:4751","NEWT:3747","NEWT:1116234","NEWT:1255228","NEWT:410289","NEWT:373153","NEWT:472","NEWT:1071661","NEWT:470","NEWT:5911","NCBITaxon:50557","NEWT:39251","NEWT:29491","NEWT:101841","NEWT:153481","NEWT:2014887","NEWT:33952","NEWT:445","NEWT:153009","NEWT:261756","NEWT:63366","NEWT:63367","NEWT:215402","NEWT:1547","NEWT:9031","NEWT:27292","NEWT:108931","NEWT:1293497","NEWT:1055524","NEWT:150475","NEWT:267872","NEWT:172269","NEWT:9534","NEWT:5180","NEWT:256737","NEWT:9541","NEWT:8694","NEWT:33936","NEWT:8692","NEWT:2903","NEWT:185579","NEWT:13076","NEWT:1006581","NEWT:33940","NEWT:550","NEWT:554","NEWT:451516","NEWT:552","NEWT:1325291","NEWT:36185","NEWT:1225786","NEWT:575412","NEWT:28112","NEWT:6493","NEWT:6494","NEWT:6491","NEWT:507601","NEWT:520","NEWT:186441","NEWT:643680","NEWT:214092","NCBITaxon:6157","NEWT:13095","NEWT:162425","NEWT:104105","NEWT:216257","NEWT:9986","NEWT:8654","NEWT:8658","NEWT:1268063","NEWT:8657","NEWT:8655","NEWT:5147","NEWT:28104","NEWT:407821","NCBITaxon:2","NEWT:568708","NEWT:986","NEWT:52641","NEWT:28532","NEWT:353152","NEWT:40674","NEWT:1194669","NEWT:51329","NEWT:443906","NEWT:519","NEWT:6063","NEWT:1328388","NEWT:1548728","NEWT:667127","NEWT:9557","NEWT:377586","NEWT:300641","NEWT:39655","NEWT:9554","NEWT:38323","NEWT:256318","NEWT:206411","NCBITaxon:6191","NEWT:229533","NEWT:2925","NEWT:214053","NEWT:80863","NEWT:90675","NEWT:52638","NEWT:57075","NEWT:8697","NEWT:8695","NEWT:884204","NEWT:1123869","NEWT:9544","NEWT:9545","NEWT:979","NEWT:7370","NEWT:83906","NEWT:1134506","NEWT:255470","NEWT:38783","NEWT:6426","NEWT:33090","NEWT:9935","NEWT:287889","NEWT:305959","NEWT:92867","NEWT:92866","NCBITaxon:3055","NEWT:51750","NEWT:202950","NEWT:295027","NCBITaxon:11320","NEWT:632957","NEWT:9925","NCBITaxon:9606","NEWT:90690","NEWT:1436183","NEWT:4232","NEWT:416348","NEWT:11298","NEWT:196627","NEWT:200308","NEWT:242507","NEWT:200302","NEWT:870435","NEWT:9913","NEWT:9915","NEWT:105841","NEWT:2666255","NEWT:999810","NCBITaxon:5693","NEWT:28995","NEWT:1392998","NEWT:380394","NEWT:114796","NEWT:226900","NEWT:1266738","NEWT:231490","NEWT:244704","NEWT:7725","NEWT:430615","NEWT:563041","NEWT:72664","NEWT:326423","NEWT:452467","NEWT:198822","NEWT:36111","NEWT:326424","NEWT:1678078","NEWT:749906","NEWT:418985","NEWT:749907","NEWT:150847","NEWT:431947","NEWT:69014","NEWT:142809","NEWT:130821","NEWT:27606","NEWT:1519788","NEWT:59202","NEWT:9975","NEWT:8643","NEWT:1159899","NEWT:502780","NEWT:860688","NEWT:13443","NEWT:8644","NEWT:5141","NEWT:46360","NCBITaxon:3044782","NEWT:202914","NEWT:16023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