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Seifert"],"technology_type":["Metaproteomics","Mass Spectrometry"],"software":[""],"submitter_keywords":["Metaproteomics","Rumen","Microplastic","Microbiome"],"full_dataset_link":["https://www.ebi.ac.uk/pride/archive/projects/PXD065755"],"tissue":["Rumen"],"sample_protocol":["Cell pellets of the respective triplicates were thawed, pooled, and mixed with a protein extraction buffer as described by Deusch et al. (2017). Protein extract (100 μg) was purified on a polyacrylamide gel and in-gel tryptic digestion was performed as described by Trautmann et al. (2020). Nano-LC-ESI-MS/MS experiments were performed on an EASY-nLC 1200 (Thermo Fisher Scientific, Germany) coupled to a Q-Exactive HF mass spectrometer (Thermo Fisher Scientific, Germany) equipped with a NanosprayFlex source (Thermo Fisher Scientific, Germany) at the Core Facility of the University of Hohenheim, Stuttgart, Germany. Tryptic digested peptides were injected into a NanoEase analytical column (NanoEase M/Z HSS C18 T3, 1.8 μm 100 Å 75 μm x 250 mm column, Waters GmbH, Germany) at a constant temperature of 35°C using a PRSO-V2 column oven (Sonation GmbH, Germany) and a flow rate of 250 nL/min. A gradient of solvent A (0.1% formic acid) and solvent B (0.1% formic acid and 80% acetonitrile) was run for 140 min (0-115-130-140 min) with increasing solvent B (1-50-56-95%). The Orbitrap of the Q-Exactive HF allowed a resolution of 60,000 with a range of 200 to 2,000 m/z and a TopN of 20. Tandem MS spectra were generated for the 20 most abundant peptide precursors using high-energy collision dissociation (HCD) at a resolution of 15,000, normalized by a collision energy of 27. Lock mass ions from ambient air were used for internal calibration (Olsen et al., 2005)."],"repository":["Pride"],"quantification_method":["Not available"],"modification":[""],"data_protocol":["Data analysis was performed using Metalab (v.2.1.1.7) (Cheng et al., 2020). Default settings were used to obtain label-free quantification (LFQ) values of proteins unsing the MaxQuant worflow. Microbial proteins were identified using a freely available rumen metagenomic database (Stewart et al., 2019)."],"omics_type":["Proteomics"],"labhead":["Prof. Dr Jana Seifert"],"instrument_platform":[""],"submission_type":["PARTIAL"],"labhead_affiliation":["University of Hohenheim, Functional Microbiology of Livestock, Stuttgart, Germany"],"species":["Bos Taurus (bovine)"],"publication":["41265274 Eichinger J, Seifert J, Sáenz JS, Amin N, Lorenz S, Eckel F, Zollfrank C, Windisch W, Brugger D. The interaction of microplastics with the ruminal ecosystem in vitro. J Hazard Mater. 2025 500:140481 10.1016/j.jhazmat.2025.140481"],"submitter_mail":["jseifert@uni-hohenheim.de"],"submitter_affiliation":["University of Hohenheim"],"submitter_country":["Germany"],"pubmed_abstract":["Mismanaged plastic waste contaminates marine and terrestrial environments, so farm animals are increasingly exposed to microplastics (MP) in feed. Yet their interactions with the rumen microbiome are largely unknown. We evaluated these interactions in vitro with the Hohenheim Gas Test. Five MP chemical species - polylactide, polyhydroxybutyrate, high‑density polyethylene, polyvinyl chloride and polypropylene - were tested in two particle‑size classes (<125 µm and 125-500 µm) and six doses (0-70 mg per incubation cylinder). Each MP variant was incubated with rumen fluid plus hay or barley. We recorded cumulative gas production, pH and dry‑matter (DM) disappearance, followed by volatile‑fatty‑acid profiling, metaproteomics and metabolomics. MP consistently reduced cumulative gas output independent of polymer type, particle size or dose, but enhanced total DM degradation dose-dependently. In barley incubations, metaproteomics revealed a shift from Bacteroidetes toward Firmicutes and higher abundance of protein categories \"replication & repair\" and \"translation\", while \"carbohydrate metabolism & transport\" and \"amino‑acid metabolism\" declined. The results show that MPs interact with, and are at least partly degraded by, the ruminal microbiota. Progressive size reduction in the rumen could facilitate MP translocation into animal tissues, underscoring the need for in‑vivo studies on animal health and food‑safety implications."],"pubmed_title":["The interaction of microplastics with the ruminal ecosystem in vitro."],"pubmed_authors":["Eichinger J J, Seifert J J, Sáenz J S JS, Amin N N, Lorenz S S, Eckel F F, Zollfrank C C, Windisch W W, Brugger D D"],"additional_accession":[]},"is_claimable":false,"name":"The interaction of microplastics with the ruminal ecosystem in vitro","description":"Mismanagement of plastic waste has contributed to plastic pollution in marine and terrestrial ecosystems. Therefore, farm animals are likely to consume microplastic (MP) contaminated feed. However, the interactions of MP with the ruminal microbial ecosystem remain poorly understood. This study investigated the interaction of MP within the ruminal ecosystem in vitro using the Hohenheim Gas Test. Different MP variants were applied, reflecting different combinations of five MP species (polylactide, polyhydroxy butyric acid, high-density polyethylene, polyvinyl chloride, polypropylene), in two particle size ranges (<125 μm; 125-500 μm) and increasing dosages (from 0 to 70 mg /incubation cylinder) together with ruminal fluid and hay or barley as substrates. Cumulative gas production, pH and dry matter disappearance were determined before analyzing volatile fatty acids, metaproteomics and metabolomics. In the presence of MP, cumulative gas production decreased regardless of the MP 63 species, dose or particle size, while total dry matter degradation increased. Microbial proteins in barley incubations showed lower Bacteroidetes and increasing Firmicutes abundance in the presence of MP and increased activities of the protein groups `replication and repair`, and `translation`, but decreased activities of `carbohydrate metabolism and transport` and `amino acids metabolism`. The data indicated that MP, regardless of their species and particle size, interact with the ruminal microbiome and may be partially degraded in vitro. This suggests a reduction of MP size in the rumen thereby increasing the likelihood to penetrate animal tissues. Future research must confirm the findings in vivo and determine their consequences for animal health and consumer safety.","dates":{"publication":"2026-03-27","submission":"2025-07-03"},"accession":"PXD065755","cross_references":{"TAXONOMY":["NEWT:3555","NEWT:71647","NEWT:330879","NEWT:260201","NEWT:35554","NCBITaxon:12939","NEWT:32046","NEWT:544496","NEWT:59529","NEWT:2042546","NEWT:32049","NEWT:1392696","NEWT:259447","NEWT:295546","NEWT:45351","NEWT:445974","NEWT:43179","NEWT:180454","NEWT:5722","NCBITaxon:1280","NEWT:112503","NEWT:1129","NEWT:309807","NEWT:10245","NEWT:55153","NEWT:89184","NEWT:309800","NEWT:281395","NEWT:1211601","NEWT:876138","NEWT:44271","NEWT:193516","NEWT:351581","NEWT:43186","NEWT:428146","NEWT:1117","NEWT:498257","NEWT:10036","NEWT:1590","NEWT:498019","NEWT:1351","NEWT:1438992","NEWT:1352","NEWT:2649997","NEWT:1147161","NEWT:661410","NEWT:638632","NEWT:43150","NEWT:263737","NEWT:224326","NEWT:1333499","NEWT:376619","NCBITaxon:79857","NEWT:1096976","NEWT:5702","NEWT:95648","NEWT:1589","NEWT:135622","NEWT:1349","NEWT:35786","NEWT:1580","NEWT:399784","NEWT:96731","NEWT:383379","NEWT:1401257","NEWT:10029","NEWT:913645","NEWT:44491","NEWT:641809","NEWT:27933","NEWT:556484","NEWT:317447","NEWT:4688","NEWT:7955","NEWT:7719","NEWT:7959","NEWT:2261","NEWT:868565","NEWT:135674","NEWT:94323","NEWT:31156","NEWT:3112","NEWT:79329","NEWT:4442","NEWT:192875","NEWT:30069","NEWT:12637","NEWT:59729","NEWT:2164133","NEWT:284218","NEWT:295105","NEWT:108061","NEWT:60711","NEWT:1316931","NEWT:224308","NEWT:3347","NEWT:511145","NEWT:160621","NEWT:212790","NEWT:931281","NEWT:4432","NEWT:5762","NEWT:5763","NEWT:658457","NEWT:1310161","NEWT:77133","NEWT:295358","NEWT:145481","NEWT:1310165","NEWT:29058","NCBITaxon:79824","NEWT:2246","NEWT:2652724","NEWT:5757","NEWT:68415","NCBITaxon:4563","NEWT:5755","NEWT:44688","NEWT:44689","NEWT:44447","NEWT:752555","NEWT:498211","NEWT:5759","NEWT:347256","NEWT:1736231","NEWT:5518","NEWT:398007","NEWT:1527468","NEWT:1392","NEWT:498217","NEWT:498216","NEWT:2242","NEWT:11320","NEWT:286","NEWT:391619","NEWT:246196","NEWT:287","NEWT:246197","NEWT:145458","NEWT:633149","NEWT:1149786","NEWT:10239","NEWT:68895","NEWT:44685","NEWT:161934","NEWT:4897","NEWT:1148","NEWT:5744","NEWT:72901","NEWT:213863","NEWT:5508","NEWT:3329","NEWT:5507","NEWT:410661","NEWT:55571","NEWT:35500","NEWT:1140","NCBITaxon:2157","NEWT:1143","NEWT:4896","NEWT:1287689","NEWT:1390","NEWT:11557","NEWT:1094343","NEWT:1462472","NEWT:1336795","NEWT:644042","NEWT:294","NEWT:1773","NEWT:1182590","NEWT:3712","NEWT:82380","NEWT:3711","NEWT:935293","NEWT:375146","NEWT:2065263","NEWT:177437","NEWT:1772","NEWT:10418","NEWT:118698","NEWT:1616117","NEWT:263","NEWT:118696","NEWT:34865","NEWT:52283","NEWT:11988","NEWT:284812","NEWT:8175","NEWT:400667","NEWT:43330","NEWT:1603293","NEWT:408169","NEWT:44664","NEWT:47946","NEWT:3702","NEWT:1245466","NEWT:243277","NEWT:1246791","NEWT:7067","NEWT:118694","NEWT:586722","NEWT:2850","NEWT:118691","NEWT:34871","NEWT:33548","NEWT:274","NEWT:7070","NEWT:408172","NEWT:408170","NEWT:96794","NEWT:3708","NEWT:332648","NEWT:44670","NEWT:536231","NEWT:376219","NEWT:219813","NEWT:1510","NEWT:1436733","NEWT:460519","NEWT:1247411","NEWT:1515","NEWT:572307","NEWT:1432138","NEWT:1424507","NEWT:1194599","NEWT:272844","NEWT:1303443","NEWT:333760","NEWT:485","NEWT:34607","NEWT:56636","NEWT:1513458","NEWT:1233681","NCBITaxon:40559","NEWT:506599","NEWT:2853422","NEWT:81077","NEWT:84588","NEWT:1679718","NEWT:480","NEWT:65349","NEWT:67767","NEWT:46835","NEWT:109757","NEWT:582580","NEWT:300852","NEWT:1502","NEWT:128017","NEWT:376686","NEWT:95486","NEWT:508771","NEWT:1883446","NEWT:253","NCBITaxon:2759","NEWT:1233435","NEWT:93061","NEWT:93062","NEWT:34613","NCBITaxon:4932","NEWT:109760","NEWT:29031","NEWT:943274","NEWT:644223","NEWT:1263082","NEWT:235443","NEWT:108458","NEWT:5936","NEWT:272623","NEWT:272624","NEWT:320637","NEWT:886559","NEWT:3750","NEWT:55521","NEWT:983964","NEWT:118499","NEWT:11706","NEWT:32644","NEWT:527796","NEWT:1130798","NEWT:55529","NEWT:499175","NEWT:109779","NEWT:3745","NEWT:1715989","NCBITaxon:4751","NEWT:476272","NEWT:3747","NEWT:195051","NEWT:3988","NEWT:1116234","NEWT:561007","NEWT:1255228","NEWT:649908","NEWT:410289","NEWT:373153","NEWT:3983","NEWT:203696","NEWT:472","NEWT:352472","NEWT:97441","NEWT:1071661","NEWT:1202531","NEWT:1202532","NEWT:360094","NEWT:1408223","NEWT:470","NEWT:1408224","NEWT:41364","NEWT:5911","NEWT:1313","NEWT:1218097","NEWT:1080348","NCBITaxon:50557","NEWT:1314","NEWT:39251","NEWT:39491","NEWT:212142","NCBITaxon:5811","NEWT:29491","NEWT:101841","NEWT:153481","NEWT:2014887","NEWT:33952","NEWT:445","NEWT:153009","NEWT:261756","NEWT:571256","NEWT:40483","NEWT:63366","NEWT:63367","NEWT:688333","NEWT:215402","NCBITaxon:548681","NEWT:318586","NCBITaxon:5820","NEWT:1547","NEWT:272634","NEWT:198107","NEWT:9031","NEWT:27292","NEWT:1872122","NEWT:1308","NEWT:7091","NEWT:1034015","NEWT:760568","NEWT:141262","NEWT:108931","NEWT:1293497","NEWT:1055524","NEWT:4087","NEWT:9778","NEWT:306","NEWT:150475","NEWT:303","NEWT:267872","NEWT:97477","NEWT:7111","NEWT:347515","NEWT:1722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