{"database":"Pride","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Xlsx":["ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD065769/protein_intensities.xlsx"],"Txt":["ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD065769/annotation_table.txt","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD065769/checksum.txt"],"Fasta":["ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD065769/UP000005640_9606.fasta"],"Other":["ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD065769/raw_data.zip","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD065769/human_lib.predicted.speclib"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"labhead_mail":["gmichlewski@iimcb.gov.pl"],"submitter":["Jacek Szymanski"],"technology_type":["Mass Spectrometry","Bottom-up proteomics"],"software":[""],"submitter_keywords":[""],"full_dataset_link":["https://www.ebi.ac.uk/pride/archive/projects/PXD065769"],"tissue":["Permanent Cell Line Cell"],"sample_protocol":["Proteins were separated on gel (NuPAGE Novex 4-12% Bis-Tris gel, Life Technologies), in NuPAGE buffer (MES) for 10 min and visualised using InstantBlue stain (Abcam). The stained gel band was excised and de-stained with 50 mM ammonium bicarbonate (Sigma Aldrich) and 100% (v/v) acetonitrile (Sigma Aldrich) and proteins were digested with trypsin, as previously described (Shevchenko et al., 1996). In brief, proteins were reduced in 10 mM dithiothreitol (Sigma Aldrich) for 30 min at 37°C and alkylated in 55 mM iodoacetamide (Sigma Aldrich) for 20 min at ambient temperature in the dark. They were then digested overnight at 37°C with 13 ng/μl trypsin (Pierce). Following digestion, samples were diluted with an equal volume of 0.1% TFA and pH was set to ~2 with 10% TFA. The equivalent of 50 ng of the digest was loaded on the Evotip™ using the standard producer protocol. We utilized EVOSEP coupled to a TimsTOF ULTRA (Bruker) mass spectrometer equipped with a Captive Spray II source (Bruker). The separation was carried out on a Performance Column OE measuring 8 cm x 150 µm ID, with a particle size of 1.5 µm, maintained at 40°C. We employed the standard 60SPD EVOSEP method, applying a 21-minute gradient for a total sample-to-sample time of 24 minutes using Solvent A: 0.1% formic acid (FA) and Solvent B: acetonitrile (ACN)/0.1% FA (Thermo Fisher Scientific™ Optima LCMS grade). The dia-PASEF acquisition scheme was optimized for a cycle time estimate of 1.38 s. The window scheme was designed to cover most of the charge 2 precursor ions in the range m/z 391−1142 and 1/K0 0.68−1.36, using 22 × 31 Th windows, with accumulation and ramp times of 100 ms. The mass spectrometer was operated in the \"high sensitivity detection\" (\"low sample amount\") mode."],"repository":["Pride"],"modification":[""],"quantification_method":[""],"data_protocol":["The DIA-NN software platform (Demichev et al., 2020) version 1.9.1. was used to process the raw files from label-free DIA and the search was conducted against the Homo sapiens reference proteome UP000005640 (Uniprot, released in 2019). Precursor ion generation was based on the chosen protein database (automatically generated spectral library) with deep-learning based spectra, retention time and IMs prediction. Digestion mode was set to specific with trypsin allowing maximum of one missed cleavage. Carbamidomethylation of cysteine was set as fixed modification. Oxidation of methionine, and acetylation of the N-terminus were set as variable modifications. MS1 and MS2 mass accuracies were set to 10 ppm. The parameters for peptide length range, precursor charge range, precursor m/z range and fragment ion m/z range as well as other software parameters were used with their default values. The precursor FDR was set to 1%.  Protein intensities were quantified from peptide intensities with directLFQ Python package (Ammar et al., 2023). Statistical analysis was performed with R [R Core Team (2021). R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. URL https://www.R-project.org/.]. Protti R package (Quast et al., 2022) was used for quality control, data filtration, imputation of missing values, and statistical significance calculation using a moderated t-test based on the limma R/Bioconductor package (Ritchie et al., 2015). For functional validation, P-values were adjusted for multiple testing with the Benjamini-Hochberg correction. Data visualisation was performed using the ggplot2 R package (Wickham, 2016). GO enrichment analysis for Biological Processes and Molecular Functions was conducted on the set of enriched proteins using the clusterProfiler package in R (Yu et al., 2012)."],"omics_type":["Proteomics"],"labhead":["Gracjan Michlewski"],"instrument_platform":[""],"labhead_affiliation":["International Institute of Molecular and Cell Biology, Laboratory of RNA-Protein Interactions - Dioscuri Centre, Warsaw, Poland"],"species":["Homo Sapiens (human)"],"submission_type":["PARTIAL"],"publication":["Not available"],"submitter_mail":["jszymanski@iimcb.gov.pl"],"submitter_affiliation":["International Institute of Molecular and Cell Biology in Warsaw, Poland"],"submitter_country":["Poland"],"additional_accession":[]},"is_claimable":false,"name":"5′-triphosphate guanosine RNAs recruit GTP-binding proteins to suppress RIG-I/IFN type I signalling","description":"The interferon (IFN) response is crucial for antiviral activity, but its overstimulation can lead to a wide range of autoimmune disorders. The cytoplasmic pattern recognition receptor RIG-I detects viral double stranded RNAs (dsRNAs) and endogenous polymerase III transcripts carrying a 5′-triphosphate (5′-ppp) or 5′-diphosphate (5′-pp) moiety, triggering phosphorylation of IRF3 and IFN immune response. While many viral RNAs initiate with 5′-ppp-adenosine (5′-pppA) and most endogenous Pol III transcripts in higher eukaryotes start with 5′-ppp-guanosine (5′-pppG), no apparent reason for this bias has been identified so far. Here we demonstrate that dsRNAs initiating with 5′-pppA trigger stronger RIG-I/IFN response than those starting with 5′-pppG. We show that several GTP-binding proteins interact preferentially with 5′-pppG RNAs. Finally, supplementation with guanosine, but not adenosine, which rapidly increases intracellular concentrations of GTP and ATP respectively, eliminates the difference in immunogenicity between 5′-pppG and 5′-pppA RNAs. Our findings suggest that 5′-pppG RNAs may enable certain RNA viruses and Pol III transcripts to limit detection by innate immune receptors. These results offer new insights into the sequence-dependent activation of the RIG-I/IFN pathway and have important implications for both antiviral immunity and the role of Pol III-derived RNAs in autoimmune diseases.","dates":{"publication":"2026-05-07","submission":"2025-07-04"},"accession":"PXD065769","cross_references":{"TAXONOMY":["NEWT:3555","NEWT:71647","NEWT:330879","NEWT:260201","NEWT:35554","NCBITaxon:12939","NEWT:32046","NEWT:544496","NEWT:59529","NEWT:2042546","NEWT:32049","NEWT:1392696","NEWT:259447","NEWT:295546","NEWT:45351","NEWT:445974","NEWT:43179","NEWT:180454","NEWT:5722","NCBITaxon:1280","NEWT:112503","NEWT:1129","NEWT:309807","NEWT:10245","NEWT:55153","NEWT:89184","NEWT:309800","NEWT:281395","NEWT:1211601","NEWT:876138","NEWT:44271","NEWT:193516","NEWT:351581","NEWT:43186","NEWT:428146","NEWT:1117","NEWT:498257","NEWT:10036","NEWT:1590","NEWT:498019","NEWT:1351","NEWT:1438992","NEWT:1352","NEWT:2649997","NEWT:1147161","NEWT:661410","NEWT:638632","NEWT:43150","NEWT:263737","NEWT:224326","NEWT:1333499","NEWT:376619","NCBITaxon:79857","NEWT:1096976","NEWT:5702","NEWT:95648","NEWT:1589","NEWT:135622","NEWT:1349","NEWT:35786","NEWT:1580","NEWT:399784","NEWT:96731","NEWT:383379","NEWT:1401257","NEWT:418106","NEWT:10029","NEWT:913645","NEWT:44491","NEWT:641809","NEWT:27933","NEWT:556484","NEWT:317447","NEWT:4688","NEWT:7955","NEWT:7719","NEWT:7959","NEWT:2261","NEWT:868565","NEWT:135674","NEWT:94323","NEWT:31156","NEWT:3112","NEWT:79329","NEWT:4442","NEWT:192875","NEWT:30069","NEWT:12637","NEWT:59729","NEWT:2164133","NEWT:284218","NEWT:295105","NEWT:108061","NEWT:60711","NEWT:1316931","NEWT:224308","NEWT:3347","NEWT:511145","NEWT:160621","NEWT:212790","NEWT:931281","NEWT:4432","NEWT:5762","NEWT:5763","NEWT:658457","NEWT:1310161","NEWT:77133","NEWT:295358","NEWT:145481","NEWT:1310165","NEWT:29058","NCBITaxon:79824","NEWT:2246","NEWT:2652724","NEWT:5757","NEWT:68415","NCBITaxon:4563","NEWT:5755","NEWT:44688","NEWT:44689","NEWT:44447","NEWT:752555","NEWT:498211","NEWT:5759","NEWT:347256","NEWT:1736231","NEWT:5518","NEWT:398007","NEWT:1527468","NEWT:1392","NEWT:498217","NEWT:498216","NEWT:2242","NEWT:11320","NEWT:286","NEWT:391619","NEWT:246196","NEWT:287","NEWT:246197","NEWT:145458","NEWT:633149","NEWT:1149786","NEWT:10239","NEWT:68895","NEWT:44685","NEWT:161934","NEWT:4897","NEWT:1148","NEWT:5744","NEWT:72901","NEWT:213863","NEWT:5508","NEWT:3329","NEWT:5507","NEWT:410661","NEWT:55571","NEWT:35500","NEWT:1235816","NEWT:1140","NCBITaxon:2157","NEWT:1143","NEWT:4896","NEWT:1287689","NEWT:1390","NEWT:11557","NEWT:1094343","NEWT:1462472","NEWT:1336795","NEWT:644042","NEWT:294","NEWT:1773","NEWT:1182590","NEWT:3712","NEWT:82380","NEWT:3711","NEWT:935293","NEWT:375146","NEWT:2065263","NEWT:177437","NEWT:1772","NEWT:10418","NEWT:118698","NEWT:1616117","NEWT:263","NEWT:118696","NEWT:34865","NEWT:52283","NEWT:11988","NEWT:284812","NEWT:8175","NEWT:400667","NEWT:43330","NEWT:1603293","NEWT:408169","NEWT:44664","NEWT:47946","NEWT:3702","NEWT:1245466","NEWT:243277","NEWT:1246791","NEWT:7067","NEWT:118694","NEWT:586722","NEWT:2850","NEWT:118691","NEWT:34871","NEWT:33548","NEWT:274","NEWT:7070","NCBITaxon:287","NEWT:408172","NEWT:408170","NEWT:96794","NEWT:3708","NEWT:332648","NEWT:44670","NEWT:536231","NEWT:376219","NEWT:219813","NEWT:1510","NEWT:1436733","NEWT:460519","NEWT:1247411","NEWT:1515","NEWT:572307","NEWT:1432138","NEWT:1424507","NEWT:1194599","NEWT:272844","NEWT:1303443","NEWT:9483","NEWT:333760","NEWT:34607","NEWT:56636","NEWT:1513458","NEWT:1233681","NCBITaxon:40559","NEWT:506599","NEWT:2853422","NEWT:81077","NEWT:84588","NEWT:1679718","NEWT:480","NEWT:65349","NEWT:67767","NEWT:46835","NEWT:109757","NEWT:582580","NEWT:300852","NEWT:1502","NEWT:128017","NEWT:376686","NEWT:95486","NEWT:508771","NEWT:1883446","NEWT:253","NCBITaxon:2759","NEWT:1233435","NEWT:93061","NEWT:93062","NEWT:34613","NCBITaxon:4932","NEWT:109760","NEWT:29031","NEWT:943274","NEWT:644223","NEWT:1263082","NEWT:235443","NEWT:108458","NEWT:5936","NEWT:272623","NEWT:272624","NEWT:320637","NEWT:886559","NEWT:3750","NEWT:55521","NEWT:983964","NEWT:118499","NEWT:11706","NEWT:32644","NEWT:527796","NEWT:1130798","NEWT:55529","NEWT:499175","NEWT:109779","NEWT:3745","NEWT:1715989","NCBITaxon:4751","NEWT:476272","NEWT:3747","NEWT:195051","NEWT:3988","NEWT:1116234","NEWT:561007","NEWT:1255228","NEWT:649908","NEWT:410289","NEWT:373153","NEWT:3983","NEWT:203696","NEWT:472","NEWT:352472","NEWT:97441","NEWT:1071661","NEWT:1202531","NEWT:1202532","NEWT:360094","NEWT:1408223","NEWT:470","NEWT:1408224","NEWT:41364","NEWT:5911","NEWT:1313","NEWT:1218097","NEWT:1080348","NCBITaxon:50557","NEWT:1314","NEWT:39251","NEWT:39491","NEWT:212142","NCBITaxon:5811","NEWT:29491","NEWT:101841","NEWT:153481","NEWT:2014887","NEWT:33952","NEWT:445","NEWT:153009","NEWT:261756","NEWT:571256","NEWT:40483","NEWT:63366","NEWT:63367","NEWT:688333","NEWT:215402","NCBITaxon:548681","NEWT:318586","NCBITaxon:5820","NEWT:1547","NEWT:272634","NEWT:198107","NEWT:9031","NEWT:27292","NEWT:1872122","NEWT:1308","NEWT:7091","NEWT:1034015","NEWT:760568","NEWT:141262","NEWT:108931","NEWT:1293497","NEWT:1055524","NEWT:4087","NEWT:9778","NEWT:306","NEWT:150475","NEWT:303","NEWT:267872","NEWT:97477","NEWT:7111","NEWT:347515","NEWT:172269","NEWT:9534","NEWT:6269","NEWT:5180","NEWT:256737","NEWT:4090","NEWT:4092","NEWT:9541","NEWT:8694","NEWT:4093","NEWT:33936","NEWT:4096","NEWT:8692","NEWT:2903","NEWT:185579","NEWT:941442","NEWT:536088","NEWT:13076","NEWT:1226408","NEWT:7108","NEWT:40479","NEWT:43989","NEWT:4076","NEWT:142615","NEWT:317","NEWT:1006581","NEWT:33940","NEWT:885318","NEWT:39488","NEWT:550","NEWT:4081","NEWT:273068","NEWT:554","NEWT:98334","NEWT:451516","NEWT:552","NEWT:231663","NEWT:4084","NEWT:1325291","NEWT:63577","NEWT:36185","NEWT:1225786","NEWT:7574","NEWT:1715256","NEWT:30640","NEWT:575412","NEWT:929793","NEWT:1507179","NEWT:29204","NEWT:28112","NEWT:114155","NEWT:6494","NEWT:6491","NEWT:507601","NEWT:520","NEWT:186441","NEWT:634955","NEWT:643680","NEWT:214092","NCBITaxon:6157","NEWT:6239","NEWT:13095","NEWT:162425","NEWT:104105","NEWT:216257","NEWT:102169","NEWT:208893","NEWT:9986","NEWT:4054","NEWT:8654","NEWT:8658","NEWT:1268063","NEWT:8657","NEWT:8655","NEWT:5147","NEWT:98351","NEWT:1263854","NEWT:118503","NEWT:2059687","NEWT:160488","NEWT:28104","NEWT:207559","NEWT:407821","NCBITaxon:2","NEWT:85057","NEWT:985076","NEWT:568708","NEWT:1215323","NEWT:986","NEWT:52641","NEWT:7159","NEWT:267671","NEWT:28532","NEWT:7160","NEWT:353152","NEWT:8496","NEWT:7165","NEWT:1257118","NEWT:1387333","NEWT:27448","NEWT:40674","NEWT:1194669","NEWT:235612","NEWT:243230","NEWT:443906","NEWT:1080772","NEWT:519","NEWT:8479","NEWT:8485","NEWT:6063","NEWT:49240","NEWT:1328388","NEWT:104395","NEWT:1548728","NEWT:667127","NEWT:9557","NEWT:9315","NEWT:6289","NEWT:377586","NEWT:6287","NEWT:38569","NEWT:300641","NEWT:727","NEWT:39655","NEWT:9796","NEWT:9554","NEWT:725","NEWT:7137","NEWT:38323","NEWT:469008","NEWT:256318","NEWT:9321","NEWT:206411","NCBITaxon:6191","NEWT:596153","NEWT:229533","NEWT:1836","NEWT:214053","NCBITaxon:10298","NEWT:80863","NEWT:90675","NEWT:105231","NEWT:104385","NEWT:74649","NEWT:52638","NEWT:57075","NEWT:206672","NEWT:4097","NEWT:8697","NEWT:8695","NEWT:884204","NEWT:71139","NEWT:9785","NEWT:6279","NEWT:1123869","NEWT:9544","NEWT:9545","NEWT:979","NEWT:7370","NEWT:9793","NEWT:83906","NCBITaxon:780","NCBITaxon:1502","NEWT:6282","NEWT:1134506","NEWT:255470","NEWT:27457","NEWT:38783","NEWT:4006","NEWT:6426","NCBITaxon:5476","NEWT:113208","NEWT:33090","NEWT:6669","NEWT:9935","NEWT:89453","NEWT:287889","NEWT:1114301","NEWT:305959","NEWT:51515","NEWT:13249","NEWT:588596","NEWT:51511","NEWT:8845","NEWT:92867","NEWT:92866","NEWT:419610","NEWT:5334","NEWT:51750","NEWT:202950","NEWT:382352","NEWT:413071","NCBITaxon:10239","NCBITaxon:714","NEWT:295027","NCBITaxon:11320","NEWT:632957","NEWT:11051","NEWT:9925","NEWT:89462","NCBITaxon:9606","NEWT:452680","NEWT:8839","NEWT:90690","NEWT:1436183","NEWT:4232","NEWT:2758385","NEWT:416348","NEWT:11298","NEWT:171101","NEWT:714","NEWT:5322","NEWT:421932","NEWT:312017","NEWT:196627","NEWT:576131","NEWT:200308","NEWT:553470","NEWT:200302","NEWT:870435","NEWT:284593","NEWT:100392","NEWT:655819","NEWT:5315","NEWT:11082","NEWT:9913","NEWT:265872","NEWT:9915","NEWT:105841","NEWT:337330","NEWT:2666255","NEWT:2285","NEWT:2287","NEWT:6645","NEWT:999810","NCBITaxon:5693","NEWT:28995","NEWT:1392998","NEWT:380394","NEWT:981087","NEWT:180066","NEWT:226900","NEWT:1266738","NEWT:231490","NEWT:244704","NEWT:7725","NCBITaxon:6312","NEWT:11072","NEWT:430615","NEWT:72664","NEWT:174633","NEWT:326423","NEWT:452467","NEWT:198822","NEWT:36111","NEWT:326424","NEWT:1416333","NEWT:35024","NEWT:135461","NEWT:1678078","NEWT:7962","NEWT:749906","NEWT:418985","NEWT:1817808","NEWT:749907","NEWT:150847","NEWT:145262","NEWT:145263","NEWT:431947","NEWT:69014","NEWT:142809","NEWT:694569","NEWT:130821","NEWT:27606","NEWT:9739","NEWT:1519788","NEWT:59202","NEWT:9975","NEWT:8643","NEWT:1159899","NEWT:51953","NEWT:502780","NEWT:57267","NEWT:3197","NEWT:13686","NEWT:2750454","NEWT:860688","NEWT:13443","NEWT:8644","NEWT:1402135","NEWT:36329","NEWT:62615","NEWT:5141","NEWT:46360","NCBITaxon:3044782","NEWT:202914","NEWT:1333550","NEWT:160235","NEWT:502779","NEWT:297246","NEWT:72407","NEWT:8639","NEWT:1928434","NEWT:8637","NEWT:349741","NEWT:1114970","NEWT:409859","NEWT:157295","NEWT:2096","NEWT:1263871","NEWT:509169","NEWT:192222","NEWT:9721","NEWT:137221","NEWT:9963","NEWT:1617910","NEWT:565050","NEWT:409860","NEWT:2785785","NEWT:411901","NEWT:8626","NEWT:105884","NCBITaxon:9615","NEWT:8621","NEWT:58334","NEWT:452659","NEWT:1193501","NEWT:58331","NEWT:6689","NEWT:8624","NEWT:5116","NEWT:8623","NEWT:5597","NCBITaxon:12637","NEWT:298315","NEWT:46105","NEWT:8618","NEWT:70448","NEWT:9704","NEWT:1049056","NEWT:698936","NEWT:1009874","NEWT:4498","NEWT:8855","NEWT:9940","NEWT:3168","NEWT:10185","NEWT:1247190","NEWT:521001","NEWT:192011","NEWT:1813887","NEWT:118702","NEWT:118700","NEWT:2126719","NEWT:224911","NEWT:118705","NCBITaxon:11552","NEWT:334249","NEWT:6945","NEWT:184922","NEWT:6703","NEWT:2104","NEWT:6943","NEWT:2","NEWT:157546","NEWT:35670","NEWT:511693","NEWT:870726","NEWT:4528","NEWT:91374","NEWT:91373","NEWT:474186","NEWT:10136","NEWT:38942","NEWT:35677","NEWT:1493","NEWT:10376","NEWT:307972","NEWT:1496","NEWT:2102","NEWT:3674","NEWT:660469","NEWT:935568","NEWT:34","NEWT:1365186","NEWT:38949","NEWT:45474","NEWT:1299114","NEWT:1590841","NEWT:2282334","NEWT:4513","NEWT:1247","NEWT:70667","NEWT:869728","NEWT:5843","NEWT:6938","NCBITaxon:39054","NCBITaxon:10407","NEWT:1736309","NEWT:4751","NEWT:10360","NEWT:194963","NEWT:47664","NEWT:260799","NEWT:317548","NEWT:15819","NEWT:109461","NEWT:3654","NEWT:237561","NEWT:1085956","NEWT:5833","NEWT:3659","NEWT:6928","NEWT:1239","NEWT:59620","NEWT:36745","NEWT:499229","NEWT:31298","NEWT:400727","NEWT:1204162","NEWT:272563","NEWT:11009","NEWT:82688","NEWT:5823","NEWT:3885","NEWT:3888","NEWT:5821","NEWT:44139","NEWT:649408","NCBITaxon:4895","NCBITaxon:4896","NEWT:315393","NEWT:6915","NEWT:3649","NEWT:101510","NEWT:28903","NEWT:3880","NEWT:272559","NEWT:216816","NEWT:153151","NEWT:28909","NEWT:515849","NEWT:3641","NEWT:10141","NEWT:95767","NEWT:466585","NEWT:1000589","NEWT:85963","NEWT:85962","NEWT:42197","NEWT:143361","NCBITaxon:5796","NEWT:12993","NEWT:398580","NEWT:4565","NEWT:1264690","NEWT:515619","NEWT:1299","NEWT:424718","NEWT:316407","NEWT:34305","NEWT:1794699","NCBITaxon:183674","NEWT:83558","NEWT:167387","NEWT:84645","NEWT:44586","NEWT:1123294","NEWT:626528","NEWT:139927","NEWT:4558","NEWT:209285","NEWT:5888","NEWT:211586","NEWT:747078","NEWT:1282","NEWT:1283","NEWT:431241","NEWT:4550","NEWT:1000561","NEWT:2133","NEWT:4555","NEWT:294381","NEWT:197","NEWT:1390363","NEWT:35889","NEWT:406072","NEWT:144030","NEWT:288705","NEWT:29176","NEWT:392815","NEWT:4787","NEWT:751585","NEWT:3217","NEWT:113549","NEWT:4547","NEWT:3218","NEWT:180788","NEWT:556182","NEWT:1270","NEWT:374990","NEWT:1432059","NEWT:154293","NEWT:388919","NEWT:156471","NEWT:4784","NEWT:3694","NEWT:360106","NEWT:156476","NEWT:4543","NEWT:4785","NEWT:210007","NEWT:360104","NEWT:1857017","NEWT:10117","NEWT:10359","NEWT:10116","NEWT:1280","NEWT:10358","NEWT:83333","NEWT:1735272","NEWT:83334","NEWT:109298","NEWT:83332","NEWT:317513","NEWT:580240","NEWT:294128","NEWT:11676","NEWT:100226","NEWT:718308","NEWT:1263","NEWT:4530","NEWT:176299","NEWT:5861","NEWT:54126","NEWT:75058","NEWT:13616","NEWT:296543","NEWT:173","NEWT:316435","NEWT:42157","NEWT:1895","NEWT:1034304","NEWT:105023","NEWT:866628","NEWT:64152","NEWT:4924","NEWT:749200","NEWT:2748","NEWT:8049","NEWT:33892","NEWT:9378","NEWT:990346","NEWT:145953","NEWT:257309","NEWT:100816","NEWT:203124","NEWT:192952","NEWT:1640346","NEWT:230741","NEWT:8296","NEWT:117008","NCBITaxon:1313","NEWT:167748","NEWT:1163394","NEWT:44544","NEWT:529818","NEWT:400540","NEWT:4911","NEWT:645463","NEWT:152480","NEWT:129249","NEWT:1077286","NEWT:943129","NEWT:1221594","NEWT:990119","NEWT:77216","NEWT:1524260","NEWT:1111708","NEWT:227321","NEWT:493760","NEWT:93163","NEWT:281677","NEWT:106590","NEWT:260710","NEWT:257313","NEWT:3827","NEWT:400772","NEWT:128161","NEWT:930945","NEWT:1162296","NEWT:106592","NEWT:106350","NEWT:46704","NEWT:482428","NEWT:1187947","NEWT:269796","NEWT:10312","NCBITaxon:1773","NEWT:54571","NEWT:190304","NEWT:412754","NEWT:9598","NEWT:8030","NEWT:1423772","NEWT:53232","NEWT:1235987","NCBITaxon:2509511","NEWT:1639","NEWT:188229","NEWT:246437","NEWT:3818","NEWT:4909","NEWT:759272","NEWT:432359","NEWT:1182263","NEWT:943146","NEWT:2711","NEWT:537457","NEWT:479249","NEWT:9103","NEWT:715877","NEWT:862238","NEWT:29159","NEWT:1155748","NEWT:10306","NEWT:9595","NEWT:8022","NEWT:6087","NEWT:145943","NEWT:595536","NEWT:240906","NEWT:593117","NEWT:89920","NEWT:29158","NEWT:3633","NEWT:319761","NEWT:3635","NEWT:5811","NEWT:3879","NEWT:180923","NEWT:1328881","NEWT:411483","NEWT:76336","NEWT:3870","NEWT:884019","NEWT:198215","NEWT:411490","NEWT:200298","NEWT:169963","NEWT:1400870","NEWT:587","NEWT:588","NEWT:585","NEWT:343","NEWT:84005","NEWT:225117","NEWT:746128","NEWT:8090","NEWT:5801","NEWT:43665","NEWT:212035","NEWT:5802","NCBITaxon:1653394","NEWT:1266464","NEWT:1205","NEWT:214693","NEWT:367830","NEWT:178616","NEWT:95145","NEWT:358","NEWT:375451","NEWT:357","NEWT:9172","NEWT:2770979","NEWT:2010198","NEWT:1277351","NEWT:1594786","NEWT:457428","NEWT:106178","NEWT:411469","NEWT:84023","NEWT:1679","NEWT:559292","NEWT:214684","NEWT:569","NEWT:411464","NEWT:411460","NEWT:2762","NEWT:1174673","NEWT:1328426","NEWT:562","NEWT:28035","NEWT:411470","NEWT:1313166","NEWT:2094720","NCBITaxon:2697049","NCBITaxon:138","NEWT:28038","NEWT:294750","NEWT:1663","NEWT:62141","NEWT:1422","NEWT:1423","NEWT:4932","NEWT:3603","NEWT:2756","NEWT:2759","NEWT:3848","NEWT:3847","NEWT:38293","NEWT:1428","NEWT:198466","NEWT:339","NEWT:327159","NEWT:178876","NEWT:1660","NEWT:2751","NEWT:327160","NEWT:573","NEWT:571","NEWT:142479","NEWT:12922","NEWT:163159","NEWT:29595","NEWT:1306413","NEWT:241368","NEWT:2813599","NEWT:518766","NEWT:42528","NEWT:2664373","NEWT:190802","NEWT:1213463","NEWT:9417","NEWT:1216979","NEWT:7237","NEWT:264483","NEWT:509924","NEWT:28450","NEWT:115104","NEWT:1121114","NEWT:5061","NEWT:663","NEWT:8570","NEWT:1081927","NEWT:1238993","NEWT:1408434","NEWT:67825","NEWT:187878","NEWT:1241935","NEWT:220668","NEWT:1821314","NEWT:1249668","NEWT:426430","NEWT:9407","NEWT:37181","NEWT:9646","NEWT:5286","NEWT:7227","NEWT:7469","NEWT:9402","NEWT:9644","NEWT:415540","NEWT:336722","NEWT:675060","NEWT:416870","NEWT:334542","NEWT:313625","NEWT:51240","NEWT:27592","NEWT:5052","NEWT:426428","NEWT:227289","NEWT:63459","NEWT:2652157","NEWT:2652158","NEWT:40324","NEWT:588858","NEWT:9638","NEWT:9639","NCBITaxon:11071","NEWT:242231","NEWT:197221","NEWT:7215","NEWT:528354","NEWT:51453","NEWT:2172103","NCBITaxon:59201","NEWT:7460","NEWT:504457","NEWT:434271","NEWT:392227","NEWT:747679","NEWT:66712","NEWT:42752","NEWT:103372","NEWT:746360","NEWT:862751","NEWT:89764","NEWT:470150","NEWT:9627","NEWT:543734","NEWT:1009714","NEWT:73239","NEWT:38018","NEWT:226186","NEWT:9870","NEWT:8782","NEWT:30538","NEWT:115357","NEWT:435590","NEWT:1902","NEWT:63436","NEWT:1908","NEWT:1169740","NEWT:13164","NEWT:1601067","NEWT:216129","NEWT:1245012","NEWT:2664179","NEWT:623","NEWT:7038","NEWT:6192","NCBITaxon:1639","NCBITaxon:38727","NEWT:74790","NEWT:2829","NEWT:62335","NEWT:366581","NEWT:757417","NEWT:216599","NEWT:405534","NEWT:216595","NEWT:40559","NEWT:51208","NEWT:216597","NEWT:9689","NEWT:8355","NEWT:633","NEWT:1607839","NEWT:9685","NEWT:7029","NEWT:6182","NEWT:1283300","NEWT:9694","NEWT:1218707","NEWT:186990","NEWT:8364","NEWT:632","NEWT:1204551","NEWT:6183","NEWT:99586","NEWT:630","NCBITaxon:11019","NEWT:334747","NEWT:3907","NEWT:61235","NEWT:392021","NEWT:343691","NEWT:1457551","NEWT:15368","NEWT:1491466","NEWT:436486","NEWT:340188","NEWT:51655","NEWT:1933298","NEWT:170187","NEWT:260707","NEWT:121845","NEWT:8595","NEWT:7263","NEWT:186763","NEWT:185431","NEWT:216591","NEWT:29760","NEWT:260704","NEWT:1719","NEWT:703612","NEWT:260705","NEWT:1202347","NEWT:692672","NEWT:2697049","NEWT:1505907","NEWT:1216981","NEWT:1109443","NEWT:1249885","NEWT:7004","NEWT:1972855","NEWT:9669","NCBITaxon:6073","NEWT:1089448","NEWT:1415167","NEWT:1329349","NEWT:607699","NEWT:6161","NEWT:208963","NEWT:208964","NEWT:27337","NEWT:575584","NEWT:181088","NEWT:185687","NEWT:3039","NEWT:669202","NEWT:2706014","NEWT:8727","NEWT:8726","NEWT:6306","NEWT:10090","NEWT:8729","NEWT:4120","NEWT:8720","NEWT:5693","NEWT:2186","NEWT:8724","NEWT:8723","NEWT:283166","NEWT:37334","NEWT:5697","NEWT:6544","NCBITaxon:10357","NCBITaxon:10114","NCBITaxon:10359","NEWT:1685931","NEWT:1203258","NEWT:242619","NEWT:49317","NEWT:557722","NEWT:160791","NEWT:1353008","NEWT:34073","NEWT:696811","NEWT:402042","NEWT:9808","NEWT:373995","NEWT:8715","NEWT:5689","NEWT:839","NEWT:544404","NEWT:92519","NEWT:2173","NEWT:943925","NEWT:4111","NEWT:37349","NEWT:4113","NEWT:837","NEWT:640459","NEWT:72568","NEWT:36015","NEWT:51641","NEWT:1232801","NEWT:81866","NEWT:1262469","NEWT:5691","NEWT:48479","NEWT:61435","NEWT:627025","NEWT:1097677","NEWT:375939","NEWT:61674","NEWT:2072580","NEWT:669465","NEWT:3258","NEWT:1117957","NEWT:6526","NEWT:112018","NEWT:8709","NEWT:4100","NEWT:1159556","NEWT:5671","NEWT:1076","NEWT:4102","NEWT:4101","NEWT:6763","NEWT:8700","NEWT:803","NEWT:29722","NEWT:1692259","NEWT:1486917","NEWT:2847306","NEWT:468911","NEWT:13373","NEWT:7604","NEWT:6756","NEWT:818","NEWT:135588","NEWT:1843183","NEWT:5661","NEWT:157592","NEWT:1061","NEWT:51866","NEWT:29719","NEWT:58002","NEWT:13136","NEWT:5665","NEWT:6754","NEWT:1179777","NEWT:6997","NEWT:452589","NEWT:509068","NEWT:5666","NEWT:4577","NEWT:813","NEWT:5664","NEWT:2157","NEWT:146479","NEWT:1042986","NEWT:1911079","NEWT:69373","NEWT:1843192","NEWT:206189","NEWT:427577","NEWT:264203","NEWT:1480154","NEWT:9859","NEWT:1274414","NEWT:9612","NEWT:38626","NEWT:1286640","NEWT:38865","NEWT:3077","NEWT:9615","NEWT:10299","NEWT:6100","NEWT:713604","NEWT:112273","NEWT:1087439","NEWT:33178","NEWT:1147787","NEWT:61408","NEWT:1440772","NEWT:1355477","NEWT:8759","NEWT:9605","NEWT:9606","NEWT:90371","NEWT:641501","NEWT:4153","NEWT:9601","NEWT:278839","NEWT:35128","NEWT:39966","NEWT:7668","NEWT:8756","NEWT:915099","NEWT:74940","NEWT:13551","NEWT:10041","NEWT:9600","NEWT:1450511","NEWT:1143193","NEWT:1122233","NEWT:890382","NEWT:174934","NEWT:179392","NEWT:2823525","NEWT:115778","NEWT:59540","NEWT:9838","NEWT:9839","NEWT:546414","NEWT:227086","NEWT:3055","NEWT:11167","NEWT:9835","NEWT:7650","NEWT:4146","NEWT:5478","NEWT:6326","NEWT:7656","NEWT:5476","NEWT:1450520","NEWT:1042311","NEWT:1123352","NEWT:1882945","NEWT:746707","NEWT:299767","NEWT:235909","NEWT:28835","NEWT:1206781","NEWT:47311","NEWT:1274432","NEWT:127785","NEWT:708248","NEWT:2053667","NEWT:1274426","NEWT:104660","NEWT:9825","NEWT:1274423","NEWT:393765","NEWT:652611","NEWT:104421","NEWT:39946","NEWT:9823","NEWT:95602","NEWT:8732","NEWT:314539","NEWT:763037","NEWT:39947","NEWT:1274420","NEWT:578458","NEWT:60520"],"ORCID":["0000-0002-1995-1637"]}}