{"database":"Pride","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Xlsx":["ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/Link_between_files.xlsx"],"Msf":["ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_42.msf","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_25.msf","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_12.msf","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_08.msf","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_38.msf","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_01b.msf","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_06.msf","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_23.msf","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_14.msf","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_31.msf","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_17.msf","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_47.msf","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_04.msf","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_29.msf","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_20.msf","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_33.msf","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_02.msf","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_19.msf","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_37.msf","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_10.msf","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_45.msf","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_35.msf","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_27.msf","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_26.msf","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_30.msf","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_13.msf","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_43.msf","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_09.msf","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_39.msf","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_15.msf","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_41.msf","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_24.msf","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_07.msf","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_32.msf","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_05.msf","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_48.msf","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_22.msf","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_34.msf","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_21.msf","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_40.msf","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_16.msf","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_46.msf","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_03.msf","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_28.msf","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_11.msf","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_36.msf","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_44.msf","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_18.msf"],"Txt":["ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/checksum.txt"],"Raw":["ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_41.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_05.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_24.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_37.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_18.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_35.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_48.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_07.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_22.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_16.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_26.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_43.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_09.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_33.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_15.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_28.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_44.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_31.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_21.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_38.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_13.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_11.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_03.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_46.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_36.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_23.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_10.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_40.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_01b.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_19.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_06.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_34.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_08.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_42.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_17.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_25.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_32.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_45.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_27.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_02.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_14.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_47.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_04.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_29.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_30.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_20.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_39.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_12.raw"],"Fasta":["ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/RP_UP000005640_Homo_sapiens_2025_01_23.fasta"],"Other":["ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_08.pdResult","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_14.pdResult","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_20.pdResult","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_44.pdResult","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_03.pdResult","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_38.pdResult","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_31.pdResult","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_16.pdResult","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_19.pdResult","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_25.pdResult","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_22.pdResult","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_41.pdResult","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_29.pdResult","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_23.pdResult","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_24.pdResult","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_06.pdResult","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_47.pdResult","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_39.pdResult","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_48.pdResult","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_33.pdResult","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_05.pdResult","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_42.pdResult","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_26.pdResult","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_32.pdResult","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_15.pdResult","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_09.pdResult","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_21.pdResult","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_01b.pdResult","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_13.pdResult","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_10.pdResult","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_40.pdResult","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_04.pdResult","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_07.pdResult","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_43.pdResult","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_34.pdResult","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_37.pdResult","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_28.pdResult","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_35.pdResult","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_17.pdResult","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_46.pdResult","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_30.pdResult","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_12.pdResult","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_18.pdResult","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_45.pdResult","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_27.pdResult","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_36.pdResult","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_11.pdResult","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067270/jh250422_02.pdResult"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"labhead_mail":["heithem.jeddou@chu-rennes.fr"],"submitter":["Dupuy Jean-William"],"technology_type":["Data-dependent acquisition","Mass Spectrometry","Bottom-up proteomics"],"software":[""],"submitter_keywords":["Biliary complications","Quantitative proteomics","Graft viability","Normothermic machine perfusion","Liver transplantation"],"full_dataset_link":["https://www.ebi.ac.uk/pride/archive/projects/PXD067270"],"tissue":["Liver"],"sample_protocol":["Fresh human liver biopsies (n = 48) were collected from 16 grafts at three time points: after static cold storage (B1), after normothermic machine perfusion (B2), and one hour after reperfusion (B3). All samples were immediately snap-frozen in liquid nitrogen and stored at –80 °C until analysis. Tissues were lysed in 100 mM Tris-HCl buffer (pH 7.6) containing 1% SDS and protease inhibitors (Complete™, Roche). Mechanical disruption was performed using tungsten beads in a tissue homogenizer, followed by ultrasonication. Lysates were clarified by centrifugation at 10,000 g for 15 minutes at 4 °C, and protein concentration was measured using a BCA assay (Thermo Fisher). Protein extracts were reduced with 30 mM DTT at 56 °C for 1 hour, alkylated with 90 mM iodoacetamide in the dark at room temperature, and processed using the SP3 (Single-Pot Solid-Phase-enhanced Sample Preparation) method on a Biomek i5 Workstation. Proteins were digested overnight with trypsin (Promega). Peptides were quantified using the Pierce™ fluorometric peptide assay kit prior to LC-MS/MS analysis. NanoLC-MS/MS analysis were performed using a Vanquish Neo UHPLC System (Thermo Scientific) associated to Orbitrap Exploris™ 480. The peptide extracts were loaded onto a 5 mm × 300 µm ID PepMap Neo Trap Cartridge (C18, 5 µm particle size, 100 Å pore size, Thermo Scientific) and separated on an analytical column (25 cm × 75 μm ID, 1.7 µm, C18 beads, Ionopticks) at a flow rate of 300 nL/min at 50°C using a multistep gradient of 3–25% mobile phase B (80% MeCN in 0.1% formic acid) for 45 minutes and 25–35% B for 15 minutes, 35–95% B for 1 minute and an 11-minute wash at 99% B. The mass spectrometer operated in positive ion mode at a 1.4 kV needle voltage, and data were acquired using Xcalibur 4.5 software in a data-dependent mode. MS scans (m/z 375–1500) were recorded at a resolution of R = 120000 (@ m/z 200), a standard AGC target, and an injection time in automatic mode, followed by a top speed duty cycle of up to 1 second for MS/MS acquisition. Precursor ions (2–6 charge states) were isolated in the quadrupole with a mass window of 2 Th and fragmented with HCD @ 30% normalized collision energy. MS/MS data were acquired with a resolution of R = 15000 (@m/z 200), a standard AGC target, and a maximum injection time in automatic mode. Selected precursors were excluded for 45 seconds."],"repository":["Pride"],"quantification_method":[""],"modification":[""],"data_protocol":["Protein identification and label-free quantification (LFQ) were done in Proteome Discoverer 3.1. The CHIMERYS node using the prediction model inferys_3.0.0 fragmentation, Sequest HT and MS Amanda were used to identify proteins in batch mode by searching against the UniProt Homo sapiens database (83095 entries, released January 2025). Two missed enzyme cleavages were allowed for trypsin. Peptide lengths of 7–30 amino acids, a maximum of 3 modifications, charges of 2–4, and 20 ppm for fragment mass tolerance were set. Oxidation (M, P), Phosphorylation (S, T, Y) and carbamidomethyl (C) were respectively searched as dynamic and static modifications by the software. Peptide validation was performed using the Percolator algorithm and only “high confidence” peptides were retained corresponding to a 1% false discovery rate at the peptide level. Minora feature detector node (LFQ) was used along with the feature mapper and precursor ions quantifier. The normalization parameters were selected as follows: (1) Unique peptides, (2) Precursor abundance based on intensity, (3) Normalization mode: total peptide amount from Homo sapiens, (4) Protein abundance calculation: summed abundances, (5) Protein ratio calculation: pairwise ratio based and (6) Missing values were replaced with random values sampled from the lower 5% of detected values. Quantitative data were considered for master proteins, quantified by a minimum of 2 unique peptides, a fold changes above 2 and a statistical p-value lower than 0.05"],"omics_type":["Proteomics"],"labhead":["Heithem Jeddou"],"instrument_platform":[""],"labhead_affiliation":["Institut de recherche en santé, environnement et travail (IRSET). 9 Av. du Professeur Léon Bernard, 35000 Rennes"],"submission_type":["PARTIAL"],"species":["Homo Sapiens (human)"],"submitter_mail":["jean-william.dupuy@u-bordeaux.fr"],"publication":["41981940 Jeddou H, Raymond AA, Dupuy JW, Dourthe C, Prudhomme H, Nejma EB, Tzedakis S, Turlin B, Allaume P, Boudjema K, Samson M. Proteomic Trajectories of Metabolic and Proteostatic Adaptation During Normothermic Liver Perfusion. Liver Int. 2026 46(5):e70629 10.1111/liv.70629"],"submitter_affiliation":["OncoProt plateform, UAR TBMCore CNRS 3427 INSERM US005 University of Bordeaux"],"submitter_country":["France"],"pubmed_abstract":["<h4>Background</h4>Normothermic machine perfusion (NMP) enables metabolic restoration and viability testing of liver grafts, but current viability criteria incompletely predict post-transplant outcomes. The molecular basis of graft resilience or biliary vulnerability remains unclear. This study aimed to characterise tissue-level proteomic trajectories during NMP and early reperfusion to identify molecular signatures associated with biliary complications after liver transplantation (LT).<h4>Methods</h4>This prospective, single-centre study was conducted at Rennes University Hospital. Twenty donation-after-brain-death (DBD) livers underwent NMP; sixteen transplanted grafts with complete sequential biopsies and ≥ 6 months of follow-up were analysed. Biopsies were collected after cold storage (B1), at the end of NMP (B2), and 1 h after graft reperfusion (B3). Proteins were quantified by high-resolution LC-MS/MS and analysed with Proteome Discoverer 3.1/Chimerys. Pathway enrichment used Ingenuity Pathway Analysis to compare grafts with and without biliary complications.<h4>Results</h4>Principal component analysis revealed distinct proteomic profiles between grafts with and without complications at all biopsy time points. During NMP (B2/B1), uncomplicated grafts showed glycolytic activation with attenuation of oxidative phosphorylation, whereas complicated grafts showed blunted glycolysis and mild OXPHOS upregulation. At reperfusion (B3/B2), complicated grafts displayed induction of translational and endoplasmic-reticulum-stress pathways, while resilient grafts maintained proteasome-related protein turnover and enrichment of a hypoxia-response signature driven by ELOC and proteasome subunits.<h4>Conclusions</h4>Sequential tissue proteomics during NMP reveals divergent metabolic and proteostatic adaptations linked to biliary outcomes. Glycolytic activation with preserved protein turnover characterises resilient grafts, whereas translational and ER-stress programmes predominate in complicated ones. These insights may refine viability assessment beyond biochemical criteria."],"pubmed_title":["Proteomic Trajectories of Metabolic and Proteostatic Adaptation During Normothermic Liver Perfusion."],"pubmed_authors":["Jeddou Heithem H, Raymond Anne-Aurélie AA, Dupuy Jean-William JW, Dourthe Cyril C, Prudhomme Hector H, Nejma Eya Ben EB, Tzedakis Stylianos S, Turlin Bruno B, Allaume Pierre P, Boudjema Karim K, Samson Michel M"],"additional_accession":[]},"is_claimable":false,"name":"Proteomic profiling during normothermic perfusion predicts liver graft quality and outcomes after transplantation","description":"This study investigates the proteomic dynamics of human liver grafts during normothermic machine perfusion (NMP), using mass spectrometry-based analysis. A total of 16 donor livers were perfused with NMP and sampled at three distinct time points to assess molecular changes and their association with post-transplant outcomes. The aim was to identify proteomic biomarkers predictive of graft quality and biliary complications.","dates":{"publication":"2026-04-27","submission":"2025-08-12"},"accession":"PXD067270","cross_references":{"TAXONOMY":["NEWT:330879","NEWT:377960","NEWT:1131","NEWT:2042546","NEWT:259447","NEWT:295546","NEWT:1334565","NEWT:625351","NEWT:258594","NCBITaxon:1280","NEWT:112503","NEWT:1129","NEWT:309807","NEWT:59753","NEWT:89184","NEWT:309800","NEWT:281395","NEWT:1211601","NEWT:876138","NEWT:44271","NEWT:193516","NEWT:1073882","NEWT:6819","NEWT:475174","NEWT:1117","NEWT:498257","NEWT:10036","NEWT:1590","NEWT:10034","NEWT:33114","NEWT:661410","NEWT:638632","NEWT:224326","NEWT:376619","NCBITaxon:79857","NEWT:1096976","NEWT:3765","NEWT:3767","NEWT:1589","NEWT:135622","NEWT:35786","NEWT:1580","NEWT:399784","NEWT:96731","NEWT:656064","NEWT:1582","NEWT:1584","NEWT:36630","NEWT:383379","NEWT:418106","NCBITaxon:12721","NEWT:10029","NEWT:913645","NEWT:641809","NEWT:1392488","NEWT:38815","NEWT:317447","NEWT:4688","NEWT:7719","NEWT:5530","NEWT:868565","NEWT:135674","NEWT:79329","NEWT:30069","NEWT:12637","NEWT:59729","NEWT:2164133","NEWT:295105","NEWT:108061","NEWT:60711","NEWT:224308","NEWT:3347","NEWT:160621","NEWT:212790","NEWT:110368","NEWT:1310161","NEWT:77133","NEWT:145481","NEWT:1310165","NEWT:29058","NCBITaxon:79824","NEWT:410658","NEWT:5516","NEWT:44688","NEWT:44689","NEWT:498211","NEWT:347256","NEWT:5518","NEWT:398007","NEWT:1527468","NEWT:498217","NEWT:498216","NEWT:11320","NEWT:246196","NEWT:246197","NEWT:145458","NEWT:1310173","NEWT:44685","NEWT:161934","NEWT:1148","NEWT:5508","NEWT:3329","NEWT:419481","NEWT:5507","NEWT:410661","NEWT:1140","NCBITaxon:2157","NEWT:1143","NEWT:1287689","NEWT:1094343","NEWT:1462472","NEWT:1336795","NEWT:644042","NEWT:150808","NEWT:1182590","NEWT:3712","NEWT:3711","NEWT:3714","NCBITaxon:37162","NEWT:2065263","NEWT:177437","NEWT:10891","NEWT:10418","NEWT:118698","NEWT:1616117","NEWT:118696","NEWT:34865","NEWT:52283","NEWT:284812","NEWT:8175","NEWT:43330","NEWT:1603293","NEWT:44664","NEWT:43346","NEWT:3702","NEWT:1245466","NEWT:3704","NEWT:244366","NEWT:1246791","NEWT:176597","NEWT:118694","NEWT:2850","NEWT:118691","NEWT:34871","NEWT:33548","NEWT:52299","NEWT:8165","NEWT:96794","NEWT:3708","NEWT:332648","NEWT:44670","NEWT:926571","NEWT:536231","NEWT:376219","NEWT:219813","NEWT:1510","NEWT:460519","NEWT:1515","NEWT:572307","NEWT:1432138","NEWT:1424507","NEWT:1194599","NEWT:272844","NEWT:1348799","NEWT:33995","NEWT:55784","NEWT:1303443","NEWT:485","NEWT:56636","NEWT:2499525","NEWT:2853422","NEWT:487","NEWT:1538553","NEWT:1679718","NEWT:480","NEWT:67767","NEWT:46835","NEWT:109757","NEWT:582580","NEWT:1185650","NEWT:216778","NEWT:1502","NEWT:128017","NEWT:376686","NEWT:237610","NEWT:95486","NEWT:1883446","NEWT:1233435","NEWT:118223","NEWT:11757","NEWT:987059","NEWT:109760","NEWT:29031","NEWT:317047","NEWT:491","NEWT:460523","NEWT:45954","NEWT:235443","NEWT:1757312","NEWT:85694","NEWT:109786","NEWT:108458","NEWT:5936","NEWT:320637","NEWT:1078283","NEWT:3750","NEWT:983964","NEWT:11706","NEWT:32644","NEWT:527796","NEWT:499175","NEWT:109779","NEWT:3745","NEWT:1715989","NCBITaxon:4751","NEWT:3747","NEWT:1116234","NEWT:1255228","NEWT:410289","NEWT:373153","NEWT:1640278","NEWT:472","NEWT:940825","NEWT:529507","NEWT:1071661","NEWT:28128","NEWT:470","NEWT:5911","NEWT:748693","NCBITaxon:50557","NEWT:39251","NEWT:29491","NEWT:101841","NEWT:446","NEWT:153481","NEWT:2014887","NEWT:33952","NEWT:445","NEWT:153009","NEWT:261756","NEWT:166313","NEWT:63366","NEWT:63367","NEWT:215402","NEWT:1547","NEWT:1290454","NEWT:906914","NEWT:28141","NEWT:9031","NEWT:27292","NEWT:1050722","NEWT:3728","NEWT:108931","NEWT:1293497","NEWT:1055524","NEWT:150475","NEWT:267872","NEWT:381666","NEWT:172269","NEWT:9534","NEWT:5180","NEWT:256737","NEWT:9541","NEWT:8694","NEWT:33936","NEWT:8692","NEWT:2903","NEWT:185579","NEWT:13076","NEWT:207340","NEWT:1006581","NEWT:8673","NEWT:33940","NEWT:550","NEWT:554","NEWT:451516","NEWT:552","NEWT:1325291","NEWT:42410","NEWT:36185","NEWT:1054211","NEWT:1225786","NEWT:771870","NEWT:51338","NEWT:575412","NEWT:28112","NEWT:49012","NEWT:6493","NEWT:10832","NEWT:6494","NEWT:6491","NEWT:507601","NEWT:520","NEWT:186441","NEWT:643680","NEWT:214092","NCBITaxon:6157","NEWT:13095","NEWT:162425","NEWT:104105","NEWT:216257","NEWT:9986","NEWT:8654","NEWT:8658","NEWT:1268063","NEWT:8657","NEWT:9983","NEWT:8655","NEWT:5147","NEWT:28108","NEWT:28104","NEWT:407821","NEWT:568703","NCBITaxon:2","NEWT:568708","NEWT:1613","NEWT:986","NEWT:52641","NEWT:28532","NEWT:353152","NEWT:298176","NEWT:353153","NEWT:227377","NEWT:1774284","NEWT:40674","NEWT:1194669","NEWT:443906","NEWT:13037","NEWT:519","NEWT:2510939","NEWT:7394","NEWT:6063","NEWT:1328388","NEWT:105487","NEWT:1548728","NEWT:667127","NEWT:9557","NEWT:377586","NEWT:300641","NEWT:39655","NEWT:9554","NEWT:475932","NEWT:256318","NEWT:206411","NCBITaxon:6191","NEWT:229533","NEWT:214053","NEWT:28550","NEWT:80863","NEWT:90675","NEWT:52639","NEWT:52638","NEWT:57075","NEWT:1666905","NEWT:8697","NEWT:861109","NEWT:8695","NEWT:884204","NEWT:1045775","NEWT:1123869","NEWT:9544","NEWT:9545","NEWT:979","NEWT:7370","NEWT:83906","NEWT:99488","NEWT:1134506","NEWT:255470","NEWT:38783","NEWT:6426","NEWT:33090","NEWT:9935","NEWT:287889","NEWT:305959","NEWT:1028307","NEWT:13489","NEWT:29829","NEWT:92867","NEWT:92866","NCBITaxon:3055","NEWT:51750","NEWT:202950","NEWT:441772","NEWT:1293091","NEWT:48106","NEWT:202956","NEWT:295027","NCBITaxon:11320","NEWT:632957","NEWT:9925","NCBITaxon:9606","NEWT:90690","NEWT:1436183","NEWT:300273","NEWT:4232","NEWT:416348","NEWT:11298","NEWT:4236","NEWT:7742","NEWT:196627","NEWT:1076878","NEWT:200308","NEWT:200302","NEWT:870435","NEWT:58370","NEWT:9913","NEWT:9915","NEWT:105841","NEWT:2666255","NEWT:999810","NCBITaxon:5693","NEWT:28995","NEWT:2144189","NEWT:1392998","NEWT:380394","NEWT:1150621","NEWT:226900","NEWT:1266738","NEWT:231490","NEWT:244704","NEWT:7725","NEWT:9909","NEWT:9902","NEWT:430615","NEWT:72664","NEWT:563041","NEWT:36599","NEWT:41949","NEWT:249161","NEWT:326423","NEWT:452467","NEWT:198822","NEWT:36111","NEWT:326424","NEWT:1678078","NEWT:749906","NEWT:418985","NEWT:749907","NEWT:150847","NEWT:29835","NEWT:431947","NEWT:69014","NEWT:142809","NEWT:1095183","NEWT:302409","NEWT:130821","NEWT:27606","NEWT:1519788","NEWT:59202","NEWT:9975","NEWT:8643","NEWT:1801631","NEWT:1159899","NEWT:502780","NEWT:860688","NEWT:13443","NEWT:35231","NEWT:1774208","NEWT:8644","NEWT:1125630","NEWT:5141","NEWT:46360","NCBITaxon:3044782","NEWT:202914","NEWT:160235","NEWT:502779","NEWT:297246","NEWT:103690","NEWT:8639","NEWT:1928434","NEWT:8637","NEWT:1114970","NEWT:2096","NEWT:285272","NEWT:192222","NEWT:9963","NEWT:1617910","NEWT:197911","NEWT:197912","NEWT:637379","NEWT:12107","NEWT:2785785","NEWT:411901","NEWT:1298722","NEWT:8626","NEWT:186801","NEWT:105884","NCBITaxon:9615","NEWT:8621","NEWT:58334","NEWT:58331","NEWT:6446","NEWT:8624","NEWT:5116","NEWT:6447","NEWT:8623","NEWT:5597","NEWT:194439","NCBITaxon:12637","NEWT:38727","NEWT:218496","NEWT:8618","NEWT:70448","NEWT:300251","NEWT:9940","NEWT:13451","NEWT:1247190","NEWT:118702","NEWT:118700","NEWT:2126719","NEWT:118705","NEWT:6945","NEWT:2104","NEWT:2627626","NEWT:6943","NEWT:157546","NEWT:870726","NEWT:91374","NEWT:91373","NEWT:1414448","NEWT:474186","NEWT:54195","NEWT:10136","NEWT:38942","NEWT:4762","NEWT:6941","NEWT:307972","NEWT:2102","NEWT:34","NEWT:38949","NEWT:1299114","NEWT:1590841","NEWT:60876","NEWT:1276473","NEWT:2282334","NEWT:1247","NEWT:70667","NEWT:869728","NEWT:6938","NCBITaxon:39054","NEWT:1736309","NEWT:4751","NEWT:36774","NEWT:194963","NEWT:77298","NEWT:15819","NEWT:109461","NEWT:1085956","NEWT:6928","NEWT:1239","NEWT:36745","NEWT:400727","NEWT:272560","NEWT:272563","NEWT:11009","NEWT:913998","NEWT:68335","NEWT:3885","NEWT:3888","NEWT:649408","NEWT:6915","NEWT:101510","NEWT:3880","NEWT:272559","NEWT:216816","NEWT:153151","NEWT:2681598","NEWT:515849","NEWT:10141","NEWT:95767","NEWT:466585","NEWT:1000589","NEWT:85963","NEWT:85962","NEWT:42197","NEWT:143361","NEWT:5656","NEWT:1292","NEWT:1295","NEWT:1299","NEWT:316407","NEWT:1794699","NCBITaxon:183674","NEWT:167387","NEWT:84645","NEWT:1123294","NEWT:6978","NEWT:209285","NEWT:211586","NEWT:747078","NEWT:1282","NEWT:1283","NEWT:1000561","NEWT:253836","NEWT:2133","NEWT:6973","NEWT:294381","NEWT:197","NEWT:1390363","NEWT:35889","NEWT:406072","NEWT:351660","NEWT:29176","NEWT:201319","NEWT:1073569","NEWT:4787","NEWT:751585","NEWT:113549","NEWT:180788","NEWT:159749","NEWT:1270","NEWT:388919","NEWT:130081","NEWT:4784","NEWT:360106","NEWT:4785","NEWT:360104","NEWT:10117","NEWT:401614","NEWT:10116","NEWT:1280","NEWT:83333","NEWT:83334","NEWT:242718","NEWT:83332","NEWT:161","NEWT:242715","NEWT:2951803","NEWT:100226","NEWT:1263","NEWT:176299","NEWT:1654360","NEWT:54126","NEWT:75058","NEWT:13616","NEWT:13613","NEWT:296543","NEWT:173","NEWT:316435","NEWT:42157","NEWT:1034304","NEWT:105023","NEWT:866628","NEWT:535026","NEWT:749200","NEWT:1036967","NEWT:266264","NEWT:272942","NEWT:272943","NEWT:1882682","NEWT:145953","NEWT:257309","NEWT:33657","NEWT:203124","NEWT:230741","NEWT:8296","NEWT:117008","NEWT:167748","NEWT:1163394","NEWT:645463","NEWT:749696","NEWT:320549","NEWT:990119","NEWT:77216","NEWT:1111708","NEWT:11855","NEWT:998086","NEWT:493760","NEWT:93163","NEWT:257313","NEWT:3827","NEWT:400772","NEWT:257310","NEWT:128161","NEWT:930945","NEWT:332521","NEWT:106350","NEWT:29170","NEWT:269796","NEWT:54571","NEWT:412754","NEWT:9598","NEWT:52389","NEWT:2665964","NEWT:1423772","NEWT:51056","NEWT:35815","NEWT:53232","NEWT:1235987","NCBITaxon:2509511","NEWT:1639","NEWT:188229","NEWT:3818","NEWT:432359","NEWT:9103","NEWT:715877","NEWT:862238","NEWT:29159","NEWT:1155748","NEWT:9593","NEWT:8260","NEWT:9595","NEWT:2665958","NEWT:246200","NEWT:6087","NEWT:145943","NEWT:595536","NEWT:1134822","NEWT:240906","NEWT:89920","NEWT:3809","NEWT:29158","NEWT:44744","NEWT:3879","NEWT:1328881","NEWT:411483","NEWT:76336","NEWT:3870","NEWT:884019","NEWT:411490","NEWT:169963","NEWT:587","NEWT:588","NEWT:585","NEWT:746128","NEWT:212035","NCBITaxon:1653394","NEWT:1205","NEWT:214693","NEWT:45609","NEWT:239935","NEWT:1680","NEWT:280148","NEWT:9172","NEWT:2770979","NEWT:112","NEWT:423477","NEWT:1277351","NEWT:1594786","NEWT:40366","NEWT:3854","NEWT:411469","NEWT:1679","NEWT:333849","NEWT:214684","NEWT:1758543","NEWT:569","NEWT:411464","NEWT:411460","NEWT:1328426","NEWT:562","NEWT:411470","NEWT:10515","NEWT:2094720","NCBITaxon:2697049","NEWT:294750","NEWT:1663","NEWT:214675","NEWT:62141","NEWT:65651","NEWT:3848","NEWT:3847","NEWT:198466","NEWT:327159","NEWT:1045010","NEWT:178876","NEWT:1660","NEWT:327160","NEWT:573","NEWT:1131757","NEWT:571","NEWT:142479","NEWT:29595","NEWT:241368","NEWT:42528","NEWT:1969471","NEWT:9657","NEWT:150596","NEWT:30540","NEWT:264483","NEWT:439733","NEWT:76777","NEWT:30545","NEWT:76773","NEWT:1121114","NEWT:663","NEWT:1081927","NEWT:1238993","NEWT:67825","NEWT:187878","NEWT:1504802","NEWT:1821314","NEWT:103351","NEWT:40354","NEWT:1249668","NEWT:426430","NEWT:37181","NEWT:929439","NEWT:9646","NEWT:5286","NEWT:7469","NEWT:9644","NEWT:426428","NEWT:63459","NEWT:2652157","NEWT:2652158","NEWT:40353","NEWT:40324","NEWT:588858","NEWT:9638","NEWT:9639","NCBITaxon:11071","NEWT:693977","NEWT:242231","NEWT:197221","NEWT:528354","NEWT:51453","NEWT:1279085","NEWT:28231","NEWT:7460","NEWT:504457","NEWT:392227","NEWT:1004024","NEWT:103372","NEWT:862751","NEWT:470150","NEWT:9627","NEWT:1009714","NEWT:73239","NEWT:38018","NEWT:226186","NEWT:381518","NEWT:30532","NEWT:8782","NEWT:115357","NEWT:5270","NEWT:63436","NEWT:63433","NEWT:13164","NEWT:1601067","NEWT:129554","NEWT:40302","NEWT:1249615","NEWT:343232","NEWT:343237","NEWT:2664179","NEWT:623","NEWT:217219","NEWT:7038","NEWT:6192","NCBITaxon:1639","NEWT:3915","NEWT:1581419","NEWT:405534","NEWT:9689","NEWT:8355","NEWT:633","NEWT:9685","NEWT:1218948","NEWT:7029","NEWT:9688","NEWT:6182","NEWT:9694","NEWT:604162","NEWT:1046723","NEWT:186990","NEWT:8364","NEWT:6185","NEWT:632","NEWT:6183","NEWT:1423800","NEWT:630","NCBITaxon:11019","NEWT:334747","NEWT:3907","NEWT:3906","NEWT:27315","NEWT:61235","NEWT:343691","NEWT:1457551","NEWT:15368","NEWT:13180","NEWT:1491466","NEWT:340188","NEWT:170187","NEWT:1755437","NEWT:1042399","NEWT:9681","NEWT:1719","NEWT:692672","NEWT:2697049","NEWT:568813","NEWT:1109443","NEWT:267566","NEWT:58042","NEWT:7004","NEWT:9669","NCBITaxon:6073","NEWT:1089448","NEWT:1329349","NEWT:1089444","NEWT:607699","NEWT:6161","NEWT:206542","NEWT:27337","NEWT:575584","NEWT:186536","NEWT:257771","NEWT:185687","NEWT:3039","NEWT:2706014","NEWT:8727","NEWT:8726","NEWT:8725","NEWT:10090","NEWT:8729","NEWT:8720","NEWT:5693","NEWT:2186","NEWT:8724","NEWT:8723","NEWT:283166","NEWT:439334","NEWT:8722","NEWT:5697","NEWT:6544","NEWT:218192","NCBITaxon:10114","NEWT:1685931","NEWT:242619","NEWT:557722","NEWT:160791","NEWT:1353008","NEWT:34073","NEWT:402042","NEWT:373995","NEWT:8715","NEWT:5689","NEWT:544404","NEWT:287535","NEWT:2173","NEWT:2175","NEWT:1232801","NEWT:5691","NEWT:61674","NEWT:2072580","NEWT:669465","NEWT:1117957","NEWT:6526","NEWT:8709","NEWT:1064539","NEWT:8707","NEWT:1306274","NEWT:5671","NEWT:13146","NEWT:6523","NEWT:8700","NEWT:1692259","NEWT:1486917","NEWT:1843183","NEWT:5661","NEWT:157592","NEWT:3482","NEWT:52714","NEWT:51866","NEWT:58002","NEWT:13136","NEWT:5660","NEWT:5665","NEWT:1179777","NEWT:6997","NEWT:5666","NEWT:1746091","NEWT:5664","NEWT:2157","NEWT:70125","NEWT:146479","NEWT:1843192","NEWT:206189","NEWT:2160","NEWT:295139","NEWT:181214","NEWT:6108","NEWT:1720309","NEWT:9612","NEWT:1286640","NEWT:38865","NEWT:3077","NEWT:9615","NEWT:6100","NEWT:713604","NEWT:3076","NEWT:112273","NEWT:33178","NEWT:1147787","NEWT:39717","NEWT:62977","NEWT:1440772","NEWT:8759","NEWT:9605","NEWT:9606","NEWT:27717","NEWT:641501","NEWT:9601","NEWT:8752","NEWT:34038","NEWT:9604","NEWT:8756","NEWT:74940","NEWT:13551","NEWT:10041","NEWT:9600","NEWT:1450511","NEWT:439375","NEWT:1857323","NEWT:890382","NEWT:174934","NEWT:179392","NEWT:2823525","NEWT:115778","NEWT:1538186","NEWT:82996","NEWT:227086","NEWT:3055","NEWT:195883","NEWT:1450520","NEWT:1042311","NEWT:1123352","NEWT:741258","NEWT:82525","NEWT:29920","NEWT:235909","NEWT:47311","NCBITaxon:813","NEWT:127785","NEWT:708248","NEWT:47314","NEWT:104660","NEWT:652611","NEWT:94993","NEWT:8732","NEWT:763037","NEWT:1250232","NEWT:1052588","NEWT:1377","NEWT:3555","NEWT:71647","NEWT:260201","NEWT:35554","NCBITaxon:12939","NEWT:935692","NEWT:32046","NEWT:2222","NEWT:544496","NEWT:59529","NEWT:32049","NEWT:1392696","NEWT:762376","NEWT:45351","NEWT:445974","NEWT:43179","NEWT:180454","NEWT:3544","NEWT:5722","NEWT:7901","NEWT:32051","NEWT:10245","NEWT:55153","NEWT:10243","NEWT:351581","NEWT:43186","NEWT:428146","NEWT:498019","NEWT:1351","NEWT:1438992","NEWT:1352","NEWT:32025","NEWT:2649997","NEWT:1147161","NEWT:43150","NEWT:69781","NEWT:85831","NEWT:263737","NEWT:1333499","NEWT:5702","NEWT:95648","NEWT:1349","NEWT:100787","NEWT:1401257","NEWT:44491","NEWT:27933","NEWT:556484","NEWT:7955","NEWT:7959","NEWT:645159","NEWT:2261","NEWT:94323","NEWT:31156","NEWT:3112","NEWT:8801","NEWT:4442","NEWT:192875","NEWT:1214916","NEWT:284218","NEWT:1316931","NEWT:511145","NEWT:213401","NEWT:931281","NEWT:4432","NEWT:5762","NEWT:5763","NEWT:118099","NEWT:32019","NEWT:658457","NEWT:420247","NEWT:35525","NEWT:295358","NEWT:2246","NEWT:2652724","NEWT:5757","NEWT:68415","NCBITaxon:4563","NEWT:5755","NEWT:44447","NEWT:752555","NEWT:39097","NEWT:347495","NEWT:5759","NEWT:1736231","NEWT:1392","NEWT:35974","NEWT:2242","NEWT:1396","NEWT:286","NEWT:391619","NEWT:287","NEWT:1367269","NEWT:633149","NEWT:1149786","NEWT:10239","NEWT:68895","NEWT:3567","NEWT:68888","NEWT:4897","NEWT:5744","NEWT:72901","NEWT:213863","NEWT:55571","NEWT:35500","NEWT:2041044","NEWT:3562","NEWT:4896","NEWT:5740","NEWT:1262161","NEWT:1314781","NEWT:1390","NEWT:11557","NEWT:294","NEWT:1773","NEWT:82380","NEWT:935293","NEWT:375146","NEWT:471876","NEWT:1772","NEWT:263","NEWT:11988","NEWT:400667","NEWT:408169","NEWT:36809","NEWT:47946","NEWT:1764","NEWT:39087","NEWT:413996","NEWT:243277","NEWT:7067","NEWT:586722","NEWT:243273","NEWT:1986198","NEWT:274","NEWT:7070","NCBITaxon:287","NEWT:408172","NEWT:408170","NEWT:283734","NEWT:1436733","NEWT:42229","NEWT:1247411","NEWT:9238","NEWT:13708","NEWT:333760","NEWT:34607","NEWT:1513458","NEWT:1233681","NEWT:2212966","NCBITaxon:40559","NEWT:506599","NEWT:81077","NEWT:84588","NEWT:1279007","NEWT:85433","NEWT:65349","NEWT:300852","NEWT:564933","NEWT:508771","NEWT:1121405","NEWT:253","NCBITaxon:2759","NEWT:93061","NEWT:93062","NEWT:1284813","NEWT:34613","NEWT:7054","NCBITaxon:4932","NEWT:1748","NEWT:108673","NEWT:2764168","NEWT:943274","NEWT:1488406","NEWT:644223","NEWT:1263082","NEWT:272623","NEWT:1288389","NEWT:272624","NEWT:886559","NEWT:55521","NEWT:118499","NEWT:1130798","NEWT:55529","NEWT:256136","NEWT:476272","NEWT:195051","NEWT:3988","NEWT:561007","NEWT:649908","NEWT:1001135","NEWT:147828","NEWT:3981","NEWT:3983","NEWT:203696","NEWT:352472","NEWT:235","NEWT:505235","NEWT:55518","NEWT:97441","NEWT:1154756","NEWT:1202531","NEWT:1202532","NEWT:360094","NEWT:1408223","NEWT:1408224","NEWT:41364","NEWT:1311","NEWT:1313","NEWT:1218097","NEWT:1080348","NEWT:1314","NEWT:39491","NEWT:212142","NCBITaxon:5811","NEWT:3972","NEWT:1499105","NEWT:192812","NEWT:408188","NEWT:571256","NEWT:40483","NEWT:688333","NEWT:1119529","NEWT:1303","NCBITaxon:548681","NEWT:318586","NCBITaxon:5820","NEWT:272634","NEWT:198107","NEWT:1979401","NEWT:155892","NEWT:691","NEWT:28384","NEWT:167879","NEWT:1872122","NEWT:1308","NEWT:7091","NEWT:1034015","NEWT:760568","NEWT:141262","NEWT:1813","NEWT:4087","NEWT:9778","NEWT:306","NEWT:303","NEWT:97477","NEWT:7111","NEWT:113287","NEWT:347515","NEWT:6269","NEWT:4090","NEWT:4092","NEWT:4093","NEWT:786","NEWT:4096","NEWT:208895","NEWT:941442","NEWT:536088","NEWT:311553","NEWT:1226408","NEWT:43984","NEWT:7108","NEWT:40479","NEWT:43989","NEWT:4076","NEWT:142615","NEWT:317","NEWT:885319","NEWT:293939","NEWT:497515","NEWT:885318","NEWT:39488","NEWT:4081","NEWT:273068","NEWT:1316582","NEWT:227166","NEWT:98334","NEWT:231663","NEWT:4084","NEWT:63577","NEWT:7574","NEWT:1715256","NEWT:30640","NEWT:348824","NEWT:929793","NEWT:1507179","NEWT:29204","NEWT:114155","NEWT:4072","NEWT:1337056","NEWT:4073","NEWT:634955","NEWT:6239","NEWT:102169","NEWT:208893","NEWT:4054","NEWT:301301","NEWT:98351","NEWT:1263854","NEWT:118503","NEWT:2059687","NEWT:160488","NEWT:63558","NEWT:61376","NEWT:207559","NEWT:107401","NEWT:85057","NEWT:985076","NEWT:1215323","NCBITaxon:565995","NEWT:7159","NEWT:267671","NEWT:72491","NEWT:7160","NEWT:8496","NEWT:7165","NEWT:1257118","NEWT:1387333","NEWT:8010","NEWT:1315282","NEWT:7162","NEWT:1859","NEWT:27448","NEWT:2708","NEWT:235612","NEWT:243232","NEWT:243230","NEWT:936053","NEWT:1080772","NEWT:8479","NEWT:8485","NEWT:119856","NEWT:72000","NEWT:119857","NEWT:49240","NEWT:161398","NEWT:2893330","NCBITaxon:3707","NEWT:391295","NEWT:1170828","NEWT:93934","NEWT:9315","NEWT:6289","NEWT:6287","NEWT:38569","NEWT:727","NEWT:9796","NEWT:725","NEWT:7137","NEWT:469008","NEWT:9321","NEWT:596153","NEWT:1836","NCBITaxon:10298","NEWT:1652998","NEWT:105231","NEWT:104385","NEWT:74649","NEWT:1037924","NEWT:206672","NEWT:9788","NEWT:4097","NEWT:9305","NEWT:436113","NEWT:71139","NEWT:9785","NEWT:6279","NEWT:1195774","NEWT:9793","NCBITaxon:780","NCBITaxon:1502","NEWT:6282","NEWT:27457","NEWT:4006","NEWT:1872635","NCBITaxon:5476","NEWT:113208","NEWT:6669","NEWT:1215360","NEWT:89453","NEWT:1114301","NEWT:51515","NEWT:13249","NEWT:588596","NEWT:51511","NEWT:8845","NEWT:7998","NEWT:419610","NEWT:5334","NEWT:382352","NEWT:413071","NCBITaxon:10239","NEWT:332097","NCBITaxon:714","NEWT:1076620","NEWT:11051","NEWT:89462","NEWT:452680","NEWT:8839","NEWT:4472","NEWT:2758385","NEWT:171101","NEWT:714","NEWT:5322","NEWT:568996","NEWT:421932","NEWT:312017","NEWT:576131","NEWT:553470","NCBITaxon:10243","NEWT:284593","NEWT:100392","NEWT:655819","NEWT:5315","NEWT:11082","NEWT:265872","NEWT:59463","NEWT:337330","NEWT:2285","NEWT:2287","NEWT:6645","NEWT:251229","NEWT:981087","NEWT:180066","NEWT:46147","NCBITaxon:6312","NEWT:11072","NEWT:174633","NEWT:52830","NEWT:1416333","NEWT:35024","NEWT:135461","NEWT:7962","NEWT:99287","NEWT:1817808","NEWT:145262","NEWT:145263","NEWT:694569","NEWT:9739","NEWT:111069","NEWT:1379791","NEWT:51953","NEWT:57267","NEWT:3197","NEWT:13686","NEWT:2750454","NEWT:264561","NEWT:1402135","NEWT:36329","NEWT:62615","NEWT:1555636","NEWT:1333550","NEWT:646099","NEWT:72407","NEWT:352914","NEWT:349741","NEWT:409859","NEWT:157295","NEWT:1263871","NEWT:509169","NEWT:6210","NEWT:9721","NEWT:137221","NEWT:565050","NEWT:409860","NEWT:92683","NEWT:1298968","NEWT:5353","NEWT:1034809","NEWT:452659","NEWT:1193501","NEWT:51930","NEWT:6689","NEWT:194675","NEWT:298315","NEWT:392547","NEWT:46105","NEWT:104782","NEWT:10181","NEWT:9704","NEWT:1049056","NEWT:698936","NEWT:13216","NEWT:1009874","NEWT:4498","NEWT:8855","NEWT:11034","NEWT:3168","NEWT:10185","NEWT:78168","NEWT:521001","NEWT:192011","NEWT:340912","NEWT:1813887","NEWT:224911","NEWT:1090946","NCBITaxon:11552","NEWT:267608","NEWT:334249","NEWT:184922","NEWT:6703","NEWT:2","NEWT:35670","NEWT:511693","NEWT:4528","NEWT:35677","NEWT:136841","NEWT:1493","NEWT:10376","NEWT:1496","NEWT:3674","NEWT:5851","NEWT:660469","NEWT:935568","NEWT:1365186","NEWT:1813019","NEWT:45474","NEWT:48500","NEWT:4513","NEWT:5843","NEWT:110205","NEWT:1117645","NCBITaxon:10407","NEWT:1000364","NEWT:10360","NEWT:1403536","NEWT:1427524","NEWT:47664","NEWT:260799","NEWT:317548","NEWT:106198","NEWT:2323","NEWT:3654","NEWT:237561","NEWT:5833","NEWT:3659","NEWT:59620","NEWT:499229","NEWT:31298","NEWT:1204162","NEWT:1532734","NEWT:82688","NEWT:5823","NEWT:5821","NEWT:44139","NCBITaxon:4895","NEWT:570417","NCBITaxon:4896","NEWT:675512","NEWT:315393","NEWT:3649","NEWT:28903","NEWT:28909","NEWT:3641","NEWT:79698","NCBITaxon:5796","NEWT:12993","NEWT:398580","NEWT:4565","NEWT:1264690","NEWT:515619","NEWT:170721","NEWT:34305","NEWT:77020","NEWT:1908323","NEWT:83558","NEWT:44586","NEWT:626528","NEWT:139927","NEWT:4558","NEWT:5888","NEWT:431241","NEWT:4550","NEWT:4555","NEWT:443226","NEWT:144036","NEWT:144030","NEWT:288705","NEWT:392815","NEWT:3217","NEWT:4547","NEWT:3218","NEWT:556182","NEWT:374990","NEWT:36941","NEWT:1432059","NEWT:154293","NEWT:156471","NEWT:3694","NEWT:156476","NEWT:4543","NEWT:210007","NEWT:1857017","NEWT:10359","NEWT:1358430","NEWT:10358","NEWT:1381693","NEWT:1735272","NEWT:109298","NEWT:317513","NEWT:707678","NEWT:580240","NEWT:294128","NEWT:11676","NEWT:1917265","NEWT:55210","NEWT:718308","NEWT:4530","NEWT:5861","NEWT:1895","NEWT:2558360","NEWT:64152","NEWT:4924","NEWT:2748","NEWT:8049","NEWT:33892","NEWT:99931","NEWT:9378","NEWT:990346","NEWT:100816","NEWT:192952","NEWT:1640346","NCBITaxon:1313","NEWT:29385","NEWT:44544","NEWT:529818","NEWT:400540","NEWT:382","NEWT:4911","NEWT:152480","NEWT:129249","NEWT:1888","NEWT:1077286","NEWT:943129","NEWT:131567","NEWT:1221594","NEWT:10760","NEWT:1524260","NEWT:227321","NEWT:192944","NEWT:492670","NEWT:281677","NEWT:106590","NEWT:260710","NEWT:4918","NEWT:1162296","NEWT:106592","NEWT:596645","NEWT:46704","NEWT:42345","NEWT:482428","NEWT:1187947","NEWT:4903","NEWT:10312","NCBITaxon:1773","NEWT:190304","NEWT:1432499","NEWT:8030","NEWT:246432","NEWT:246437","NEWT:36909","NEWT:4909","NEWT:1279365","NEWT:759272","NEWT:1182263","NEWT:943146","NEWT:646532","NEWT:2711","NEWT:537457","NEWT:479249","NEWT:435623","NEWT:33889","NEWT:10306","NEWT:12967","NEWT:8022","NEWT:42353","NEWT:593117","NEWT:3633","NEWT:319761","NEWT:3635","NEWT:5811","NEWT:86662","NEWT:180923","NEWT:1451","NEWT:198215","NEWT:200298","NEWT:12916","NEWT:1400870","NEWT:343","NEWT:84005","NEWT:225117","NEWT:34708","NEWT:8090","NEWT:5801","NEWT:43665","NEWT:5802","NEWT:4952","NEWT:1266464","NEWT:367830","NEWT:1093790","NEWT:178616","NEWT:95145","NEWT:358","NEWT:375451","NEWT:54788","NEWT:357","NEWT:74381","NEWT:2010198","NCBITaxon:186538","NEWT:457428","NEWT:316275","NEWT:84023","NEWT:589904","NEWT:559292","NEWT:2762","NEWT:1174673","NEWT:28035","NEWT:1313166","NEWT:690307","NCBITaxon:138","NEWT:28038","NEWT:1422","NEWT:84030","NEWT:1423","NEWT:4932","NEWT:1205903","NEWT:3603","NEWT:2756","NEWT:2759","NEWT:38293","NEWT:1428","NEWT:339","NEWT:2751","NEWT:330","NEWT:139077","NEWT:391904","NEWT:12922","NEWT:316277","NEWT:163159","NEWT:1306413","NEWT:2813599","NEWT:518766","NEWT:2664373","NEWT:190802","NEWT:1213463","NEWT:7234","NEWT:9417","NEWT:1216979","NEWT:9895","NEWT:7237","NEWT:5059","NEWT:31631","NEWT:509924","NEWT:28450","NEWT:115104","NEWT:5061","NEWT:7240","NEWT:8570","NEWT:127569","NEWT:5062","NEWT:1408434","NEWT:1241935","NEWT:220668","NEWT:9407","NEWT:7227","NEWT:193079","NEWT:9402","NEWT:415540","NEWT:336722","NEWT:675060","NEWT:416870","NEWT:334542","NEWT:313625","NEWT:51240","NEWT:27592","NEWT:5052","NEWT:227289","NEWT:1985738","NEWT:7215","NEWT:196139","NEWT:5037","NEWT:651182","NEWT:2172103","NCBITaxon:59201","NEWT:7220","NEWT:1876254","NEWT:434271","NEWT:1915","NEWT:747679","NEWT:66712","NEWT:42752","NEWT:746360","NEWT:89764","NEWT:543734","NEWT:49390","NEWT:9870","NEWT:256648","NEWT:435590","NEWT:1902","NEWT:208526","NEWT:1908","NEWT:1169740","NEWT:217459","NEWT:216129","NEWT:1245012","NEWT:171250","NEWT:528135","NEWT:1637254","NCBITaxon:38727","NEWT:176946","NEWT:74790","NEWT:254472","NEWT:2829","NEWT:126279","NEWT:1228997","NEWT:1428006","NEWT:62335","NEWT:366581","NEWT:757417","NEWT:216599","NEWT:216595","NEWT:40559","NEWT:51208","NEWT:216597","NEWT:42736","NEWT:1607839","NEWT:1283300","NEWT:1218707","NEWT:1204551","NEWT:99586","NEWT:228577","NEWT:2060328","NEWT:48038","NEWT:392021","NEWT:436486","NEWT:51655","NEWT:1933298","NEWT:260707","NEWT:121845","NEWT:8595","NEWT:7263","NEWT:186763","NEWT:447135","NEWT:185431","NEWT:216591","NEWT:29760","NEWT:260704","NEWT:703612","NEWT:260705","NEWT:1295743","NEWT:546805","NEWT:1505907","NEWT:1216981","NEWT:1249885","NEWT:853","NEWT:7244","NEWT:1415167","NEWT:36036","NCBITaxon:662","NEWT:9430","NEWT:851","NEWT:71251","NEWT:208963","NEWT:208964","NEWT:181088","NEWT:48498","NEWT:669202","NEWT:1193806","NEWT:6306","NEWT:4120","NEWT:37334","NCBITaxon:10357","NEWT:2040765","NCBITaxon:10358","NCBITaxon:10359","NEWT:1203258","NEWT:49317","NEWT:1899318","NEWT:696811","NEWT:9808","NEWT:839","NEWT:9803","NEWT:1097670","NEWT:92519","NEWT:943925","NEWT:4111","NEWT:37349","NEWT:4113","NEWT:837","NEWT:640459","NEWT:72568","NEWT:36015","NEWT:51641","NEWT:35168","NEWT:81866","NEWT:334147","NEWT:1262469","NEWT:555778","NEWT:277944","NEWT:48479","NEWT:61435","NEWT:627025","NEWT:1097677","NEWT:375939","NEWT:712938","NEWT:3258","NEWT:112018","NEWT:1906951","NEWT:52945","NEWT:4100","NEWT:1159556","NEWT:1076","NEWT:4102","NEWT:1028688","NEWT:4101","NEWT:6763","NEWT:803","NEWT:29722","NEWT:37319","NEWT:419947","NEWT:2847306","NEWT:468911","NEWT:13373","NEWT:266834","NEWT:7604","NEWT:6756","NEWT:817","NEWT:818","NEWT:135588","NEWT:1061","NEWT:29719","NEWT:6754","NEWT:452589","NEWT:509068","NEWT:2794344","NEWT:4577","NEWT:813","NEWT:1365218","NEWT:337677","NEWT:1042986","NEWT:1911079","NEWT:69373","NEWT:427577","NEWT:264203","NEWT:1480154","NEWT:9858","NEWT:9859","NEWT:512623","NEWT:1274414","NEWT:2907833","NEWT:38626","NEWT:10298","NEWT:10299","NEWT:1087439","NEWT:9852","NEWT:9860","NEWT:660025","NEWT:61408","NEWT:1355477","NEWT:90371","NEWT:55194","NEWT:2907829","NEWT:4153","NEWT:11137","NEWT:278839","NEWT:35128","NEWT:39966","NEWT:7668","NEWT:2929635","NEWT:58228","NEWT:915099","NEWT:1143193","NEWT:687914","NEWT:1122233","NEWT:859313","NEWT:59540","NEWT:9838","NEWT:9839","NEWT:546414","NEWT:11167","NEWT:9835","NEWT:7650","NEWT:4146","NEWT:5478","NEWT:6326","NEWT:7656","NEWT:5476","NEWT:5477","NEWT:1882945","NEWT:746707","NEWT:299767","NEWT:28835","NEWT:1206781","NEWT:5480","NEWT:1274432","NEWT:222863","NEWT:2053667","NEWT:859321","NEWT:1274426","NEWT:9825","NEWT:1274423","NEWT:393765","NEWT:104421","NEWT:39946","NEWT:9823","NEWT:95602","NEWT:39947","NEWT:1274420","NEWT:859314","NEWT:578458","NEWT:60520"],"pubmed":["41981940"],"ORCID":["0000-0002-2448-4797"]}}