{"database":"Pride","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Xlsx":["ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD067605/MS_CircMT-RNR2.xlsx.zip"],"Txt":["ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD067605/checksum.txt"],"Raw":["ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD067605/202240620_06_HF1_GN3_IVC_3.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD067605/202240620_05_HF1_GN3_IVC_2.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD067605/202240620_01_HF1_GN3_CircRNR2_1.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD067605/202240620_02_HF1_GN3_CircRNR2_2.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD067605/202240620_03_HF1_GN3_CircRNR2_3.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD067605/202240620_04_HF1_GN3_IVC_1.raw"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"labhead_mail":["ning.xu@ki.se"],"submitter":["Ning Xu Landén"],"technology_type":["Mass Spectrometry","Gel-based experiment"],"software":[""],"submitter_keywords":["Wound repair","Diabetic foot ulcers","Mitochondrial circrna"],"full_dataset_link":["https://www.ebi.ac.uk/pride/archive/projects/PXD067605"],"tissue":["Skin"],"sample_protocol":["The circMT-RNR2 pulldown assay was conducted using biotin-labeled probes and streptavidin-coated magnetic beads. A probe specific to circMT-RNR2 was designed, with a control probe included to assess specificity. Briefly, cell lysates were prepared in Co-IP buffer under RNase-free conditions, supplemented with RNase inhibitors. The pulldown probe was denatured at 90°C in a thermal cycler and then added to the lysate, followed by incubation at 4°C for 4 hours with rotation to allow RNA-protein complexes to form. Streptavidin-coated beads were added in 1× Native Binding Buffer and incubated at room temperature for 1 hour with rotation. After pulldown using a magnetic rack, beads were washed several times with B&W buffer to remove non-specifically bound molecules. The captured RNA-protein complexes were eluted; bound proteins were analyzed by mass spectrometry at the Proteomics Biomedicum Core Facility (Karolinska Institute), and associated RNAs were extracted using TRIzol and analyzed by qRT-PCR to confirm enrichment of circMT-RNR2."],"repository":["Pride"],"quantification_method":["Not available"],"modification":[""],"data_protocol":["MS/MS raw data were analyzed using Mascot (Matrix Science, London, UK; version 2.5.1). Mascot was set up to search the SwissProt_2020_02 database (selected for Homo sapiens, 20368 entries) assuming the digestion enzyme trypsin. Mascot was searched with a fragment ion mass tolerance of 0.020 Da and a parent ion tolerance of 10.0 PPM. Carbamidomethyl of cysteine was specified in Mascot as a fixed modification. Deamidated of asparagine and glutamine, oxidation of methionine and acetyl of the n-terminus were specified in Mascot as variable modifications. Scaffold (version Scaffold_4.11.0, Proteome Software Inc., Portland, OR) was used to validate MS/MS based peptide and protein identifications. Peptide identifications were accepted if they could be established at greater than 10.0% probability by the Scaffold Local FDR algorithm. Protein identifications were accepted if they could be established at greater than 96.0% probability and contained at least 2 identified peptides."],"omics_type":["Proteomics"],"labhead":["Ning Xu Landén"],"instrument_platform":[""],"labhead_affiliation":["Dermatology and Venereology Division, Department of Medicine (Solna), Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden"],"submission_type":["PARTIAL"],"species":["Homo Sapiens (human)"],"submitter_mail":["ning.xu@ki.se"],"publication":["41655237 Niu G, Geara J, Chen Y, Luo L, Xiao Y, Liu Z, Gaborieau M, Pan L, Loh E, Li D, Sommar P, Wang A, Zheng X, Xu Landén N. Mitochondrial CircRNA CircMT-RNR2 Safeguards Antioxidant Defense to Support Fibroblast Functions in Wound Repair. Adv Sci (Weinh). 2026 13(26):e17141 10.1002/advs.202517141"],"submitter_affiliation":["Karolinska Institutet"],"submitter_country":["Sweden"],"pubmed_abstract":["Diabetic foot ulcers (DFUs) are a debilitating diabetes complication in which mitochondrial dysfunction and oxidative stress are prominent but mechanistically unresolved features. Here, we identify the mitochondria-encoded circular RNA (mecciRNA) circMT-RNR2 as a novel modulator of mitochondrial redox homeostasis in human skin wound healing. CircMT-RNR2 is reduced in DFU patient tissue and diabetic mouse wounds, enriched in dermal fibroblasts, and localized to mitochondria. Its loss impairs fibroblast proliferation, migration, extracellular matrix production, and contraction by destabilizing the mitochondrial antioxidant protein PRDX3, leading to elevated oxidative stress, mitochondrial damage, and mitophagy. In murine and human ex vivo wound models, circMT-RNR2 knockdown delays healing, whereas overexpression accelerates repair and boosts antioxidant defenses. These findings position circMT-RNR2 as a mitochondrial guardian of skin healing and a promising therapeutic target for DFU."],"pubmed_title":["Mitochondrial CircRNA CircMT-RNR2 Safeguards Antioxidant Defense to Support Fibroblast Functions in Wound Repair."],"pubmed_authors":["Niu Guanglin G, Geara Jennifer J, Chen Yongjian Y, Luo Lihua L, Xiao Yanwei Y, Liu Zhuang Z, Gaborieau Margaux M, Pan Ling L, Loh Edmund E, Li Dongqing D, Sommar Pehr P, Wang Aoxue A, Zheng Xiaowei X, Xu Landén Ning N"],"additional_accession":[]},"is_claimable":false,"name":"Mitochondrial CircRNA CircMT-RNR2 Safeguards Antioxidant Defense to Support Fibroblast Functions in Wound Repair","description":"Diabetic foot ulcers (DFUs) are a debilitating diabetes complication in which mitochondrial dysfunction and oxidative stress are prominent but mechanistically unresolved features. Here, we identify the mitochondria-encoded circular RNA circMT-RNR2 as a novel modulator of mitochondrial redox homeostasis in human skin wound healing. CircMT-RNR2 is reduced in DFU patient tissue and diabetic mouse wounds, enriched in dermal fibroblasts, and localized to mitochondria. Its loss impairs fibroblast proliferation, migration, extracellular matrix production, and contraction by destabilizing the mitochondrial antioxidant protein PRDX3, leading to elevated oxidative stress, mitochondrial damage, and mitophagy. In murine and human ex vivo wound models, circMT-RNR2 knockdown delays healing, whereas overexpression accelerates repair and boosts antioxidant defenses. These findings position circMT-RNR2 as a mitochondrial guardian of skin healing and a promising therapeutic target for DFUs.","dates":{"publication":"2026-06-08","submission":"2025-08-22"},"accession":"PXD067605","cross_references":{"TAXONOMY":["NEWT:330879","NEWT:377960","NEWT:2042546","NEWT:259447","NEWT:295546","NCBITaxon:2719036","NEWT:625351","NCBITaxon:1280","NEWT:112503","NEWT:1129","NEWT:309807","NEWT:59753","NEWT:89184","NEWT:309800","NEWT:281395","NEWT:1211601","NEWT:876138","NEWT:44271","NEWT:193516","NEWT:1073882","NEWT:6819","NEWT:475174","NEWT:1117","NEWT:498257","NEWT:10036","NEWT:1590","NEWT:10034","NEWT:661410","NEWT:638632","NEWT:224326","NEWT:376619","NCBITaxon:79857","NEWT:1096976","NEWT:3765","NEWT:1589","NEWT:135622","NEWT:35786","NEWT:1580","NEWT:399784","NEWT:96731","NEWT:656064","NEWT:1582","NEWT:36630","NEWT:383379","NEWT:418106","NCBITaxon:12721","NEWT:10029","NEWT:913645","NEWT:641809","NEWT:1392488","NEWT:38815","NEWT:317447","NEWT:4688","NEWT:7719","NEWT:868565","NEWT:135674","NEWT:79329","NEWT:30069","NEWT:12637","NEWT:59729","NEWT:2164133","NEWT:295105","NEWT:108061","NEWT:60711","NEWT:224308","NEWT:3347","NEWT:160621","NEWT:212790","NEWT:110368","NEWT:1310161","NEWT:77133","NEWT:145481","NEWT:1310165","NEWT:29058","NCBITaxon:79824","NEWT:410658","NEWT:44688","NEWT:44689","NEWT:498211","NEWT:347256","NEWT:5518","NEWT:398007","NEWT:1527468","NEWT:498217","NEWT:498216","NEWT:11320","NEWT:246196","NEWT:246197","NEWT:145458","NEWT:44685","NEWT:161934","NEWT:156587","NEWT:1148","NEWT:5508","NEWT:3329","NEWT:419481","NEWT:5507","NEWT:410661","NEWT:1140","NCBITaxon:2157","NEWT:1143","NEWT:1287689","NEWT:1094343","NEWT:1462472","NEWT:1336795","NEWT:644042","NEWT:1182590","NEWT:3712","NEWT:3711","NEWT:3714","NEWT:270643","NEWT:2065263","NEWT:177437","NEWT:10418","NEWT:118698","NEWT:1616117","NEWT:118696","NEWT:34865","NEWT:52283","NEWT:28174","NEWT:284812","NEWT:8175","NEWT:43330","NEWT:1603293","NEWT:44664","NEWT:43346","NEWT:3702","NEWT:1245466","NEWT:3704","NEWT:244366","NEWT:1246791","NEWT:176597","NEWT:118694","NEWT:2850","NEWT:118691","NEWT:34871","NEWT:33548","NEWT:52299","NEWT:8165","NEWT:96794","NEWT:3708","NEWT:332648","NEWT:44670","NEWT:536231","NEWT:376219","NEWT:219813","NEWT:1510","NEWT:460519","NEWT:1515","NEWT:572307","NEWT:1432138","NEWT:1424507","NEWT:1194599","NEWT:272844","NEWT:1348799","NEWT:33995","NEWT:55784","NEWT:1303443","NEWT:9483","NEWT:485","NEWT:56636","NEWT:2499525","NEWT:2853422","NEWT:487","NEWT:1679718","NEWT:480","NEWT:67767","NEWT:46835","NEWT:109757","NEWT:582580","NEWT:1185650","NEWT:216778","NEWT:1502","NEWT:128017","NEWT:376686","NEWT:237610","NEWT:95486","NEWT:1883446","NEWT:1233435","NEWT:118223","NEWT:11757","NEWT:109760","NEWT:29031","NEWT:317047","NEWT:491","NEWT:460523","NEWT:45954","NEWT:235443","NEWT:1757312","NEWT:85694","NEWT:109786","NEWT:108458","NEWT:5936","NEWT:320637","NEWT:1078283","NEWT:3750","NEWT:983964","NEWT:11706","NEWT:32644","NEWT:527796","NEWT:499175","NEWT:109779","NEWT:3745","NEWT:1715989","NCBITaxon:4751","NEWT:3747","NEWT:1116234","NEWT:1255228","NEWT:410289","NEWT:373153","NEWT:1640278","NEWT:472","NEWT:940825","NEWT:529507","NEWT:1071661","NEWT:28128","NEWT:470","NEWT:5911","NEWT:748693","NCBITaxon:50557","NEWT:39251","NEWT:29491","NEWT:101841","NEWT:446","NEWT:153481","NEWT:2014887","NEWT:33952","NEWT:445","NEWT:153009","NEWT:261756","NEWT:166313","NEWT:63366","NEWT:63367","NEWT:215402","NEWT:1547","NEWT:906914","NEWT:9031","NEWT:27292","NEWT:1050722","NEWT:3728","NEWT:108931","NEWT:1293497","NEWT:1055524","NEWT:150475","NEWT:267872","NEWT:381666","NEWT:172269","NEWT:9534","NEWT:5180","NEWT:256737","NEWT:9541","NEWT:8694","NEWT:33936","NEWT:8692","NEWT:2903","NEWT:185579","NEWT:13076","NEWT:207340","NEWT:1006581","NEWT:8673","NEWT:33940","NEWT:550","NEWT:554","NEWT:451516","NEWT:552","NEWT:1325291","NEWT:36185","NEWT:1054211","NEWT:1225786","NEWT:771870","NEWT:51338","NEWT:575412","NEWT:28112","NEWT:6493","NEWT:10832","NEWT:6494","NEWT:6491","NEWT:507601","NEWT:520","NEWT:186441","NEWT:643680","NEWT:214092","NCBITaxon:6157","NEWT:13095","NEWT:162425","NEWT:104105","NEWT:216257","NEWT:9986","NEWT:8654","NEWT:8658","NEWT:1268063","NEWT:8657","NEWT:9983","NEWT:8655","NEWT:5147","NEWT:28108","NEWT:28104","NEWT:407821","NEWT:568703","NCBITaxon:2","NEWT:568708","NEWT:1613","NEWT:986","NEWT:52641","NEWT:28532","NEWT:353152","NEWT:298176","NEWT:353153","NEWT:227377","NEWT:1774284","NEWT:40674","NEWT:1194669","NEWT:51329","NEWT:443906","NEWT:519","NEWT:2510939","NEWT:7394","NEWT:6063","NEWT:1328388","NEWT:105487","NEWT:1548728","NEWT:667127","NEWT:9557","NEWT:377586","NEWT:300641","NEWT:39655","NEWT:9554","NEWT:38323","NEWT:475932","NEWT:256318","NEWT:206411","NCBITaxon:6191","NEWT:229533","NEWT:214053","NEWT:28550","NEWT:80863","NEWT:90675","NEWT:52639","NEWT:52638","NEWT:57075","NEWT:1666905","NEWT:8697","NEWT:8695","NEWT:884204","NEWT:1045775","NEWT:1123869","NEWT:9544","NEWT:9545","NEWT:979","NEWT:7370","NEWT:83906","NEWT:99488","NEWT:1134506","NEWT:255470","NEWT:38783","NEWT:6426","NEWT:33090","NEWT:9935","NEWT:287889","NEWT:305959","NEWT:1028307","NEWT:13489","NEWT:29829","NEWT:92867","NEWT:92866","NCBITaxon:3055","NEWT:51750","NEWT:202950","NEWT:441772","NEWT:1293091","NEWT:48106","NEWT:202956","NEWT:295027","NCBITaxon:11320","NEWT:632957","NEWT:9925","NCBITaxon:9606","NEWT:90690","NEWT:1436183","NEWT:300273","NEWT:4232","NEWT:416348","NEWT:11298","NEWT:4236","NEWT:7742","NEWT:196627","NEWT:200308","NEWT:200302","NEWT:870435","NEWT:9913","NEWT:9915","NEWT:105841","NEWT:2666255","NEWT:999810","NCBITaxon:5693","NEWT:28995","NEWT:2144189","NEWT:1392998","NEWT:380394","NEWT:1150621","NEWT:226900","NEWT:1266738","NEWT:231490","NEWT:244704","NEWT:7725","NEWT:9909","NEWT:9902","NEWT:430615","NEWT:72664","NEWT:563041","NEWT:36599","NEWT:41949","NEWT:249161","NEWT:326423","NEWT:452467","NEWT:198822","NEWT:36111","NEWT:326424","NEWT:1678078","NEWT:749906","NEWT:418985","NEWT:749907","NEWT:150847","NEWT:29835","NEWT:431947","NEWT:69014","NEWT:142809","NEWT:302409","NEWT:130821","NEWT:27606","NEWT:1519788","NEWT:59202","NEWT:9975","NEWT:8643","NEWT:1801631","NEWT:1159899","NEWT:502780","NEWT:860688","NEWT:13443","NEWT:35231","NEWT:8644","NEWT:1125630","NEWT:5141","NEWT:46360","NCBITaxon:3044782","NEWT:202914","NEWT:160235","NEWT:502779","NEWT:297246","NEWT:103690","NEWT:8639","NEWT:1928434","NEWT:8637","NEWT:1114970","NEWT:2096","NEWT:285272","NEWT:192222","NEWT:9963","NEWT:1617910","NEWT:197911","NEWT:197912","NEWT:637379","NEWT:12107","NEWT:2785785","NEWT:411901","NEWT:1298722","NEWT:8626","NEWT:186801","NEWT:105884","NCBITaxon:9615","NEWT:8621","NEWT:58334","NEWT:58331","NEWT:6446","NEWT:8624","NEWT:5116","NEWT:8623","NEWT:5597","NCBITaxon:3077","NEWT:194439","NCBITaxon:12637","NEWT:38727","NEWT:218496","NEWT:8618","NEWT:70448","NEWT:300251","NEWT:9940","NEWT:1247190","NEWT:118702","NEWT:118700","NEWT:2126719","NEWT:118705","NEWT:6945","NEWT:2104","NEWT:2627626","NEWT:6943","NEWT:157546","NEWT:870726","NEWT:91374","NEWT:91373","NEWT:474186","NEWT:54195","NEWT:10136","NEWT:38942","NEWT:4762","NEWT:6941","NEWT:307972","NEWT:2102","NEWT:34","NEWT:38949","NEWT:1299114","NEWT:1590841","NEWT:60876","NEWT:1276473","NEWT:2282334","NEWT:1247","NEWT:70667","NEWT:869728","NEWT:6938","NCBITaxon:39054","NEWT:1736309","NEWT:4751","NEWT:36774","NEWT:194963","NEWT:77298","NEWT:15819","NEWT:109461","NEWT:1085956","NEWT:6928","NEWT:1239","NEWT:36745","NEWT:400727","NEWT:272563","NEWT:11009","NEWT:913998","NEWT:68335","NEWT:3885","NEWT:3888","NEWT:649408","NEWT:6915","NEWT:101510","NEWT:3880","NEWT:272559","NEWT:216816","NEWT:153151","NEWT:2681598","NEWT:515849","NEWT:10141","NEWT:95767","NEWT:466585","NEWT:1000589","NEWT:85963","NEWT:29","NEWT:85962","NEWT:42197","NEWT:143361","NEWT:5656","NEWT:1292","NEWT:1299","NEWT:424718","NEWT:316407","NEWT:1794699","NCBITaxon:183674","NEWT:167387","NEWT:84645","NEWT:1123294","NEWT:6978","NEWT:209285","NEWT:211586","NEWT:747078","NEWT:1282","NEWT:1283","NEWT:1000561","NEWT:253836","NEWT:2133","NEWT:6973","NEWT:294381","NEWT:197","NEWT:1390363","NEWT:35889","NEWT:406072","NEWT:351660","NEWT:29176","NEWT:201319","NEWT:1073569","NEWT:4787","NEWT:751585","NEWT:113549","NEWT:180788","NEWT:159749","NEWT:1270","NEWT:388919","NEWT:130081","NEWT:4784","NEWT:360106","NEWT:4785","NEWT:360104","NEWT:10117","NEWT:401614","NEWT:10116","NEWT:1280","NEWT:83333","NEWT:83334","NEWT:242718","NEWT:83332","NEWT:242715","NEWT:100226","NEWT:1263","NEWT:176299","NEWT:54126","NEWT:75058","NEWT:13616","NEWT:13613","NEWT:296543","NEWT:173","NEWT:316435","NEWT:42157","NEWT:1034304","NEWT:105023","NEWT:866628","NEWT:535026","NEWT:749200","NEWT:1036967","NEWT:266264","NEWT:272942","NEWT:272943","NEWT:1882682","NEWT:145953","NEWT:257309","NEWT:203124","NEWT:230741","NEWT:8296","NEWT:117008","NEWT:167748","NEWT:1163394","NEWT:645463","NEWT:749696","NEWT:320549","NEWT:990119","NEWT:77216","NEWT:1111708","NEWT:998086","NEWT:493760","NEWT:93163","NEWT:257313","NEWT:3827","NEWT:400772","NEWT:257310","NEWT:128161","NEWT:930945","NEWT:332521","NEWT:106350","NEWT:269796","NEWT:54571","NEWT:412754","NEWT:9598","NEWT:2665964","NEWT:1423772","NEWT:51056","NEWT:35815","NEWT:53232","NEWT:1235987","NCBITaxon:2509511","NEWT:1639","NEWT:188229","NEWT:3818","NEWT:432359","NEWT:9103","NEWT:715877","NEWT:862238","NEWT:29159","NEWT:1155748","NEWT:9593","NEWT:8260","NEWT:9595","NEWT:2665958","NEWT:246200","NEWT:6087","NEWT:145943","NEWT:595536","NEWT:1134822","NEWT:240906","NEWT:89920","NEWT:29158","NEWT:44744","NEWT:3879","NEWT:1328881","NEWT:411483","NEWT:76336","NEWT:3870","NEWT:884019","NEWT:411490","NEWT:169963","NEWT:587","NEWT:588","NEWT:585","NCBITaxon:43925","NEWT:746128","NEWT:212035","NCBITaxon:1653394","NEWT:1205","NEWT:214693","NEWT:45609","NEWT:239935","NEWT:1680","NEWT:9172","NEWT:2770979","NEWT:112","NEWT:423477","NEWT:1277351","NEWT:1594786","NEWT:3854","NEWT:411469","NEWT:1679","NEWT:333849","NEWT:214684","NEWT:1758543","NEWT:569","NEWT:411464","NEWT:411460","NEWT:1328426","NEWT:562","NEWT:411470","NEWT:10515","NEWT:2094720","NCBITaxon:2697049","NEWT:294750","NEWT:1663","NEWT:62141","NEWT:3848","NEWT:3847","NEWT:198466","NEWT:327159","NEWT:1045010","NEWT:178876","NEWT:1660","NEWT:327160","NEWT:573","NEWT:571","NEWT:142479","NEWT:29595","NEWT:241368","NEWT:42528","NEWT:1969471","NEWT:9657","NEWT:150596","NEWT:30540","NEWT:264483","NEWT:439733","NEWT:76777","NEWT:30545","NEWT:76773","NEWT:1121114","NEWT:663","NEWT:1081927","NEWT:1238993","NEWT:67825","NEWT:187878","NEWT:1504802","NEWT:1821314","NEWT:1249668","NEWT:426430","NEWT:37181","NEWT:929439","NEWT:9646","NEWT:5286","NEWT:7469","NEWT:9644","NEWT:426428","NEWT:63459","NEWT:2652157","NEWT:2652158","NEWT:40353","NEWT:1276815","NEWT:40324","NEWT:588858","NEWT:9638","NEWT:9639","NCBITaxon:11071","NEWT:693977","NEWT:242231","NEWT:197221","NEWT:528354","NEWT:51453","NEWT:1279085","NEWT:28231","NEWT:7460","NEWT:504457","NEWT:392227","NEWT:1004024","NEWT:103372","NEWT:862751","NEWT:470150","NEWT:9627","NEWT:1009714","NEWT:73239","NEWT:38018","NEWT:226186","NEWT:381518","NEWT:30532","NEWT:8782","NEWT:30538","NEWT:115357","NEWT:5270","NEWT:63436","NEWT:63433","NEWT:13164","NEWT:1601067","NEWT:129554","NEWT:40302","NEWT:1249615","NEWT:2664179","NEWT:623","NEWT:217219","NEWT:7038","NEWT:6192","NCBITaxon:1639","NEWT:3915","NEWT:1581419","NEWT:405534","NEWT:9689","NEWT:8355","NEWT:633","NEWT:9685","NEWT:1218948","NEWT:7029","NEWT:9688","NEWT:6182","NEWT:9694","NEWT:604162","NEWT:1046723","NEWT:186990","NEWT:8364","NEWT:632","NEWT:6183","NEWT:1423800","NEWT:630","NCBITaxon:11019","NEWT:334747","NEWT:3907","NEWT:3906","NEWT:61235","NEWT:343691","NEWT:1457551","NEWT:15368","NEWT:13180","NEWT:1491466","NEWT:340188","NEWT:170187","NEWT:1755437","NEWT:1042399","NEWT:1719","NEWT:692672","NEWT:2697049","NEWT:568813","NEWT:1109443","NEWT:267566","NEWT:58042","NEWT:7004","NEWT:9669","NCBITaxon:6073","NEWT:1089448","NEWT:1329349","NEWT:1089444","NEWT:607699","NEWT:6161","NEWT:206542","NEWT:27337","NEWT:575584","NEWT:186536","NEWT:257771","NEWT:185687","NEWT:3039","NEWT:2706014","NEWT:8727","NEWT:8726","NEWT:8725","NEWT:10090","NEWT:8729","NEWT:8720","NEWT:5693","NEWT:2186","NEWT:8724","NEWT:8723","NEWT:283166","NEWT:8722","NEWT:5697","NEWT:6544","NEWT:218192","NCBITaxon:10114","NEWT:2190","NEWT:1685931","NEWT:242619","NEWT:557723","NEWT:557722","NEWT:160791","NEWT:1353008","NEWT:34073","NEWT:402042","NEWT:373995","NEWT:5689","NEWT:8715","NEWT:544404","NEWT:287535","NEWT:2173","NEWT:2175","NEWT:1232801","NEWT:5691","NEWT:61674","NEWT:2072580","NEWT:669465","NEWT:1117957","NEWT:6526","NEWT:8709","NEWT:8707","NEWT:1306274","NEWT:5671","NEWT:13146","NEWT:6523","NEWT:8700","NEWT:1692259","NEWT:1486917","NEWT:1843183","NEWT:5661","NEWT:157592","NEWT:3482","NEWT:51866","NEWT:58002","NEWT:13136","NEWT:5660","NEWT:5665","NEWT:1179777","NEWT:6997","NEWT:5666","NEWT:1746091","NEWT:5664","NEWT:2157","NEWT:70125","NEWT:146479","NEWT:1843192","NEWT:206189","NEWT:2160","NEWT:295139","NEWT:6108","NEWT:1720309","NEWT:9612","NEWT:1286640","NEWT:38865","NEWT:3077","NEWT:9615","NEWT:6100","NEWT:713604","NEWT:3076","NEWT:112273","NEWT:33178","NEWT:1147787","NEWT:1440772","NEWT:8759","NEWT:9605","NEWT:9606","NEWT:27717","NEWT:641501","NEWT:9601","NEWT:8752","NEWT:34038","NEWT:8756","NEWT:74940","NEWT:13551","NEWT:10041","NEWT:9600","NEWT:1450511","NEWT:439375","NEWT:1857323","NEWT:890382","NEWT:174934","NEWT:179392","NEWT:2823525","NEWT:115778","NEWT:1538186","NEWT:82996","NEWT:227086","NEWT:3055","NEWT:195883","NEWT:1450520","NEWT:1042311","NEWT:1123352","NEWT:741258","NEWT:82525","NEWT:29920","NEWT:235909","NEWT:47311","NCBITaxon:813","NEWT:127785","NEWT:708248","NEWT:104660","NEWT:652611","NEWT:94993","NEWT:8732","NEWT:763037","NEWT:1250232","NEWT:1052588","NEWT:1377","NEWT:3555","NEWT:71647","NEWT:260201","NEWT:35554","NCBITaxon:12939","NEWT:935692","NEWT:32046","NEWT:2222","NEWT:544496","NEWT:59529","NEWT:32049","NEWT:1392696","NEWT:762376","NEWT:45351","NEWT:445974","NEWT:43179","NEWT:180454","NEWT:3544","NEWT:5722","NEWT:7901","NEWT:32051","NEWT:10245","NEWT:55153","NEWT:351581","NEWT:43186","NEWT:428146","NEWT:498019","NEWT:1351","NEWT:1438992","NEWT:1352","NEWT:32025","NEWT:2649997","NEWT:1147161","NEWT:43150","NEWT:263737","NEWT:1333499","NEWT:5702","NEWT:95648","NEWT:1349","NEWT:67593","NEWT:1401257","NEWT:44491","NEWT:27933","NEWT:556484","NEWT:7955","NEWT:7959","NEWT:645159","NEWT:2261","NEWT:94323","NEWT:31156","NEWT:3112","NEWT:8801","NEWT:4442","NEWT:192875","NEWT:1214915","NEWT:1214916","NEWT:284218","NEWT:1316931","NEWT:511145","NEWT:213401","NEWT:931281","NEWT:4432","NEWT:5762","NEWT:5763","NEWT:118099","NEWT:658457","NEWT:35525","NEWT:295358","NEWT:2246","NEWT:2652724","NEWT:5757","NEWT:68415","NCBITaxon:4563","NEWT:5755","NEWT:44447","NEWT:752555","NEWT:39097","NEWT:347495","NEWT:5759","NEWT:1736231","NEWT:1392","NEWT:35974","NEWT:2242","NEWT:1396","NEWT:286","NEWT:391619","NEWT:287","NEWT:1367269","NEWT:633149","NEWT:1149786","NEWT:10239","NEWT:68895","NEWT:3567","NEWT:68888","NEWT:4897","NEWT:5744","NEWT:72901","NEWT:213863","NEWT:55571","NEWT:35500","NEWT:1235816","NEWT:2041044","NEWT:3562","NEWT:4896","NEWT:1262161","NEWT:1314781","NEWT:1390","NEWT:11557","NEWT:294","NEWT:1773","NEWT:82380","NEWT:935293","NEWT:375146","NEWT:471876","NEWT:1772","NEWT:263","NEWT:11988","NEWT:400667","NEWT:408169","NEWT:47946","NEWT:459758","NEWT:1764","NEWT:39087","NEWT:413996","NEWT:243277","NEWT:7067","NEWT:586722","NEWT:243273","NEWT:1986198","NEWT:274","NEWT:7070","NCBITaxon:287","NEWT:408172","NEWT:408170","NEWT:1436733","NEWT:42229","NEWT:1247411","NEWT:9238","NEWT:13708","NEWT:333760","NEWT:34607","NEWT:1513458","NEWT:1233681","NEWT:2212966","NCBITaxon:40559","NEWT:506599","NEWT:81077","NEWT:84588","NEWT:1279007","NEWT:85433","NEWT:65349","NEWT:300852","NEWT:564933","NEWT:508771","NEWT:1121405","NEWT:253","NCBITaxon:2759","NEWT:93061","NEWT:93062","NEWT:1284813","NEWT:34613","NEWT:7054","NCBITaxon:4932","NEWT:1748","NEWT:108673","NEWT:2764168","NEWT:943274","NEWT:644223","NEWT:1263082","NEWT:272623","NEWT:1288389","NEWT:272624","NEWT:886559","NEWT:55521","NEWT:118499","NEWT:1130798","NEWT:55529","NEWT:256136","NEWT:476272","NEWT:195051","NEWT:3988","NEWT:561007","NEWT:649908","NEWT:1001135","NEWT:147828","NEWT:3981","NEWT:3983","NEWT:203696","NEWT:223283","NEWT:352472","NEWT:235","NEWT:505235","NEWT:55518","NEWT:97441","NEWT:1154756","NEWT:1202531","NEWT:1202532","NEWT:360094","NEWT:1408223","NEWT:1408224","NEWT:41364","NEWT:1311","NEWT:1313","NEWT:1218097","NEWT:1080348","NEWT:1314","NEWT:39491","NEWT:212142","NCBITaxon:5811","NEWT:1499105","NEWT:192812","NEWT:408188","NEWT:571256","NEWT:40483","NEWT:688333","NEWT:1303","NCBITaxon:548681","NEWT:318586","NCBITaxon:5820","NEWT:272634","NEWT:198107","NEWT:1979401","NEWT:155892","NEWT:691","NEWT:28384","NEWT:167879","NEWT:1872122","NEWT:1308","NEWT:7091","NEWT:1034015","NEWT:760568","NEWT:141262","NEWT:1813","NEWT:4087","NEWT:9778","NEWT:306","NEWT:303","NEWT:97477","NEWT:7111","NEWT:113287","NEWT:347515","NEWT:6269","NEWT:4090","NEWT:4092","NEWT:4093","NEWT:786","NEWT:4096","NEWT:208895","NEWT:941442","NEWT:536088","NEWT:311553","NEWT:1226408","NEWT:43984","NEWT:7108","NEWT:40479","NEWT:43989","NEWT:4076","NEWT:142615","NEWT:317","NEWT:885319","NEWT:293939","NEWT:497515","NEWT:885318","NEWT:39488","NEWT:4081","NEWT:273068","NEWT:1316582","NEWT:227166","NEWT:98334","NEWT:231663","NEWT:4084","NEWT:63577","NEWT:7574","NEWT:1715256","NEWT:30640","NEWT:348824","NEWT:929793","NEWT:1507179","NEWT:29204","NEWT:114155","NEWT:4072","NEWT:1337056","NEWT:4073","NEWT:634955","NEWT:6239","NEWT:102169","NEWT:208893","NEWT:4054","NEWT:301301","NEWT:98351","NEWT:1263854","NEWT:118503","NEWT:2059687","NEWT:160488","NEWT:63558","NEWT:61376","NEWT:207559","NEWT:107401","NEWT:85057","NEWT:985076","NEWT:1215323","NEWT:7159","NEWT:267671","NEWT:72491","NEWT:7160","NEWT:8496","NEWT:7165","NEWT:1257118","NEWT:1387333","NEWT:8010","NEWT:1315282","NEWT:7162","NEWT:1859","NEWT:27448","NEWT:235612","NEWT:243230","NEWT:936053","NEWT:1080772","NEWT:8479","NEWT:8485","NEWT:119856","NEWT:72000","NEWT:119857","NEWT:49240","NEWT:2893330","NCBITaxon:3707","NEWT:391295","NEWT:1170828","NEWT:104395","NEWT:93934","NEWT:9315","NEWT:6289","NEWT:6287","NEWT:38569","NEWT:727","NEWT:9796","NEWT:118562","NEWT:725","NEWT:7137","NEWT:469008","NEWT:9321","NEWT:596153","NEWT:8472","NEWT:1836","NCBITaxon:10298","NEWT:105231","NEWT:104385","NEWT:74649","NEWT:1037924","NEWT:206672","NEWT:9788","NEWT:4097","NEWT:9305","NEWT:436113","NEWT:71139","NEWT:9785","NEWT:6279","NEWT:1195774","NEWT:9793","NCBITaxon:780","NCBITaxon:1502","NEWT:6282","NEWT:27457","NEWT:4006","NEWT:1872635","NCBITaxon:5476","NEWT:113208","NEWT:6669","NEWT:1215360","NEWT:89453","NEWT:1114301","NEWT:51515","NEWT:13249","NEWT:588596","NEWT:51511","NEWT:8845","NEWT:7998","NEWT:419610","NEWT:5334","NEWT:382352","NEWT:413071","NCBITaxon:10239","NEWT:332097","NCBITaxon:714","NEWT:1076620","NEWT:11051","NEWT:89462","NEWT:452680","NEWT:8839","NEWT:4472","NEWT:2758385","NEWT:171101","NEWT:714","NEWT:5322","NEWT:34199","NEWT:568996","NEWT:421932","NEWT:312017","NEWT:576131","NEWT:553470","NEWT:284593","NEWT:100392","NEWT:655819","NEWT:5315","NEWT:11082","NEWT:265872","NEWT:59463","NEWT:337330","NEWT:2285","NEWT:2287","NEWT:6645","NEWT:251229","NEWT:981087","NEWT:180066","NEWT:46147","NCBITaxon:6312","NEWT:11072","NEWT:174633","NEWT:52830","NEWT:1416333","NEWT:35024","NEWT:135461","NEWT:7962","NEWT:99287","NEWT:1817808","NEWT:145262","NEWT:145263","NEWT:694569","NEWT:9739","NEWT:111069","NEWT:1379791","NEWT:51953","NEWT:57267","NEWT:3197","NEWT:13686","NEWT:2750454","NEWT:264561","NEWT:1402135","NEWT:36329","NEWT:62615","NEWT:1555636","NEWT:1333550","NEWT:72407","NEWT:352914","NEWT:349741","NEWT:409859","NEWT:157295","NEWT:1263871","NEWT:509169","NEWT:6210","NEWT:9721","NEWT:137221","NEWT:565050","NEWT:409860","NEWT:92683","NEWT:1298968","NEWT:5353","NEWT:1034809","NEWT:452659","NEWT:1193501","NEWT:51930","NEWT:6689","NEWT:194675","NEWT:298315","NEWT:392547","NEWT:46105","NEWT:104782","NEWT:10181","NEWT:9704","NEWT:1049056","NEWT:698936","NEWT:13216","NEWT:1009874","NEWT:4498","NEWT:8855","NEWT:11034","NEWT:3168","NEWT:10185","NEWT:78168","NEWT:521001","NEWT:192011","NEWT:340912","NEWT:1813887","NEWT:224911","NEWT:1090946","NCBITaxon:11552","NEWT:334249","NEWT:184922","NEWT:6703","NEWT:2","NEWT:35670","NEWT:511693","NEWT:4528","NEWT:35677","NEWT:1493","NEWT:10376","NEWT:1496","NEWT:3674","NEWT:5851","NEWT:660469","NEWT:935568","NEWT:1365186","NEWT:1813019","NEWT:45474","NEWT:48500","NEWT:4513","NEWT:5843","NEWT:1117645","NCBITaxon:10407","NEWT:1000364","NEWT:10360","NEWT:1403536","NEWT:1427524","NEWT:47664","NEWT:260799","NEWT:317548","NEWT:106198","NEWT:2323","NEWT:3654","NEWT:237561","NEWT:5833","NEWT:3659","NEWT:59620","NEWT:499229","NEWT:31298","NEWT:1204162","NEWT:1532734","NEWT:82688","NEWT:5823","NEWT:5821","NEWT:44139","NCBITaxon:4895","NCBITaxon:4896","NEWT:675512","NEWT:315393","NEWT:3649","NEWT:28903","NEWT:28909","NEWT:3641","NEWT:79698","NCBITaxon:5796","NEWT:12993","NEWT:398580","NEWT:4565","NEWT:1264690","NEWT:515619","NEWT:170721","NEWT:34305","NEWT:77020","NEWT:1908323","NEWT:83558","NEWT:44586","NEWT:626528","NEWT:139927","NEWT:4558","NEWT:5888","NEWT:431241","NEWT:4550","NEWT:4555","NEWT:144036","NEWT:144030","NEWT:288705","NEWT:392815","NEWT:3217","NEWT:4547","NEWT:3218","NEWT:556182","NEWT:374990","NEWT:36941","NEWT:1432059","NEWT:154293","NEWT:156471","NEWT:3694","NEWT:156476","NEWT:4543","NEWT:210007","NEWT:1857017","NEWT:10359","NEWT:1358430","NEWT:10358","NEWT:1381693","NEWT:1735272","NEWT:109298","NEWT:317513","NEWT:580240","NEWT:294128","NEWT:11676","NEWT:1917265","NEWT:55210","NEWT:718308","NEWT:4530","NEWT:5861","NEWT:1895","NEWT:2558360","NEWT:64152","NEWT:4924","NEWT:2748","NEWT:8049","NEWT:33892","NEWT:99931","NEWT:9378","NEWT:990346","NEWT:100816","NEWT:192952","NEWT:1640346","NCBITaxon:1313","NEWT:29385","NEWT:44544","NEWT:529818","NEWT:400540","NEWT:382","NEWT:4911","NEWT:152480","NEWT:129249","NEWT:1888","NEWT:1077286","NEWT:943129","NEWT:1221594","NEWT:1524260","NEWT:227321","NEWT:192944","NEWT:492670","NEWT:281677","NEWT:106590","NEWT:260710","NEWT:4918","NEWT:1162296","NEWT:106592","NEWT:596645","NEWT:46704","NEWT:42345","NEWT:482428","NEWT:1187947","NEWT:4903","NEWT:10312","NCBITaxon:1773","NEWT:190304","NEWT:1432499","NEWT:8030","NEWT:246432","NEWT:246437","NEWT:36909","NEWT:4909","NEWT:443256","NEWT:1279365","NEWT:759272","NEWT:1182263","NEWT:943146","NEWT:646532","NEWT:2711","NEWT:537457","NEWT:479249","NEWT:435623","NEWT:33889","NEWT:10306","NEWT:8022","NEWT:42353","NEWT:593117","NEWT:3633","NEWT:319761","NEWT:3635","NEWT:5811","NEWT:86662","NEWT:180923","NEWT:1451","NEWT:198215","NEWT:200298","NEWT:12916","NEWT:1400870","NEWT:343","NEWT:84005","NEWT:225117","NEWT:34708","NEWT:8090","NEWT:537012","NEWT:5801","NEWT:43665","NEWT:5802","NEWT:4952","NEWT:1266464","NEWT:367830","NEWT:1093790","NEWT:178616","NEWT:95145","NEWT:358","NEWT:375451","NEWT:54788","NEWT:357","NEWT:74381","NEWT:2010198","NEWT:457428","NEWT:106178","NEWT:84023","NEWT:589904","NEWT:559292","NEWT:2762","NEWT:1174673","NEWT:28035","NEWT:1313166","NEWT:690307","NCBITaxon:138","NEWT:28038","NEWT:1422","NEWT:84030","NEWT:1423","NEWT:4932","NEWT:1205903","NEWT:3603","NEWT:2756","NEWT:2759","NEWT:38293","NEWT:1428","NEWT:339","NEWT:2751","NEWT:330","NEWT:139077","NEWT:391904","NEWT:12922","NEWT:316277","NEWT:163159","NEWT:1306413","NEWT:2813599","NEWT:518766","NEWT:2664373","NEWT:190802","NEWT:1213463","NEWT:9417","NEWT:1216979","NEWT:7237","NEWT:5059","NEWT:31631","NEWT:509924","NEWT:28450","NEWT:115104","NEWT:5061","NEWT:8570","NEWT:127569","NEWT:5062","NEWT:1408434","NEWT:1241935","NEWT:220668","NEWT:9407","NEWT:7227","NEWT:193079","NEWT:9402","NEWT:415540","NEWT:336722","NEWT:675060","NEWT:416870","NEWT:334542","NEWT:313625","NEWT:51240","NEWT:27592","NEWT:5052","NEWT:227289","NEWT:1985738","NEWT:7215","NEWT:196139","NEWT:5037","NEWT:651182","NEWT:2172103","NCBITaxon:59201","NEWT:1876254","NEWT:434271","NEWT:1915","NEWT:747679","NEWT:66712","NEWT:42752","NEWT:746360","NEWT:89764","NEWT:543734","NEWT:49390","NEWT:9870","NEWT:256648","NEWT:435590","NEWT:1902","NEWT:208526","NEWT:1908","NEWT:1169740","NEWT:217459","NEWT:216129","NEWT:1245012","NEWT:171250","NEWT:528135","NEWT:1637254","NCBITaxon:38727","NEWT:176946","NEWT:74790","NEWT:2829","NEWT:126279","NEWT:1428006","NEWT:62335","NEWT:366581","NEWT:757417","NEWT:216599","NEWT:216595","NEWT:40559","NEWT:51208","NEWT:216597","NEWT:42736","NEWT:1607839","NEWT:1283300","NEWT:1218707","NEWT:1204551","NEWT:99586","NEWT:228577","NEWT:2060328","NEWT:48038","NEWT:392021","NEWT:436486","NEWT:51655","NEWT:1933298","NEWT:260707","NEWT:121845","NEWT:8595","NEWT:7263","NEWT:186763","NEWT:447135","NEWT:185431","NEWT:216591","NEWT:29760","NEWT:260704","NEWT:703612","NEWT:260705","NEWT:1202347","NEWT:1295743","NEWT:546805","NEWT:1505907","NEWT:1216981","NEWT:1249885","NEWT:1972855","NEWT:853","NEWT:1415167","NEWT:36036","NCBITaxon:662","NEWT:9430","NEWT:851","NEWT:71251","NEWT:208963","NEWT:208964","NEWT:181088","NEWT:48498","NEWT:669202","NEWT:6306","NEWT:4120","NEWT:37334","NCBITaxon:10357","NCBITaxon:10358","NCBITaxon:10359","NEWT:1203258","NEWT:49317","NEWT:1899318","NEWT:696811","NEWT:9808","NEWT:839","NEWT:1097670","NEWT:92519","NEWT:943925","NEWT:4111","NEWT:37349","NEWT:4113","NEWT:837","NEWT:640459","NEWT:72568","NEWT:36015","NEWT:51641","NEWT:35168","NEWT:81866","NEWT:334147","NEWT:1262469","NEWT:277944","NEWT:48479","NEWT:61435","NEWT:627025","NEWT:1097677","NEWT:375939","NEWT:712938","NEWT:3258","NEWT:112018","NEWT:1906951","NEWT:52945","NEWT:4100","NEWT:1159556","NEWT:1076","NEWT:4102","NEWT:1028688","NEWT:4101","NEWT:6763","NEWT:803","NEWT:29722","NEWT:419947","NEWT:2847306","NEWT:468911","NEWT:13373","NEWT:266834","NEWT:817","NEWT:7604","NEWT:6756","NEWT:818","NEWT:135588","NEWT:1061","NEWT:29719","NEWT:6754","NEWT:452589","NEWT:509068","NEWT:2794344","NEWT:4577","NEWT:813","NEWT:1365218","NEWT:337677","NEWT:1042986","NEWT:1911079","NEWT:69373","NEWT:427577","NEWT:264203","NEWT:1480154","NEWT:9858","NEWT:9859","NEWT:512623","NEWT:1274414","NEWT:2907833","NEWT:38626","NEWT:10298","NEWT:10299","NEWT:1087439","NEWT:9852","NEWT:9860","NEWT:660025","NEWT:61408","NEWT:1355477","NEWT:90371","NEWT:55194","NEWT:2907829","NEWT:4153","NEWT:11137","NEWT:278839","NEWT:35128","NEWT:39966","NEWT:7668","NEWT:2929635","NEWT:58228","NEWT:915099","NEWT:1143193","NEWT:687914","NEWT:1122233","NEWT:277988","NEWT:859313","NEWT:59540","NEWT:9838","NEWT:9839","NEWT:546414","NEWT:11167","NEWT:9835","NEWT:7650","NEWT:4146","NEWT:5478","NEWT:6326","NEWT:7656","NEWT:5476","NEWT:5477","NEWT:1882945","NEWT:746707","NEWT:299767","NEWT:28835","NEWT:1206781","NEWT:5480","NEWT:1274432","NEWT:222863","NEWT:2053667","NEWT:859321","NEWT:1274426","NEWT:9825","NEWT:1274423","NEWT:393765","NEWT:104421","NEWT:39946","NEWT:9823","NEWT:95602","NEWT:314539","NEWT:39947","NEWT:718274","NEWT:1274420","NEWT:859314","NEWT:578458","NEWT:60520"],"pubmed":["41655237"]}}