{"database":"Pride","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Txt":["ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/sdrf_.txt","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/checksum.txt","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/Protein_report_Celiac_plasma_ZED.txt","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/Pooled_serumQC_runs.txt"],"Raw":["ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220120_Evo_HF_DIA33_Serum800ng_TG2_D01.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220119_Evo_HF_DIA33_Serum800ng_TG2_B06.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220120_Evo_HF_DIA33_Serum800ng_TG2_E12.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220118_Evo_HF_DIA33_Serum800ng_Pool2.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220118_Evo_HF_DIA33_Serum800ng_TG2_D04.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220120_Evo_HF_DIA33_Serum800ng_TG2_G09.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220119_Evo_HF_DIA33_Serum800ng_TG2_A08.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220118_Evo_HF_DIA33_Serum800ng_TG2_E09.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220119_Evo_HF_DIA33_Serum800ng_TG2_D09.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220119_Evo_HF_DIA33_Serum800ng_TG2_A12.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220118_Evo_HF_DIA33_Serum800ng_TG2_B12.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220118_Evo_HF_DIA33_Serum800ng_TG2_C04.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220118_Evo_HF_DIA33_Serum800ng_TG2_H08.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220120_Evo_HF_DIA33_Serum800ng_TG2_C05.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220119_Evo_HF_DIA33_Serum800ng_TG2_C10.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220120_Evo_HF_DIA33_Serum800ng_TG2_F06.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220120_Evo_HF_DIA33_Serum800ng_TG2_B05.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220119_Evo_HF_DIA33_Serum800ng_TG2_F11.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220118_Evo_HF_DIA33_Serum800ng_TG2_G01.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220120_Evo_HF_DIA33_Serum800ng_TG2_E08.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220118_Evo_HF_DIA33_Serum800ng_TG2_C12.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220120_Evo_HF_DIA33_Serum800ng_TG2_Pool3_3.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220120_Evo_HF_DIA33_Serum800ng_TG2_C03.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220120_Evo_HF_DIA33_Serum800ng_TG2_G02.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220120_Evo_HF_DIA33_Serum800ng_TG2_G10.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220119_Evo_HF_DIA33_Serum800ng_TG2_G06.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220118_Evo_HF_DIA33_Serum800ng_TG2_D08.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220119_Evo_HF_DIA33_Serum800ng_TG2_D10.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220120_Evo_HF_DIA33_Serum800ng_TG2_D05.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220118_Evo_HF_DIA33_Serum800ng_TG2_H11.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220120_Evo_HF_DIA33_Serum800ng_TG2_G11.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220118_Evo_HF_DIA33_Serum800ng_TG2_C02.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220119_Evo_HF_DIA33_Serum800ng_TG2_B01.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220119_Evo_HF_DIA33_Serum800ng_TG2_A04.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220120_Evo_HF_DIA33_Serum800ng_TG2_H02.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220118_Evo_HF_DIA33_Serum800ng_TG2_E05.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220119_Evo_HF_DIA33_Serum800ng_TG2_F09.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220120_Evo_HF_DIA33_Serum800ng_TG2_B09.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220120_Evo_HF_DIA33_Serum800ng_TG2_C06.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220119_Evo_HF_DIA33_Serum800ng_TG2_Pool3_2.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220119_Evo_HF_DIA33_Serum800ng_TG2_H01.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220118_Evo_HF_DIA33_Serum800ng_TG2_E03.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220119_Evo_HF_DIA33_Serum800ng_TG2_F07.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220118_Evo_HF_DIA33_Serum800ng_TG2_C09.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220120_Evo_HF_DIA33_Serum800ng_TG2_E04.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220118_Evo_HF_DIA33_Serum800ng_TG2_E11.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220119_Evo_HF_DIA33_Serum800ng_TG2_A10.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220118_Evo_HF_DIA33_Serum800ng_TG2_H03.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220119_Evo_HF_DIA33_Serum800ng_TG2_B08.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220119_Evo_HF_DIA33_Serum800ng_TG2_B11.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220120_Evo_HF_DIA33_Serum800ng_TG2_E07.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220118_Evo_HF_DIA33_Serum800ng_TG2_C11.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220119_Evo_HF_DIA33_Serum800ng_TG2_H07.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220118_Evo_HF_DIA33_Serum800ng_TG2_F08.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220120_Evo_HF_DIA33_Serum800ng_TG2_D02.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220119_Evo_HF_DIA33_Serum800ng_TG2_E06.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220118_Evo_HF_DIA33_Serum800ng_TG2_A02.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220120_Evo_HF_DIA33_Serum800ng_TG2_F03.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220120_Evo_HF_DIA33_Serum800ng_TG2_A01.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220118_Evo_HF_DIA33_Serum800ng_TG2_G04.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220120_Evo_HF_DIA33_Serum800ng_TG2_B04.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220118_Evo_HF_DIA33_Serum800ng_TG2_B07.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220119_Evo_HF_DIA33_Serum800ng_TG2_F02.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220120_Evo_HF_DIA33_Serum800ng_TG2_Pool3_4.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220119_Evo_HF_DIA33_Serum800ng_TG2_A07.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220120_Evo_HF_DIA33_Serum800ng_TG2_G03.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220118_Evo_HF_DIA33_Serum800ng_TG2_F04.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220119_Evo_HF_DIA33_Serum800ng_TG2_F10.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220120_Evo_HF_DIA33_Serum800ng_TG2_F05.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220118_Evo_HF_DIA33_Serum800ng_TG2_A09.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220119_Evo_HF_DIA33_Serum800ng_TG2_B03.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220118_Evo_HF_DIA33_Serum800ng_TG2_E10.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220119_Evo_HF_DIA33_Serum800ng_TG2_H04.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220120_Evo_HF_DIA33_Serum800ng_TG2_C07.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220119_Evo_HF_DIA33_Serum800ng_TG2_F12.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220118_Evo_HF_DIA33_Serum800ng_TG2_C01.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220119_Evo_HF_DIA33_Serum800ng_TG2_G05.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220120_Evo_HF_DIA33_Serum800ng_TG2_A06.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220118_Evo_HF_DIA33_Serum800ng_TG2_D07.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220118_Evo_HF_DIA33_Serum800ng_TG2_H10.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220119_Evo_HF_DIA33_Serum800ng_TG2_A03.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220118_Evo_HF_DIA33_Serum800ng_TG2_H06.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220120_Evo_HF_DIA33_Serum800ng_TG2_G08.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220120_Evo_HF_DIA33_Serum800ng_TG2_D12.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220119_Evo_HF_DIA33_Serum800ng_TG2_A11.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220119_Evo_HF_DIA33_Serum800ng_TG2_D03.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220118_Evo_HF_DIA33_Serum800ng_TG2_G07.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220120_Evo_HF_DIA33_Serum800ng_TG2_E01.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220118_Evo_HF_DIA33_Serum800ng_TG2_B02.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220119_Evo_HF_DIA33_Serum800ng_TG2_H09.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220118_Evo_HF_DIA33_Serum800ng_TG2_F01.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220118_Evo_HF_DIA33_Serum800ng_TG2_A05.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220120_Evo_HF_DIA33_Serum800ng_TG2_H05.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220119_Evo_HF_DIA33_Serum800ng_TG2_Pool3_1.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220118_Evo_HF_DIA33_Serum800ng_TG2_B10.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220118_Evo_HF_DIA33_Serum800ng_TG2_E02.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220120_Evo_HF_DIA33_Serum800ng_TG2_D06.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220119_Evo_HF_DIA33_Serum800ng_TG2_D11.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597/220118_Evo_HF_DIA33_Serum800ng_TG2_C08.raw"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"labhead_mail":["rilahes@utu.fi"],"submitter":["Robert Moulder"],"technology_type":["Mass Spectrometry","Data-independent acquisition"],"disease":["Celiac Disease"],"software":[""],"submitter_keywords":["Human","Celiac disease","Plasma","Lc_msms"],"full_dataset_link":["https://www.ebi.ac.uk/pride/archive/projects/PXD069597"],"tissue":["Blood Plasma"],"sample_protocol":["Plasma protein digests were prepared in a 96-well plate format. Briefly, serum aliquots were diluted and denatured with urea, reduced with dithiothreitol, alkylated with iodoacetamide and digested with trypsin. The digests were desalted and concentrated using C18 solid-phase extraction (SepPak C18, Waters). Aliquots of the samples (800 ng) were analysed using liquid chromatography-tandem mass spectrometry with an Evosep One liquid chromatograph (Evosep) coupled to a Q Exactive HF Orbitrap (Thermo Scientific). A C18 reversed-phase column (15 cm x 150 µm, 1.9 µm EV-1106, Evosep Endurance) was used for the 30 sample/day method. Data were acquired using a data independent acquisition (DIA) strategy with 33 variable windows from 365 to 1005 Da. The MS1 and MS2 resolution were 120 k and 30 k, with AGCs of 3 x 10-6 and 1 x 10-6, respectively."],"repository":["Pride"],"quantification_method":[""],"modification":[""],"data_protocol":["The data were analysed using Spectronaut software (version 19), with comparison against a UniProt human reference protein sequence database (20,435 entries, 26/09/2024) and common contaminants (381 entries). Protein detection by more than one unique peptide was required and matches to the contaminants were excluded for downstream analysis. Normalized protein intensity values from Spectronaut were log2-transformed prior to statistical analysis.  Differentially abundant proteins were identified using the reproducibility-optimized test statistic (ROTS v1.34.0) with default parameters. The maximum top list size K was set to 75 % of all proteins, and the seed was set to 1. For the comparison between gluten-free diet and post-gluten challenge samples from the same placebo-treated individuals (PGCp vs GFDp), ROTS was applied in paired mode. The comparison between post-gluten challenge samples of drug-treated and placebo-treated individuals (PGCp vs PGCd) was performed using unpaired mode. P values were corrected for multiple testing using the Benjamini-Hochberg procedure. To assess the overall similarity of expression changes between the two comparisons, log₂ fold changes of all proteins were used to determine the Pearson correlation coefficient and its statistical significance. All statistical analyses were performed using the statistical software R version 4.4.3 (R Foundation for Statistical Computing"],"omics_type":["Proteomics"],"labhead":["Professor Riitta Lahesmaa"],"instrument_platform":[""],"submission_type":["PARTIAL"],"labhead_affiliation":["Turku Bioscience Centre, University of Turku and Åbo Akademi University"],"species":["Homo Sapiens (human)"],"publication":["38914866 Dotsenko V, Tewes B, Hils M, Pasternack R, Isola J, Taavela J, Popp A, Sarin J, Huhtala H, Hiltunen P, Zimmermann T, Mohrbacher R, Greinwald R, Lundin KEA, Schuppan D, Mäki M, Viiri K, CEC-3 Investigators. Transcriptomic analysis of intestine following administration of a transglutaminase 2 inhibitor to prevent gluten-induced intestinal damage in celiac disease. Nat Immunol. 2024 25(7):1218-1230 10.1038/s41590-024-01867-0","42032651 Dotsenko V, Le HH, Rajić S, Moulder R, Kettunen J, Hirvonen MK, Dickens AM, Hyötyläinen T, Tewes B, Zimmermann T, Mohrbacher R, Suomi T, Lehtimäki T, Lahesmaa R, Orešič M, Elo LL, Raitoharju E, Schuppan D, Mäki M, Viiri K, CEC-3 Investigators. Therapeutic TG2 inhibition reverses systemic multiomic dysregulation in celiac disease. BMC Med. 2026 24(1):350 10.1186/s12916-026-04892-y"],"submitter_mail":["rmoulder@btk.fi"],"submitter_affiliation":["Turku Biosciences"],"submitter_country":["Finland"],"pubmed_title":["Therapeutic TG2 inhibition reverses systemic multiomic dysregulation in celiac disease.","Transcriptomic analysis of intestine following administration of a transglutaminase 2 inhibitor to prevent gluten-induced intestinal damage in celiac disease."],"pubmed_authors":["Dotsenko Valeriia V, Tewes Bernhard B, Hils Martin M, Pasternack Ralf R, Isola Jorma J, Taavela Juha J, Popp Alina A, Sarin Jani J, Huhtala Heini H, Hiltunen Pauliina P, Zimmermann Timo T, Mohrbacher Ralf R, Greinwald Roland R, Lundin Knut E A KEA, Schuppan Detlef D, Mäki Markku M, Viiri Keijo K","Dotsenko Valeriia V, Le Hana Hien HH, Rajić Sonja S, Moulder Robert R, Kettunen Jalmari J, Hirvonen M Karoliina MK, Dickens Alex M AM, Hyötyläinen Tuulia T, Tewes Bernhard B, Zimmermann Timo T, Mohrbacher Ralf R, Suomi Tomi T, Lehtimäki Terho T, Lahesmaa Riitta R, Orešič Matej M, Elo Laura L LL, Raitoharju Emma E, Schuppan Detlef D, Mäki Markku M, Viiri Keijo K"],"pubmed_abstract":["Transglutaminase 2 (TG2) plays a pivotal role in the pathogenesis of celiac disease (CeD) by deamidating dietary gluten peptides, which facilitates antigenic presentation and a strong anti-gluten T cell response. Here, we elucidate the molecular mechanisms underlying the efficacy of the TG2 inhibitor ZED1227 by performing transcriptional analysis of duodenal biopsies from individuals with CeD on a long-term gluten-free diet before and after a 6-week gluten challenge combined with 100 mg per day ZED1227 or placebo. At the transcriptome level, orally administered ZED1227 effectively prevented gluten-induced intestinal damage and inflammation, providing molecular-level evidence that TG2 inhibition is an effective strategy for treating CeD. ZED1227 treatment preserved transcriptome signatures associated with mucosal morphology, inflammation, cell differentiation and nutrient absorption to the level of the gluten-free diet group. Nearly half of the gluten-induced gene expression changes in CeD were associated with the epithelial interferon-γ response. Moreover, data suggest that deamidated gluten-induced adaptive immunity is a sufficient step to set the stage for CeD pathogenesis. Our results, with the limited sample size, also suggest that individuals with CeD might benefit from an HLA-DQ2/HLA-DQ8 stratification based on gene doses to maximally eliminate the interferon-γ-induced mucosal damage triggered by gluten."],"additional_accession":[]},"is_claimable":false,"name":"Plasma Proteomics Analysis of a Transglutaminase 2 inhibitor in Celiac Disease","description":"Individuals with celiac disease (CeD) on a long-term gluten-free diet (GFD) underwent a 6-week gluten challenge combined with 100mg per day of the transglutaminase 2 enzyme -inhibitor, ZED1227 (PGCd, n = 28) or placebo (PGCp, n = 19). The samples were collected at baseline (GFD) and post-gluten challenge (PGC). Mass spectrometry-based lipidomic and proteomics profiling, along with genome-wide DNA methylation analysis, were applied to plasma samples obtained from 47 CeD patients. Comparative analyses were performed between the groups, with adjustment for BMI, age, sex, and country of origin.","dates":{"publication":"2026-06-15","submission":"2025-10-17"},"accession":"PXD069597","cross_references":{"TAXONOMY":["NEWT:330879","NEWT:377960","NEWT:2042546","NEWT:259447","NEWT:295546","NCBITaxon:2719036","NCBITaxon:1280","NEWT:112503","NEWT:1129","NEWT:309807","NEWT:59753","NEWT:89184","NEWT:309800","NEWT:281395","NEWT:1211601","NEWT:876138","NEWT:44271","NEWT:193516","NEWT:1073882","NEWT:6819","NEWT:475174","NEWT:111205","NEWT:1117","NEWT:498257","NEWT:10036","NEWT:1590","NEWT:10034","NEWT:661410","NEWT:638632","NEWT:224326","NEWT:376619","NCBITaxon:79857","NEWT:1096976","NEWT:3765","NEWT:1589","NEWT:135622","NEWT:35786","NEWT:1580","NEWT:399784","NEWT:96731","NEWT:656064","NEWT:36630","NEWT:383379","NEWT:418106","NCBITaxon:12721","NEWT:10029","NEWT:913645","NEWT:641809","NEWT:38815","NEWT:317447","NEWT:4688","NEWT:111225","NEWT:7719","NEWT:868565","NEWT:135674","NEWT:79329","NEWT:30069","NEWT:12637","NEWT:59729","NEWT:2164133","NEWT:295105","NEWT:108061","NEWT:60711","NEWT:224308","NEWT:3347","NEWT:160621","NEWT:212790","NEWT:110368","NEWT:1310161","NEWT:77133","NEWT:145481","NEWT:1310165","NEWT:29058","NCBITaxon:79824","NEWT:410658","NEWT:44688","NEWT:44689","NEWT:498211","NEWT:347256","NEWT:5518","NEWT:398007","NEWT:1527468","NEWT:498217","NEWT:498216","NEWT:11320","NEWT:246196","NEWT:246197","NEWT:145458","NEWT:44685","NEWT:161934","NEWT:156587","NEWT:1148","NEWT:5508","NEWT:3329","NEWT:419481","NEWT:5507","NEWT:410661","NEWT:1140","NCBITaxon:2157","NEWT:1143","NEWT:1287689","NEWT:1094343","NEWT:1462472","NEWT:1336795","NEWT:644042","NEWT:1182590","NEWT:3712","NEWT:3711","NEWT:270643","NEWT:2065263","NEWT:177437","NEWT:10418","NEWT:118698","NEWT:1616117","NEWT:118696","NEWT:34865","NEWT:52283","NEWT:28174","NEWT:284812","NEWT:8175","NEWT:43330","NEWT:1603293","NEWT:44664","NEWT:43346","NEWT:3702","NEWT:1245466","NEWT:244366","NEWT:1246791","NEWT:118694","NEWT:2850","NEWT:118691","NEWT:34871","NEWT:33548","NEWT:52299","NEWT:8165","NEWT:96794","NEWT:3708","NEWT:332648","NEWT:44670","NEWT:536231","NEWT:376219","NEWT:219813","NEWT:1510","NEWT:460519","NEWT:1515","NEWT:572307","NEWT:1432138","NEWT:1424507","NEWT:1194599","NEWT:272844","NEWT:33995","NEWT:55784","NEWT:1303443","NEWT:9483","NEWT:485","NEWT:56636","NEWT:2853422","NEWT:1679718","NEWT:480","NEWT:67767","NEWT:46835","NEWT:109757","NEWT:582580","NEWT:1185650","NEWT:216778","NEWT:294607","NEWT:1502","NEWT:128017","NEWT:376686","NEWT:95486","NEWT:1883446","NEWT:1233435","NEWT:109760","NEWT:29031","NEWT:317047","NEWT:491","NEWT:460523","NEWT:235443","NEWT:1757312","NEWT:85694","NEWT:108458","NEWT:5936","NEWT:320637","NEWT:1078283","NEWT:3750","NEWT:983964","NEWT:11706","NEWT:32644","NEWT:527796","NEWT:499175","NEWT:109779","NEWT:3745","NEWT:1715989","NCBITaxon:4751","NEWT:3747","NEWT:1116234","NEWT:1255228","NEWT:410289","NEWT:373153","NEWT:472","NEWT:940825","NEWT:529507","NEWT:1071661","NEWT:470","NEWT:5911","NEWT:748693","NCBITaxon:50557","NEWT:39251","NEWT:29491","NEWT:101841","NEWT:446","NEWT:153481","NEWT:2014887","NEWT:33952","NEWT:445","NEWT:153009","NEWT:261756","NEWT:166313","NEWT:63366","NEWT:63367","NEWT:215402","NEWT:1547","NEWT:906914","NEWT:9031","NEWT:27292","NEWT:1050722","NEWT:108931","NEWT:1293497","NEWT:1055524","NEWT:150475","NEWT:267872","NEWT:381666","NEWT:172269","NEWT:9534","NEWT:5180","NEWT:256737","NEWT:9541","NEWT:8694","NEWT:33936","NEWT:8692","NEWT:2903","NEWT:185579","NEWT:13076","NEWT:1006581","NEWT:8673","NEWT:33940","NEWT:550","NEWT:554","NEWT:451516","NEWT:552","NEWT:1325291","NEWT:36185","NEWT:1054211","NEWT:1225786","NEWT:51338","NEWT:575412","NEWT:28112","NEWT:6493","NEWT:6494","NEWT:6491","NEWT:507601","NEWT:520","NEWT:186441","NEWT:643680","NEWT:214092","NCBITaxon:6157","NEWT:13095","NEWT:162425","NEWT:104105","NEWT:216257","NEWT:9986","NEWT:8654","NEWT:8658","NEWT:1268063","NEWT:8657","NEWT:9983","NEWT:8655","NEWT:5147","NEWT:28108","NEWT:28104","NEWT:407821","NEWT:568703","NCBITaxon:2","NEWT:568708","NEWT:986","NEWT:52641","NEWT:28532","NEWT:353152","NEWT:298176","NEWT:227377","NEWT:1774284","NEWT:40674","NEWT:1194669","NEWT:51329","NEWT:443906","NEWT:519","NEWT:2510939","NEWT:7394","NEWT:6063","NEWT:1328388","NEWT:105487","NEWT:1548728","NEWT:667127","NEWT:9557","NEWT:377586","NEWT:300641","NEWT:39655","NEWT:9554","NEWT:38323","NEWT:475932","NEWT:256318","NEWT:206411","NCBITaxon:6191","NEWT:229533","NEWT:214053","NEWT:80863","NEWT:90675","NEWT:52638","NEWT:57075","NEWT:1666905","NEWT:8697","NEWT:8695","NEWT:884204","NEWT:1123869","NEWT:9544","NEWT:9545","NEWT:979","NEWT:7370","NEWT:83906","NEWT:99488","NEWT:1134506","NEWT:255470","NEWT:38783","NEWT:6426","NEWT:33090","NEWT:9935","NEWT:287889","NEWT:305959","NEWT:13489","NEWT:29829","NEWT:92867","NEWT:92866","NCBITaxon:3055","NEWT:51750","NEWT:202950","NEWT:441772","NEWT:48106","NEWT:295027","NCBITaxon:11320","NEWT:632957","NEWT:9925","NCBITaxon:9606","NEWT:90690","NEWT:1436183","NEWT:300273","NEWT:4232","NEWT:416348","NEWT:11298","NEWT:4236","NEWT:7742","NEWT:196627","NEWT:200308","NEWT:200302","NEWT:870435","NEWT:9913","NEWT:9915","NEWT:105841","NEWT:2666255","NEWT:999810","NCBITaxon:5693","NEWT:28995","NEWT:1392998","NEWT:380394","NEWT:226900","NEWT:1266738","NEWT:231490","NEWT:244704","NEWT:7725","NEWT:9909","NEWT:9902","NEWT:430615","NEWT:563041","NEWT:72664","NEWT:36599","NEWT:41949","NEWT:249161","NEWT:326423","NEWT:452467","NEWT:198822","NEWT:36111","NEWT:326424","NEWT:1678078","NEWT:749906","NEWT:418985","NEWT:749907","NEWT:150847","NEWT:29835","NEWT:431947","NEWT:69014","NEWT:142809","NEWT:302409","NEWT:130821","NEWT:27606","NEWT:1519788","NEWT:59202","NEWT:9975","NEWT:8643","NEWT:1159899","NEWT:502780","NEWT:860688","NEWT:13443","NEWT:35231","NEWT:8644","NEWT:1125630","NEWT:5141","NEWT:46360","NCBITaxon:3044782","NEWT:202914","NEWT:160235","NEWT:502779","NEWT:297246","NEWT:8639","NEWT:1928434","NEWT:8637","NEWT:1114970","NEWT:2096","NEWT:285272","NEWT:192222","NEWT:9963","NEWT:1617910","NEWT:637379","NEWT:12107","NEWT:2785785","NEWT:411901","NEWT:1298722","NEWT:8626","NEWT:186801","NEWT:105884","NCBITaxon:9615","NEWT:8621","NEWT:58334","NEWT:58331","NEWT:8624","NEWT:5116","NEWT:8623","NEWT:5597","NCBITaxon:3077","NEWT:194439","NCBITaxon:12637","NEWT:38727","NEWT:218496","NEWT:8618","NEWT:70448","NEWT:300251","NEWT:9940","NEWT:1247190","NEWT:118702","NEWT:118700","NEWT:2126719","NEWT:118705","NEWT:6945","NEWT:2104","NEWT:2627626","NEWT:6943","NEWT:157546","NEWT:870726","NEWT:91374","NEWT:91373","NEWT:474186","NEWT:54195","NEWT:10136","NEWT:38942","NEWT:4762","NEWT:6941","NEWT:307972","NEWT:2102","NEWT:34","NEWT:38949","NEWT:1299114","NEWT:1590841","NEWT:1276473","NEWT:2282334","NEWT:1247","NEWT:70667","NEWT:869728","NEWT:6938","NCBITaxon:39054","NEWT:1736309","NEWT:4751","NEWT:194963","NEWT:15819","NEWT:109461","NEWT:1085956","NEWT:6928","NEWT:1239","NEWT:36745","NEWT:400727","NEWT:272563","NEWT:11009","NEWT:913998","NEWT:68335","NEWT:3885","NEWT:3888","NEWT:649408","NEWT:6915","NEWT:101510","NEWT:3880","NEWT:272559","NEWT:216816","NEWT:153151","NEWT:2681598","NEWT:515849","NEWT:10141","NEWT:95767","NEWT:466585","NEWT:1000589","NEWT:85963","NEWT:29","NEWT:85962","NEWT:42197","NEWT:143361","NEWT:5656","NEWT:1299","NEWT:424718","NEWT:316407","NEWT:1794699","NCBITaxon:183674","NEWT:167387","NEWT:84645","NEWT:1123294","NEWT:209285","NEWT:211586","NEWT:747078","NEWT:1282","NEWT:1283","NEWT:1000561","NEWT:2133","NEWT:294381","NEWT:197","NEWT:1390363","NEWT:35889","NEWT:406072","NEWT:1454958","NEWT:29176","NEWT:201319","NEWT:1073569","NEWT:4787","NEWT:751585","NEWT:113549","NEWT:180788","NEWT:159749","NEWT:1270","NEWT:388919","NEWT:130081","NEWT:4784","NEWT:360106","NEWT:4785","NEWT:360104","NEWT:10117","NEWT:401614","NEWT:10116","NEWT:1280","NEWT:83333","NEWT:83334","NEWT:242718","NEWT:83332","NEWT:242715","NEWT:100226","NEWT:1263","NEWT:176299","NEWT:54126","NEWT:75058","NEWT:13616","NEWT:13613","NEWT:296543","NEWT:173","NEWT:316435","NEWT:42157","NEWT:1034304","NEWT:105023","NEWT:866628","NEWT:535026","NEWT:749200","NEWT:1036967","NEWT:266264","NEWT:272943","NEWT:145953","NEWT:257309","NEWT:203124","NEWT:230741","NEWT:8296","NEWT:117008","NEWT:167748","NEWT:1163394","NEWT:645463","NEWT:749696","NEWT:990119","NEWT:77216","NEWT:1111708","NEWT:998086","NEWT:493760","NEWT:93163","NEWT:257313","NEWT:3827","NEWT:400772","NEWT:128161","NEWT:930945","NEWT:332521","NEWT:106350","NEWT:269796","NEWT:54571","NEWT:412754","NEWT:9598","NEWT:1423772","NEWT:51056","NEWT:53232","NEWT:1235987","NCBITaxon:2509511","NEWT:1639","NEWT:188229","NEWT:3818","NEWT:432359","NEWT:9103","NEWT:715877","NEWT:862238","NEWT:29159","NEWT:1155748","NEWT:9593","NEWT:9595","NEWT:2665958","NEWT:246200","NEWT:6087","NEWT:145943","NEWT:595536","NEWT:1134822","NEWT:240906","NEWT:89920","NEWT:29158","NEWT:44744","NEWT:3879","NEWT:1328881","NEWT:411483","NEWT:76336","NEWT:3870","NEWT:884019","NEWT:411490","NEWT:169963","NEWT:587","NEWT:588","NEWT:585","NCBITaxon:43925","NEWT:746128","NEWT:212035","NCBITaxon:1653394","NEWT:1205","NEWT:214693","NEWT:45609","NEWT:9172","NEWT:2770979","NEWT:112","NEWT:1277351","NEWT:1594786","NEWT:3854","NEWT:411469","NEWT:1679","NEWT:333849","NEWT:214684","NEWT:1758543","NEWT:569","NEWT:411464","NEWT:411460","NEWT:1328426","NEWT:562","NEWT:411470","NEWT:2094720","NCBITaxon:2697049","NEWT:294750","NEWT:1663","NEWT:62141","NEWT:3848","NEWT:3847","NEWT:198466","NEWT:327159","NEWT:1045010","NEWT:178876","NEWT:1660","NEWT:327160","NEWT:573","NEWT:571","NEWT:142479","NEWT:29595","NEWT:241368","NEWT:42528","NEWT:1969471","NEWT:9657","NEWT:30540","NEWT:264483","NEWT:439733","NEWT:76777","NEWT:30545","NEWT:76773","NEWT:1121114","NEWT:663","NEWT:1081927","NEWT:1238993","NEWT:67825","NEWT:187878","NEWT:1504802","NEWT:1821314","NEWT:1249668","NEWT:426430","NEWT:37181","NEWT:929439","NEWT:9646","NEWT:5286","NEWT:7469","NEWT:9644","NEWT:426428","NEWT:63459","NEWT:2652157","NEWT:2652158","NEWT:40353","NEWT:1276815","NEWT:40324","NEWT:588858","NEWT:9638","NEWT:9639","NCBITaxon:11071","NEWT:693977","NEWT:242231","NEWT:197221","NEWT:528354","NEWT:51453","NEWT:1279085","NEWT:28231","NEWT:7460","NEWT:504457","NEWT:392227","NEWT:1004024","NEWT:103372","NEWT:862751","NEWT:470150","NEWT:9627","NEWT:1009714","NEWT:73239","NEWT:38018","NEWT:226186","NEWT:381518","NEWT:30532","NEWT:8782","NEWT:30538","NEWT:115357","NEWT:63436","NEWT:63433","NEWT:13164","NEWT:1601067","NEWT:129554","NEWT:40302","NEWT:1249615","NEWT:2664179","NEWT:623","NEWT:7038","NEWT:6192","NCBITaxon:1639","NEWT:3915","NEWT:1581419","NEWT:405534","NEWT:9689","NEWT:8355","NEWT:633","NEWT:9685","NEWT:7029","NEWT:9688","NEWT:6182","NEWT:9694","NEWT:604162","NEWT:186990","NEWT:8364","NEWT:632","NEWT:6183","NEWT:1423800","NEWT:630","NCBITaxon:11019","NEWT:334747","NEWT:3907","NEWT:61235","NEWT:343691","NEWT:1457551","NEWT:15368","NEWT:1491466","NEWT:340188","NEWT:170187","NEWT:1755437","NEWT:1042399","NEWT:1719","NEWT:692672","NEWT:2697049","NEWT:1109443","NEWT:267566","NEWT:58042","NEWT:7004","NEWT:9669","NCBITaxon:6073","NEWT:1089448","NEWT:1329349","NEWT:1089444","NEWT:607699","NEWT:6161","NEWT:206542","NEWT:27337","NEWT:575584","NEWT:186536","NEWT:185687","NEWT:3039","NEWT:2706014","NEWT:8727","NEWT:8726","NEWT:10090","NEWT:8729","NEWT:8720","NEWT:5693","NEWT:2186","NEWT:8724","NEWT:8723","NEWT:283166","NEWT:8722","NEWT:5697","NEWT:6544","NEWT:218192","NCBITaxon:10114","NEWT:2190","NEWT:1685931","NEWT:242619","NEWT:557723","NEWT:557722","NEWT:160791","NEWT:1353008","NEWT:34073","NEWT:402042","NEWT:373995","NEWT:5689","NEWT:8715","NEWT:544404","NEWT:287535","NEWT:2173","NEWT:2175","NEWT:1232801","NEWT:5691","NEWT:61674","NEWT:2072580","NEWT:669465","NEWT:1117957","NEWT:6526","NEWT:8709","NEWT:8707","NEWT:1306274","NEWT:5671","NEWT:8700","NEWT:1692259","NEWT:1486917","NEWT:1843183","NEWT:5661","NEWT:157592","NEWT:51866","NEWT:58002","NEWT:13136","NEWT:5665","NEWT:1179777","NEWT:6997","NEWT:5666","NEWT:5664","NEWT:2157","NEWT:70125","NEWT:146479","NEWT:1843192","NEWT:206189","NEWT:295139","NEWT:6108","NEWT:1720309","NEWT:9612","NEWT:1286640","NEWT:38865","NEWT:3077","NEWT:9615","NEWT:6100","NEWT:713604","NEWT:3076","NEWT:112273","NEWT:33178","NEWT:1147787","NEWT:1440772","NEWT:8759","NEWT:9605","NEWT:9606","NEWT:27717","NEWT:641501","NEWT:9601","NEWT:8752","NEWT:8756","NEWT:74940","NEWT:13551","NEWT:10041","NEWT:9600","NEWT:1450511","NEWT:439375","NEWT:890382","NEWT:174934","NEWT:179392","NEWT:2823525","NEWT:115778","NEWT:1538186","NEWT:227086","NEWT:3055","NEWT:195883","NEWT:1450520","NEWT:1042311","NEWT:1123352","NEWT:29920","NEWT:235909","NEWT:47311","NCBITaxon:813","NEWT:127785","NEWT:708248","NEWT:104660","NEWT:652611","NEWT:94993","NEWT:8732","NEWT:763037","NEWT:3555","NEWT:71647","NEWT:260201","NEWT:35554","NCBITaxon:12939","NEWT:32046","NEWT:2222","NEWT:544496","NEWT:59529","NEWT:32049","NEWT:1392696","NEWT:45351","NEWT:445974","NEWT:43179","NEWT:180454","NEWT:5722","NEWT:7901","NEWT:32051","NEWT:10245","NEWT:55153","NEWT:351581","NEWT:43186","NEWT:428146","NEWT:498019","NEWT:1351","NEWT:1438992","NEWT:1352","NEWT:2649997","NEWT:1147161","NEWT:43150","NEWT:263737","NEWT:1333499","NEWT:5702","NEWT:95648","NEWT:1349","NEWT:67593","NEWT:1401257","NEWT:44491","NEWT:27933","NEWT:556484","NEWT:7955","NEWT:7959","NEWT:2261","NEWT:94323","NEWT:31156","NEWT:3112","NEWT:8801","NEWT:4442","NEWT:192875","NEWT:1214915","NEWT:1214916","NEWT:284218","NEWT:1316931","NEWT:511145","NEWT:213401","NEWT:931281","NEWT:4432","NEWT:5762","NEWT:5763","NEWT:118099","NEWT:658457","NEWT:35525","NEWT:295358","NEWT:2246","NEWT:2652724","NEWT:5757","NEWT:68415","NCBITaxon:4563","NEWT:5755","NEWT:44447","NEWT:752555","NEWT:39097","NEWT:347495","NEWT:5759","NEWT:1736231","NEWT:1392","NEWT:35974","NEWT:2242","NEWT:1396","NEWT:286","NEWT:391619","NEWT:287","NEWT:633149","NEWT:1149786","NEWT:10239","NEWT:68895","NEWT:4897","NEWT:5744","NEWT:72901","NEWT:213863","NEWT:55571","NEWT:35500","NEWT:1235816","NEWT:2041044","NEWT:3562","NEWT:4896","NEWT:1262161","NEWT:1314781","NEWT:1390","NEWT:11557","NEWT:294","NEWT:1773","NEWT:82380","NEWT:935293","NEWT:375146","NEWT:471876","NEWT:1772","NEWT:263","NEWT:11988","NEWT:400667","NEWT:408169","NEWT:47946","NEWT:459758","NEWT:1764","NEWT:39087","NEWT:413996","NEWT:243277","NEWT:7067","NEWT:586722","NEWT:274","NEWT:7070","NCBITaxon:287","NEWT:408172","NEWT:408170","NEWT:1436733","NEWT:42229","NEWT:1247411","NEWT:9238","NEWT:13708","NEWT:333760","NEWT:34607","NEWT:1513458","NEWT:1233681","NCBITaxon:40559","NEWT:506599","NEWT:81077","NEWT:84588","NEWT:1279007","NEWT:65349","NEWT:300852","NEWT:508771","NEWT:1121405","NEWT:253","NCBITaxon:2759","NEWT:93061","NEWT:93062","NEWT:1284813","NEWT:34613","NCBITaxon:4932","NEWT:1748","NEWT:108673","NEWT:943274","NEWT:644223","NEWT:1263082","NEWT:272623","NEWT:1288389","NEWT:272624","NEWT:886559","NEWT:55521","NEWT:118499","NEWT:1130798","NEWT:55529","NEWT:256136","NEWT:476272","NEWT:195051","NEWT:3988","NEWT:561007","NEWT:649908","NEWT:147828","NEWT:3983","NEWT:203696","NEWT:352472","NEWT:55518","NEWT:97441","NEWT:1154756","NEWT:1202531","NEWT:1202532","NEWT:360094","NEWT:1408223","NEWT:1408224","NEWT:41364","NEWT:1311","NEWT:1313","NEWT:1218097","NEWT:1080348","NEWT:1314","NEWT:39491","NEWT:212142","NCBITaxon:5811","NEWT:1499105","NEWT:192812","NEWT:571256","NEWT:40483","NEWT:688333","NCBITaxon:548681","NEWT:318586","NCBITaxon:5820","NEWT:272634","NEWT:198107","NEWT:1979401","NEWT:155892","NEWT:691","NEWT:167879","NEWT:1872122","NEWT:1308","NEWT:7091","NEWT:1034015","NEWT:760568","NEWT:141262","NEWT:1813","NEWT:4087","NEWT:9778","NEWT:306","NEWT:303","NEWT:97477","NEWT:7111","NEWT:113287","NEWT:347515","NEWT:6269","NEWT:4090","NEWT:4092","NEWT:4093","NEWT:4096","NEWT:208895","NEWT:941442","NEWT:536088","NEWT:311553","NEWT:1226408","NEWT:43984","NEWT:7108","NEWT:40479","NEWT:43989","NEWT:4076","NEWT:142615","NEWT:317","NEWT:885319","NEWT:293939","NEWT:497515","NEWT:885318","NEWT:39488","NEWT:4081","NEWT:273068","NEWT:1316582","NEWT:227166","NEWT:98334","NEWT:231663","NEWT:4084","NEWT:63577","NEWT:7574","NEWT:1715256","NEWT:30640","NEWT:348824","NEWT:929793","NEWT:1507179","NEWT:29204","NEWT:114155","NEWT:4072","NEWT:1337056","NEWT:634955","NEWT:6239","NEWT:102169","NEWT:208893","NEWT:4054","NEWT:98351","NEWT:1263854","NEWT:118503","NEWT:2059687","NEWT:160488","NEWT:63558","NEWT:207559","NEWT:107401","NEWT:85057","NEWT:985076","NEWT:1215323","NEWT:7159","NEWT:267671","NEWT:7160","NEWT:8496","NEWT:7165","NEWT:1257118","NEWT:1387333","NEWT:8010","NEWT:1315282","NEWT:27448","NEWT:235612","NEWT:243230","NEWT:936053","NEWT:1080772","NEWT:8479","NEWT:8485","NEWT:119856","NEWT:119857","NEWT:49240","NCBITaxon:3707","NEWT:391295","NEWT:1170828","NEWT:104395","NEWT:93934","NEWT:9315","NEWT:6289","NEWT:6287","NEWT:38569","NEWT:727","NEWT:9796","NEWT:118562","NEWT:725","NEWT:7137","NEWT:469008","NEWT:9321","NEWT:596153","NEWT:8472","NEWT:1836","NCBITaxon:10298","NEWT:105231","NEWT:104385","NEWT:74649","NEWT:1037924","NEWT:206672","NEWT:9788","NEWT:4097","NEWT:9305","NEWT:71139","NEWT:9785","NEWT:6279","NEWT:1195774","NEWT:9793","NCBITaxon:780","NCBITaxon:1502","NEWT:6282","NEWT:27457","NEWT:4006","NEWT:1872635","NCBITaxon:5476","NEWT:113208","NEWT:6669","NEWT:1215360","NEWT:89453","NEWT:1114301","NEWT:51515","NEWT:13249","NEWT:588596","NEWT:51511","NEWT:8845","NEWT:7998","NEWT:419610","NEWT:5334","NEWT:382352","NEWT:413071","NCBITaxon:10239","NCBITaxon:714","NEWT:11051","NEWT:89462","NEWT:452680","NEWT:8839","NEWT:2758385","NEWT:171101","NEWT:714","NEWT:5322","NEWT:34199","NEWT:421932","NEWT:312017","NEWT:576131","NEWT:553470","NEWT:284593","NEWT:100392","NEWT:655819","NEWT:5315","NEWT:11082","NEWT:265872","NEWT:59463","NEWT:337330","NEWT:2285","NEWT:2287","NEWT:6645","NEWT:251229","NEWT:981087","NEWT:180066","NEWT:46147","NCBITaxon:6312","NEWT:11072","NEWT:174633","NEWT:1416333","NEWT:35024","NEWT:135461","NEWT:7962","NEWT:99287","NEWT:1817808","NEWT:145262","NEWT:145263","NEWT:694569","NEWT:9739","NEWT:111069","NEWT:1379791","NEWT:51953","NEWT:57267","NEWT:3197","NEWT:13686","NEWT:2750454","NEWT:264561","NEWT:1402135","NEWT:36329","NEWT:62615","NEWT:1555636","NEWT:1333550","NEWT:72407","NEWT:352914","NEWT:349741","NEWT:409859","NEWT:157295","NEWT:1263871","NEWT:509169","NEWT:6210","NEWT:9721","NEWT:137221","NEWT:565050","NEWT:409860","NEWT:5353","NEWT:1034809","NEWT:452659","NEWT:1193501","NEWT:51930","NEWT:6689","NEWT:194675","NEWT:298315","NEWT:46105","NEWT:10181","NEWT:9704","NEWT:1049056","NEWT:698936","NEWT:1009874","NEWT:4498","NEWT:8855","NEWT:3168","NEWT:10185","NEWT:78168","NEWT:521001","NEWT:192011","NEWT:340912","NEWT:1813887","NEWT:224911","NCBITaxon:11552","NEWT:334249","NEWT:184922","NEWT:6703","NEWT:2","NEWT:35670","NEWT:511693","NEWT:4528","NEWT:35677","NEWT:1493","NEWT:10376","NEWT:1496","NEWT:3674","NEWT:5851","NEWT:660469","NEWT:935568","NEWT:1365186","NEWT:1813019","NEWT:45474","NEWT:48500","NEWT:4513","NEWT:5843","NEWT:1117645","NCBITaxon:10407","NEWT:1000364","NEWT:10360","NEWT:1403536","NEWT:1427524","NEWT:47664","NEWT:260799","NEWT:317548","NEWT:3654","NEWT:237561","NEWT:5833","NEWT:3659","NEWT:59620","NEWT:499229","NEWT:31298","NEWT:1204162","NEWT:82688","NEWT:5823","NEWT:5821","NEWT:44139","NCBITaxon:4895","NCBITaxon:4896","NEWT:675512","NEWT:315393","NEWT:3649","NEWT:28903","NEWT:325176","NEWT:28909","NEWT:3641","NEWT:79698","NCBITaxon:5796","NEWT:12993","NEWT:398580","NEWT:4565","NEWT:1264690","NEWT:515619","NEWT:170721","NEWT:34305","NEWT:77020","NEWT:83558","NEWT:44586","NEWT:626528","NEWT:139927","NEWT:4558","NEWT:5888","NEWT:431241","NEWT:4550","NEWT:4555","NEWT:144030","NEWT:288705","NEWT:392815","NEWT:3217","NEWT:4547","NEWT:3218","NEWT:556182","NEWT:374990","NEWT:1432059","NEWT:154293","NEWT:156471","NEWT:3694","NEWT:156476","NEWT:4543","NEWT:210007","NEWT:1857017","NEWT:10359","NEWT:1358430","NEWT:10358","NEWT:1735272","NEWT:109298","NEWT:317513","NEWT:580240","NEWT:294128","NEWT:11676","NEWT:1917265","NEWT:55210","NEWT:718308","NEWT:4530","NEWT:5861","NEWT:1895","NEWT:2558360","NEWT:64152","NEWT:4924","NEWT:2748","NEWT:8049","NEWT:33892","NEWT:99931","NEWT:9378","NEWT:990346","NEWT:100816","NEWT:192952","NEWT:1640346","NCBITaxon:1313","NEWT:44544","NEWT:529818","NEWT:400540","NEWT:382","NEWT:4911","NEWT:152480","NEWT:129249","NEWT:1888","NEWT:1077286","NEWT:943129","NEWT:1221594","NEWT:1524260","NEWT:227321","NEWT:281677","NEWT:106590","NEWT:260710","NEWT:4918","NEWT:1162296","NEWT:106592","NEWT:596645","NEWT:46704","NEWT:482428","NEWT:1187947","NEWT:4903","NEWT:10312","NCBITaxon:1773","NEWT:190304","NEWT:1432499","NEWT:8030","NEWT:246437","NEWT:36909","NEWT:4909","NEWT:443256","NEWT:1279365","NEWT:759272","NEWT:1182263","NEWT:943146","NEWT:646532","NEWT:2711","NEWT:537457","NEWT:479249","NEWT:33889","NEWT:10306","NEWT:8022","NEWT:42353","NEWT:593117","NEWT:3633","NEWT:319761","NEWT:3635","NEWT:5811","NEWT:86662","NEWT:180923","NEWT:1451","NEWT:198215","NEWT:200298","NEWT:12916","NEWT:1400870","NEWT:343","NEWT:84005","NEWT:225117","NEWT:8090","NEWT:5801","NEWT:43665","NEWT:5802","NEWT:4952","NEWT:1266464","NEWT:367830","NEWT:1093790","NEWT:178616","NEWT:95145","NEWT:358","NEWT:375451","NEWT:54788","NEWT:357","NEWT:74381","NEWT:2010198","NEWT:457428","NEWT:106178","NEWT:84023","NEWT:559292","NEWT:2762","NEWT:1174673","NEWT:28035","NEWT:1313166","NCBITaxon:138","NEWT:28038","NEWT:1422","NEWT:1423","NEWT:4932","NEWT:1205903","NEWT:3603","NEWT:2756","NEWT:2759","NEWT:38293","NEWT:1428","NEWT:339","NEWT:2751","NEWT:139077","NEWT:391904","NEWT:12922","NEWT:316277","NEWT:163159","NEWT:1306413","NEWT:2813599","NEWT:518766","NEWT:2664373","NEWT:190802","NEWT:1213463","NEWT:9417","NEWT:1216979","NEWT:7237","NEWT:5059","NEWT:31631","NEWT:509924","NEWT:28450","NEWT:115104","NEWT:5061","NEWT:8570","NEWT:127569","NEWT:5062","NEWT:1408434","NEWT:1241935","NEWT:220668","NEWT:9407","NEWT:7227","NEWT:9402","NEWT:415540","NEWT:336722","NEWT:675060","NEWT:416870","NEWT:334542","NEWT:313625","NEWT:51240","NEWT:27592","NEWT:5052","NEWT:227289","NEWT:7215","NEWT:196139","NEWT:5037","NEWT:651182","NEWT:2172103","NCBITaxon:59201","NEWT:1876254","NEWT:434271","NEWT:1915","NEWT:747679","NEWT:66712","NEWT:42752","NEWT:746360","NEWT:89764","NEWT:543734","NEWT:49390","NEWT:9870","NEWT:256648","NEWT:435590","NEWT:1902","NEWT:208526","NEWT:1908","NEWT:1169740","NEWT:217459","NEWT:216129","NEWT:1245012","NEWT:528135","NCBITaxon:38727","NEWT:74790","NEWT:2829","NEWT:126279","NEWT:1428006","NEWT:62335","NEWT:366581","NEWT:757417","NEWT:216599","NEWT:216595","NEWT:40559","NEWT:51208","NEWT:216597","NEWT:1607839","NEWT:1283300","NEWT:1218707","NEWT:1204551","NEWT:99586","NEWT:228577","NEWT:2060328","NEWT:392021","NEWT:436486","NEWT:51655","NEWT:1933298","NEWT:260707","NEWT:121845","NEWT:8595","NEWT:7263","NEWT:186763","NEWT:447135","NEWT:185431","NEWT:216591","NEWT:29760","NEWT:260704","NEWT:703612","NEWT:260705","NEWT:1202347","NEWT:546805","NEWT:1505907","NEWT:1216981","NEWT:1249885","NEWT:1972855","NEWT:1415167","NEWT:36036","NEWT:71251","NEWT:208963","NEWT:208964","NEWT:181088","NEWT:48498","NEWT:669202","NEWT:6306","NEWT:4120","NEWT:37334","NCBITaxon:10357","NCBITaxon:10358","NCBITaxon:10359","NEWT:1203258","NEWT:49317","NEWT:696811","NEWT:9808","NEWT:839","NEWT:92519","NEWT:943925","NEWT:4111","NEWT:37349","NEWT:4113","NEWT:837","NEWT:640459","NEWT:72568","NEWT:36015","NEWT:51641","NEWT:81866","NEWT:1262469","NEWT:277944","NEWT:48479","NEWT:61435","NEWT:627025","NEWT:1097677","NEWT:375939","NEWT:712938","NEWT:3258","NEWT:112018","NEWT:4100","NEWT:1159556","NEWT:1076","NEWT:4102","NEWT:1028688","NEWT:4101","NEWT:6763","NEWT:803","NEWT:29722","NEWT:419947","NEWT:2847306","NEWT:468911","NEWT:13373","NEWT:817","NEWT:7604","NEWT:6756","NEWT:818","NEWT:135588","NEWT:1061","NEWT:29719","NEWT:6754","NEWT:452589","NEWT:509068","NEWT:4577","NEWT:813","NEWT:1365218","NEWT:1042986","NEWT:1911079","NEWT:69373","NEWT:427577","NEWT:264203","NEWT:1480154","NEWT:9858","NEWT:9859","NEWT:512623","NEWT:1274414","NEWT:2907833","NEWT:38626","NEWT:10298","NEWT:10299","NEWT:1087439","NEWT:660025","NEWT:61408","NEWT:1355477","NEWT:90371","NEWT:55194","NEWT:2907829","NEWT:4153","NEWT:11137","NEWT:278839","NEWT:35128","NEWT:39966","NEWT:7668","NEWT:2929635","NEWT:58228","NEWT:915099","NEWT:1143193","NEWT:1122233","NEWT:859313","NEWT:59540","NEWT:9838","NEWT:9839","NEWT:546414","NEWT:11167","NEWT:9835","NEWT:7650","NEWT:4146","NEWT:5478","NEWT:6326","NEWT:7656","NEWT:5476","NEWT:5477","NEWT:1882945","NEWT:746707","NEWT:299767","NEWT:28835","NEWT:1206781","NEWT:5480","NEWT:1274432","NEWT:222863","NEWT:2053667","NEWT:859321","NEWT:1274426","NEWT:9825","NEWT:1274423","NEWT:393765","NEWT:104421","NEWT:39946","NEWT:9823","NEWT:95602","NEWT:314539","NEWT:39947","NEWT:718274","NEWT:1274420","NEWT:859314","NEWT:578458","NEWT:60520"],"pubmed":["42032651","38914866"],"ORCID":["0000-0003-4742-0566"]}}