{"database":"Pride","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Tabular":["ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD070456/3053_lib_MBR_forManuscript-lib.tsv.speclib","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD070456/3053_report_MBR_forManuscript.tsv","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD070456/PRIDE_3053_Experiment.tsv"],"Txt":["ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD070456/3053_report_MBR_forManuscript.log.txt","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD070456/checksum.txt"],"Raw":["ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD070456/E2_ColID406_3053_01.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD070456/E2_ColID406_3053_07.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD070456/E2_ColID406_3053_04.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD070456/E2_ColID406_3053_09.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD070456/E2_ColID406_3053_10.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD070456/E2_ColID406_3053_11.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD070456/E2_ColID406_3053_08.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD070456/E2_ColID406_3053_03.raw"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"labhead_mail":["Michael.schroeter@uk-koeln.de"],"submitter":["Proteomics Facility"],"technology_type":["Mass Spectrometry","Data-independent acquisition"],"software":[""],"submitter_keywords":["Muscle atrophy","Autoimmune neuritis","Neuropathy"],"full_dataset_link":["https://www.ebi.ac.uk/pride/archive/projects/PXD070456"],"tissue":["Muscle"],"sample_protocol":["The aliquots were further lyzed by adding 200 µl ice-cold Urea lysis buffer (8M Urea in 50mM Triethylammoniumbicarbonate supplemented with 50x protease inhibitor cocktail (Roche, Mannheim, Germany)). Supernatants were collected after repetitive vertexing and centrifugation, incubated with 25 Units Benzonase HC for 30 minutes at 37°C to degrade nucleic acids and centrifuged. 50 µg of protein per sample were transferred to a 1.5 ml tube and incubated with Dithiothreitol to a final concentration of 5 mM for 1 hour at room temperature. In a next step, the samples were incubated with Chloroacetamide at a final concentration of 40 mM for 30 minutes in the dark and, subsequently, with Lys-C protease at a ratio of 1:75 for 4 hours. 50 mM TEAB was added to achieve a final concentration of Urea ≤ 2 M and the samples were incubated with Trypsin (1:75) overnight. Formic acid at a final concentration of 1% was added to stop enzymatic digestion. Peptides were purified with SDB-RPS polymer sorbent StageTips (CDS Analytical, Oxford, Pennsylvania, USA).  Samples were analyzed by the CECAD Proteomics Facility on an Orbitrap Exploris 480 (Thermo Scientific, granted by the German Research Foundation under INST 1856/71-1 FUGG) mass spectrometer equipped with a FAIMSpro differential ion mobility device that was coupled to an UltiMate 3000 (Thermo Scientific). Samples were loaded onto a precolumn (Acclaim 5µm PepMap 300 µ Cartridge) for 2 min at 15 ul flow before reverse-flushed onto an in-house packed analytical column (30 cm length, 75 µm inner diameter, filled with 2.7 µm Poroshell EC120 C18, Agilent). Peptides were chromatographically separated at a constant flow rate of 300 nL/min and the following gradient: initial 6% B (0.1% formic acid in 80 % acetonitrile), up to 32% B in 72 min, up to 55% B within 7.0 min and up to 95% solvent B within 2.0 min, followed by column wash with 95% solvent B and reequilibration to initial condition. The FAIMS pro was operated at -50V compensation voltage and electrode temperatures of 99.5 °C for the inner and 85 °C for the outer electrode. MS1 scans were acquired from 399 m/z to 1001 m/z at 15k resolution. Maximum injection time was set to 22 ms and the AGC target to 100%. MS2 scans ranged from 400 m/z to 1000 m/z and were acquired at 15 k resolution with a maximum injection time of 22 ms and an AGC target of 100%. DIA scans covering the precursor range from 400 - 1000 m/z and were acquired in 60 x 10 m/z windows with an overlap of 1 m/z. All scans were stored as centroid."],"repository":["Pride"],"quantification_method":[""],"modification":[""],"data_protocol":["Samples were analyzed in DIA-NN 1.8.1. Uniprot Swissprot and TrEMBL rat databases (UP2494, downloaded 15/01/25) were merged and used for library building with settings matching acquisition parameters and the match-between-runs function enabled. Here, samples are directly used to refine the library for a second search of the sample data. DIA-NN was run with the additional command line prompts “—report-lib-info”. Further output settings were: filtered at 0.01 FDR, N-terminal methionine excision enabled, maximum number of missed cleavages set to 1, min peptide length set to 7, max peptide length set to 30, min precursor m/z set to 400, max precursor m/z set to 1000, cysteine carbamidomethylation enabled as a fixed modification. Afterwards, DIA-NN output was further filtered on library q-value and global q-value <= 0.01 and at least one peptide per protein using R (4.1.3). Finally, LFQ values calculated using the DIA-NN R-package. Afterwards, analysis of results was performed in Perseus 1.6.15 (82). Student’s t test was used to test for significant (false discovery rate <0.05) changes in protein abundance across the biological conditions. GO terms were added to the dataset. The relative enrichment of GO terms in the group of significantly changed proteins was determined using Fisher’s exact test. The whole dataset was inserted into the STRING-database to explore any protein-network interactions in the organism Rattus norvegicus."],"omics_type":["Proteomics"],"labhead":["Prof. Michael Schroeter"],"instrument_platform":[""],"labhead_affiliation":["Department of Neurology, Faculty of Medicine, University of Cologne and University Hospital Cologne, Kerpener Strasse 62, 50937 Cologne, Germany"],"submission_type":["PARTIAL"],"species":["Rattus Rattus (black Rat)"],"submitter_mail":["proteomics-facility@uni-koeln.de"],"publication":["41896993 Gerlach I, Koch M, Gatto G, Lackmann JW, Lehmann HC, Schroeter M, Kohle F. ActIIR inhibition improves motor outcome and preserves muscle fibers after experimental autoimmune neuritis. Acta Neuropathol Commun. 2026 14(1):86 10.1186/s40478-026-02277-z"],"submitter_affiliation":["CECAD Research Center"],"submitter_country":["Germany"],"pubmed_title":["ActIIR inhibition improves motor outcome and preserves muscle fibers after experimental autoimmune neuritis."],"pubmed_authors":["Gerlach Ivo I, Koch Manuel M, Gatto Graziana G, Lackmann Jan-Wilm JW, Lehmann Helmar C HC, Schroeter Michael M, Kohle Felix F"],"additional_accession":[]},"is_claimable":false,"name":"Targeting Secondary Muscle Atrophy to Enhance Motor Recovery in Experimental Autoimmune Neuritis","description":"Secondary muscle atrophy due to neuronal denervation is a key determinant of poor functional recovery in immune-mediated neuropathies, even after resolution of inflammation. Activin II receptors (ActIIRs) are central mediators of muscle atrophy, and their inhibition has shown variable efficacy in primary myopathies. We investigated the therapeutic potential of ActIIR inhibition in promoting motor recovery in immune-mediated neuropathies using the experimental autoimmune neuritis (EAN) model in Lewis rats. Motor performance was evaluated through a composite of clinical neuritis scoring, grip strength testing, and balance beam performance combined with kinematic gait analysis. High-dose antibody treatment significantly improved motor outcome. This improvement was not associated with changes in peripheral nerve inflammation or remyelination but correlated with preservation of muscle fiber size. Muscle proteomic analysis revealed modulation of the FoxO signaling pathway and reduced expression of the atrophy-related E3 ligases Atrogin-1 and MuRF1. These findings indicate that ActIIR inhibition prevents secondary muscle atrophy and enhances motor recovery in autoimmune neuritis. Targeting ActIIR signaling may represent a promising therapeutic strategy to improve motor outcomes in patients with immune-mediated neuropathies.","dates":{"publication":"2026-04-13","submission":"2025-11-07"},"accession":"PXD070456","cross_references":{"TAXONOMY":["NEWT:330879","NEWT:377960","NEWT:2042546","NEWT:259447","NEWT:295546","NCBITaxon:2719036","NCBITaxon:1280","NEWT:112503","NEWT:1129","NEWT:309807","NEWT:59753","NEWT:89184","NEWT:309800","NEWT:281395","NEWT:1211601","NEWT:876138","NEWT:44271","NEWT:193516","NEWT:1073882","NEWT:6819","NEWT:475174","NEWT:1117","NEWT:498257","NEWT:10036","NEWT:1590","NEWT:10034","NEWT:661410","NEWT:638632","NEWT:224326","NEWT:376619","NCBITaxon:79857","NEWT:1096976","NEWT:3765","NEWT:1589","NEWT:135622","NEWT:35786","NEWT:1580","NEWT:399784","NEWT:96731","NEWT:656064","NEWT:36630","NEWT:383379","NEWT:418106","NCBITaxon:12721","NEWT:10029","NEWT:913645","NEWT:641809","NEWT:1392488","NEWT:38815","NEWT:317447","NEWT:4688","NEWT:7719","NEWT:868565","NEWT:135674","NEWT:79329","NEWT:30069","NEWT:12637","NEWT:59729","NEWT:2164133","NEWT:295105","NEWT:108061","NEWT:60711","NEWT:224308","NEWT:3347","NEWT:160621","NEWT:212790","NEWT:110368","NEWT:1310161","NEWT:77133","NEWT:145481","NEWT:1310165","NEWT:29058","NCBITaxon:79824","NEWT:410658","NEWT:44688","NEWT:44689","NEWT:498211","NEWT:347256","NEWT:5518","NEWT:398007","NEWT:1527468","NEWT:498217","NEWT:498216","NEWT:11320","NEWT:246196","NEWT:246197","NEWT:145458","NEWT:44685","NEWT:161934","NEWT:156587","NEWT:1148","NEWT:5508","NEWT:3329","NEWT:419481","NEWT:5507","NEWT:410661","NEWT:1140","NCBITaxon:2157","NEWT:1143","NEWT:1287689","NEWT:1094343","NEWT:1462472","NEWT:1336795","NEWT:644042","NEWT:1182590","NEWT:3712","NEWT:3711","NEWT:3714","NEWT:270643","NEWT:2065263","NEWT:177437","NEWT:10418","NEWT:118698","NEWT:1616117","NEWT:118696","NEWT:34865","NEWT:52283","NEWT:28174","NEWT:284812","NEWT:8175","NEWT:43330","NEWT:1603293","NEWT:44664","NEWT:43346","NEWT:3702","NEWT:1245466","NEWT:3704","NEWT:244366","NEWT:1246791","NEWT:118694","NEWT:2850","NEWT:118691","NEWT:34871","NEWT:33548","NEWT:52299","NEWT:8165","NEWT:96794","NEWT:3708","NEWT:332648","NEWT:44670","NEWT:536231","NEWT:376219","NEWT:219813","NEWT:1510","NEWT:460519","NEWT:1515","NEWT:572307","NEWT:1432138","NEWT:1424507","NEWT:1194599","NEWT:272844","NEWT:1348799","NEWT:33995","NEWT:55784","NEWT:1303443","NEWT:9483","NEWT:485","NEWT:56636","NEWT:2853422","NEWT:1679718","NEWT:480","NEWT:67767","NEWT:46835","NEWT:109757","NEWT:582580","NEWT:1185650","NEWT:216778","NEWT:1502","NEWT:128017","NEWT:376686","NEWT:95486","NEWT:1883446","NEWT:1233435","NEWT:118223","NEWT:109760","NEWT:29031","NEWT:317047","NEWT:491","NEWT:460523","NEWT:235443","NEWT:1757312","NEWT:85694","NEWT:108458","NEWT:5936","NEWT:320637","NEWT:1078283","NEWT:3750","NEWT:983964","NEWT:11706","NEWT:32644","NEWT:527796","NEWT:499175","NEWT:109779","NEWT:3745","NEWT:1715989","NCBITaxon:4751","NEWT:3747","NEWT:1116234","NEWT:1255228","NEWT:410289","NEWT:373153","NEWT:1640278","NEWT:472","NEWT:940825","NEWT:529507","NEWT:1071661","NEWT:470","NEWT:5911","NEWT:748693","NCBITaxon:50557","NEWT:39251","NEWT:29491","NEWT:101841","NEWT:446","NEWT:153481","NEWT:2014887","NEWT:33952","NEWT:445","NEWT:153009","NEWT:261756","NEWT:166313","NEWT:63366","NEWT:63367","NEWT:215402","NEWT:1547","NEWT:906914","NEWT:9031","NEWT:27292","NEWT:1050722","NEWT:108931","NEWT:1293497","NEWT:1055524","NEWT:150475","NEWT:267872","NEWT:381666","NEWT:172269","NEWT:9534","NEWT:5180","NEWT:256737","NEWT:9541","NEWT:8694","NEWT:33936","NEWT:8692","NEWT:2903","NEWT:185579","NEWT:13076","NEWT:1006581","NEWT:8673","NEWT:33940","NEWT:550","NEWT:554","NEWT:451516","NEWT:552","NEWT:1325291","NEWT:36185","NEWT:1054211","NEWT:1225786","NEWT:771870","NEWT:51338","NEWT:575412","NEWT:28112","NEWT:6493","NEWT:10832","NEWT:6494","NEWT:6491","NEWT:507601","NEWT:520","NEWT:186441","NEWT:643680","NEWT:214092","NCBITaxon:6157","NEWT:13095","NEWT:162425","NEWT:104105","NEWT:216257","NEWT:9986","NEWT:8654","NEWT:8658","NEWT:1268063","NEWT:8657","NEWT:9983","NEWT:8655","NEWT:5147","NEWT:28108","NEWT:28104","NEWT:407821","NEWT:568703","NCBITaxon:2","NEWT:568708","NEWT:986","NEWT:52641","NEWT:28532","NEWT:353152","NEWT:298176","NEWT:227377","NEWT:1774284","NEWT:40674","NEWT:1194669","NEWT:51329","NEWT:443906","NEWT:519","NEWT:2510939","NEWT:7394","NEWT:6063","NEWT:1328388","NEWT:105487","NEWT:1548728","NEWT:667127","NEWT:9557","NEWT:377586","NEWT:300641","NEWT:39655","NEWT:9554","NEWT:38323","NEWT:475932","NEWT:256318","NEWT:206411","NCBITaxon:6191","NEWT:229533","NEWT:214053","NEWT:28550","NEWT:80863","NEWT:90675","NEWT:52639","NEWT:52638","NEWT:57075","NEWT:1666905","NEWT:8697","NEWT:8695","NEWT:884204","NEWT:1123869","NEWT:9544","NEWT:9545","NEWT:979","NEWT:7370","NEWT:83906","NEWT:99488","NEWT:1134506","NEWT:255470","NEWT:38783","NEWT:6426","NEWT:33090","NEWT:9935","NEWT:287889","NEWT:305959","NEWT:13489","NEWT:29829","NEWT:92867","NEWT:92866","NCBITaxon:3055","NEWT:51750","NEWT:202950","NEWT:441772","NEWT:48106","NEWT:202956","NEWT:295027","NCBITaxon:11320","NEWT:632957","NEWT:9925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