{"database":"Pride","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Txt":["ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/09/PXD070850/msmsScans.txt","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/09/PXD070850/evidence.txt","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/09/PXD070850/parameters.txt","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/09/PXD070850/proteinGroups.txt","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/09/PXD070850/peptides.txt","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/09/PXD070850/summary.txt","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/09/PXD070850/msms.txt","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/09/PXD070850/mzRange.txt"],"Pdf":["ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/09/PXD070850/tables.pdf"],"Raw":["ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/09/PXD070850/EC240415_0809_c_ich.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/09/PXD070850/EC240415_0818_c_ich.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/09/PXD070850/EC240415_0810_c_ich.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/09/PXD070850/EC240415_0812_c_ich.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/09/PXD070850/EC240415_0819_c_ich.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/09/PXD070850/EC240415_0813_c_ich.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/09/PXD070850/EC240415_0815_c_ich.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/09/PXD070850/EC240415_0816_c_ich.raw"],"Mztab":["ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/09/PXD070850/mzTab.mzTab"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"labhead_mail":["joelle.vinh@espci.fr"],"submitter":["Iman haddad"],"technology_type":["Data-dependent acquisition","Mass Spectrometry","Bottom-up proteomics"],"software":[""],"submitter_keywords":[""],"full_dataset_link":["https://www.ebi.ac.uk/pride/archive/projects/PXD070850"],"tissue":["Epithelial Cell","Cell Culture"],"sample_protocol":["The strategy was to perform a double immunoprecipitation of the Flag-GFP tagged proteins: first with the Flag, then with GFP.The samples are reduced (DTT 10mM final, 56°C, 30min) and alkylated (Iodoacetamide 50mM, room temperature, 20 min), before being digested by a trypsin-LysC mix (0.5μg) at 37°C overnight. The peptides are then desalinated/concentrated and then taken up in 15 μl of injection buffer A''. 2μl of this rework will be injected for analysis. Analyses are performed on the Orbitrap Eclipse Tribrid (Thermo Scientific) LC-MS/MS: Liquid Chromatography Separation (C18 Waters NanoEase Column, UltiMate™ 3000 RSLCnano System - Thermo Fisher Scientific)"],"repository":["Pride"],"quantification_method":[""],"modification":[""],"data_protocol":["The queries are carried out via the Maxquant software (v 2.0.3.0) on the Homo Sapiens database of SwissProt + the FLAG-GFP sequence provided, according to the usual specifications (Oxidation M+16 Da, Carbamidomethylation C+57Da, Acetylation N-term+42Da ) in progress in our laboratory"],"omics_type":["Proteomics"],"labhead":["Dr Joelle"],"instrument_platform":[""],"labhead_affiliation":["ESPCI Paris, Université PSL, UAR2051 CNRS, 75005, Paris, France"],"submission_type":["COMPLETE"],"species":["Homo Sapiens (human)"],"publication":["42595116 Tsydenzhapova E, Fokin AI, David NB, Rocques N, Polesskaya A, Haddad I, Vinh J, Guérois R, Gautreau AM. The Nance-Horan syndrome protein NHS regulates cell migration persistence by organizing WAVE and N-WASP nucleation-promoting factor complexes. J Biol Chem. 2026 302(10):113443 10.1016/j.jbc.2026.113443"],"submitter_mail":["iman.haddad@espci.fr"],"submitter_affiliation":["SMBP"],"submitter_country":["France"],"doi":["10.6019/PXD070850"],"pubmed_abstract":["The function of the NHS gene that is responsible for Nance-Horan Syndrome has remained elusive at the cellular level. Using CRISPR/Cas9, we inactivated the NHS gene in MCF10A cells and characterized the isoforms expressed in these cells. NHS KO cells displayed reduced migration persistence, a phenotype that was fully rescued by the long isoform 1 (i1) that contains an N-terminal WAVE Homology Domain (WHD), but only partially rescued by the short isoform two (i2), which does not. Patient mutations resulting in NHS proteins truncated at their C-terminus also reduced the ability of NHS i1 to rescue migration persistence. Using Tandem Affinity Purification (TAP) of NHS i1 and mass spectrometry, we identified as major NHS partners all subunits of the WAVE Regulatory Complex (WRC) except WAVE subunits themselves, indicating that the WHD of NHS assembles a WAVE Shell Complex (WSC). The Arp2/3 complex and the Nucleation Promoting Factor (NPF) WAVE that activates it are critical for migration persistence. To investigate the role of the NHS-containing WSC, we performed TAP of the ABI1 subunit in parental and NHS KO cells and identified differential partners associated with ABI1 only in parental cells, but not in NHS KO cells. The most abundant of these were the WIPF2/N-WASP complex, which together with the kinase ABL2, was also critical for migration persistence. These results suggest that NHS controls cell migration by remodeling NPF complexes and their higher order assembly."],"pubmed_title":["The Nance-Horan syndrome protein NHS regulates cell migration persistence by organizing WAVE and N-WASP nucleation-promoting factor complexes."],"pubmed_authors":["Tsydenzhapova Ekaterina E, Fokin Artem I AI, David Nicolas B NB, Rocques Nathalie N, Polesskaya Anna A, Haddad Iman I, Vinh Joëlle J, Guérois Raphaël R, Gautreau Alexis M AM"],"additional_accession":[]},"is_claimable":false,"name":"Study partners of NHS protein by proteomics","description":"I am studying the NHS, the founding member of the NHS protein family, following the work of Yanan Wang, that discovered the WAVE shell complex, containing NHSL1 instead of WAVE (https://doi.org/10.1038/s41467-023-39276-w) Our recent experiments of the single cell migration show that NHS KO cells have decreased migration persistence (unlike NHSL1), that is why we are now interested in finding possible partners of the NHS. The strategy was to perform TAP of the Flag-GFP tagged NHS. The results suggest that NHS is embedded into a stoichiometric 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