{"database":"Pride","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Xlsx":["ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/SampleKey.xlsx"],"Msf":["ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IgG_14.msf","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IP_2.msf","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IgG_2.msf","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IP_13.msf","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IP_4.msf","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IgG_7.msf","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IP_11.msf","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IgG_9.msf","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IgG_16.msf","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IP_10.msf","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IP_7.msf","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IP_5.msf","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IgG_6.msf","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IP_15.msf","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IgG_11.msf","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IP_9.msf","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IgG_4.msf","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IP_14.msf","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IgG_15.msf","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IgG_13.msf","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IP_1.msf","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IgG_1.msf","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IP_12.msf","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IgG_8.msf","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IP_3.msf","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IgG_10.msf","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IgG_5.msf","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IP_6.msf","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IP_8.msf","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IgG_12.msf","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IgG_3.msf","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IP_16.msf"],"Txt":["ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/checksum.txt"],"Mzml":["ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IP_8.mzML","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IP_11.mzML","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IP_5.mzML","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IgG_3.mzML","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IP_14.mzML","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IP_2.mzML","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IgG_4.mzML","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IgG_11.mzML","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IP_15.mzML","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IgG_10.mzML","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IP_3.mzML","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IgG_1.mzML","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IP_4.mzML","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IgG_5.mzML","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IgG_2.mzML","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IgG_8.mzML","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IP_16.mzML","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IP_6.mzML","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IgG_12.mzML","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IP_10.mzML","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IgG_16.mzML","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IP_7.mzML","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IP_1.mzML","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IgG_13.mzML","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IgG_9.mzML","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IgG_6.mzML","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IP_13.mzML","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IgG_15.mzML","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IP_9.mzML","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IgG_7.mzML","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IgG_14.mzML","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IP_12.mzML"],"Raw":["ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IgG_11.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IP_8.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IgG_8.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IP_12.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IgG_1.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IP_6.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IP_14.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IgG_3.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IgG_16.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IP_16.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IP_3.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IgG_5.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IP_1.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IgG_14.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IgG_7.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IP_11.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IgG_12.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IgG_9.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IP_9.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IgG_10.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IP_5.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IP_13.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IgG_2.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IP_7.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IP_15.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IgG_4.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IP_4.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IgG_13.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IP_2.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IgG_15.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IgG_6.raw","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IP_10.raw"],"Mzid":["ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IgG_8.mzid","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IgG_5.mzid","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IgG_2.mzid","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IP_13.mzid","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IP_10.mzid","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IP_16.mzid","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IP_6.mzid","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IgG_16.mzid","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IP_1.mzid","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IP_7.mzid","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IP_12.mzid","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IgG_9.mzid","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IgG_15.mzid","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IgG_12.mzid","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IgG_6.mzid","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IP_9.mzid","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IgG_13.mzid","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IP_11.mzid","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IgG_7.mzid","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IP_8.mzid","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IgG_14.mzid","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IP_5.mzid","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IP_2.mzid","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IgG_3.mzid","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IP_14.mzid","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IgG_4.mzid","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IgG_11.mzid","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IP_15.mzid","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IgG_10.mzid","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IP_3.mzid","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IgG_1.mzid","ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077277/IP_4.mzid"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"submitter":["Belinda Willard"],"software":[""],"tissue":["Heart","Cardiac Muscle Cell"],"sample_protocol":["For the protein digestion, 30 samples were cut from the gel, and the bands were then washed/destained in 50% ethanol, 5% acetic acid and then dehydrated in acetonitrile. The samples were then reduced with DTT and alkylated with iodoacetamide prior to the in-gel digestion. All bands were digested in-gel using trypsin/chymotrypsin, by adding 10 μL 5 ng/μL trypsin /chymotrypsin in 50 mM ammonium bicarbonate and incubating overnight at room temperature to achieve complete digestion. The peptides that were formed were extracted from the polyacrylamide in two aliquots of 30μL 50% acetonitrile with 5% formic acid. These extracts were combined and evaporated to <10 μL in Speedvac and then resuspended in 0.1% formic acid to make up a final volume of ~30 μL for LC-MS analysis.  The LC-MS system was a Finnigan LTQ-Obitrap Fusion Lumos hybrid mass spectrometer system. The HPLC column was a Dionex 15 cm x 75 µm id  Acclaim Pepmap C18, 2μm, 100 Å reversed-phase capillary chromatography column. Five μL volumes of the extract were injected and the peptides eluted from the column by an acetonitrile/0.1% formic acid gradient at a flow rate of 0.25 μL/min were introduced into the source of the mass spectrometer on-line. The microelectrospray ion source is operated at 2.5 kV. The digest was analyzed using the data dependent multitask capability of the instrument acquiring full scan mass spectra to determine peptide molecular weights and product ion spectra to determine amino acid sequence in successive instrument scans.  The instrument conditions used for the data acquisition are summarized below. LC-MS Method Instrument Fusion Lumos Dionex Ultimate 3000 RSLCnano  Method 2hr-Gradient_CID  Trapping Column Acclaim Pepmap C18 100µm x 2cm, 5µm, 100Å  Analytical Column Acclaim Pepmap C18 75µm x 25cm, 2µm, 100Å  Solvent A 0.1 Formic Acid in H¬2O  Solvent B 0.1 Formic Acid in Acetonitrile  Gradient Time (%B) 0 (2%) 5 (2%) 110 (35%) 120 (90%) 127 (90%) 129 (2%) 140 (2%)  MS1 Resolution 120000  MS1 Range 350-1500 Da  MS1 AGC 4.0e5  MS2 Method CID, Ion Trap Detection  MS2 Isolation Window 1.6 Da  MS2 Collision Energy 35%  MS2 AGC 2.0e3  DDA settings 3 second duty cycle  Dynamic Exclusion 1 repeat 10 ppm window 60 s exclusion"],"repository":["Pride"],"labhead":["Jianjun Zhao MD PhD"],"instrument_platform":[""],"labhead_affiliation":["Department of Cancer Sciences, Cleveland Clinic, 9500 Euclid Avenue, NE60, Cleveland, OH, 44195, USA."],"submission_type":["COMPLETE"],"publication":["Not available"],"submitter_affiliation":["Cleveland Clinic"],"labhead_mail":["zhaoj4@ccf.org"],"technology_type":["Mass Spectrometry","Bottom-up proteomics"],"disease":["Cardiovascular System Disease"],"submitter_keywords":["Top2b","Smyd1"],"full_dataset_link":["https://www.ebi.ac.uk/pride/archive/projects/PXD077277"],"quantification_method":[""],"modification":[""],"data_protocol":["The digest was analyzed using the data dependent multitask capability of the instrument acquiring full scan mass spectra to determine peptide molecular weights and product ion spectra to determine amino acid sequence in successive instrument scans. The data were searched against the Mouse SwissProtKB protein database and specifically against TOP2B with the program Proteome Discoverer.  Some additional search parameters are given below.  Search Parameters Program: Protein ID Proteome Discoverer v2.5  Database Mouse SwissProtKB Downloaded on 3-23-2022 Entries 17552 Mouse TOP2B (Q02880)  Protease Trypsin, full  Missed Cleavages 2  Mass Accuracy 10 ppm MS1 0.6 Da MS2  Variable Modifications Oxidation of Met N-terminal Acetyl: Protein Met-Loss: Protein Met-loss+Acetyl: Protein  Static Modifications Carbamidomethylation of Cis  Program: Protein/Peptide validation Percolator  Protein ID Requirements 2 Peptides, Sequest HT > 4.0  FDR Rate: PSM Percolator 1%  FDR Rate: Peptide Peptide Prophet 0.1%  FDR Rate: Protein Peptide Prophet 1%   Feature Detection Minora Node  Peptides used for Quant Unique and Razor  Precursor Quant Intensity based, Normalized to total peptide intensity"],"omics_type":["Proteomics"],"species":["Mus Musculus (mouse)"],"submitter_mail":["willarb@ccf.org"],"submitter_country":["United States"],"doi":["10.6019/PXD077277"],"additional_accession":[]},"is_claimable":false,"name":"Novel Mechanism and Therapy of Anthracycline-Induced Cardiotoxicity (AIC)","description":"Anthracyclines are potent chemotherapeutic agents known for their efficacy in treating various cancers via inhibition of topoisomerase II alpha (TOP2A). However, their clinical use is limited due to cardiotoxicity, primarily attributed to off-target inhibition of topoisomerase II beta (TOP2B) in cardiomyocytes. The well-accepted mechanism involves TOP2B inhibition as a key driver of this toxicity. Here, we identify a novel mechanism of anthracycline-induced cardiotoxicity (AIC) involving upregulated TOP2B expression and its direct impact on cardiomyocyte function. Our data show that doxorubicin significantly increased TOP2B protein levels in cardiomyocytes in AIC mouse model. The cardiomyocyte-specific, tamoxifen-inducible TOP2B transgenic mice exhibited pathophysiological features consistent with doxorubicin-induced cardiotoxicity, even without exposure to anthracyclines. Additionally, we discovered that TOP2B binds to SMYD1, a histone methyltransferase critical for muscle cell function. Mutations in SMYD1 are known to cause cardiomyopathy and heart failure in humans, and loss of Smyd1 in mice results in a phenotype resembling AIC. More importantly, TOP2B ASO pretreatment can succussfully prevent the AIC in TOP2B transgenic mice and AIC mouse models. Our findings reveal a novel role for TOP2B in AIC, demonstrating that its upregulation disrupts SMYD1 function in cardiomyocytes, contributing to cardiotoxicity. This study also highlights the therapeutic potential of targeting TOP2B using ASO for preventing AIC in cancer patients, offering new insights into cardioprotective strategies","dates":{"publication":"2026-05-05","submission":"2026-04-17"},"accession":"PXD077277","cross_references":{"TAXONOMY":["NEWT:3555","NEWT:71647","NEWT:330879","NEWT:35554","NEWT:32046","NEWT:544496","NEWT:2042546","NEWT:32049","NEWT:1392696","NEWT:259447","NEWT:295546","NEWT:45351","NEWT:445974","NEWT:43179","NEWT:180454","NEWT:5722","NCBITaxon:1280","NEWT:1129","NEWT:309807","NEWT:55153","NEWT:309800","NEWT:281395","NEWT:1211601","NEWT:876138","NEWT:44271","NEWT:193516","NEWT:43186","NEWT:428146","NEWT:498257","NEWT:10036","NEWT:1590","NEWT:498019","NEWT:1351","NEWT:1438992","NEWT:1352","NEWT:2649997","NEWT:1147161","NEWT:661410","NEWT:638632","NEWT:263737","NEWT:224326","NEWT:1333499","NCBITaxon:79857","NEWT:1096976","NEWT:5702","NEWT:95648","NEWT:1589","NEWT:135622","NEWT:1349","NEWT:35786","NEWT:1580","NEWT:399784","NEWT:96731","NEWT:383379","NEWT:1401257","NEWT:418106","NEWT:10029","NEWT:913645","NEWT:44491","NEWT:641809","NEWT:27933","NEWT:556484","NEWT:317447","NEWT:4688","NEWT:7955","NEWT:7959","NEWT:2261","NEWT:31156","NEWT:3112","NEWT:79329","NEWT:4442","NEWT:192875","NEWT:12637","NEWT:59729","NEWT:2164133","NEWT:295105","NEWT:108061","NEWT:60711","NEWT:1316931","NEWT:224308","NEWT:3347","NEWT:511145","NEWT:160621","NEWT:212790","NEWT:931281","NEWT:4432","NEWT:5762","NEWT:5763","NEWT:658457","NEWT:1310161","NEWT:77133","NEWT:295358","NEWT:145481","NCBITaxon:79824","NEWT:2246","NEWT:2652724","NEWT:5757","NCBITaxon:4563","NEWT:5755","NEWT:44689","NEWT:44447","NEWT:752555","NEWT:498211","NEWT:5759","NEWT:1736231","NEWT:5518","NEWT:398007","NEWT:1392","NEWT:498217","NEWT:498216","NEWT:2242","NEWT:11320","NEWT:286","NEWT:391619","NEWT:246196","NEWT:287","NEWT:246197","NEWT:145458","NEWT:633149","NEWT:1149786","NEWT:10239","NEWT:68895","NEWT:44685","NEWT:161934","NEWT:4897","NEWT:1148","NEWT:5744","NEWT:5508","NEWT:3329","NEWT:5507","NEWT:410661","NEWT:55571","NEWT:35500","NEWT:1235816","NEWT:1140","NCBITaxon:2157","NEWT:1143","NEWT:4896","NEWT:1287689","NEWT:1390","NEWT:11557","NEWT:1094343","NEWT:1462472","NEWT:1336795","NEWT:644042","NEWT:294","NEWT:1773","NEWT:1182590","NEWT:3712","NEWT:82380","NEWT:3711","NEWT:935293","NEWT:375146","NEWT:2065263","NEWT:1772","NEWT:118698","NEWT:1616117","NEWT:263","NEWT:118696","NEWT:52283","NEWT:11988","NEWT:284812","NEWT:8175","NEWT:400667","NEWT:43330","NEWT:1603293","NEWT:408169","NEWT:44664","NEWT:47946","NEWT:3702","NEWT:243277","NEWT:1246791","NEWT:7067","NEWT:118694","NEWT:2850","NEWT:118691","NEWT:33548","NEWT:274","NEWT:7070","NCBITaxon:287","NEWT:408172","NEWT:408170","NEWT:96794","NEWT:3708","NEWT:332648","NEWT:44670","NEWT:536231","NEWT:376219","NEWT:219813","NEWT:1510","NEWT:1436733","NEWT:460519","NEWT:1247411","NEWT:1515","NEWT:572307","NEWT:1432138","NEWT:1424507","NEWT:1194599","NEWT:272844","NEWT:9483","NEWT:333760","NEWT:56636","NEWT:1513458","NEWT:1233681","NCBITaxon:40559","NEWT:506599","NEWT:2853422","NEWT:81077","NEWT:84588","NEWT:1679718","NEWT:480","NEWT:65349","NEWT:67767","NEWT:46835","NEWT:109757","NEWT:582580","NEWT:300852","NEWT:1502","NEWT:376686","NEWT:95486","NEWT:508771","NEWT:1883446","NEWT:253","NCBITaxon:2759","NEWT:1233435","NEWT:93061","NEWT:93062","NCBITaxon:4932","NEWT:109760","NEWT:943274","NEWT:644223","NEWT:235443","NEWT:108458","NEWT:5936","NEWT:272623","NEWT:272624","NEWT:320637","NEWT:983964","NEWT:118499","NEWT:11706","NEWT:32644","NEWT:527796","NEWT:1130798","NEWT:55529","NEWT:499175","NEWT:109779","NEWT:3745","NEWT:1715989","NCBITaxon:4751","NEWT:476272","NEWT:3747","NEWT:195051","NEWT:3988","NEWT:1116234","NEWT:1255228","NEWT:649908","NEWT:410289","NEWT:373153","NEWT:3983","NEWT:352472","NEWT:1071661","NEWT:1202532","NEWT:360094","NEWT:470","NEWT:41364","NEWT:1313","NEWT:1218097","NCBITaxon:50557","NEWT:39251","NEWT:39491","NCBITaxon:5811","NEWT:29491","NEWT:101841","NEWT:2014887","NEWT:33952","NEWT:153009","NEWT:261756","NEWT:571256","NEWT:40483","NEWT:63366","NEWT:63367","NEWT:688333","NEWT:215402","NCBITaxon:548681","NEWT:318586","NEWT:272634","NEWT:198107","NEWT:9031","NEWT:1872122","NEWT:1308","NEWT:7091","NEWT:1034015","NEWT:760568","NEWT:141262","NEWT:108931","NEWT:1055524","NEWT:4087","NEWT:9778","NEWT:306","NEWT:150475","NEWT:303","NEWT:267872","NEWT:97477","NEWT:7111","NEWT:347515","NEWT:172269","NEWT:9534","NEWT:5180","NEWT:256737","NEWT:4090","NEWT:4092","NEWT:9541","NEWT:8694","NEWT:4093","NEWT:4096","NEWT:8692","NEWT:2903","NEWT:185579","NEWT:941442","NEWT:536088","NEWT:13076","NEWT:1226408","NEWT:7108","NEWT:40479","NEWT:43989","NEWT:4076","NEWT:142615","NEWT:317","NEWT:1006581","NEWT:885318","NEWT:39488","NEWT:550","NEWT:4081","NEWT:273068","NEWT:554","NEWT:98334","NEWT:451516","NEWT:4084","NEWT:63577","NEWT:36185","NEWT:1225786","NEWT:7574","NEWT:1715256","NEWT:30640","NEWT:575412","NEWT:929793","NEWT:29204","NEWT:28112","NEWT:114155","NEWT:6494","NEWT:6491","NEWT:507601","NEWT:520","NEWT:186441","NEWT:643680","NEWT:214092","NCBITaxon:6157","NEWT:6239","NEWT:162425","NEWT:216257","NEWT:102169","NEWT:9986","NEWT:4054","NEWT:8654","NEWT:8658","NEWT:1268063","NEWT:8655","NEWT:5147","NEWT:98351","NEWT:1263854","NEWT:118503","NEWT:2059687","NEWT:160488","NEWT:28104","NEWT:207559","NEWT:407821","NCBITaxon:2","NEWT:85057","NEWT:985076","NEWT:568708","NEWT:1215323","NEWT:986","NEWT:52641","NEWT:7159","NEWT:267671","NEWT:28532","NEWT:353152","NEWT:8496","NEWT:7165","NEWT:27448","NEWT:40674","NEWT:1194669","NEWT:243230","NEWT:1080772","NEWT:519","NEWT:8479","NEWT:8485","NEWT:6063","NEWT:49240","NEWT:1328388","NEWT:104395","NEWT:9557","NEWT:6289","NEWT:6287","NEWT:300641","NEWT:727","NEWT:9796","NEWT:9554","NEWT:725","NEWT:7137","NEWT:469008","NEWT:256318","NEWT:9321","NEWT:206411","NCBITaxon:6191","NEWT:596153","NEWT:229533","NEWT:1836","NEWT:214053","NEWT:80863","NEWT:90675","NEWT:105231","NEWT:104385","NEWT:74649","NEWT:52638","NEWT:57075","NEWT:206672","NEWT:4097","NEWT:8697","NEWT:8695","NEWT:884204","NEWT:9785","NEWT:6279","NEWT:1123869","NEWT:9544","NEWT:9545","NEWT:7370","NEWT:9793","NEWT:83906","NCBITaxon:780","NCBITaxon:1502","NEWT:6282","NEWT:1134506","NEWT:255470","NEWT:27457","NEWT:38783","NEWT:4006","NEWT:6426","NCBITaxon:5476","NEWT:6669","NEWT:9935","NEWT:89453","NEWT:287889","NEWT:1114301","NEWT:51515","NEWT:588596","NEWT:51511","NEWT:8845","NEWT:92867","NEWT:92866","NEWT:419610","NEWT:5334","NEWT:51750","NEWT:202950","NEWT:382352","NEWT:413071","NCBITaxon:10239","NCBITaxon:714","NEWT:295027","NCBITaxon:11320","NEWT:632957","NEWT:11051","NEWT:9925","NEWT:89462","NCBITaxon:9606","NEWT:452680","NEWT:8839","NEWT:90690","NEWT:1436183","NEWT:4232","NEWT:2758385","NEWT:416348","NEWT:11298","NEWT:171101","NEWT:714","NEWT:5322","NEWT:421932","NEWT:312017","NEWT:196627","NEWT:200308","NEWT:553470","NEWT:200302","NEWT:870435","NEWT:284593","NEWT:100392","NEWT:5315","NEWT:9913","NEWT:265872","NEWT:105841","NEWT:337330","NEWT:2666255","NEWT:2285","NEWT:999810","NCBITaxon:5693","NEWT:28995","NEWT:1392998","NEWT:380394","NEWT:981087","NEWT:180066","NEWT:226900","NEWT:1266738","NEWT:231490","NEWT:244704","NEWT:7725","NEWT:430615","NEWT:326423","NEWT:452467","NEWT:198822","NEWT:36111","NEWT:326424","NEWT:1416333","NEWT:35024","NEWT:135461","NEWT:1678078","NEWT:7962","NEWT:749906","NEWT:418985","NEWT:1817808","NEWT:749907","NEWT:145262","NEWT:145263","NEWT:69014","NEWT:142809","NEWT:694569","NEWT:27606","NEWT:9739","NEWT:59202","NEWT:9975","NEWT:8643","NEWT:51953","NEWT:3197","NEWT:860688","NEWT:13443","NEWT:8644","NEWT:36329","NEWT:62615","NEWT:5141","NEWT:46360","NCBITaxon:3044782","NEWT:1333550","NEWT:160235","NEWT:72407","NEWT:8639","NEWT:1928434","NEWT:8637","NEWT:349741","NEWT:409859","NEWT:157295","NEWT:2096","NEWT:509169","NEWT:192222","NEWT:9721","NEWT:137221","NEWT:9963","NEWT:1617910","NEWT:565050","NEWT:409860","NEWT:2785785","NEWT:411901","NEWT:8626","NEWT:105884","NCBITaxon:9615","NEWT:8621","NEWT:58334","NEWT:452659","NEWT:1193501","NEWT:58331","NEWT:6689","NEWT:8624","NEWT:5116","NEWT:8623","NEWT:5597","NEWT:298315","NEWT:8618","NEWT:70448","NEWT:9704","NEWT:698936","NEWT:8855","NEWT:9940","NEWT:3168","NEWT:1247190","NEWT:521001","NEWT:192011","NEWT:1813887","NEWT:118702","NEWT:118700","NEWT:2126719","NEWT:224911","NEWT:118705","NCBITaxon:11552","NEWT:334249","NEWT:6945","NEWT:184922","NEWT:6703","NEWT:2104","NEWT:6943","NEWT:2","NEWT:157546","NEWT:870726","NEWT:474186","NEWT:38942","NEWT:1493","NEWT:307972","NEWT:1496","NEWT:2102","NEWT:3674","NEWT:660469","NEWT:1365186","NEWT:38949","NEWT:45474","NEWT:1299114","NEWT:1590841","NEWT:2282334","NEWT:4513","NEWT:1247","NEWT:70667","NEWT:869728","NEWT:5843","NEWT:6938","NCBITaxon:39054","NCBITaxon:10407","NEWT:1736309","NEWT:4751","NEWT:10360","NEWT:47664","NEWT:317548","NEWT:15819","NEWT:3654","NEWT:237561","NEWT:1085956","NEWT:5833","NEWT:3659","NEWT:6928","NEWT:1239","NEWT:36745","NEWT:499229","NEWT:400727","NEWT:272563","NEWT:11009","NEWT:82688","NEWT:5823","NEWT:3885","NEWT:3888","NEWT:5821","NEWT:44139","NEWT:649408","NCBITaxon:4895","NCBITaxon:4896","NEWT:6915","NEWT:3649","NEWT:101510","NEWT:28903","NEWT:3880","NEWT:272559","NEWT:28909","NEWT:515849","NEWT:3641","NEWT:466585","NEWT:1000589","NEWT:85963","NEWT:85962","NEWT:42197","NEWT:143361","NEWT:12993","NEWT:398580","NEWT:4565","NEWT:1264690","NEWT:515619","NEWT:1299","NEWT:316407","NEWT:34305","NCBITaxon:183674","NEWT:167387","NEWT:84645","NEWT:44586","NEWT:1123294","NEWT:626528","NEWT:139927","NEWT:4558","NEWT:209285","NEWT:5888","NEWT:211586","NEWT:747078","NEWT:1282","NEWT:1283","NEWT:431241","NEWT:4550","NEWT:1000561","NEWT:2133","NEWT:4555","NEWT:294381","NEWT:197","NEWT:1390363","NEWT:35889","NEWT:288705","NEWT:29176","NEWT:4787","NEWT:3217","NEWT:4547","NEWT:3218","NEWT:556182","NEWT:1270","NEWT:374990","NEWT:1432059","NEWT:154293","NEWT:156471","NEWT:4784","NEWT:3694","NEWT:360106","NEWT:156476","NEWT:4543","NEWT:4785","NEWT:360104","NEWT:1857017","NEWT:10117","NEWT:10359","NEWT:10116","NEWT:1280","NEWT:10358","NEWT:1735272","NEWT:83334","NEWT:83332","NEWT:317513","NEWT:580240","NEWT:294128","NEWT:11676","NEWT:100226","NEWT:718308","NEWT:4530","NEWT:54126","NEWT:75058","NEWT:13616","NEWT:296543","NEWT:173","NEWT:316435","NEWT:42157","NEWT:1895","NEWT:1034304","NEWT:105023","NEWT:866628","NEWT:64152","NEWT:4924","NEWT:749200","NEWT:2748","NEWT:8049","NEWT:9378","NEWT:990346","NEWT:145953","NEWT:257309","NEWT:100816","NEWT:203124","NEWT:192952","NEWT:230741","NEWT:8296","NEWT:117008","NCBITaxon:1313","NEWT:167748","NEWT:44544","NEWT:529818","NEWT:400540","NEWT:4911","NEWT:645463","NEWT:152480","NEWT:129249","NEWT:1077286","NEWT:943129","NEWT:1221594","NEWT:990119","NEWT:77216","NEWT:1111708","NEWT:227321","NEWT:493760","NEWT:281677","NEWT:106590","NEWT:260710","NEWT:257313","NEWT:3827","NEWT:400772","NEWT:128161","NEWT:930945","NEWT:1162296","NEWT:106592","NEWT:46704","NEWT:482428","NEWT:1187947","NEWT:269796","NEWT:10312","NCBITaxon:1773","NEWT:54571","NEWT:9598","NEWT:8030","NEWT:1423772","NEWT:53232","NEWT:1639","NEWT:188229","NEWT:246437","NEWT:3818","NEWT:4909","NEWT:759272","NEWT:432359","NEWT:1182263","NEWT:943146","NEWT:2711","NEWT:537457","NEWT:9103","NEWT:715877","NEWT:862238","NEWT:29159","NEWT:10306","NEWT:9595","NEWT:8022","NEWT:145943","NEWT:595536","NEWT:240906","NEWT:593117","NEWT:89920","NEWT:29158","NEWT:3633","NEWT:3635","NEWT:5811","NEWT:3879","NEWT:180923","NEWT:1328881","NEWT:411483","NEWT:76336","NEWT:3870","NEWT:884019","NEWT:198215","NEWT:411490","NEWT:200298","NEWT:169963","NEWT:587","NEWT:588","NEWT:585","NEWT:343","NEWT:225117","NEWT:746128","NEWT:5801","NEWT:43665","NEWT:212035","NCBITaxon:1653394","NEWT:1266464","NEWT:1205","NEWT:367830","NEWT:178616","NEWT:375451","NEWT:357","NEWT:9172","NEWT:2770979","NEWT:2010198","NEWT:1277351","NEWT:457428","NEWT:106178","NEWT:411469","NEWT:84023","NEWT:1679","NEWT:559292","NEWT:569","NEWT:411464","NEWT:411460","NEWT:2762","NEWT:1174673","NEWT:1328426","NEWT:562","NEWT:28035","NEWT:411470","NEWT:2094720","NCBITaxon:2697049","NCBITaxon:138","NEWT:28038","NEWT:1663","NEWT:62141","NEWT:1423","NEWT:4932","NEWT:3603","NEWT:2756","NEWT:2759","NEWT:3848","NEWT:3847","NEWT:38293","NEWT:1428","NEWT:339","NEWT:327159","NEWT:178876","NEWT:1660","NEWT:2751","NEWT:327160","NEWT:573","NEWT:571","NEWT:12922","NEWT:241368","NEWT:518766","NEWT:42528","NEWT:2664373","NEWT:190802","NEWT:9417","NEWT:1216979","NEWT:7237","NEWT:509924","NEWT:115104","NEWT:1121114","NEWT:663","NEWT:8570","NEWT:1081927","NEWT:1238993","NEWT:67825","NEWT:187878","NEWT:220668","NEWT:1821314","NEWT:1249668","NEWT:426430","NEWT:9407","NEWT:9646","NEWT:5286","NEWT:7227","NEWT:7469","NEWT:9402","NEWT:9644","NEWT:415540","NEWT:675060","NEWT:334542","NEWT:313625","NEWT:27592","NEWT:426428","NEWT:227289","NEWT:63459","NEWT:40324","NEWT:588858","NEWT:9638","NEWT:9639","NCBITaxon:11071","NEWT:242231","NEWT:197221","NEWT:7215","NEWT:2172103","NCBITaxon:59201","NEWT:7460","NEWT:504457","NEWT:434271","NEWT:747679","NEWT:66712","NEWT:42752","NEWT:103372","NEWT:746360","NEWT:862751","NEWT:89764","NEWT:470150","NEWT:9627","NEWT:543734","NEWT:1009714","NEWT:73239","NEWT:38018","NEWT:226186","NEWT:9870","NEWT:8782","NEWT:115357","NEWT:435590","NEWT:1902","NEWT:1908","NEWT:1169740","NEWT:13164","NEWT:216129","NEWT:2664179","NEWT:623","NEWT:7038","NEWT:6192","NCBITaxon:1639","NCBITaxon:38727","NEWT:74790","NEWT:2829","NEWT:366581","NEWT:216599","NEWT:405534","NEWT:216595","NEWT:40559","NEWT:51208","NEWT:216597","NEWT:9689","NEWT:8355","NEWT:633","NEWT:1607839","NEWT:9685","NEWT:7029","NEWT:6182","NEWT:1283300","NEWT:9694","NEWT:186990","NEWT:632","NEWT:1204551","NEWT:6183","NEWT:99586","NEWT:630","NCBITaxon:11019","NEWT:334747","NEWT:61235","NEWT:392021","NEWT:343691","NEWT:1457551","NEWT:15368","NEWT:1491466","NEWT:436486","NEWT:340188","NEWT:51655","NEWT:170187","NEWT:260707","NEWT:121845","NEWT:8595","NEWT:7263","NEWT:186763","NEWT:185431","NEWT:216591","NEWT:29760","NEWT:260704","NEWT:1719","NEWT:703612","NEWT:260705","NEWT:692672","NEWT:2697049","NEWT:1505907","NEWT:1216981","NEWT:1109443","NEWT:1249885","NEWT:7004","NEWT:1972855","NEWT:9669","NCBITaxon:6073","NEWT:1089448","NEWT:1415167","NEWT:1329349","NEWT:607699","NEWT:208963","NEWT:208964","NEWT:27337","NEWT:575584","NEWT:185687","NEWT:3039","NEWT:669202","NEWT:2706014","NEWT:8727","NEWT:8726","NEWT:10090","NEWT:8729","NEWT:4120","NEWT:8720","NEWT:5693","NEWT:2186","NEWT:8724","NEWT:8723","NEWT:283166","NEWT:37334","NEWT:5697","NCBITaxon:10357","NCBITaxon:10114","NCBITaxon:10359","NEWT:1685931","NEWT:1203258","NEWT:242619","NEWT:49317","NEWT:557722","NEWT:160791","NEWT:1353008","NEWT:34073","NEWT:696811","NEWT:402042","NEWT:373995","NEWT:8715","NEWT:5689","NEWT:544404","NEWT:92519","NEWT:2173","NEWT:943925","NEWT:37349","NEWT:4113","NEWT:837","NEWT:640459","NEWT:36015","NEWT:1232801","NEWT:81866","NEWT:5691","NEWT:48479","NEWT:61435","NEWT:627025","NEWT:1097677","NEWT:375939","NEWT:61674","NEWT:2072580","NEWT:1117957","NEWT:6526","NEWT:8709","NEWT:4100","NEWT:1159556","NEWT:5671","NEWT:1076","NEWT:4102","NEWT:4101","NEWT:6763","NEWT:8700","NEWT:803","NEWT:29722","NEWT:1692259","NEWT:1486917","NEWT:468911","NEWT:7604","NEWT:818","NEWT:135588","NEWT:1843183","NEWT:5661","NEWT:157592","NEWT:51866","NEWT:29719","NEWT:58002","NEWT:5665","NEWT:6754","NEWT:6997","NEWT:452589","NEWT:509068","NEWT:5666","NEWT:4577","NEWT:813","NEWT:5664","NEWT:2157","NEWT:146479","NEWT:1042986","NEWT:1911079","NEWT:69373","NEWT:1843192","NEWT:206189","NEWT:427577","NEWT:264203","NEWT:1480154","NEWT:1274414","NEWT:9612","NEWT:38626","NEWT:1286640","NEWT:38865","NEWT:3077","NEWT:9615","NEWT:10299","NEWT:6100","NEWT:713604","NEWT:112273","NEWT:1147787","NEWT:1440772","NEWT:1355477","NEWT:8759","NEWT:9605","NEWT:9606","NEWT:90371","NEWT:641501","NEWT:4153","NEWT:9601","NEWT:278839","NEWT:35128","NEWT:39966","NEWT:7668","NEWT:8756","NEWT:915099","NEWT:74940","NEWT:13551","NEWT:10041","NEWT:9600","NEWT:1450511","NEWT:1143193","NEWT:1122233","NEWT:890382","NEWT:174934","NEWT:179392","NEWT:2823525","NEWT:115778","NEWT:9838","NEWT:9839","NEWT:546414","NEWT:227086","NEWT:3055","NEWT:11167","NEWT:9835","NEWT:4146","NEWT:5478","NEWT:6326","NEWT:7656","NEWT:5476","NEWT:1450520","NEWT:1042311","NEWT:1123352","NEWT:1882945","NEWT:299767","NEWT:235909","NEWT:28835","NEWT:47311","NEWT:1274432","NEWT:2053667","NEWT:1274426","NEWT:104660","NEWT:9825","NEWT:1274423","NEWT:393765","NEWT:652611","NEWT:39946","NEWT:9823","NEWT:95602","NEWT:8732","NEWT:314539","NEWT:39947","NEWT:1274420","NEWT:578458","NEWT:60520"],"ORCID":["0000-0001-6884-6369"]}}