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Kim"],"technology_type":["Data-dependent acquisition","Mass Spectrometry"],"software":[""],"submitter_keywords":["Obesity","Nafld","Proteomics","Platycodon radix"],"full_dataset_link":["https://www.ebi.ac.uk/pride/archive/projects/PXD080181"],"tissue":["Liver"],"sample_protocol":["Five-week-old wild-type male C57BL/6J mice (Orient Bio, Seongnam, Korea) were acclimatized for one week on a normal chow diet (NCD; AIN-93G) and then randomly assigned to three groups fed ad libitum for 12 weeks: NCD, high-fat diet (HFD; 60 kcal% fat), and HFD supplemented with 5% (w/w) *Platycodi Radix* extract (PRE). At the end of the dietary period, mice were fasted for 12 h, anesthetized, and sacrificed; liver tissue was excised, rinsed in PBS, snap-frozen in liquid nitrogen, and stored at −70 °C until use. Liver proteins were extracted from the frozen tissue, reduced and alkylated, and digested with trypsin to generate peptides for bottom-up proteomics. Each sample was analyzed by multidimensional protein identification technology (MudPIT): the peptide mixture was separated into 10 sequential fractions, and each fraction was resolved by reversed-phase liquid chromatography using a linear gradient of 0–65% (v/v) acetonitrile over 120 min and analyzed on an Orbitrap Velos mass spectrometer (Thermo Fisher Scientific, Waltham, MA, USA) operated in positive-ion, data-dependent acquisition mode, in which precursor ions were automatically selected for MS/MS fragmentation. Three biological replicates were analyzed per diet group (n = 3 per group; 10 LC-MS/MS fractions per sample)."],"repository":["Pride"],"quantification_method":["Not available"],"modification":[""],"data_protocol":["The original MASCOT 2.4 result files were no longer available, so the acquired tandem mass spectra were re-searched in MASCOT (version 2.7.0; Matrix Science, London, UK) to generate the identification results (.dat) provided in this partial submission. MS/MS spectra were searched against a mouse UniProt protein sequence database (2014 release) with an automatically generated decoy database enabled. Trypsin was specified as the enzyme, allowing up to 2 missed cleavages. Precursor and fragment ion mass tolerances were set to 0.6 Da and 0.8 Da, respectively (monoisotopic masses; 13C = 2). Carbamidomethylation of cysteine and oxidation of methionine were set as variable modifications (no fixed modification). MudPIT protein scoring was applied. Peptide matches were thresholded at FDR < 0.01 and validated using a target–decoy strategy (peptide-level FDR ≈ 0.4%). MS/MS analysis was performed for three biological replicates per group (n = 3); proteins identified in at least two of the three replicates in at least one comparison group were retained for exploratory comparative analysis.For one biological replicate per group, the original raw MS data files could not be recovered owing to an instrument storage failure; for these specific runs, the corresponding MASCOT result files (.dat) are provided in place of the raw data. These .dat files contain the complete peptide and protein identification results for the affected runs, so identification-level information is preserved for every replicate in the study and no identification data are missing as a result of the lost raw files. All other runs are provided with both raw and result files. The affected runs were searched and processed identically to all other runs, and downstream protein inclusion required identification in at least two of three biological replicates per group, a criterion that is by design robust to the absence of any single raw file."],"omics_type":["Proteomics"],"labhead":["Edmond Changkyun Park"],"instrument_platform":[""],"labhead_affiliation":["Korean Basic Science Instittue"],"submission_type":["PARTIAL"],"species":["Mus Musculus (mouse)"],"publication":["38542804 Kim W, Baek WH, Yun SH, Lee H, Kim MJ, Lee SY, Kim GH, Kim SI, Jeong HG, Park EC. <i>Platycodi Radix</i> Extract Prevents Hepatic Steatosis by Enhancing Bile Acid Synthesis in a High-Fat Diet-Induced Fatty Liver Mouse Model. Nutrients. 2024 16(6):893 10.3390/nu16060893"],"submitter_mail":["wykim91@kbsi.re.kr"],"curator_keywords":["Liver (b/d-hpp)","Human proteome project","Biology/disease-driven human proteome project (b/d-hpp)","Food and nutrition (b/d-hpp)"],"submitter_affiliation":["Korea Basic Science Institute"],"submitter_country":["South Korea"],"pubmed_abstract":["We aimed to identify the mechanism underlying the preventive effects of non-alcoholic fatty liver disease (NAFLD) through <i>Platycodi Radix</i> consumption using liver proteomic and bioinformatic analysis. C57BL/6J mice were categorized into three groups: those receiving a standard chow diet (NCD), those on a high-fat diet (HFD), and those on an HFD supplemented with 5% <i>Platycodi Radix</i> extract (PRE). After a 12-week period, PRE-fed mice exhibited a noteworthy prevention of hepatic steatosis. Protein identification and quantification in liver samples were conducted using LC-MS/MS. The identified proteins were analyzed through Ingenuity Pathway Analysis software, revealing a decrease in proteins associated with FXR/RXR activation and a concurrent increase in cholesterol biosynthesis proteins in the PRE-treated mouse liver. Subsequent network analysis predicted enhanced bile acid synthesis from these proteins. Indeed, the quantity of bile acids, which was reduced in HFD conditions, increased in the PRE group, accompanied by an elevation in the expression of synthesis-related proteins. Our findings suggest that the beneficial effects of PRE in preventing hepatic steatosis may be mediated, at least in part, through the modulation of FXR/RXR activation, cholesterol biosynthesis, and bile acid synthesis pathways."],"pubmed_title":["<i>Platycodi Radix</i> Extract Prevents Hepatic Steatosis by Enhancing Bile Acid Synthesis in a High-Fat Diet-Induced Fatty Liver Mouse Model."],"pubmed_authors":["Kim Wooyoung W, Baek Woon Hee WH, Yun Sung Ho SH, Lee Hayoung H, Kim Mi Jeong MJ, Lee Sang-Yeop SY, Kim Gun-Hwa GH, Kim Seung Il SI, Jeong Hye Gwang HG, Park Edmond Changkyun EC"],"additional_accession":[]},"is_claimable":false,"name":"Platycodi Radix Extract Prevents Hepatic Steatosis by Enhancing Bile Acid Synthesis in a High-Fat Diet-Induced Fatty Liver Mouse Model","description":"This project investigated the molecular mechanism by which *Platycodi Radix* extract (PRE; the ethanol extract of the root of *Platycodon grandiflorum*) prevents non-alcoholic fatty liver disease (NAFLD) in a high-fat diet (HFD)-induced fatty liver mouse model, using a liver-tissue shotgun proteomic and bioinformatic approach. Five-week-old male C57BL/6J mice were acclimatized and then maintained for 12 weeks on one of three diets: a normal chow diet (NCD), a high-fat diet (HFD), or an HFD supplemented with 5% (w/w) PRE. PRE supplementation prevented HFD-induced body-weight gain, fat accumulation, and hepatic steatosis, and improved glucose tolerance and serum lipid profiles. To elucidate the underlying mechanism, liver proteomes of the NCD, HFD, and PRE groups were profiled by LC-MS/MS (n = 3 per group), and proteins differing in relative abundance between NCD vs HFD and HFD vs PRE were interpreted by Ingenuity Pathway Analysis. This LC-MS/MS dataset was designed as a discovery-stage, exploratory screen for hypothesis generation rather than as standalone quantitative proof of differential expression; the resulting candidate proteins and pathways (notably decreased FXR/RXR-activation proteins and increased cholesterol-biosynthesis proteins, predicting enhanced bile-acid synthesis) were subsequently validated by targeted Western blotting and biochemical bile-acid measurement, on which the mechanistic conclusions of the study are based. This dataset comprises the liver-tissue LC-MS/MS data and the protein identification/quantification results supporting the conclusion that PRE prevents hepatic steatosis through modulation of FXR/RXR activation, cholesterol biosynthesis, and bile-acid synthesis pathways.","dates":{"publication":"2026-07-04","submission":"2026-06-25"},"accession":"PXD080181","cross_references":{"TAXONOMY":["NEWT:330879","NEWT:377960","NEWT:2042546","NEWT:259447","NEWT:295546","NCBITaxon:2719036","NCBITaxon:1280","NEWT:112503","NEWT:1129","NEWT:309807","NEWT:59753","NEWT:89184","NEWT:309800","NEWT:281395","NEWT:1211601","NEWT:876138","NEWT:44271","NEWT:193516","NEWT:1073882","NEWT:111205","NEWT:1117","NEWT:498257","NEWT:10036","NEWT:1590","NEWT:10034","NEWT:661410","NEWT:638632","NEWT:224326","NEWT:376619","NCBITaxon:79857","NEWT:1096976","NEWT:1589","NEWT:135622","NEWT:35786","NEWT:1580","NEWT:399784","NEWT:96731","NEWT:383379","NEWT:418106","NEWT:10029","NEWT:913645","NEWT:641809","NEWT:38815","NEWT:317447","NEWT:4688","NEWT:111225","NEWT:7719","NEWT:868565","NEWT:135674","NEWT:79329","NEWT:30069","NEWT:12637","NEWT:59729","NEWT:2164133","NEWT:295105","NEWT:108061","NEWT:60711","NEWT:224308","NEWT:3347","NEWT:160621","NEWT:212790","NEWT:110368","NEWT:1310161","NEWT:77133","NEWT:145481","NEWT:1310165","NEWT:29058","NCBITaxon:79824","NEWT:1912919","NEWT:44688","NEWT:44689","NEWT:498211","NEWT:347256","NEWT:5518","NEWT:398007","NEWT:1527468","NEWT:498217","NEWT:498216","NEWT:11320","NEWT:246196","NEWT:246197","NEWT:145458","NEWT:44685","NEWT:161934","NEWT:1148","NEWT:5508","NEWT:3329","NEWT:419481","NEWT:5507","NEWT:410661","NEWT:1140","NCBITaxon:2157","NEWT:1143","NEWT:1287689","NEWT:1094343","NEWT:1462472","NEWT:1336795","NEWT:644042","NEWT:1182590","NEWT:3712","NEWT:3711","NEWT:270643","NEWT:2065263","NEWT:177437","NEWT:10418","NEWT:118698","NEWT:1616117","NEWT:118696","NEWT:34865","NEWT:52283","NEWT:284812","NEWT:8175","NEWT:43330","NEWT:1603293","NEWT:44664","NEWT:43346","NEWT:3702","NEWT:1245466","NEWT:244366","NEWT:1246791","NEWT:118694","NEWT:2850","NEWT:118691","NEWT:34871","NEWT:33548","NEWT:52299","NEWT:96794","NEWT:3708","NEWT:332648","NEWT:44670","NEWT:536231","NEWT:376219","NEWT:219813","NEWT:1510","NEWT:460519","NEWT:1515","NEWT:572307","NEWT:1432138","NEWT:1424507","NEWT:1194599","NEWT:272844","NEWT:1303443","NEWT:9483","NEWT:485","NEWT:56636","NEWT:2709072","NEWT:2853422","NEWT:1679718","NEWT:480","NEWT:67767","NEWT:46835","NEWT:109757","NEWT:582580","NEWT:294607","NEWT:1502","NEWT:128017","NEWT:376686","NEWT:95486","NEWT:1883446","NEWT:1233435","NEWT:109760","NEWT:29031","NEWT:317047","NEWT:460523","NEWT:235443","NEWT:1757312","NEWT:85694","NEWT:108458","NEWT:5936","NEWT:320637","NEWT:3750","NEWT:983964","NEWT:11706","NEWT:32644","NEWT:527796","NEWT:499175","NEWT:109779","NEWT:3745","NEWT:1715989","NCBITaxon:4751","NEWT:3747","NEWT:1116234","NEWT:1255228","NEWT:410289","NEWT:373153","NEWT:472","NEWT:940825","NEWT:529507","NEWT:1071661","NEWT:470","NEWT:5911","NCBITaxon:50557","NEWT:39251","NEWT:29491","NEWT:101841","NEWT:446","NEWT:153481","NEWT:2014887","NEWT:33952","NEWT:445","NEWT:153009","NEWT:261756","NEWT:166313","NEWT:63366","NEWT:63367","NEWT:215402","NEWT:1547","NEWT:9031","NEWT:27292","NEWT:1050722","NEWT:108931","NEWT:1293497","NEWT:1055524","NEWT:150475","NEWT:267872","NEWT:172269","NEWT:9534","NEWT:5180","NEWT:256737","NEWT:9541","NEWT:8694","NEWT:33936","NEWT:8692","NEWT:2903","NEWT:185579","NEWT:13076","NEWT:1006581","NEWT:8673","NEWT:33940","NEWT:550","NEWT:554","NEWT:451516","NEWT:552","NEWT:1325291","NEWT:36185","NEWT:1054211","NEWT:1225786","NEWT:51338","NEWT:575412","NEWT:28112","NEWT:6493","NEWT:6494","NEWT:6491","NEWT:507601","NEWT:520","NEWT:186441","NEWT:643680","NEWT:214092","NCBITaxon:6157","NEWT:13095","NEWT:162425","NEWT:104105","NEWT:216257","NEWT:9986","NEWT:8654","NEWT:8658","NEWT:1268063","NEWT:8657","NEWT:8655","NEWT:5147","NEWT:28104","NEWT:407821","NEWT:568703","NCBITaxon:2","NEWT:568708","NEWT:986","NEWT:52641","NEWT:28532","NEWT:353152","NEWT:40674","NEWT:1194669","NEWT:51329","NEWT:443906","NEWT:519","NEWT:2510939","NEWT:7394","NEWT:6063","NEWT:1328388","NEWT:1548728","NEWT:667127","NEWT:9557","NEWT:377586","NEWT:300641","NEWT:39655","NEWT:9554","NEWT:38323","NEWT:256318","NEWT:206411","NCBITaxon:6191","NEWT:229533","NEWT:214053","NEWT:80863","NEWT:90675","NEWT:52638","NEWT:57075","NEWT:1666905","NEWT:8697","NEWT:8695","NEWT:884204","NEWT:1123869","NEWT:9544","NEWT:9545","NEWT:979","NEWT:7370","NEWT:83906","NEWT:1134506","NEWT:255470","NEWT:38783","NEWT:6426","NEWT:33090","NEWT:9935","NEWT:287889","NEWT:305959","NEWT:13489","NEWT:29829","NEWT:92867","NEWT:92866","NCBITaxon:3055","NEWT:51750","NEWT:202950","NEWT:295027","NCBITaxon:11320","NEWT:632957","NEWT:9925","NCBITaxon:9606","NEWT:90690","NEWT:1436183","NEWT:300273","NEWT:4232","NEWT:416348","NEWT:11298","NEWT:4236","NEWT:7742","NEWT:196627","NEWT:200308","NEWT:200302","NEWT:870435","NEWT:9913","NEWT:9915","NEWT:105841","NEWT:2666255","NEWT:999810","NCBITaxon:5693","NEWT:28995","NEWT:1392998","NEWT:380394","NEWT:226900","NEWT:1266738","NEWT:231490","NEWT:244704","NEWT:7725","NEWT:9909","NEWT:9902","NEWT:430615","NEWT:563041","NEWT:72664","NEWT:36599","NEWT:41949","NEWT:32642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