ENAapplication/xmlftp://ftp.sra.ebi.ac.uk/vol1/fastq/DRR255/DRR255116/DRR255116.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/DRR255/DRR255118/DRR255118.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/DRR255/DRR255124/DRR255124.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/DRR255/DRR255121/DRR255121.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/DRR255/DRR255119/DRR255119.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/DRR255/DRR255123/DRR255123.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/DRR255/DRR255122/DRR255122.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/DRR255/DRR255120/DRR255120.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/DRR255/DRR255117/DRR255117.fastq.gzprimaryOK200GenomicsBrain Research Institute, Niigata University., Laboratory for Comprehensive Genomic Analysis, Center for Integrative Medical Sciences, RIKENhttps://www.ebi.ac.uk/ena/browser/view/PRJDB10757Mus musculusRNA-seq analysis of pial arteries of 4-month-old wild-type, and candesartan-nontreated and treated HTRA1-KO mice for 1 week. CARASIL is hereditary CSVD caused by loss of HTRA1 protease activity. HTRA1-KO mice accumulated matrisome proteins with fibronectin as a central hub in the intima, and the mice exhibited reduced cerebral blood flow. Candesartan normalized fibronectin accumulation and cerebral blood flow. Our results indicate that arteriopathy in HTRA1-KO mice is due to the accumulation of matrisome proteins with fibronectin as a central hub in the intima, suggesting that these accumulated matrisome proteins may be potential therapeutic targets for CARASIL.ENA3.4.22.-, "disease of artery [Ambiguous]" EXACT [SNOMEDCT_2005_07_31:77735004], arterial disorder, CV-11974, disease or disorder of artery, Laboratory, Mus domesticus, CASP14, mouse, "Arterial disease" EXACT [SNOMEDCT_2005_07_31:155413007], cerebrovascular disease with thin skin, ARMD7, mini-ICE, CASP-14, with subcortical infarcts and leukoencephalopathy, HtrA, and Disc Disease, House Mouse, "Arterial disease" EXACT [SNOMEDCT_2005_07_31:266317000], disease of artery, House, Mus, PRSS11, cerebral arteriopathy, Cerebrovascular Disease with Thin Skin, Maeda syndrome, Mini-ICE, 2-ethoxy-1-((2'-(1H-tetrazol-5-yl)(1, Progressive, Mus musculus domesticus, Nemoto Disease, Alopecia, 2-ethoxy-7-carboxy-1-(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methylbenzimidazole, alopecia, "Arteriopath" EXACT [SNOMEDCT_2005_07_31:39823006], Mice, Mus musculus., "disorder of artery [Ambiguous]" EXACT [SNOMEDCT_2005_07_31:271948001], and disk disease, autosomal recessive, 2-ethoxy-1-(p-(o-1H-tetrazol-5-ylphenyl)benzyl)-7-benzimidazolecarboxylic acid, Mus musculus, Subcortical Vascular Encephalopathy, CARASIL, 1'-biphenyl)-4-yl)methyl)-1H-benzimidazole-7-carboxylic acid, Caspase-14 subunit p10, Swiss, MAEDA Syndrome, mice, 2-ethoxy-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4ethyl]}-1H-benzimidazole-7-carboxylic acid, "disorder of artery (disorder)" EXACT [SNOMEDCT_2005_07_31:359557001], Swiss Mouse, "disorder of artery" EXACT [SNOMEDCT_2005_07_31:359560008], House Mice, Swiss Mice, Caspase-14 subunit p19, arteriopathy, MICE, 2-ethoxy-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylic acid, Laboratory Mice, domesticus, CV 11974, Cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy, Familial Young-Adult-Onset Arteriosclerotic Leukoencephalopathy with Alopecia and Lumbago without Arterial Hypertension, "Arterial disorder" EXACT [NCI2004_11_17:C35317], Blopress, and disc disease, subcortical vascular encephalopathy, CV11974, artery disease, arterial disease, L56, Mouse, progressive, "Arterial disease" EXACT [SNOMEDCT_2005_07_31:367395004], ORF480, Laboratory Mouse, disorder of artery, artery disease or disorderMus musculus, Laboratory Mice., House, Mus, Laboratory, Swiss, Mus domesticus, mouse, Mus musculus domesticus, Swiss Mouse, mouse <Mus musculus>, Mouse, House Mice, Swiss Mice, house mouse, Mice, Laboratory Mouse, House Mouse, mice C57BL/6xCBA/CaJ hybrid, domesticus, Mus muscarisfalseMus musculusCandesartan prevents the progression of arteriopathy in CARASIL model mice.2025-09-242021-11-22PRJDB1075710090