ENAapplication/xmlftp://ftp.sra.ebi.ac.uk/vol1/fastq/DRR439/DRR439694/DRR439694_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/DRR437/DRR437024/DRR437024_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/DRR437/DRR437025/DRR437025_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/DRR437/DRR437023/DRR437023_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/DRR439/DRR439693/DRR439693_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/DRR439/DRR439696/DRR439696_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/DRR439/DRR439695/DRR439695_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/DRR437/DRR437024/DRR437024_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/DRR439/DRR439696/DRR439696_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/DRR439/DRR439695/DRR439695_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/DRR439/DRR439694/DRR439694_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/DRR437/DRR437023/DRR437023_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/DRR439/DRR439693/DRR439693_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/DRR437/DRR437025/DRR437025_2.fastq.gzprimaryOK200GenomicsGraduate School of Frontier Sciences, The University of Tokyohttps://www.ebi.ac.uk/ena/browser/view/PRJDB15125Homo sapiensAdult T-cell leukemia/lymphoma (ATL) is characterized by a high frequency of chromosomal aberrations however, the molecular mechanisms underlying this chromosomal instability are poorly understood. We previously reported the presence of a biological link between the expression of CD30, which serves as a marker for ATL progression, and the actively proliferating fraction of HTLV-1-infected cells that display polylobulation. We demonstrate that CD30 signaling triggers chromosomal instability with clonal expansion in primary CD30-expressing ATL cells and clarifies the molecular mechanisms. Furthermore, we investigate the expression mechanism of CD30, whose gene name is TNFRSF8, using the ChIP-Sequence and Hi-C methods. This study highlights that CD30 signaling is one of the oncogenic factors of ATL progression with clonal evolution and that CD30 is a promising therapeutic target for ATL.ENAfalseHomo sapiensThe oncogenic driving force of CD30 signaling-induced chromosomal instability in adult T-cell leukemia/lymphoma2025-09-242025-06-04PRJDB151259606