{"database":"ENA","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Fastqsanger.gz":["ftp://ftp.sra.ebi.ac.uk/vol1/fastq/DRR120/DRR120518/DRR120518_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/DRR120/DRR120518/DRR120518_2.fastq.gz"]},"type":"primary"},"statusCodeValue":200,"statusCode":"OK"}],"scores":null,"additional":{"omics_type":["Genomics"],"center_name":["Laboratory for Intestinal Ecosystem, Center for Integrative Medical Sciences, RIKEN"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJDB6618"],"scientific_name":["Erysipelotrichaceae bacterium OTU0002"],"long_description":["Accumulating evidence indicates that gut microbes play a pathogenic role in autoimmune diseases including multiple sclerosis (MS). Here, we show that two distinct signals from gut microbes coordinately activate myelin oligodendrocyte glycoprotein (MOG)-specific autoreactive T cells in the small intestine (SI). After induction of experimental autoimmune encephalomyelitis (EAE), an animal model for MS, MOG-specific CD4 T cells can be observed in the SI. Germ-free (GF) mice monocolonized with SI microbes demonstrated that a newly isolated Erysipelotrichaceae strain adheres to SI epithelial cells and enhances Th17 responses, via inducing serum amyloid A and IL-23, that were associated with an increased susceptibility to EAE. Shotgun sequencing of SI contents revealed that a Lactobacillus strain possesses potential mimicry peptides to MOG. While monocolonization of GF mice with the Lactobacillus strain did not enhance EAE development or severity, co-colonized mice with Erysipelotrichaceae and Lactobacillus strains resulted in more severe EAE."],"repository":["ENA"],"additional_accession":[]},"is_claimable":false,"name":"Erysipelotrichaceae bacterium OTU0002","description":"Erysipelotrichaceae bacterium OTU0002 isolated from mouse small intestine","dates":{"last_updated":"2023-05-19","first_public":"2019-12-21"},"accession":"PRJDB6618","cross_references":{"taxon":["2066131"]}}