ENAapplication/xmlftp://ftp.sra.ebi.ac.uk/vol1/fastq/DRR131/DRR131066/DRR131066.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/DRR131/DRR131067/DRR131067.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/DRR131/DRR131068/DRR131068.fastq.gzprimaryOK200GenomicsCellular Molecular Biology, Translational Medicine, Graduate School of Medicine, Chiba Universityhttps://www.ebi.ac.uk/ena/browser/view/PRJDB7031Mus musculusBivalent domain is characterized by repressive trimethylation of histone H3 at lysine 27 (H3K27me3) marks and active trimethylation of histone H3 at lysine 4 (H3K4me3) marks. Although maintenance and dynamic resolution of these histone marks play an important role in regulation of differentiation process in a variety of stem cell systems, little is known in hepatic stem/progenitor cells. In the present study, we conducted chromatin immunoprecipitation (ChIP) followed by high- throughput DNA sequencing (ChIP-seq) analyses in purified delta-like 1 protein (Dlk)+ hepatic stem/progenitor cells and successfully identified 562 bivalent genes showing bivalent domain in the region within 2 kb of the transcriptional start sites. Gene Ontology analysis revealed that these genes were enriched in developmental function and differentiation process.ENAwide/broad, Genomes, axis, stalk, whole genome, Scanning Transmission, broad, Histone H1(s), Histone, culm, Electron Microscopy, Histone H2b, wide, Histone H2a, primary axis, STEM, Histone H5, Histone H4, Histone H7, Scanning Transmission Electron Microscopy, Cell., primary stem, Histone H1, Histone H3.3, Histone H3Mus musculus, Laboratory Mice., House, Mus, Laboratory, Swiss, Mus domesticus, mouse, Mus musculus domesticus, Swiss Mouse, mouse <Mus musculus>, Mouse, House Mice, Swiss Mice, house mouse, Mice, Laboratory Mouse, House Mouse, mice C57BL/6xCBA/CaJ hybrid, domesticus, Mus muscarisfalseMus musculusGenome-wide mapping of bivalent histone modifications in hepatic stem/progenitor cells2025-09-242018-05-22PRJDB703110090