ENAapplication/xmlftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR135/006/ERR1353656/ERR1353656.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR135/008/ERR1353658/ERR1353658.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR135/004/ERR1353654/ERR1353654.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR135/005/ERR1353655/ERR1353655.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR135/009/ERR1353659/ERR1353659.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR135/001/ERR1353651/ERR1353651.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR135/002/ERR1353652/ERR1353652.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR135/003/ERR1353653/ERR1353653.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR135/007/ERR1353657/ERR1353657.fastq.gzprimaryOK200GenomicsMRC-University of Glasgow Centre for Virus Researchhttps://www.ebi.ac.uk/ena/browser/view/PRJEB13366xref:PubMed:27009961xref:EuropePMC:PMC4934764In this study we show that a non-structural protein of BTV (NS4) is critical to counteract the innate immune response of the host. Infection of cells with a BTV mutant lacking NS4 results in increased synthesis of IFN-β and upregulation of interferon stimulated genes. In addition, we show that NS4 is a virulence factor for BTV by favouring viral replication in sheep, the animal species most susceptible to bluetongue.ENAfalseBluetongue virus NS4 protein is an interferon antagonist and a determinant of virus virulence2016-05-202016-04-11PRJEB1336627009961