{"database":"ENA","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Fastqsanger.gz":["ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR203/004/ERR2030974/ERR2030974.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR203/006/ERR2030976/ERR2030976.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR203/005/ERR2030975/ERR2030975.fastq.gz"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Genomics"],"center_name":["STANFORD UNIVERSITY","European Bioinformatics Institute"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJEB21724"],"broker_name":["ArrayExpress"],"tag":["xref:ArrayExpress:E-MTAB-5866"],"long_description":["We undertook a unbiased genome-wide haploid genetic screen to identify new components in interferon lambda signaling. In addition, we performed a genome-wide screen to identify genes that repress spontaneous activation of interferon stimulated genes in the absence of interferon. Both of these screens were performed using a HAP1 cell line containing GFP reporter under the transcriptional regulation of the Interferon-Stimulated Response Element from IFIT2. We also overexpressed IL28RA (IFNLR1) in this cell line, in order to sensitize the cells to type III interferon"],"repository":["ENA"],"description_synonyms":["Type III IFNs, Haploid Cells, Interferons, human being, wide/broad, Man (Taxonomy), Genomes, III IFNs, interferon lambda, Type III Interferons, Modern, Type III, type III interferon, IFN-Lambda, whole genome, III IFN, broad, interferon type III, Haploid Cell, man, Cell, Lambda, human, III Interferons, Type III Interferon, IFNs, Human, Type III IFN, Interferon Type, wide, Interferon-Lambda, III, III Interferon, signalling process, Homo sapiens, Haploids, Modern Man, Cells, Interferon Type III, Type, Cell., Haploid, Haploidies, Interferon, Man, single organism signaling, Lambda Interferons"],"name_synonyms":["Type III IFNs, Haploid Cells, Interferons, human being, wide/broad, Man (Taxonomy), Genomes, III IFNs, interferon lambda, Type III Interferons, Modern, Type III, type III interferon, IFN-Lambda, whole genome, III IFN, broad, interferon type III, Haploid Cell, man, Cell, Lambda, human, III Interferons, Type III Interferon, IFNs, Human, Type III IFN, Interferon Type, wide, Interferon-Lambda, III, III Interferon, signalling process, Homo sapiens, Haploids, Modern Man, Cells, Interferon Type III, Type, Cell., Haploid, Haploidies, Interferon, Man, single organism signaling, Lambda Interferons"],"additional_accession":[]},"is_claimable":false,"name":"Haploid genome-wide screens for essential components and negative regulators of interferon lambda signaling in human cells","description":"Haploid genome-wide screens for essential components and negative regulators of interferon lambda signaling in human cells","dates":{"last_updated":"2017-07-11","first_public":"2017-07-25"},"accession":"PRJEB21724","cross_references":{}}