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Bioinformatics Institute","Division of Cardiovascular Sciences School of Medicine Faculty of Biology Medicine and Health Manchester Academic Health Science Centre The University of Manchester"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJEB21889"],"broker_name":["ArrayExpress"],"tag":["xref:ArrayExpress:E-MTAB-5836"],"long_description":["Translation factors eIF4E and eIF4G form eIF4F, which binds to mRNAs to promote ribosome recruitment and translation initiation. We were interested in analysing the effects of stresses on eIF4F interactions with individual mRNAs. We used a RIP-seq approach to assess how mRNA associations with eIF4E, eIF4G1 and eIF4G2 change in response to three stresses: 1) addition of hydrogen peroxide 2) amino acids withdrawal and, 3) glucose withdrawal. We find that acute stress leads to changes in eIF4F–mRNA interactions that are shared among each factor and across the stresses imposed."],"repository":["ENA"],"description_synonyms":["Saccharomyces oviformis, Initiation Factor-4F, EIF4A, Eukaryotic Initiation Factor 4F, Yeast, P220, Peptide Initiation Factor EIF-4F, EIF4EL1, Protein Initiation Factor EIF-4F, ligand, CBP, BM-010., Eukaryotic Initiation Factor-(iso)4F, Saccharomyes cerevisiae, baker's yeast, EIF4GI, Saccharomyces uvarum var. melibiosus, EIF4F, EIF4G, AUTS19, EIF-4G1, Saccharomyces italicus, Saccaromyces cerevisiae, EIF-(iso)4F, Peptide Initiation Factor EIF 4F, Sccharomyces cerevisiae, EIF4F Translation Initiation Complex, Candida robusta, Saccharomyces capensis, yeast, PARK18, Protein Initiation Factor EIF 4F, EIF 4F, eIF4A-II, DDX2B, brewer's yeast, eIF-4A-II, lager beer yeast, EIF4E1, Eukaryotic, EIF-4F"],"name_synonyms":["Saccharomyces oviformis, Initiation Factor-4F, EIF4A, Eukaryotic Initiation Factor 4F, Yeast, P220, Peptide Initiation Factor EIF-4F, EIF4EL1, Protein Initiation Factor EIF-4F, ligand, CBP, BM-010., Eukaryotic Initiation Factor-(iso)4F, Saccharomyes cerevisiae, baker's yeast, EIF4GI, Saccharomyces uvarum var. melibiosus, EIF4F, EIF4G, AUTS19, EIF-4G1, Saccharomyces italicus, Saccaromyces cerevisiae, EIF-(iso)4F, Peptide Initiation Factor EIF 4F, Sccharomyces cerevisiae, EIF4F Translation Initiation Complex, Candida robusta, Saccharomyces capensis, yeast, PARK18, Protein Initiation Factor EIF 4F, EIF 4F, eIF4A-II, DDX2B, brewer's yeast, eIF-4A-II, lager beer yeast, EIF4E1, Eukaryotic, EIF-4F"],"additional_accession":[]},"is_claimable":false,"name":"Effect of stress on the binding affinity of yeast eIF4F components to their target RNAs","description":"Effect of stress on the binding affinity of yeast eIF4F components to their target RNAs","dates":{"last_updated":"2017-07-21","first_public":"2017-10-11"},"accession":"PRJEB21889","cross_references":{}}