ENAapplication/xmlftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR218/000/ERR2188110/ERR2188110.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR218/007/ERR2188087/ERR2188087.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR218/003/ERR2188093/ERR2188093.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR218/001/ERR2188101/ERR2188101.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR218/006/ERR2188096/ERR2188096.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR218/004/ERR2188104/ERR2188104.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR218/000/ERR2188090/ERR2188090.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR218/005/ERR2188105/ERR2188105.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR218/007/ERR2188097/ERR2188097.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR218/008/ERR2188108/ERR2188108.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR218/001/ERR2188111/ERR2188111.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR218/006/ERR2188106/ERR2188106.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR218/008/ERR2188098/ERR2188098.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR218/002/ERR2188112/ERR2188112.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR218/004/ERR2188094/ERR2188094.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR218/002/ERR2188102/ERR2188102.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR218/009/ERR2188109/ERR2188109.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR218/008/ERR2188088/ERR2188088.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR218/001/ERR2188091/ERR2188091.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR218/009/ERR2188099/ERR2188099.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR218/007/ERR2188107/ERR2188107.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR218/002/ERR2188092/ERR2188092.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR218/009/ERR2188089/ERR2188089.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR218/000/ERR2188100/ERR2188100.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR218/003/ERR2188103/ERR2188103.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR218/005/ERR2188095/ERR2188095.fastq.gzprimaryOK200GenomicsETHZhttps://www.ebi.ac.uk/ena/browser/view/PRJEB23275Research in recent years focusing on brown adipose tissue functionality emphasizes an important role of this organ in energy homeostasis. Utilizing a transcriptome analysis of human brown and white adipose tissue, we identified an enrichment of the mevalonate pathway in BAT suggesting its importance in regulating BAT function. By inhibiting different intermediate steps of the mevalonate pathway, using pharmacological and genetic approaches in vitro and in vivo, we show that mevalonate pathway controls brown adipocyte functionality in mouse and men by providing geranylgeranyl pyrophosphate, the substrate for protein prenylation of small GTP-binding proteins. Taken together, our study demonstrates the importance of the mevalonate pathway for brown fat functionality in mouse and men.ENAPrenylation, Farnesylation, (+-)-mevalonate, Multiple endocrine neoplasms, DmelCG10120, Laboratory, multiple endocrine neoplasia syndrome, Geranylgeranylation, Mus domesticus, Multiple Endocrine Neoplasia, MDH, mouse, men syndromes, Mevalonic, Multiple endocrine neoplasia, ME, Protein Geranylgeranylation, House Mouse, Cell, familial endocrine, Pentanoic acid, Fat Cells, adipose cell, House, Mus, (RS)-mevalonate, Protein, Familial endocrine adenomatosis, Mus musculus domesticus, Mevalonate, 3, Protein Polyisoprenylation, adipocyte, MEN, Men, Me, multiple endocrine adenomatosis, Mice, mevalonic acid anion, Adipocyte, Acid, Mus musculus, 5-dihydroxy-3-methyl-, Swiss, mice, Swiss Mouse, Adenomatosis, mem, multiple endocrine neoplasia, House Mice, Swiss Mice, men, Boys, RS-mevalonate, racemic mevalonate, fat cell, domesticus, Laboratory Mice, C-terminal protein prenylation, Protein Isoprenylation, Endocrine neoplasia, men syndrome, PPP1R68, Protein Farnesylation., multiple, Fat Cell, Post-Translational Isoprenylation, C19orf17, Lipocytes, ELL1, Ell1, Cells, Lipocyte, anon-WO0118547.278, Multiple endocrine adenomatosis, lipocyte, Mouse, rac-mevalonate, house mouse, multiple endocrine neoplasia syndrome(s), Fat, Laboratory Mouse, Mdh-NADP, Polyisoprenylation, CG10120Prenylation, Farnesylation, (+-)-mevalonate, Multiple endocrine neoplasms, DmelCG10120, Laboratory, multiple endocrine neoplasia syndrome, Geranylgeranylation, Mus domesticus, Multiple Endocrine Neoplasia, MDH, mouse, men syndromes, Mevalonic, Multiple endocrine neoplasia, ME, Protein Geranylgeranylation, House Mouse, Cell, familial endocrine, Pentanoic acid, Fat Cells, adipose cell, House, Mus, (RS)-mevalonate, Protein, Familial endocrine adenomatosis, Mus musculus domesticus, Mevalonate, 3, Protein Polyisoprenylation, adipocyte, MEN, Men, Me, multiple endocrine adenomatosis, Mice, mevalonic acid anion, Adipocyte, Acid, Mus musculus, 5-dihydroxy-3-methyl-, Swiss, mice, Swiss Mouse, Adenomatosis, mem, multiple endocrine neoplasia, House Mice, Swiss Mice, men, Boys, RS-mevalonate, racemic mevalonate, fat cell, domesticus, Laboratory Mice, C-terminal protein prenylation, Protein Isoprenylation, Endocrine neoplasia, men syndrome, PPP1R68, Protein Farnesylation., multiple, Fat Cell, Post-Translational Isoprenylation, C19orf17, Lipocytes, ELL1, Ell1, Cells, Lipocyte, anon-WO0118547.278, Multiple endocrine adenomatosis, lipocyte, Mouse, rac-mevalonate, house mouse, multiple endocrine neoplasia syndrome(s), Fat, Laboratory Mouse, Mdh-NADP, Polyisoprenylation, CG10120falseInhibition of mevalonate pathway prevents adipocyte browning in mouse and men by affecting protein prenylationInhibition of mevalonate pathway prevents adipocyte browning in mouse and men by affecting protein prenylation2017-10-312018-10-31PRJEB23275