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For this, we study the evolution of both of these species during coinfection of a CF patient for 4.4 years using genome sequences of 9 B. multivorans and 11 B. cenocepacia. This co-infection spanned at least 3 years following initial infection by B. multivorans and ultimately ended in the patient’s death by cepacia syndrome. This study contributes to the understanding of shared and species-specific evolutionary patterns of B. cenocepacia and B. multivorans evolving in the same CF lung environment. The sequences are deposited herein. This work is the result of a collaboration between members of the research group of Isabel Sá-Correia: A. Amir Hassan and Sandra C. dos Santos at the Institute for Bioengineering and Biosciences (iBB), Instituto Superior Técnico, Universidade de Lisboa, Portugal, and Vaughn Cooper from the Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, USA. Original Research published in Front. Microbiol. - Evolutionary and Genomic Microbiology, Submitted on: 20 Jun 2020, Edited by: Jianying Gu Reviewed by: Joanna Goldberg, Jonathan J Dennis DOI: 10.3389/fmicb.2020.574626"],"tag":["xref:EuropePMC:PMC7545829"],"repository":["ENA"],"description_synonyms":["Cystic fibrosis NOS, pseudomonas aeruginosa, pulmo, susceptibility to chronic infection by, Meconium obstruction of intestine in mucoviscidosis, Mucoviscidosis, lung parenchyma, Infestations and Infections, Cystic fibrosis NOS (disorder), Pancreas Fibrocystic Diseases, Client, CF - Cystic fibrosis, cystic fibrosis with pulmonary manifestations, CYSTIC FIBROS W/O ILEUS, Infection, lung, cystic fibrosis with other manifestations (disorder), cystic fibrosis lung disease, Pancreatic, Fibrosis, modifier of, neoplasm, Meconium ileus in cystic fibrosis (disorder), neoplasms, Pulmonary, in cystic fibrosis, Cystic fibrosis (disorder), Pancreatic Cystic Fibrosis, cystic fibrosis with meconium ileus, Cystic Fibrosis of Pancreas, cystic fibrosis with other manifestations, Cystic fibrosis without mention of meconium ileus, Infection and Infestation, cystic fibrosis with combined manifestations, cystic fibrosis, patient, cystic fibrosis with meconium ileus (disorder), clinical infection, cystic fibrosis with gastrointestinal manifestations, Fibrocystic Disease of Pancreas, parenchyma of lung., Fibrocystic disease, Cystic, Infestation and Infection, CF, Cystic Fibrosis, Burkholderia cepacia genomovar II, Patient, pulmonary, mucoviscidosis, Clients, Pancreas Fibrocystic Disease, Chronic, Pulmonary Cystic Fibrosis, Lungs, Infections and Infestations, cystic fibrosis with pulmonary manifestations (disorder), Burkholderia cepacia genomovar III"],"name_synonyms":["lung, parenchyma of lung., lung parenchyma, Lungs, species, pulmo, pulmonary, neoplasm, neoplasms"],"additional_accession":[]},"is_claimable":false,"name":"Burkholderia cepacia complex species co-evolution in CF lung","description":"Comparative evolutionary patterns of Burkholderia cenocepacia and Burkholderia multivorans during chronic co-infection of a cystic fibrosis patient lung","dates":{"last_updated":"2020-09-01","first_public":"2020-09-01"},"accession":"PRJEB35836","cross_references":{}}