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OF HELSINKIhttps://www.ebi.ac.uk/ena/browser/view/PRJEB38491Narcolepsy type 1 (N1) is an orphan disorder characterized by excessive daytime sleepiness, cataplexy, hallucinations, sleep paralysis and disturbed nighttime sleep. In order to identify a possible relation between Narcolepsy type 1 and Gut Microbiota, investigation motivated by a growing body of evidence supporting the complex interactions between the gut microbiota and the central nervous system, we sequenced the V3-V4 regions of the 16S rRNA gene of DNA extracted from stool samples to determine gut microbiota composition of 35 narcoleptic patients and 41 controls. We have investigated alpha, beta diversity, differential abundance and Predicted functional metagenomic potential.ENAMGC130048, digestive canal, Microbial Community Composition, Narcolepsy-Cataplexy Syndromes, Community Composition, Narcolepsy-Cataplexy Syndrome, narcolepsy, Narcoleptic Syndrome, Bowel, narcolepsy cataplexy, Narcolepsy NOS, SGCG_HUMAN, 35 kDa dystrophin-associated glycoprotein, Paroxysmal, narcolepsy-cataplexy syndrome, Gelineau Syndrome, SG-gamma, A4, Microbial, TYPE, SGCG, narcolepsy cataplexy syndrome, Human, DAGA4, Narcoleptic Syndromes, gut tube, Gus, Gur, Gelineaus Syndrome, Gut, Gelineau, Narcolepsy (disorder), 35DAG, sarcoglycan, narcolepsy-cataplexy, LGMD2C., Paroxysmal Sleep, MAM, gamma-SG, SCG3, Microbial Communities, Microbiome, gamma sarcoglycan, AI747421, gut, Microbiomes, DMDA1, Microbial Community Compositions, Microbial Community, Microbial Community Structure, Gus-u, alimentary tract, Community Structure, Gelineau's Syndrome, Gus-t, Gus-s, Gus-r, syndrome, Gelineau's Syndromes, gamma (35kDa dystrophin-associated glycoprotein), Narcolepsy Cataplexy Syndrome, Composition, DMDA, g, Syndromes, gastrointestinal system, 35kD dystrophin-associated glycoprotein, Narcolepsy-Cataplexy, heterogeneity, Syndrome, SCARMD2, Gelineau's, Microbial Community Structures, Narcoleptic, gamma-sarcoglycan, Microbiotas, asd, Sleep, adult alimentary canal, alimentary system, without cataplexy, intestines, Human Microbiomes, Community, Human MicrobiomeMGC130048, digestive canal, Microbial Community Composition, Narcolepsy-Cataplexy Syndromes, Community Composition, Narcolepsy-Cataplexy Syndrome, narcolepsy, Narcoleptic Syndrome, Bowel, narcolepsy cataplexy, Narcolepsy NOS, SGCG_HUMAN, 35 kDa dystrophin-associated glycoprotein, Paroxysmal, narcolepsy-cataplexy syndrome, Gelineau Syndrome, SG-gamma, A4, Microbial, TYPE, SGCG, narcolepsy cataplexy syndrome, Human, DAGA4, Narcoleptic Syndromes, gut tube, Gus, Gur, Gelineaus Syndrome, Gut, Gelineau, Narcolepsy (disorder), 35DAG, sarcoglycan, narcolepsy-cataplexy, LGMD2C., Paroxysmal Sleep, MAM, gamma-SG, SCG3, Microbial Communities, Microbiome, gamma sarcoglycan, AI747421, gut, Microbiomes, DMDA1, Microbial Community Compositions, Microbial Community, Microbial Community Structure, Gus-u, alimentary tract, Community Structure, Gelineau's Syndrome, Gus-t, Gus-s, Gus-r, syndrome, Gelineau's Syndromes, gamma (35kDa dystrophin-associated glycoprotein), Narcolepsy Cataplexy Syndrome, Composition, DMDA, g, Syndromes, gastrointestinal system, 35kD dystrophin-associated glycoprotein, Narcolepsy-Cataplexy, heterogeneity, Syndrome, SCARMD2, Gelineau's, Microbial Community Structures, Narcoleptic, gamma-sarcoglycan, Microbiotas, asd, Sleep, adult alimentary canal, alimentary system, without cataplexy, intestines, Human Microbiomes, Community, Human MicrobiomefalseGut microbiota heterogeneity is associated with Narcolepsy type 1Gut microbiota heterogeneity is associated with Narcolepsy type 12020-05-262020-11-30PRJEB38491