{"database":"ENA","file_versions":[],"scores":null,"additional":{"omics_type":["Genomics"],"center_name":["NEWCASTLE UNIVERSITY, UK"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJEB39670"],"tag":["xref:EuropePMC:PMC8883198","xref:PubMed:35243393","xref:PubMed:36480295"],"long_description":["Background: AnTIC trial data showed continuous low-dose antibiotic prophylaxis to be effective in reducing symptomatic urinary tract infections (UTIs) compared to no treatment, in clean intermittent self-catheterisation (CISC) users. Antibiotic prophylaxis was however associated with increased antibiotic resistance. The mechanisms by which prophylaxis benefitted such patients are not known. Prophylactic treatments involving β-lactam based antibiotics and nitrofurantoin appeared to select against E. coli. However, 17 patients were characterised by uro-associated E.coli that acquired multi drug resistance (MDR) during the trial. Sequencing of these E. coli isolates, associated with bacterial loads (>104 CFU/ml), showed patients prescribed prophylactic antibiotics tended to harbour one E. coli strain while patients in the non-prophylactic study arm were colonised by >1 E. coli strain. Interpretation: These findings suggest that continuous low-dose antibiotic treatments in some CISC patients selected for MDR bacteria, which resulted in a stable personalised uromicrobiota and a lower rate of symptomatic UTIs."],"repository":["ENA"],"additional_accession":[]},"is_claimable":false,"name":"AnTIC_Ecoli","description":"AnTIC: Uro-associated E. coli Genome Analysis","dates":{"last_updated":"2025-01-27","first_public":"2021-01-05"},"accession":"PRJEB39670","cross_references":{"PubMed":["36480295","35243393"]}}