{"database":"ENA","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Fastqsanger.gz":["ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/000/ERR6575610/ERR6575610_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/002/ERR6575622/ERR6575622_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/003/ERR6575603/ERR6575603_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/002/ERR6575592/ERR6575592_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/005/ERR6575585/ERR6575585_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/008/ERR6575618/ERR6575618_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/004/ERR6575624/ERR6575624_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/005/ERR6575605/ERR6575605_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/007/ERR6575617/ERR6575617_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/007/ERR6575587/ERR6575587_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/001/ERR6575581/ERR6575581_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/001/ERR6575631/ERR6575631_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/005/ERR6575595/ERR6575595_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/003/ERR6575583/ERR6575583_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/002/ERR6575612/ERR6575612_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/000/ERR6575600/ERR6575600_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/009/ERR6575609/ERR6575609_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/001/ERR6575591/ERR6575591_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/007/ERR6575627/ERR6575627_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/005/ERR6575615/ERR6575615_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/008/ERR6575628/ERR6575628_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/008/ERR6575608/ERR6575608_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/006/ERR6575596/ERR6575596_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/000/ERR6575630/ERR6575630_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/009/ERR6575589/ERR6575589_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/003/ERR6575593/ERR6575593_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/004/ERR6575604/ERR6575604_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/008/ERR6575588/ERR6575588_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/003/ERR6575623/ERR6575623_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/009/ERR6575629/ERR6575629_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/005/ERR6575625/ERR6575625_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/004/ERR6575584/ERR6575584_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/006/ERR6575606/ERR6575606_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/009/ERR6575619/ERR6575619_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/000/ERR6575600/ERR6575600_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/001/ERR6575621/ERR6575621_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/006/ERR6575616/ERR6575616_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/008/ERR6575598/ERR6575598_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/003/ERR6575613/ERR6575613_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/003/ERR6575603/ERR6575603_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/004/ERR6575584/ERR6575584_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/004/ERR6575594/ERR6575594_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/006/ERR6575616/ERR6575616_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/006/ERR6575626/ERR6575626_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/007/ERR6575597/ERR6575597_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/009/ERR6575629/ERR6575629_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/002/ERR6575612/ERR6575612_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/007/ERR6575607/ERR6575607_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/001/ERR6575631/ERR6575631_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/000/ERR6575590/ERR6575590_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/005/ERR6575605/ERR6575605_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/000/ERR6575620/ERR6575620_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/004/ERR6575594/ERR6575594_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/007/ERR6575587/ERR6575587_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/009/ERR6575609/ERR6575609_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/001/ERR6575601/ERR6575601_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/000/ERR6575590/ERR6575590_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/008/ERR6575598/ERR6575598_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/006/ERR6575626/ERR6575626_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/007/ERR6575607/ERR6575607_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/003/ERR6575583/ERR6575583_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/005/ERR6575615/ERR6575615_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/002/ERR6575622/ERR6575622_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/005/ERR6575585/ERR6575585_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/007/ERR6575597/ERR6575597_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/008/ERR6575588/ERR6575588_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/004/ERR6575614/ERR6575614_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/000/ERR6575610/ERR6575610_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/002/ERR6575602/ERR6575602_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/001/ERR6575581/ERR6575581_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/003/ERR6575593/ERR6575593_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/009/ERR6575619/ERR6575619_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/007/ERR6575617/ERR6575617_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/005/ERR6575625/ERR6575625_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/003/ERR6575613/ERR6575613_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/001/ERR6575621/ERR6575621_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/006/ERR6575606/ERR6575606_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/001/ERR6575611/ERR6575611_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/006/ERR6575586/ERR6575586_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/007/ERR6575627/ERR6575627_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/002/ERR6575602/ERR6575602_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/009/ERR6575599/ERR6575599_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/001/ERR6575591/ERR6575591_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/002/ERR6575582/ERR6575582_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/003/ERR6575623/ERR6575623_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/008/ERR6575618/ERR6575618_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/004/ERR6575604/ERR6575604_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/001/ERR6575601/ERR6575601_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/006/ERR6575586/ERR6575586_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/009/ERR6575599/ERR6575599_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/000/ERR6575620/ERR6575620_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/006/ERR6575596/ERR6575596_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/009/ERR6575589/ERR6575589_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/002/ERR6575582/ERR6575582_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/000/ERR6575630/ERR6575630_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/001/ERR6575611/ERR6575611_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/008/ERR6575608/ERR6575608_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/008/ERR6575628/ERR6575628_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/002/ERR6575592/ERR6575592_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/004/ERR6575624/ERR6575624_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/004/ERR6575614/ERR6575614_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR657/005/ERR6575595/ERR6575595_2.fastq.gz"]},"type":"primary"},"statusCodeValue":200,"statusCode":"OK"}],"scores":null,"additional":{"omics_type":["Genomics"],"center_name":["UNIVERSITY OF STIRLING"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJEB47196"],"long_description":["Antibiotics play a vital role in aquaculture where they are commonly used to treat bacterial dis-eases. However, the impact of antibiotic treatment on the gut microbiome and development of an-timicrobial resistance in Nile tilapia (Oreochromis niloticus) over time, remains to be fully under-stood. In this study, fish were fed a single treatment of oxytetracycline (100 mg kg bodyweight-1) for eight days, followed by a 14-day withdrawal period. Changes in the distal gut microbiome were measured using 16S rRNA sequencing. In addition, the abundance of antimicrobial re-sistance genes was quantified using real-time qPCR methods. Overall, the gut microbiome com-munity diversity and structure of Nile tilapia was resilient to oxytetracycline treatment. Howev-er, antibiotic treatment was associated with an enrichment in Plesiomonas, accompanied by a de-cline in other bacteria taxa. Oxytetracycline treatment increased the proportion of tetA in the dis-tal gut of fish and tank biofilms in the OTC-group. Furthermore, the abundance of tetA along with other tetracycline resistance genes was strongly correlated with a number of microbiome mem-bers, including Plesiomonas. Findings from this study demonstrate that antibiotic treatment can exert selective pressures on the gut microbiome of fish, in favour of resistant populations which may have long-term impacts on fish health."],"repository":["ENA"],"additional_accession":[]},"is_claimable":false,"name":"The impact of oxytetracycline on the gut microbiome and antimicrobial resistance in Nile tilapia","description":"Investigating the effect of an oxytetracycline treatment on the gut microbiome and antimicrobial resistance gene dynamics in Nile tilapia (Oreochromis niloticus)","dates":{"last_updated":"2022-01-05","first_public":"2022-01-05"},"accession":"PRJEB47196","cross_references":{}}