{"database":"ENA","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Fastqsanger.gz":["ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR120/019/ERR12072619/ERR12072619_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR120/043/ERR12072643/ERR12072643_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR120/019/ERR12072619/ERR12072619_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR120/043/ERR12072643/ERR12072643_2.fastq.gz"]},"type":"primary"},"statusCodeValue":200,"statusCode":"OK"}],"scores":null,"additional":{"omics_type":["Genomics"],"center_name":["LIVUNI","University of Cambridge"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJEB50307"],"long_description":["Antagonistic bacterial interactions often rely on antimicrobial bacteriocins, which attack only a narrow range of target bacteria. However, rapidly changing microbiomes may promote antimicrobials with broader activity. We report here a new type of antimicrobial, epifadin, produced by nasal Staphylococcus epidermidis. It encompasses two non-ribosomally synthesized peptide moieties and a polyketide linker in an unprecedented architecture. Epifadin combines a wide antimicrobial target spectrum with an extraordinarily short life span. It is surprisingly unstable under in vivo-like, ambient conditions, presumably as a means to limit collateral damage of mutualistic interactions by epifadin-producing S. epidermidis cells. However, Staphylococcus aureus is effectively eliminated by epifadin-producing S. epidermidis during co-cultivation in vitro and in vivo indicating that epifadin-producing commensals could help to prevent nasal S. aureus carriage. Our study describes a new microbiome-derived antimicrobial class and suggests that limiting the half-life of an antimicrobial may help to balance its beneficial and detrimental activities against other bacteria."],"repository":["ENA"],"additional_accession":[]},"is_claimable":false,"name":"Staphylococcus competition","description":"Novel short-lived, broadly acting peptide-polyene bacteriocin from nasal microbiome shapes bacterial communities and eliminates Staphylococcus aureus","dates":{"last_updated":"2023-09-21","first_public":"2022-09-26"},"accession":"PRJEB50307","cross_references":{}}