ENAapplication/xmlftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR987/001/ERR9874011/ERR9874011.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR987/003/ERR9874013/ERR9874013.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR987/008/ERR9874018/ERR9874018.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR987/009/ERR9874019/ERR9874019.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR987/001/ERR9874021/ERR9874021.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR987/004/ERR9874014/ERR9874014.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR987/006/ERR9874016/ERR9874016.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR987/000/ERR9874020/ERR9874020.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR987/007/ERR9874017/ERR9874017.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR987/005/ERR9874015/ERR9874015.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR987/002/ERR9874012/ERR9874012.fastq.gzprimaryOK200GenomicsEuropean Bioinformatics InstituteThe Inne ear and Olfaction laboratory, Department of Clinical Neurosciences, Medical Faculty, University of Genevahttps://www.ebi.ac.uk/ena/browser/view/PRJEB53826ArrayExpressWe have previously identified and characterized the phoenix auditory neuroprogenitors (ANPGs) as highly proliferative progenitor cells isolated from the A/J mouse cochlea. In the present study, we aimed at identifying signaling pathways responsible for the intrinsic high stemness of phoenix ANPGs. A transcriptomic comparison of traditionally low stemness ANPGs, isolated from C57Bl/6 and A/J mice at early passages, and high stemness phoenix ANPGs was performed.ENAfalseWNT activation and TGFβ-smad inhibition potentiate stemness of mammalian auditory neuroprogenitors for high throughput generation of functional auditory neurons in vitroWNT activation and TGFβ-smad inhibition potentiate stemness of mammalian auditory neuroprogenitors for high throughput generation of functional auditory neurons in vitro2022-08-312022-08-31PRJEB53826