ENAapplication/xmlftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR135/001/ERR13511401/ERR13511401_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR135/036/ERR13580136/ERR13580136_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR135/006/ERR13511406/ERR13511406.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR135/008/ERR13511408/ERR13511408_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR135/003/ERR13511403/ERR13511403_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR135/097/ERR13511397/ERR13511397_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR135/038/ERR13580138/ERR13580138_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR135/000/ERR13511400/ERR13511400_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR135/005/ERR13511405/ERR13511405.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR135/002/ERR13511402/ERR13511402_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR135/039/ERR13580139/ERR13580139_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR135/007/ERR13511407/ERR13511407.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR135/099/ERR13511399/ERR13511399_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR135/001/ERR13511401/ERR13511401_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR135/005/ERR13511405/ERR13511405_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR135/004/ERR13511404/ERR13511404_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR135/008/ERR13511408/ERR13511408_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR135/007/ERR13511407/ERR13511407_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR135/003/ERR13511403/ERR13511403_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR135/038/ERR13580138/ERR13580138_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR135/098/ERR13511398/ERR13511398_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR135/006/ERR13511406/ERR13511406_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR135/007/ERR13511407/ERR13511407_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR135/008/ERR13511408/ERR13511408.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR135/040/ERR13580140/ERR13580140_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR135/037/ERR13580137/ERR13580137_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR135/002/ERR13511402/ERR13511402_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR135/099/ERR13511399/ERR13511399_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR135/005/ERR13511405/ERR13511405_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR135/037/ERR13580137/ERR13580137_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR135/004/ERR13511404/ERR13511404_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR135/006/ERR13511406/ERR13511406_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR135/000/ERR13511400/ERR13511400_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR135/036/ERR13580136/ERR13580136_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR135/040/ERR13580140/ERR13580140_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR135/039/ERR13580139/ERR13580139_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR135/097/ERR13511397/ERR13511397_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/ERR135/098/ERR13511398/ERR13511398_2.fastq.gzprimary200OKGenomicsIBENSInstitut des Sciences des Plantes - Paris-Saclay (France)https://www.ebi.ac.uk/ena/browser/view/PRJEB65878The mobilization of retrotransposons yields major-effect mutations. Here, we report an adaptive retrotransposon insertion within the first intron of the Arabidopsis floral-repressor locus FLOWERING LOCUS C (FLC). The insertion-mutation augments the environmental sensitivity of FLC by affecting the balance between coding and non-coding transcript isoforms in response to environmental threads. We show that this balance is modulated epigenetically by DNA methylation and orchestrated by IBM2, a factor involved in the processing of intronic heterochromatin. The stress-sensitive allele of FLC has recently spread across populations subjected to recurrent chemical weeding, and we demonstrate that retrotransposon-driven acceleration of life cycle represents a rapid response to herbicide. Our findings illustrate how retrotransposition can create environmentally-sensitive alleles that facilitate adaptation to anthropogenic disturbances of the environment.ENAfalseRetrotransposon-driven environmental regulation of FLCHerbicide response through retrotransposon-mediated environmentally-sensitive epigenetic regulation of FLC in Arabidopsis2023-10-312023-10-31PRJEB65878